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Comparison of Long-term Outcomes in Patients with Premature Triple-vessel Coronary Disease Undergoing Three Different Treatment Strategies： A Prospective Cohort Study

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Chinese Medical Journal 2018年第1期131卷 1-9页

作者： Jing-Jing Xu Yin Zhang Lin Jiang Jian Tian Lei Song Zhan Gao Xin-Xing Feng xue-yan zhao yan-yan zhao Dong Wang Kai Sun Lian-Jun Xu Ru Liu Run-Lin Gao Bo Xu Lei Song Jin-Qing Yuan Department of Cardiology Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Science and Peking Union Medical College Beijing 100037 China Department of Endocrinology Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Science and Peking Union Medical College Beijing 100037 China Medical Research and Biometrics Center Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Science and Peking Union Medical College Beijing 100037 China Department of State Key Laboratory of Cardiovascular Disease State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Science and Peking Union Medical College Beijing 100037 China Department of Hypertension Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Science and Peking Union Medical College Beijing 100037 China

Background： Patients with premature triple-vessel disease （PTVD） have a higher risk of recurrent coronary events and repeat revascularization： however, the long-term outcome of coronary artery bypass grafting （CABG）, percutaneous coronary intervention （PCI）, and medical therapy （MT） alone for PTVD patients is controversial. The aim of this study is to evaluate the long-term outcome of PTVD patients among these three treatment strategies, to find out the most appropriate treatment methods lbr these patients. Methods： One thousand seven hundred and ninety-two patients with PTVD （age： men 〈50 years and women _〈60 years） were enrolled between 2004 and 2011. The primary end point was all-cause death. The secondary end points were cardiac death, myocardial infarction, stroke, or repeat revascularization. Results： PCI, CABG, and MT alone were performed in 933 （52.1%）, 459 （25.6%）, and 400 （22.3%） patients. Both PCI and CABG were associated with lower all-cause death （4.6% vs. 4.1% vs. 15.5%, respectively, P 〈 0.01） and cardiac death （2.8% vs. 2.0% vs. 9.8%, respectively, P 〈 0.01 ） versus MT alone. The rate of repeat revascularization in the CABG group was significantly lower than those in the PCI and MT groups. After adjusting for baseline factors, PCI and CABG were still associated with similar lower risk of all-cause death and cardiac death versus MT alone （all-cause death： hazard ratio [HR]： 0.35, 95% confidence interval [CI]： 0.23-0.53, P 〈 0.01 and HR： 0.35, 95% CI： 0.18-0.70, P= 0.003, respectively, and cardiac death： HR： 0.32, 95% CI： 0.19-0.54, P〈 0.01 and HR： 0.36, 95% CI：0.14-0.93, P = 0.03, respectively）. Conclusions： PCI and CABG provided equal long-term benefits for all-cause death and cardiac death for PTVD patients. Patients undergoing MT alone had the worst long-term clinical outcomes.

关键词： Coronary Artery Bypass Grafting Medical Therapy: Percutaneous Coronary Intervention: Premature Coronary Heart Disease Triple-vessel Coronary Disease

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Risk Factors of Contrast-induced Acute Kidney Injury in Patients Undergoing Emergency Percutaneous Coronary Intervention

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Chinese Medical Journal 2017年第1期130卷 45-50页

作者： Ying Yuan Hong Qiu Xiao-Ying Hu Tong Luo Xiao-Jin Gao xue-yan zhao Jun Zhang Yuan Wu Hong-Bing yan Shu-Bin Qiao Yue-Jin yang Run-Lin Gao Department of Cardiology Center for Coronary Heart Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China

Background： Previous studies of contrast-induced acute kidney injury （CI-AK1） were mostly based on selective percutaneous coronary intervention （PCI） cases, and risk factors of CI-AKI after emergency PCI are unclear. The aim of this study was to explore the risk factors of CI-AKi in a Chinese population undergoing emergency PCI. Methods： A total of 1061 consecutive patients undergoing emergency PCI during January 2013 and June 2015 were enrolled and divided into CI-AK1 and non-CI-AKl group. Univariable and multivariable analyses were used to identity the risk factors of CI-AKI in emergency PCI patients. CI-AKI was defined as an increase in serum creatinine ≥25% or ≥0.5 mg/dl （44.2 μmol/L） above baseline within 3 days alter exposure to contrast medium. Results： The incidence of C1-AKI in patients undergoing emergency PCI was 22.7% （241/1061）. Logistic multivariable analysis showed that body surface area （BSA）（odds ratio [OR] 0.213, 95% confidence interval [CI]： 0.075-0.607, P = 0.004）, history, of myocardial infarction （MI）（OR 1.642, 95% CI. 1.079-2.499, P- 0.021 ）, left ventricular ejection fraction （LVEF）（OR 0.969, 95% CI： 0.944-0.994, P = 0.015）, hemoglobin （Hb）（OR 0.988, 95% CI. 0.976-1.000, P 1.018 1.037, P 〈 0.001 ）, left anterior descending （LAD） stented （OR 1 0.009 0.987, P- 0.049）, and diuretics use （OR 1.850, 95% CI： 1.233-2 0.045）, estimated glomerular filtration rate （OR 1.027, 95% CI： 464, 95% CI： 1.000 2.145, P 0.050）, aspirin （OR 0.097, 95%CI： .777, P - 0.003） were independent predictors of CI-AKI in patients undergoing emergency PCI. Conclusion： History of MI, low BSA, LVEF and Hb level, LAD stented, and diuretics use are associated with increased risk of CI-AK1 in patients undergoing emergency PCI.

关键词： Contrast-induced Acute Kidney Injury Emergency Percutaneous Coronary Intervention Risk Factors

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Relationship between High Level of Estimated Glomerular Filtration Rate and Contrast-Induced Acute Kidney Injury in Patients who Underwent an Emergency Percutaneous Coronary Intervention

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Chinese Medical Journal 2018年第17期131卷 2041-2048页

作者： Ying Yuan Hong Qiu Xiao-Ying Hu Tong Luo Xiao-Jin Gao xue-yan zhao Jun Zhang Yuan Wu Shu-Bin Qiao Yue-Jin yang Run-Lin Gao Coronary Heart Disease Center Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China

Background： Mounts of studies have shown that low estimated glomerular filtration rate （eGFR） is associated with increased risk of adverse outcomes in patients with coronary artery disease. However, high level of eGFR was less reported. In the study, we aimed to explore the relationship between the baseline eGFR, especially the high level, and contrast-induced acute kidney injury （CI-AKI） in a Chinese population who underwent an emergency percutaneous coronary intervention （PCI）. Methods： Patients who underwent an emergency PCI from 2013 to 2015 were enrolled and divided into five groups as eGFR decreasing. Baseline characteristics were collected and analyzed. The rates of CI-AKI and the composite endpoint （including nonfatal myocardial infarction, revascularization, stroke, and all-cause death） at 6- and 12-month follow-up were compared. Logistic analysis for CI-AKI was ***： A total of 1061 patients were included and the overall CI-AKI rate was 22.7% （241 / 1061）. The separate rates were 77.8% （7/9） in Group 1 （eGFR 〉 120 ml·min^-1 -1.73 m^-2）, 26.0% （118/454） in Group 2 （120 ml·min^-1·min^-11.73 m^-2〉 eGFR≥90 ml·min^-1 1.73^-2）, 18.3% （86/469） in Group 3 （90 ml·min^-1 1.73 m^-2〉 eGFR 〉60 ml·min^-1·min^-11.73 m^-2）, 21.8% （26/119） in Group 4 （60 ml·min^-1·1.73 m^-2〉 eGFR≥30 ml·min^-1·min^-11.73 m^-2）, and 40.0% （4/10） in Group 5 （eGFR 〈30 ml·min^-1·min^-1·min^-11.73 m^-2）, with statistical significance （χ^2 = 25.19, P 〈 0.001）. The rates of CI-AKI in five groups were 77.8%, 26.0%, 18.3%, 21.8%, and 40.0%, respectively, showing a U-typed curve as eGFR decreasing （the higher the level of eGFR, the higher the CI-AKI occurrence in case ofeGFR_〉60 ml·min^-1·1.73 m^-2）. The composite endpoint rates in five groups were 0, 0.9%, 2.1%, 6.7%, and 0 at 6-month follow-up, respectively, and 0, 3.3%, 3.4%, 16.0%, and 30.0% at 12-month follow-up, respectively, both with significant differences （χ^2 = 16.26, P = 0.009 at 6-month follow-up, and χ^2 = 49.05, P 〈 0.001

关键词： Contrast-Induced Acute Kidney Injury Emergency Percutaneous Coronary Intervention Estimated Glomerular Filtration Rate

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Synthesis and Crystal Structure of Trimethylsilyl Cyanohydrin Ether of 1,1 ’-Bis（p-methoxybenzoyl）ferrocene

Synthesis and Crystal Structure of Trimethylsilyl Cyanohydri...

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中国化学会第四届有机化学学术会议

作者： BIAN, Zhan-Xi WANG, yan-xue zhao, Hai-Ying (College of Chemistry and Chemical Engineering, Inner Mongolia University, Huhhot 010021)

＜正＞The development of practical technology for the preparation of cyanohydrins, α,β-unsaturated nitriles and β-aminoalcohols from readily available carbonyl compounds is an important area in organic chemistry. One straightforward method for synthesizing such compounds makes use of cyanohydrin trimethylsilyl ethers, which are generally prepared by the addition of trimethylsilyl cyanide （TMSCN） to carbonyl compounds in the presence of catalysts commonly used in asymmetry synthesis.

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Impact of Residual SYNTAX Score and Its Derived Indexes on Clinical Outcomes after Percutaneous Coronary Intervention：Data from a Large Single Center

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Chinese Medical Journal 2018年第12期131卷 1390-1396页

作者： Ying Song Zhan Gao Xiao-Fang Tang Ping Jiang Jing-Jing Xu Yi Yao Jian-Xin Li xue-yan zhao Shu-Bin Qiao Yue-Jin yang Run-Lin Gao Bo Xu Jin-Qing Yuan Department of Cardiology State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing100037 China

Background： Residual SYNTAX score （rSS） and its derived indexes including SYNTAX revascularization index （SRI） and clinical rSS had been developed to quantify and describe the extent of incomplete revascularization. This study was conducted to explore the utility of the three scores among real-world patients alter percutaneous coronary intervention （PCI）. Methods： From January 2013 to December 2013, patients underwent PCI treatment at Fuwai Hospital were included. Tile primary endpoints were all-cause death and major adverse cardiovascular and cerebrovascular events. The secondary endpoints were myocardial infarction, revascularization, stroke, and stent thrombosis. Kaptan-Meier methodology was used to determine the outcomes. Cox multivariable regression was to test the associations between scores and all-cause mortality. Results： A total of 10,344 patients were finally analyzed in this study. Kaplan-Meier survival analysis indicated that greater residual coronary lesions quantified by rSS and its derived indexes were associated with increased risk of adverse cardiovascular events. However, atier multivariate analysis, only clinical rSS was an independent predictor of 2-year all-cause death （hazard ratio： 1.02, 95% confidence interval： 1.01-1.03, P 〈 0.01）. By receiver operating characteristic （ROC） curve analysis, clinical rSS had superior predictability of 2-year all-cause death than rSS and SRI （area under ROC curve [AUC]： 0.50 vs. 0.56 vs. 0.56, all P 〈 0.01 ）, whereas rSS was superior in predicting repeat revascularization than clinical rSS and SRI （AUC： 0.62 vs. 0.61 vs. 0.61： all P 〈 0.01）. When comparing the predictive capability of rSS 〉8 with SRI 〈70%, their predictabilities were not significantly different.

关键词： Clinical Outcome: Percutaneous Coronary Intervention: Risk Assessment Risk Stratification

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The complex roles of m^(6)A modifications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative diseases

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Neural Regeneration Research 2025年第6期20卷 1582-1598页

作者： yanxi Li Jing xue Yuejia Ma Ke Ye xue zhao Fangliang Ge Feifei Zheng Lulu Liu Xu Gao Dayong Wang Qing Xia Department of Biochemistry and Molecular Biology College of Basic Medical SciencesHarbin Medical UniversityHarbinHeilongjiang ProvinceChina College of Basic Medical Sciences Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Basic Medical Institute Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Key Laboratory of Heilongjiang Province for Genetically Modified Animals Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Translational Medicine Research and Cooperation Center of Northern China Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

N6-methyladenosine(m^(6)A), the most prevalent and conserved RNA modification in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis and neural regeneration, where it is highly concentrated and actively involved in these processes. Changes in m^(6)A modification levels and the expression levels of related enzymatic proteins can lead to neurological dysfunction and contribute to the development of neurological diseases. Furthermore, the proliferation and differentiation of neural stem cells, as well as nerve regeneration, are intimately linked to memory function and neurodegenerative diseases. This paper presents a comprehensive review of the roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, as well as its implications in memory and neurodegenerative diseases. m^(6)A has demonstrated divergent effects on the proliferation and differentiation of neural stem cells. These observed contradictions may arise from the time-specific nature of m^(6)A and its differential impact on neural stem cells across various stages of development. Similarly, the diverse effects of m^(6)A on distinct types of memory could be attributed to the involvement of specific brain regions in memory formation and recall. Inconsistencies in m^(6)A levels across different models of neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease, suggest that these disparities are linked to variations in the affected brain regions. Notably, the opposing changes in m^(6)A levels observed in Parkinson's disease models exposed to manganese compared to normal Parkinson's disease models further underscore the complexity of m^(6)A's role in neurodegenerative processes. The roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, and its implications in memory and neurodegenerative diseases, appear contradictory. These inconsistencies may be a

关键词： Alzheimer's disease cell self-renewal central nervous system memory microglia nerve regeneration neurodegenerative diseases neurogenesis RNA methylation

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重庆渝利线市郊列车通勤化开行方案

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交通运输工程与信息学报 2017年第3期15卷 35-40页

作者：薛锋周焱赵蕾西南交通大学交通运输与物流学院成都610031 西南交通大学综合交通运输智能化国家地方联合工程实验室成都610031 上海铁路局杭州站杭州310009

重庆具有典型的组团特征,利用既有铁路开行市郊列车能够有效缓解重庆主城区的交通压力。从开行数量、开行时段、停站情况三个方面分析了渝利线市郊列车的开行现状,给出了全日站间客流表及客流密度,以确定市郊列车的开行区段及数量。在... 详细信息

重庆具有典型的组团特征,利用既有铁路开行市郊列车能够有效缓解重庆主城区的交通压力。从开行数量、开行时段、停站情况三个方面分析了渝利线市郊列车的开行现状,给出了全日站间客流表及客流密度,以确定市郊列车的开行区段及数量。在现有列车开行方案基础上,根据渝利铁路沿线市郊客流的需求进行了改进,即在6:00~21:30,分别开行3.5对"重庆北—涪陵北"区段、7对"重庆北—石柱县"区段的站站停市郊列车,并在早晚高峰时段,增加市郊列车开行频率。相对于现有列车开行方案,改进的方案方便乘客记忆,且能够保证乘客出行的便利性。

关键词：渝利线市郊列车通勤开行方案客流分析

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Validation of Predictive Value of Patterns of Nonadherence to Antiplatelet Regimen in Stented Patients Thrombotic Risk Score in Chinese Population Undergoing Percutaneous Coronary Intervention:A Prospective Observational Study

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Chinese Medical Journal 2018年第22期131卷 2699-2704页

作者： xue-yan zhao Jian-Xin Li Xiao-Fang Tang Jing-Jing Xu Ying Song Lin Jiang Jue Chen Lei Song Li-Jian Gao Zhan Gao Shu-Bin Qiao Yue-Jin yang Run-Lin Gao Ro Xu Jin-Qing Yuan Coronary Heart Disease Center State Key Laboratory of Cardiovascular DiseaseFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China Department of Epidemiology State Key Laboratory of Cardiovascular DiseaseFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China

Background: The patterns of nonadherence to antiplatelet regimen in stented patients(PARIS) thrombotic risk score are a novel score for predicting the risk of coronary thrombotic events(CTEs) after percutaneous coronary intervention(PCI) with drug?eluting ***, the prognostic value of this score has not been fully evaluated in non?Euro?American PCI ***: We performed a prospective, observational study of 10,724 patients who underwent PCI in Fuwai hospital, China and evaluated the PARIS thrombotic risk score’s predictive value of CTEs in the PCI population. The area under the receiver operating characteristic curve(AUROC) was used to assess the predictive value of the PARIS score for ***: Among 9782 patients without in?hospital events, a total of 95 CTEs occurred during the 2?year follow?up. The PARIS score was significantly higher in patients with CTEs(3.38 ± 2.04) compared with patients without events(2.53 ± 1.70, P < 0.001).According to the risk stratification of the PARIS thrombotic score, the risk of CTEs in the high?risk group was 3.14 times higher than that in the low?risk group(hazard ratio [HR], 3.14; 95% confidence interval [CI], 1.92–5.13; P < 0.001). However, the risk of CTEs in the intermediate?risk and low?risk groups was not significant(HR, 1.39; 95% CI, [0.86–2.24]; P = 0.184). The PARIS score showed prognostic value in evaluating CTEs in the overall population(AUROC, 0.621; 95% CI, 0.561–0.681), the acute coronary syndrome(ACS) population(AUROC, 0.617; 95% CI, 0.534–0.700; P = 0.003), and the non?ACS population(AUROC, 0.647; 95%CI, 0.558–0.736; P = 0.001).Conclusions: In a real?world Chinese population, the PARIS thrombotic risk score shows a modest prognostic value for CTEs in patients after PCI. This score also has a predictive value for CTEs in the ACS and non?ACS subgroup populations.

关键词： Coronary Thrombosis Percutaneous Coronary Intervention Prognosis Risk Assessment

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Evaluation of the Patterns of Non-Adherence to Anti-Platelet Regimens in Stented Patients Bleeding Score for Predicting the Long-term Out-of-hospital Bleeding Risk in Chinese Patients after Percutaneous Coronary Intervention

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Chinese Medical Journal 2018年第12期131卷 1406-1411页

作者： xue-yan zhao Jian-Xin Li Xiao-Fang Tang Jing-Jing Xu Ying Song Lin Jiang Jue Chen Lei Song Li-Jian Gao Zhan Gao Shu-Bin Qiao Yue-Jin yang Run-Lin Gao Bo Xu Jin-Qing Yuan Department of Cardiology State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China Department of Epidemiology State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China

Background： The Patterns of Non-Adherence to Anti-Platelet Regimens in Stented Patients （PARIS） bleeding score is a novel score for predicting the out-of-hospital bleeding risk after percutaneous coronary intervention （PCI）. However, whether this score has the same value in non-European and American populations is unclear. This study aimed to assess the PARIS bleeding score＇s predictive value of bleeding in patients alter PCI in the Chinese population. Methods： We perforined a prospective, observational study of 10,724 patients who underwent PCI from January to December 2013, in Fuwai Hospital, China. We defined the primary end point as major bleeding （MB） according to Bleeding Academic Research Consortium definition criteria including Type 2, 3, or 5. The predictive value of the PARIS bleeding score was assessed with the area under the receiver operating characteristic （AUROC） curve. Results： Of 9782 patients, 245 （2.50%） MB events occurred during the 2 years of follow-up. The PAP, IS bleeding score was significantly higher in the MB group than that of non-MB group （4.00 [3.00, 5.00] vs. 3.00 [2.00, 5.00], Z=3.71, P 〈 0.001 ）. According to risk stratification of the PARIS bleeding score, the bleeding risk in the intermediate- and high-risk groups was 1.50 times （hazard ratio [HR]： 1.50; 95% confidence interval [CI]： 1.160-1.950; P=0.002） and 2.27 times higher （HR： 2.27; 95% CI： 1,320-3.900： P=0.003） than that in the low-risk group. The PARIS bleeding score showed a moderate predictive value for MB in the overall population （AUROC： 0.568, 95% CI： 0.532-0.605; P 〈 0.001 ） and acute coronary syndrome （ACS） subgroup （AUROC： 0.578, 95% CI： 0.530-0.626; P = 0.001 ） and tended to be predictive in the non-ACS subgroup （AUROC： 0.556, 95% CI： 0,501 0.611; P = 0.054）.

关键词： Bleeding: Percutaneous Coronary Intervention Prognosis

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“Zero‑Strain” NiNb_(2)O_(6) Fibers for All‑Climate Lithium Storage

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Nano-Micro Letters 2025年第1期17卷 348-360页

作者： yan zhao Qiang Yuan Liting yang Guisheng Liang Yifeng Cheng Limin Wu Chunfu Lin Renchao Che College of Physics Donghua UniversityShanghai 201620People’s Republic of China School of Materials Science and Engineering Institute of Materials for Energy and EnvironmentQingdao UniversityQingdao 266071People’s Republic of China Laboratory of Advanced Materials Shanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsAcademy for Engineering&TechnologyFudan UniversityShanghai 200438People’s Republic of China Zhejiang Laboratory Hangzhou 311100People’s Republic of China Inner Mongolia University Hohhot 010021People’s Republic of China

Niobates are promising all-climate Li^(+)-storage anode material due to their fast charge transport,large specific capacities,and resistance to electrolyte ***,their moderate unit-cellvolume expansion(generally 5%–10%)during Li^(+)storage causes unsatisfactory long-term ***,“zero-strain”NiNb_(2)O_(6) fibers are explored as a new anode material with comprehensively good electrochemical *** Li^(+)storage,the expansion of electrochemical inactive NiO_(6) octahedra almost fully offsets the shrinkage of active NbO_(6) octahedra through reversible O *** superior volume-accommodation capability of the NiO_(6) layers guarantees the“zero-strain”behavior of NiNb_(2)O_(6) in a broad temperature range(0.53%//0.51%//0.74%at 25//−10//60℃),leading to the excellent cyclability of the NiNb_(2)O_(6) fibers(92.8%//99.2%//91.1%capacity retention after 1000//2000//1000 cycles at 10C and 25//−10//60℃).This NiNb_(2)O_(6) material further exhibits a large reversible capacity(300//184//318 mAh g−1 at 0.1C and 25//−10//60℃)and outstanding rate performance(10 to 0.5C capacity percentage of 64.3%//50.0%//65.4%at 25//−10//60℃).Therefore,the NiNb_(2)O_(6) fibers are especially suitable for large-capacity,fast-charging,long-life,and all-climate lithium-ion batteries.

关键词： NiNb_(2)O_(6)porous fiber “Zero-strain”mechanism Electrochemical property Harsh-temperature operation Operando characterization

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