检索结果-南通市图书馆

“新四联”背景下伊伐布雷定治疗CHF的药物经济学评价

在线全文

学校读者我要写书评

暂无评论

中国药房 2024年第1期35卷 63-68页

作者：陈琮玲吴韩周洁张若彬张晋萍鲍雪杨贤南京鼓楼医院药学部南京210008 中国药科大学基础医学与临床药学学院南京211198 南京鼓楼医院心脏科南京210008

目的从卫生体系角度出发,评价伊伐布雷定在“新四联”背景下治疗慢性心力衰竭(CHF)的经济性。方法基于真实世界队列研究数据,根据CHF疾病自然发展进程构建Markov模型,循环周期设为3个月,研究时限为20年,贴现率为5%;以质量调整生命年(QA... 详细信息

目的从卫生体系角度出发,评价伊伐布雷定在“新四联”背景下治疗慢性心力衰竭(CHF)的经济性。方法基于真实世界队列研究数据,根据CHF疾病自然发展进程构建Markov模型,循环周期设为3个月,研究时限为20年,贴现率为5%;以质量调整生命年(QALY)和增量成本-效果比(ICER)为产出指标,采用成本-效用分析法评价伊伐布雷定联合“新四联”方案相较于“新四联”方案治疗CHF的经济性,并通过单因素敏感性分析、概率敏感性分析验证基础分析结果的稳健性。结果基础分析结果显示,伊伐布雷定联合“新四联”方案相较于“新四联”方案的ICER为165065.54元/QALY,低于以3倍我国2022年人均国内生产总值(GDP)作为的意愿支付(WTP)阈值(257094元/QALY)。单因素敏感性分析结果显示,贴现率对模型的稳健性影响最大。概率敏感性分析结果显示,在本研究的WTP阈值下,伊伐布雷定联合“新四联”方案具有经济性的概率为59.50%。结论当采用3倍我国2022年人均GDP(257094元/QALY)作为WTP阈值时,伊伐布雷定联合“新四联”方案治疗CHF具有经济性。

关键词：慢性心力衰竭伊伐布雷定新四联 Markov模型药物经济学

Internal collision double ionization of molecules driven by co-rotating two-color circularly polarized laser pulses

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Chinese Physics B 2024年第1期33卷 355-361页

作者：李雪峰乔月吴丹蔚瑞贤陈基根王俊郭福明杨玉军 Institute of Atomic and Molecular Physics Jilin UniversityChangchun 130012China Jilin Provincial Key Laboratory of Applied Atomic and Molecular Spectroscopy Changchun 130012China School of Science Jilin Institute of Chemical TechnologyJilin 132022China Zhejiang Provincial Key Laboratory for Cutting Tools Taizhou UniversityJiaojiang 318000China

The double ionization process of molecules driven by co-rotating two-color circularly polarized fields is investigated with a three-dimensional classical ensemble model. Numerical results indicate that a considerable part of the sequential double ionization(DI) events of molecules occur through internal collision double ionization(ICD), and the ICD recollision mechanism is significantly different from that in non-sequential double ionization(NSDI). By analyzing the results of internuclear distances R = 5 a.u. and 2 a.u., these two recollision mechanisms are studied in depth. It is found that the dynamic behaviors of the recollision mechanisms of NSDI and ICD are similar. For NSDI, the motion range of electrons after the ionization is relatively large, and the electrons will return to the core after a period of time. In the ICD process,electrons will rotate around the parent ion before ionization, and the distance of the electron motion is relatively small. After a period of time, the electrons will come back to the core and collide with another electron. Furthermore, the molecular internuclear distance has a significant effect on the electron dynamic behavior of the two ionization mechanisms. This study will help to understand the multi-electron ionization process of complex systems.

关键词： non-sequential double ionization internuclear distance internal-collision circularly polarized laser field

Direct Observation of Ethanol Photocatalysis on Rutile TiO2(110) Surface

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemical Physics 2015年第4期28卷 -页

作者： Dong Wei xian-chi Jin Dong-xu Dai Zhi-bo Ma xue-ming yang State Key Laboratory of Molecular Reaction Dynamics Dalian Institute of Chemical Physics Chinese Academy of Science Dalian 116023 China

Photocatalytic dissociation of ethanol molecules on the rutile TiO2(110) surface after UVirradiation has been investigated by scanning tunneling microscope at 80 K. Most of the ethanol molecules adsorb molecularly at Ti sites, similar to the case of methanol. After UVirradiation, two different protrusions of products were observed, one of them has been identified by the technique of tip manipulation, which was likely composed of an acetaldehyde in the middle and two bridge-bonded hydroxyls on both neighbored oxygen sites. Multi-time irradiation experiments have also been performed to further understand the relationship between the two protrusions and the process of ethanol photocatalytic dissociation. These results provide detailed insights into the photocatalysis of ethanol on rutile TiO2(110), which would help us to understand how phtotocatalytic reactions of ethnaol proceed at the fundamental level.

关键词： Titanium dioxide Scanning tunneling microscope Photocatalysis

Effects of Plant Density on Yield and Canopy Micro Environment in Hybrid Cotton

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2014年第10期13卷 2154-2163页

作者： yang Guo-zheng LUO xue-jiao NIE Yi-chun ZHANG xian-long College of Plant Science and Technology Huazhong Agricultural University Key Laboratory of Crop Ecophysiology and Farming System in Middle Reaches of the yangtze River Ministry of Agriculture

A rational plant population is an important attribute to high yield of cotton, because it can provide a beneficial micro environment within the canopy for plant growth and development as well as yield formation. A 2-yr field experiment was conducted to determine the optimal plant density based on cotton yield in relation to the canopy micro environment （canopy temperature, relative humidity and light transmittance）. Six plant densities （1.2-5.7 plants m^-2） were arranged with a completely randomized block design. The highest cotton yield （1 507 kg ha^-1） was obtained at 3.0 plants m^-2 due to more bolls per unit ground area （79 bolls m2）, while the lowest yield （1 091 kg ha1） was obtained at 1.2 plants m^-2. Under the moderate plant density （3.0 plants m^-2）, there was a lower mean daily temperature （MDT, 27. 1℃） attributing to medium daily minimum temperature （Train, 21.9℃） and the lowest daily maximum temperature （Tmax, 35.8℃）, a moderate mean canopy light transmittance of 0.51, and lower mean daily relative humidity （MRH） of 79.7% from June to October. The results suggest that 3.0 plants m^-2 would be the optimal plant density because it provides a better canopy micro environment.

关键词： cotton canopy environment plant density yield light transmittance

许氏平鲉(Sebastes schlegelii)TRAF基因的鉴定及其响应杀鱼爱德华氏菌侵染的表达模式研究

在线全文

学校读者我要写书评

暂无评论

海洋与湖沼 2024年第1期55卷 232-242页

作者：刘显通王宁宁吴瑞雪李超曹敏青岛农业大学海洋科学与工程学院山东青岛266109

TRAF是机体内一种具有信息传导作用的胞内因子,承担多个受体家族的信号转导工作,在固有免疫以及获得性免疫方面都发挥出重要作用。TRAF作为一类胞内接头蛋白,对多条信号途径的活化具有一定的影响,包括细胞的增殖、生存、凋亡、炎症反应... 详细信息

TRAF是机体内一种具有信息传导作用的胞内因子,承担多个受体家族的信号转导工作,在固有免疫以及获得性免疫方面都发挥出重要作用。TRAF作为一类胞内接头蛋白,对多条信号途径的活化具有一定的影响,包括细胞的增殖、生存、凋亡、炎症反应、免疫反应等。目前已有研究表明鱼类中的TRAF基因也发挥重要的免疫防疫作用。以许氏平鲉为研究对象,基于基因组和转录组的数据库,进行了许氏平鲉TRAF基因家族的系统鉴定。在许氏平鲉中共鉴定到9个TRAF基因,并对这些TRAF基因的长度和氨基酸个数进行了统计分析。同时,分析了这9个TRAF基因的结构特征。选取了包括许氏平鲉在内的6种鱼类进行了TRAF基因的共线性分析。结果显示,TRAF基因在硬骨鱼类中具有保守的共线性。通过系统发育分析,更好地解析了TRAF家族基因的进化关系,同时也证明了对其鉴定及命名的准确性。此外,还进行了TRAF家族基因的蛋白质相互作用网络预测以及表达模式分析。通过蛋白质相互作用的网络分析,得到TRAF基因与其互作蛋白的关联状况。在杀鱼爱德华氏菌侵染许氏平鲉后的不同时间点,探究TRAF基因在杀鱼爱德华氏菌刺激下的表达模式。定量结果显示,除TRAF4.1外,其他TRAF基因在感染后均存在不同程度的上调。综上所述,从分子水平上揭示了许氏平鲉TRAF家族基因的结构和功能,揭示了TRAF可能依赖的免疫通路,为进一步探究TRAF家族基因在许氏平鲉先天免疫过程中的作用奠定了基础。

关键词： TRAF 信号传导表达模式许氏平鲉免疫应答

基于可变形注意力transformer的胃肠癌病理图像细胞核自动分割方法

在线全文

学校读者我要写书评

暂无评论

复旦学报（医学版） 2024年第3期51卷 396-403页

作者：唐智贤李镇郭俏胡家祺王雪姚旭峰上海健康医学院医学影像学院医学影像技术教研室上海201318 上海理工大学健康科学与工程学院生物医学工程研究所上海200093 上海交通大学医学院附属瑞金医院病理科上海200025

目的使用深度学习算法实现胃肠癌病理图像的细胞核自动分割,辅助后续病理图像的定量分析。方法以2022年1月—2022年2月在上海交通大学医学院附属瑞金医院就诊的59例胃肠癌患者为研究对象,采用python和LabelMe对患者的病理图像进行数据... 详细信息

目的使用深度学习算法实现胃肠癌病理图像的细胞核自动分割,辅助后续病理图像的定量分析。方法以2022年1月—2022年2月在上海交通大学医学院附属瑞金医院就诊的59例胃肠癌患者为研究对象,采用python和LabelMe对患者的病理图像进行数据脱敏、图片切割和感兴趣区域标注,共纳入944张病理图像,标注了9703个细胞核。通过构建一种基于深度学习的新型语义分割模型,模型引入可变型注意力transformer(deformable attention transformer,DAT),实现了病理图像细胞核自动、精准、高效分割,并采用多种分割评价标准评估模型性能。结果模型分割结果的平均绝对误差值(mean absolute error,MAE)为0.1126,骰子系数(dice coefficient,Dice)为0.7215,其效果明显优于U-net基线模型,并领先于ResU-net++、R2Unet和R2AttUnet等模型,且分割结果相对稳定,泛化性好。结论本研究建立的分割模型能够精准识别并分割出病理图像中的细胞核,鲁棒性和泛化性较好,有助于在实际应用中辅助诊断。

关键词：深度学习模型病理图像细胞核分割胃肠癌诊断

rs3735664 Polymorphism Affecting ELFN1-AS1 Adsorption on miR-1231 is Associated with Colorectal Cancer Susceptibility and Tumor Stage

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2023年第4期36卷 381-383页

作者： LI xian yang HUANG Zhi Jun LI Jian Ping GAO xue Ren School of Pharmacy Yancheng Teachers'UniversityYancheng 224007JiangsuChina Department of Surgery Yancheng First People's HospitalYancheng 224007JiangsuChina Department of Oncology Yancheng First People's HospitalYancheng 224007JiangsuChina

Colorectal cancer(CRC)is a common and deadly disease,with over two million new cases and one million deaths in 2020[1].Risk factors include lack of exercise,obesity,high red meat consumption,low intake of fiber,smoking,and alcohol consumption,as well as genetic factors[2,3].ELFN1-AS1,located on chromosome 7p22.3,expresses a pro-oncogenic lncRNA[4-7].Wang et al.

关键词： Colorectal intake Cancer

新时代、新使命:以习近平文化思想为指导开展中华民族共同体研究——中国民族理论学会2024年学术年会暨“铸牢中华民族共同体意识与建设中华民族现代文明研究”研讨会综述

在线全文

学校读者我要写书评

暂无评论

满语研究 2024年第1期 5-16页

作者：张雪莹左岫仙烟台大学马克思主义学院山东烟台264005 烟台大学中华民族共同体研究院山东烟台264005

中国民族理论学会2024年学术年会于5月11日至12日在延边大学召开。本次会议由中国民族理论学会、中国社会科学院民族学与人类学研究所、延边大学共同举办。会议主题为“铸牢中华民族共同体意识与建设中华民族现代文明研究”。参加会议... 详细信息

中国民族理论学会2024年学术年会于5月11日至12日在延边大学召开。本次会议由中国民族理论学会、中国社会科学院民族学与人类学研究所、延边大学共同举办。会议主题为“铸牢中华民族共同体意识与建设中华民族现代文明研究”。参加会议的专家学者围绕学习贯彻习近平文化思想、建设中华民族现代文明研究、中华民族共同体理论体系及经验研究、中华民族共同体重大现实问题研究等问题展开深入交流与探讨。

关键词：习近平文化思想中华民族现代文明铸牢中华民族共同体意识

The 2022 report of synergetic roadmap on carbon neutrality and clean air for China:Accelerating transition in key sectors

在线全文

学校读者我要写书评

暂无评论

Environmental Science and Ecotechnology 2024年第3期19卷 4-18页

作者： Yu Lei Zhicong Yin Xi Lu Qiang Zhang Jicheng Gong Bofeng Cai Cilan Cai Qimin Chai Huopo Chen Renjie Chen Shi Chen Wenhui Chen Jing Cheng Xiyuan Chi Hancheng Dai xiangzhao Feng Guannan Geng Jianlin Hu Shan Hu Cunrui Huang Tiantian Li Wei Li Xiaomei Li Jun Liu Xin Liu Zhu Liu Jinghui Ma Yue Qin Dan Tong Xuhui Wang Xuying Wang Rui Wu Qingyang Xiao yang Xie Xiaolong Xu Tao xue Haipeng Yu Da Zhang Ning Zhang Shaohui Zhang Shaojun Zhang xian Zhang Xin Zhang Zengkai Zhang Bo Zheng Yixuan Zheng Jian Zhou Tong Zhu Jinnan Wang Kebin He Center of Air Quality Simulation and System Analysis Chinese Academy of Environmental PlanningBeijing100041China Center for Carbon Neutrality Chinese Academy of Environmental PlanningBeijing100041China Key Laboratory of Meteorological Disaster Ministry of Education/Joint International Research Laboratory of Climate and Environment Change(ILCEC)/Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters(CIC-FEMD)Nanjing University of Information Science&TechnologyNanjing210044China State Key Joint Laboratory of Environment Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing100084China Institute for Carbon Neutrality Tsinghua UniversityBeijing100084China Ministry of Education Key Laboratory for Earth System Modelling Department of Earth System ScienceTsinghua UniversityBeijing100084China State Key Joint Laboratory for Environment Simulation and Pollution Control College of Environmental Sciences and Engineering and Center for Environment and HealthPeking UniversityBeijing100871China National Center for Climate Change Strategy and International CooperationBeijing100035China Nansen-Zhu International Research Centre Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing100029China School of Public Health Key Lab of Public Health Safety of the Ministry of Education and Key Lab of Health Technology Assessment of the Ministry of HealthFudan UniversityShanghai200032China School of Economics and Management Beijing University of Chemical TechnologyBeijing100029China Department of Earth System Science University of CaliforniaIrvineCA92697USA National Meteorological Center China Meteorological AdministrationBeijing100081China College of Environmental Sciences and Engineering Peking UniversityBeijing100871China Policy Research Center for Environment and Economy Ministry of Ecology and Environment of the People's Republic of ChinaBeijing100029China Jiangsu Key Laboratory of Atmospheric Environment Monitoring

China is now confronting the intertwined challenges of air pollution and climate *** the high synergies between air pollution abatement and climate change mitigation,the Chinese government is actively promoting synergetic control of these two *** Synergetic Roadmap project was launched in 2021 to track and analyze the progress of synergetic control in China by developing and monitoring key *** Synergetic Roadmap 2022 report is the first annual update,featuring 20 indicators across five aspects:synergetic governance system and practices,progress in structural transition,air pollution and associated weather-climate interactions,sources,sinks,and mitigation pathway of atmospheric composition,and health impacts and benefits of coordinated *** to the comprehensive review presented in the 2021 report,the Synergetic Roadmap 2022 report places particular emphasis on progress in 2021 with highlights on actions in key sectors and the relevant *** milestones include the proportion of non-fossil power generation capacity surpassing coal-fired capacity for the first time,a decline in the production of crude steel and cement after years of growth,and the surging penetration of electric ***,in 2022,China issued the first national policy that synergizes abatements of pollution and carbon emissions,marking a new era for China's pollution-carbon *** changes highlight China's efforts to reshape its energy,economic,and transportation structures to meet the demand for synergetic control and sustainable ***,the country has witnessed a slowdown in carbon emission growth,improved air quality,and increased health benefits in recent years.

关键词： Synergetic roadmap Carbon neutrality Clean air