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Chinese Journal of Natural Medicines 2024年第4期22卷 291-292页

作者： DU Jinfa liao Pan LU Xu State Key Laboratory of Natural Medicines School of Traditional Chinese PharmacyChina Pharmaceutical UniversityNanjing 210009China Department of Biology Hong Kong Baptist UniversityKowloon TongHong KongChina State Key Laboratory of Agrobiotechnology The Chinese University of Hong KongHong KongChina State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Beijing 100700China Medical Botanical Garden China Pharmaceutical UniversityNanjing 210009China

Paclitaxel,a tetracyclic diterpenoid,has garnered attention for its potent anti-cancer properties and intricate molecular structure,making it a significant target for chemical synthesis and biosynthesis[1].However,its natural sources are extremely limited,as it is derived exclusively from the bark of endangered genus Taxus plants,which contain paclitaxel in very low concentrations(0.01%−0.05%)[2-3].Recent advances in synthetic biology present promising opportunities to enhance paclitaxel levels in Taxus cell cultures or to enable the reconstitution of its production in heterologous hosts,such as yeast or tobacco(Nicotiana benthamiana).

关键词： Paclitaxel biosynthesis Baccatin III Cytochrome P450 Taxane oxetanase 1 Heterologous reconstitution

Partnering crops with root-associated microbes for soil health and agricultural sustainability

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Pedosphere 2024年第1期34卷 26-29页

作者： Cunhu WANG Yongjia ZHONG Hong liao Root Biology Center College of Resources and EnvironmentFujian Agriculture and Forestry UniversityFuzhou 350002China

Increasing global demand for food presents a significant challenge to maintaining soil health and sustainable production of agricultural crops. As plant root-associated microbial fitness is greatly impacted by community growth, development, and nutrient acquisition, the cultivation of functional assembly of root-associated microbes may provide solutions for achieving food security while maintaining healthy soils. Here, we propose a four-part strategy to promote soil health and agricultural productivity by partnering crops with root-associated microbes.

关键词： crops soil agricultural

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Elucidating the Role of Probiotics in Modulating Depression Pathophysiology: Insights from Animal Models and Clinical Trials-A Narrative Review

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Food Science and Human Wellness 2024年

作者： Sashuang Dong Fanyu Hao Bin xue Sitong Wu Ruimin Zhong Zhenlin liao Hongying Han Xiang Fang Guangdong Provincial Key Laboratory of Utilization and Conservation of Food and Medicinal Resources in Northern Region， Shaoguan University College of Food Science， South China Agricultural University Department of Psychiatry， The Third Affiliated Hospital of Sun Yat-Sen University

With the ongoing COVID-19， a significant increase in global depression rates has placed a considerable strain on healthcare systems. Conventional pharmaceutical methods have shown limitations in treating this rise in depression. Therefore， identifying new potential treatments for depression is crucial. Maintaining a balanced gut microbiota is vital for human health and immune system function due to its complex bidirectional relationship with the brain. Numerous studies have established a robust correlation between anxiety and depression disorders， as well as the composition of microbial communities in the gastrointestinal tract， providing a fresh perspective. Adjusting the balance of gut microbiota may help alleviate depression symptoms. Probiotics， live microorganisms in the human gut， can improve the microbial community， help maintain homeostasis and stress resilience to remission in patients with depression. It’s essential to explore how probiotics affect gut microbiota since their impact can differ between animal experiments and clinical trials. The variation in results may be attributed to factors like the probiotic type， administered dosage， and treatment duration. The purpose of this review is to summarize the potential mechanisms by which probiotics affect gut microbiota， drawing from recent animal and clinical studies and observations on gut microbial ecology shifts. Additionally， this review will spotlight effective probiotic species for depression relief and discuss treatments centered on restoring gut microbial balance. Furthermore， it will also discuss the potential of probiotics on host microbiota in other organs to improve depressive symptoms and demonstrate the transient nature of the need for a more nuanced understanding of the safety and potential adverse effects of probiotics.

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Practical cloud storage auditing using serverless computing

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Science China(Information Sciences) 2024年第3期67卷 33-47页

作者： Fei CHEN Jianquan CAI Tao XIANG Xiaofeng liao College of Computer Science and Software Engineering Shenzhen University College of Computer Science Chongqing University

Cloud storage auditing research is dedicated to solving the data integrity problem of outsourced storage on the cloud. In recent years, researchers have proposed various cloud storage auditing schemes using different techniques. While these studies are elegant in theory, they assume an ideal cloud storage model;that is, they assume that the cloud provides the storage and compute interfaces as required by the proposed schemes. However, this does not hold for mainstream cloud storage systems because these systems only provide read and write interfaces but not the compute interface. To bridge this gap, this work proposes a serverless computing-based cloud storage auditing system for existing mainstream cloud object storage. The proposed system leverages existing cloud storage auditing schemes as a basic building block and makes two adaptations. One is that we use the read interface of cloud object storage to support block data requests in a traditional cloud storage auditing scheme. Another is that we employ the serverless computing paradigm to support block data computation as traditionally required. Leveraging the characteristics of serverless computing, the proposed system realizes economical, pay-as-you-go cloud storage auditing. The proposed system also supports mainstream cloud storage upper layer applications(e.g., file preview) by not modifying the data formats when embedding authentication tags for later auditing. We prototyped and open-sourced the proposed system to a mainstream cloud service, i.e., Tencent Cloud. Experimental results show that the proposed system is efficient and promising for practical use. For 40 GB of data, auditing takes approximately 98 s using serverless computation. The economic cost is 120.48 CNY per year, of which serverless computing only accounts for 46%. In contrast, no existing studies reported cloud storage auditing results for real-world cloud services.

关键词： cloud storage auditing serverless computing object storage usability

Analysis of multi-objective optimisation method for main insulation structure configuration scheme of valve-side winding of ultra-high voltage converter transformer considering multi-field coupling

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High Voltage 2024年第2期9卷 296-308页

作者： Lijun Yang Zhidong Cheng Li Cheng Ruijin liao State Key Laboratory of Power Transmission Equipment Technology School of Electrical EngineeringChongqing UniversityChongqingChina

Because DC conductivities of oil-paper materials can be easily affected by electric field and temperature,the electrical properties under electro-thermal coupling of oil-paper materials should be considered when optimising the insulation structure of valve-side winding of the converter *** on the finite element multi-physical field coupling simulation,the multi-objective optimisation of main insulation structure of valve-side winding is carried *** view of the high time consuming of multi-physical field calculation and the actual needs of an insulation structure optimisation,the Kriging method and technique for order preference by similarity to the ideal solution(TOPSIS)method are introduced,and combines them with NSGA-II to obtain a joint algorithm that can be used for the optimisation of insulation structure of the converter *** using the joint algorithm of multi-objective optimisation,the insulation structure configuration scheme of valve-side winding is *** can be seen from the experiment result that,on the one hand,the joint algorithm adopted can obtain the insulation structure configuration scheme that meets the design *** the other hand,when facing the configuration scheme optimisation under multi-field coupling,the computational time required by this method is only 0.15%of that required by original genetic algorithm.

关键词： converter insulation coupling

FPR1 Antagonist (BOC-MLF) Inhibits Amniotic Epithelial-mesenchymal Transition

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Current Medical Science 2024年第1期44卷 187-194页

作者： Xiao-mei HUANG E liao Jun-qun liao Ya-ling LIU Yong SHAO Department of Obstetrics and Gynecology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400042China Department of Obstetrics Maternal and Child Health Hospital of Hubei ProvinceWuhan 430070China Medical Laboratory Science The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400042China Department of Obstetrics Yubei Maternity and Child Healthcare HospitalChongqing 400042China

Objective:Premature rupture of membranes(PROM)is a common pregnancy disorder that is closely associated with structural weakening of fetal *** have found that formyl peptide receptor 1(FPR1)activates inflammatory pathways and amniotic epithelial-mesenchymal transition(EMT),stimulates collagen degradation,and leads to membrane weakening and membrane *** purpose of this study was to investigate the anti-inflammatory and EMT inhibitory effects of FPR1 antagonist(BOC-MLF)to provide a basis for clinical prevention of ***:The relationship between PROM,FPR1,and EMT was analyzed in human fetal membrane tissue and plasma samples using Western blotting,PCR,Masson staining,and ELISA ***(LPS)was used to establish a fetal membrane inflammation model in pregnant rats,and BOC-MLF was used to treat the LPS rat *** detected interleukin(IL)-6 in blood from the rat hearts to determine whether the inflammatory model was successful and whether the anti-inflammatory treatment was *** used electron microscopy to analyze the structure and collagen expression of rat fetal ***:Western blotting,PCR and Masson staining indicated that the expression of FPR1 was significantly increased,the expression of collagen was decreased,and EMT appeared in *** rat model indicated that LPS caused the collapse of fetal membrane epithelial cells,increased intercellular gaps,and decreased ***-MLF promoted an increase in fetal membrane collagen,inhibited EMT,and reduced the weakening of fetal ***:The expression of FPR1 in the fetal membrane of PROM was significantly increased,and EMT of the amniotic membrane was ***-MLF can treat inflammation and inhibit amniotic EMT.

关键词： formyl peptide receptor 1 BOC-MLF epithelial-mesenchymal transition premature rupture of membranes

Tailored architecture of composite electrolyte for all-solid-state sodium batteries with superior rate performance and cycle life

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Nano Research 2024年第5期17卷 4171-4180页

作者： Xiang Guan Zhenhua Jian Xingan liao Wenchao liao Yanfei Huang Dazhu Chen Robert K.Y.Li Chen Liu Shenzhen Key Laboratory of Polymer Science and Technology Guangdong Research Center for Interfacial Engineering of Functional MaterialsCollege of Materials Science and EngineeringShenzhen UniversityShenzhen 518055China Department of Materials Science and Engineering City University of Hong KongHong KongChina

Seeking for composite electrolytes reinforced all-solid-state sodium ion batteries with superior long lifespan and rate performance remains a great ***,a unique strategy to tailor the architecture of composite electrolyte via inserting polymer chains into a small quantity of sulfate sodium grafted C_(48)0H_(28)O_(32)Zr_(6)(UIOSNa)is *** intimate contact between polymer segments and UIOSNa with limited pore size facilitates the anion immobilization of sodium salts and reduction of polymer crystallinity,thereby providing rapid ion conduction and reducing the adverse effect caused by the immigration of *** tNa+grafting of-SO_(3)Na groups on fillers allows the free movement of more sodium ions to further improve and ionic ***,even with the low content of UIOSNa fillers,a high ionic conductivity of 6.62×10^(-4) S·cm^(-1) at 60℃ and a transference number of 0.67 for the special designed composite electrolyte are *** assembled all-solid-state sodium cell exhibits a remarkable rate performance for 500 cycles with 95.96%capacity retention at a high current rate of 4 *** corresponding pouch cell can stably work for 1000 cycles with 97.03%capacity retention at 1 C,which is superior to most of the reported composite electrolytes in the literature.

关键词： solid state sodium battery composite electrolyte rate performance cycle life

Tumor-infiltrating T-Lymphocyte immunity-related immune tolerance and anti–programmed cell death protein 1/ligand of programmed cell death protein 1 therapy for advanced hepatocellular carcinoma

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Oncology and Translational Medicine 2024年第4期10卷 162-170页

作者： Lingzhen Hu Zongren Wang Yang liao Xiaomeng Jiang Huojun lian Zhuoying Lin Department of Gastroenterology Shangrao People’s HospitalShangrao 334000Jiangxi ProvinceChina

Systemic therapy has become the standard treatment for patients with advanced hepatocellular carcinoma(HCC)whose treatment options are ***,the long-term patient response to drugs and the survival outcomes remain a *** increasing exploration of the HCC microenvironment,particularly in terms of T lymphocyte immunity,a new era of immunomolecular targeted therapy,based on molecular signaling,has arrived for advanced *** the study of immune tolerance of the intrinsic HCC microenvironment,we found that multiple immunosuppressive mechanisms and immune checkpoint inhibitors,such as anti–programmed cell death protein 1/ligand of programmed cell death protein 1 therapy,have improved clinical outcomes in some patients with advanced ***,various combination therapies have been investigated,and HCC types have been categorized into different types based on anti–programmed cell death protein 1(PD-1)/ligand of programmed cell death protein 1(PD-L1)*** this paper,we first discuss the tumor-infiltrating T lymphocyte immunity and immune tolerance of *** then clarify the basic mechanism of anti–PD-1/PD-L1 therapy and discuss the types of HCC based on anti–PD-1/PD-L1 ***,we explain the relevant studies and mechanisms of combination therapy of anti–PD-1/PD-L1 with antiangiogenesis drugs or multikinase kinase inhibitors,anti–T lymphocyte–related signaling pathways in HCC,and other anti-CD8+T cell immune *** this way,this review offers a deeper understanding of anti–PD-1/PD-L1 immunotherapy for advanced HCC,in order to provide better individualized treatments for patients with advanced HCC.

关键词： Anti–PD-1/PD-L1 treatment Combination therapy Hepatocellular carcinoma Immune tolerance Tumor-infiltrating T lymphocyte immunity

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KeyEE:Enhancing Low-Resource Generative Event Extraction with Auxiliary Keyword Sub-Prompt

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Big Data Mining and Analytics 2024年第2期7卷 547-560页

作者： Junwen Duan Xincheng liao Ying An Jianxin Wang Hunan Key Laboratory of Bioinformatics School of Computer Science and EngineeringCentral South UniversityChangsha 410083China Big Data Institute Central South UniversityChangsha 410083China

Event Extraction(EE)is a key task in information extraction,which requires high-quality annotated data that are often costly to *** classification-based methods suffer from low-resource scenarios due to the lack of label semantics and fine-grained *** recent approaches have endeavored to address EE through a more data-efficient generative process,they often overlook event keywords,which are vital for *** tackle these challenges,we introduce KeyEE,a multi-prompt learning strategy that improves low-resource event extraction by Event Keywords Extraction(EKE).We suggest employing an auxiliary EKE sub-prompt and concurrently training both EE and EKE with a shared pre-trained language *** the auxiliary sub-prompt,KeyEE learns event keywords knowledge implicitly,thereby reducing the dependence on annotated ***,we investigate and analyze various EKE sub-prompt strategies to encourage further research in this *** experiments on benchmark datasets ACE2005 and ERE show that KeyEE achieves significant improvement in low-resource settings and sets new state-of-the-art results.

关键词： natural language processing Event Extraction(EE) Multi-Prompt Learning(MPL) low-resource

Positive definiteness of real quadratic forms resulting from the variable-step L1-type approximations of convolution operators

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Science China Mathematics 2024年第2期67卷 237-252页

作者： Hong-Lin liao Tao Tang Tao Zhou School of Mathematics Nanjing University of Aeronautics and AstronauticsNanjing 211106China Division of Science and Technology BNU-HKBU United International CollegeZhuhai 519087China SUSTech International Center for Mathematics Shenzhen 518055China NCMIS&LSEC Institute of Computational Mathematics and Scientific/Engineering ComputingAcademy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing 100190China

The positive definiteness of real quadratic forms with convolution structures plays an important rolein stability analysis for time-stepping schemes for nonlocal operators. In this work, we present a novel analysistool to handle discrete convolution kernels resulting from variable-step approximations for convolution *** precisely, for a class of discrete convolution kernels relevant to variable-step L1-type time discretizations, weshow that the associated quadratic form is positive definite under some easy-to-check algebraic conditions. Ourproof is based on an elementary constructing strategy by using the properties of discrete orthogonal convolutionkernels and discrete complementary convolution kernels. To our knowledge, this is the first general result onsimple algebraic conditions for the positive definiteness of variable-step discrete convolution kernels. Using theunified theory, we obtain the stability for some simple nonuniform time-stepping schemes straightforwardly.

关键词： discrete convolution kernels positive definiteness variable time-stepping orthogonal convolution kernels complementary convolution kernels

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