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Influence of heat treatment on microstructure of a newβ-solidifyingγ-TiAl alloy

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Journal of Iron and Steel Research International 2025年第1期32卷 239-248页

作者： li Quan Xiao-bing li Peng xue Jun-jie Hao Kun Qian Bo Chen Jian-zhong li Kui liu School of Metallurgy Northeastern UniversityShenyang110819LiaoningChina Department of Materials Science and Technology Ji Hua LaboratoryFoshan528200GuangdongChina

The high strength and stability of the full-lamellar structure guarantee the industrial application of theβ-solidifyingγ-TiAl ***,it is a huge challenge to design an alloy with good hot-deformability as well as the full-lamellar *** low-cost Ti-42.5Al-2Mn-0.4Mo-0.1B-0.1C(at.%)alloy was designed,which undergoes bothβandαsingle-phase region during the *** is found that the full-lamellar structure can be obtained by the solution heat treatment at 1230℃ for 20 min and then aging treatment at 800℃ for 3 ***,a new microstructure,namely,the pearlitic-like microstructure(PM)induced by theα_(2)/γ→βo+γcellular reaction was observed when the aging temperature is increased to above 800℃.The volume fraction of the PM is gradually increased from 0%to 25.5%,65%,and 94%according to elevated aging temperature from 800 to 900,1000,and 1050℃,*** mechanism of the reducedα_(2)/γlamellae and PM formation was discussed regarding the heterogeneous distribution ofβstabilizing elements and the interface energy stored inα_(2)/γlamellae.

关键词： β-γ-TiAl Alloy design Two-step heat treatment Full-lamellar structure Cellular reaction

Mechanisms behind the surprising observation of supra-thermal ions in NIF’s fusion burning plasmas

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Science Bulletin 2025年第3期70卷 359-364页

作者： Yuhan xue Dong Wu jie Zhang Key Laboratory for Laser Plasmas and Department of Physics and Astronomy Collaborative Innovation Center of IFSA(CICIFSA)Shanghai Jiao Tong UniversityShanghai 200240China Institute of Physics Chinese Academy of SciencesBeijing 100190China

Although ignition had been achieved at the National Ignition Facility(NIF),recent observations of the experiments indicate novel physics that beyond theoretical predictions emerge,e.g.,the neutron analysis of experiments has revealed deviations from the Maxwellian distributions in ion relative kinetic energies of burning plasmas,with the surprising emergence of supra-thermal deuterium and tritium(DT)ions that fall outside the predictions of macroscopic statistical hydrodynamic *** our newly developed hybrid-particle-in-cell code,incorporating the newly-proposed model of large-angle collisions,we infer that that this could be attributed to the increased significance of large-angle collisions among DT ions andα-particles in the burning *** and unprecedented kinetic investigations into the implications of large-angle collisions in the burning plasma have yielded several key findings,including an ignition moment promotion by~10 ps,the presence of supra-thermal ions below an energy threshold,and approximately twice the expected deposition ofα-particles *** rationality of our findings is confirmed through the congruency between the neutron spectral moment analyses conducted by the NIF and our kinetic simulations,both highlighting progressively widening disparities between neutron spectral moment analyses and hydrodynamics predictions,which becomes more pronounced as the yield *** kinetic simulations with large-angle collisions not only provide novel insights for experiment interpretation but also open new research opportunities for the largely unexplored regime of the nuclear burning plasmas,which are distinguished by their exceptionally high energy densities and hold immense potential for illuminating the intricate physics that underpins the evolution of the early universe.

关键词： lon kinetics Supra-thermal ions Large-angle collisions Non-equilibrium ignition Inertial confinement fusion Burning plasmas

Mesospheric tide comparisons at low latitudes observed by two collocated meteor radars

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Earth and Planetary Physics 2025年第1期9卷 54-68页

作者： Jian li Wen Yi XiangHui xue jie Zeng HaiLun Ye JianYuan Wang JinSong Chen Na li TingDi Chen Chinese Academy of Sciences(CAS)Key Laboratory of Geospace Environment Department of Geophysics and Planetary SciencesUniversity of Science and Technology of ChinaHefei 230026China CAS Center for Excellence in Comparative Planetology Anhui Mengcheng Geophysics National Observation and Research StationUniversity of Science and Technology of ChinaHefei 230026China Hefei National Laboratory University of Science and Technology of ChinaHefei 230026China Collaborative Innovation Center of Astronautical Science and Technology Harbin 150001China National Key Laboratory of Electromagnetic Environment China Research Institute of Radiowave PropagationQingdao 266107China Yunnan Kunming Electromagnetic Environment National Observation and Research Station Qujing Kunming 655000China

Accurate knowledge of mesospheric winds and waves is essential for studying the dynamics and climate in the mesosphere and lower thermosphere(MLT)*** this study,we conduct a comparative analysis of the mesosphere tidal results obtained from two adjacent meteor radars at low latitudes in Kunming,China,from November 2013 to December *** two radars operate at different frequencies of 37.5 MHz and 53.1 MHz,***,overall good agreement is observed between the two radars in terms of horizontal winds and tide *** results show that the dominant tidal waves of the zonal and meridional winds are diurnal and semidiurnal ***,we conduct an exhaustive statistical analysis to compare the tidal amplitudes and vertical wavelengths recorded by the dual radar systems,which reveals a high degree of alignment in tidal *** investigation includes variances and covariances of tidal amplitudes,which demonstrate remarkable consistency across measurements from both *** finding highlights clear uniformity in the mesospheric tidal patterns observed at low latitudes by the two neighboring meteor *** of the comparative analysis specifically underscore the significant correlation in vertical wavelength measurements,validating the robustness of radar observations for tidal research.

关键词： mesosphere and lower thermosphere region meteor radar mesospheric winds tides

The influence of marital status on the social dysfunction of schizophrenia patients in community

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International Journal of Nursing Sciences 2015年第2期2卷 149-152页

作者： xue-jie li Jing-hua Wu Jun-biao liu Kai-ping li Fang Wang Xiao-hui Sun Shi-hong Ma Guangdong Medical College GuangdongDongguanPeople's Republic of China Dongguan Xinyong Hospital GuangdongDongguanPeople's Republic of China The University of Texas at Dallas DallasTXUSA

Objective:Estimate predictive associations of marital status with social dysfunction in schizophrenia ***:817 schizophrenia patients lived in the community of Dongguan,Guangdong province,China,were investigated with the Social Disability Screening Schedule(SDSS)during a three-month period(1.2010e3.2010).The demographic data were *** c2 test,t test,and fisher's exact were used for comparisons between groups,as *** logistic regression(MLR)was used to analyze the predictive associations of demographic variables to the grading of social ***:The study group consisted of male and female patients aged 16e59 years,407 females,and 410 males with the mean age(40.7±9.5)*** of the data revealed significant differences in course of disease and marital status among patients(with and without dysfunction).The married patient made a significant difference with divorced/widowed patient in mildlyemoderately social *** was a significant difference in married and never-married patient with mildly and profoundly social *** differences were noticed in the self care and occupational roles of the married patient with that of the ***:This study confirmed that bad marital status is associated with higher odds of social dysfunction among patients with schizophrenia living in the *** effects should be included in considerations of public health investments in preventing and treating mental disorders.

关键词： China Community Marital status Schizophrenia Social dysfunction

Pegylated interferon α-2b up-regulates specific CD8+ T cells in patients with chronic hepatitis B

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World Journal of Gastroenterology 2010年第48期16卷 6145-6150页

作者： Ji Chen,Yan Wang,xue-jie Wu,Jun li,Feng-Qin Hou,Gui-Qiang Wang,Department of Infectious Diseases,Center for liver Diseases,Peking University First Hospital,Beijing 100034,China Department of Infectious Diseases Center for Liver Diseases Peking University First Hospital No. 8 Xishiku Street Xicheng District Beijing 10034 China. wanggq@***

AIM:To investigate the effect of pegylated interferon (IFN) α-2b on specific CD8+ T lymphocytes in patients with chronic hepatitis B (CHB). METHODS:Twenty-one patients with CHB were treated with pegylated IFN α-2b. Periphery blood mononuclear cells were isolated from fresh heparinized blood by Ficoll-Hypaque density gradient centrifugation (density:1.077 g/L,Pharmingen) at weeks 0,4,8,12,and 24,respectively. Frequency of circulating hepatitis B virus (HBV) epitope-specific CD8 T cells was detected by flow cytometry. Cytokines were detected by cytometric bead assay. RESULTS:The frequency of circulating HBV core or env-specific CD8 T cells was higher (P lization of ALT in CHB patients (positive predict value = 56%,negative predict value = 92%). CONCLUSION:Pegylated IFN α-2b can enhance the immune response of CHB patients by increasing the frequency of HBV specific CD8+ T cells and regulating the Th1/Th2 cytokines.

关键词： Chronic hepatitis B Pegylated interferon α-2b therapy Immune response Cytokine

RGS22 maintains the physiological function of ependymal cells to prevent hydrocephalus

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Science China(life Sciences) 2025年第2期68卷 441-453页

作者： xue Pang lin Gu Qiu-Ying Han Jia-Qing Xing Ming Zhao Shao-Yi Huang Jun-Xi Yi jie Pan Hao Hong Wen xue xue-Qing Zhou Zhi-Hui Su Xin-Ran Zhang li-Ming Sun Shao-Zhen Jiang Dan Luo ling Chen Zheng-jie Wang Yu Yu Tian Xia xue-Min Zhang Ai-ling li Tao Zhou Hong Cai Tao li Nanhu Laboratory National Center of Biomedical AnalysisBeijing 100039China School of Basic Medical Sciences Fudan UniversityShanghai 200032China Department of Basic Medical Sciences School of MedicineTsinghua UniversityBeijing 100084China

Ependymal cells line the wall of cerebral ventricles and ensure the unidirectional cerebrospinal fluid(CSF)flow by beating their motile cilia *** ependymal denudation or ciliary dysfunction causes ***,we report that the deficiency of regulator of Gprotein signaling 22(RGS22)results in severe congenital hydrocephalus in both mice and ***,RGS22 is specifically expressed in ependymal cells within the *** conditional knock-out mice,we further demonstrate that the deletion of Rgs22 exclusively in nervous system is sufficient to induce ***,we show that Rgs22 deficiency leads to the ependymal denudation and impaired *** phenomenon can be attributed to the excessive activation of lysophosphatidic acid receptor(LPAR)signaling under Rgs22^(-/-)condition,as the LPAR blockade effectively alleviates hydrocephalus in Rgs22^(-/-)***,our findings unveil a previously unrecognized role of RGS22 in the central nervous system,and present RGS22 as a potential diagnostic and therapeutic target for hydrocephalus.

关键词： RGS22 hydrocephalus ependymal cells

Targeting cholesterol trafficking to mitigate axonal degeneration in hereditary spastic paraplegia

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Neural Regeneration Research 2025年第5期20卷 1397-1398页

作者： Zhenyu Chen xue-Jun li Department of Biomedical Sciences University of Illinois College of Medicine RockfordRockfordILUSA Department of Bioengineering University of Illinois at ChicagoChicagoILUSA

Axonal degeneration underlies many debilitating diseases including hereditary spastic paraplegia(HSP),a genetically and clinically diverse group of disorders characterized by spasticity and weakness of the lower *** is one significant cause of chronic neurodisability due to the lack of effective treatments and a wide range of onset ages from early childhood to 70 years.

关键词： degeneration diseases hereditary

Cyano migration-mediated radical-polar crossover cyclopropanation

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Science China Chemistry 2025年第1期68卷 241-248页

作者： Ziqiang Wang Yasu Chen jie li Chen Zhu Key Laboratory of Organic Synthesis of Jiangsu Province College of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China Frontiers Science Center for Transformative Molecules Zhangjiang Institute for Advanced Study and Shanghai Key Laboratory for Molecular Engineering of Chiral DrugsShanghai Jiao Tong UniversityShanghai 200240China

We report a novel cyano migration-mediated radical-polar crossover process,whereby both the sulfonylcyanation of aliphatic alkenes and the formation of cyclopropanes are concurrently *** transformation yields a diverse array of multisubstituted cyclopropanes under mild photocatalytic *** studies elucidate that the reaction proceeds via intramolecular nucleophilic substitution,leading to the formation of the cyclopropane derivatives.

关键词： cyclopropanation cyano migration radical-polar crossover radical reactions

Turbulent Agglomeration of Microparticles in a Cylinder Wake Flow Using LES-DEM:Focusing on the Effect of the Reynolds Number

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Journal of Thermal Science 2025年第1期34卷 34-49页

作者： WANG Shuang MU lin li xue XIE Jun DONG Ming School of Energy and Power Engineering Dalian University of TechnologyDalian 116024China School of Optical Information and Energy Engineering Wuhan Institute of TechnologyWuhan 430205China School of Energy and Environment Shenyang Aerospace UniversityShenyang 110136China

Turbulent agglomeration is viewed as a promising technology for enhancing fine particle removal *** better understand particle transport,agglomeration behaviors,and fluid-particle interactions,we numerically explored these phenomena under cylindrical vortex wake influence using a coupled large eddy simulation and discrete element method(LES-DEM)*** validity of the LES approach was verified by comparison with available direct numerical simulation(DNS)*** adopted the Johnson-Kendall-Roberts(JKR)contact model for particle-particle *** particle dispersion and agglomeration characteristics of particles with different diameters(d_(p)=2-20μm)in the laminar and transition of shear layer(TrSL)flow regimes were *** particles were concentrated at the vortex centers,while larger particles accumulated around the *** agglomeration efficiency exhibited an M-shaped profile spanwise(y-direction).With increasing Reynolds number,the agglomeration efficiency and turbulence intensity *** particle agglomeration efficiency peaks at a certain Reynolds ***,at higher Reynolds numbers,reducing the residence time of particles in the flow field decreases the agglomeration efficiency.

关键词： microparticle particle agglomeration discrete element method large eddy simulation