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Risk Factors of Depression Screened by Two-Sample Mendelian Randomization Analysis:A Systematic Review

Biomedical and Environmental Sciences 2024年第1期37卷 85-95页

作者： WANG Han Lin xue yan feng CUI Bao Qiu LIU Hong SHEN Xin Xin Shandong Provincial Research Center for Bioinformatic Engineering and Technique School of Life SciencesShandong University of TechnologyZibo 255049ShandongChina Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical UniversityTaiyuan 030013ShanxiChina State Key Laboratory of Infectious Disease Prevention and Control National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China

Objective This study explored the potentially modifiable factors for depression and major depressive disorder(MDD)from the MR-Base database and further evaluated the associations between drug targets with *** We analyzed two-sample of Mendelian randomization(2SMR)using genetic variant depression(n=113,154)and MDD(n=208,811)from Genome-Wide Association Studies(GWAS).Separate calculations were performed with modifiable risk factors from MR-Base for 1,001 *** MR analysis was performed by screening drug targets with MDD in the DrugBank database to explore the therapeutic targets for *** variance weighted(IVW),fixed-effect inverse variance weighted(FE-IVW),MR-Egger,weighted median,and weighted mode were used for complementary *** The potential causal relationship between modifiable risk factors and depression contained 459 results for depression and 424 for ***,the associations between drug targets and MDD showed that SLC6A4,GRIN2A,GRIN2C,SCN10A,and IL1B expression are associated with an increased risk of *** contrast,ADRB1,CHRNA3,HTR3A,GSTP1,and GABRG2 genes are candidate protective factors against *** This study identified the risk factors causally associated with depression and MDD,and estimated 10 drug targets with significant impact on MDD,providing essential information for formulating strategies to prevent and treat depression.

关键词： Risk factors Drug targets Depression Major depressive disorder Two-sample Mendelian randomization

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Effects of Lactobacillus paracasei N1115 on gut microbial imbalance and liver function in patients with hepatitis B-related cirrhosis

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World Journal of Gastroenterology 2024年第11期30卷 1556-1571页

作者： yan-Chao Hu Xiang-Chun Ding Hui-Juan Liu Wan-Long Ma xue-yan feng Li-Na Ma Department of Infectious Disease General Hospital of Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Infectious Disease Clinical Research Center of Ningxia Yinchuan 750004Ningxia Hui Autonomous RegionChina

BACKGROUND Hepatitis B cirrhosis(HBC)is a chronic disease characterized by irreversible diffuse liver damage and aggravated by intestinal microbial imbalance and metabolic *** the relationship between certain single probiotics and HBC has been explored,the impact of the complex ready-to-eat Lactobacillus paracasei N1115(LP N1115)supplement on patients with HBC has not been *** To compare the changes in the microbiota,inflammatory factor levels,and liver function before and after probiotic treatment in HBC *** This study included 160 HBC patients diagnosed at the General Hospital of Ningxia Medical University between October 2018 and December *** were randomly divided into an intervention group that received LP N1115 supplementation and routine treatment and a control group that received routine treatment *** samples were collected at the onset and conclusion of the 12-wk intervention *** structure of the intestinal microbiota and the levels of serological indicators,such as liver function and inflammatory factors,were *** Following LP N1115 intervention,the intestinal microbial diversity significantly increased in the intervention group(P<0.05),and the structure of the intestinal microbiota was characterized by an increase in the proportions of probiotic microbes and a reduction in harmful ***,the intervention group demonstrated notable improvements in liver function indices and significantly lower levels of inflammatory factors(P<0.05).CONCLUSION LP N1115 is a promising treatment for ameliorating intestinal microbial imbalance in HBC patients by modulating the structure of the intestinal microbiota,improving liver function,and reducing inflammatory factor levels.

关键词： Hepatitis B cirrhosis N1115 ready-to-eat lactobacillus Inflammation Liver function Lachnospiraceae incertae sedis Probiotic

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融合改进的A*算法和动态窗口法的机器人路径规划

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兰州文理学院学报（自然科学版） 2024年第1期38卷 50-54,65页

作者：丰雪艳李振璧安徽理工大学电气与信息工程学院安徽淮南232000 亳州学院电子与信息工程系安徽亳州236000

传统A*算法在进行路径规划时存在搜索效率低、冗余点多、不能及时躲避环境中的未知障碍物等问题,现将改进A*算法和动态窗口法(Dynamic Window Approach,DWA)融合后进行机器人路径规划.首先在传统A*算法的启发函数前引入动态权重系数;然... 详细信息

传统A*算法在进行路径规划时存在搜索效率低、冗余点多、不能及时躲避环境中的未知障碍物等问题,现将改进A*算法和动态窗口法(Dynamic Window Approach,DWA)融合后进行机器人路径规划.首先在传统A*算法的启发函数前引入动态权重系数;然后采用关键点选取策略剔除路径上的冗余节点;最后将改进A*算法所规划的路径上的关键点作为DWA算法的中间目标点,在全局路径的基础上实现动态避障.仿真结果表明,该融合算法能在躲避动态障碍物的同时快速规划出一条全局最优路径.

关键词： A*算法动态窗口法权重系数关键点选取策略融合算法

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Statistical process monitoring based on improved principal component analysis and its application to chemical processes

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2013年第7期14卷 520-534页

作者： Chu-dong TONG xue-feng yan Yu-xin MA Key Laboratory of Advanced Control and Optimization for Chemical Processes of Ministry of Education East China University of Science and Technology

In this paper, a novel criterion is proposed to determine the retained principal components (PCs) that capture the dominant variability of online monitored data. The variations of PCs were calculated according to their mean and covariance changes between the modeling sample and the online monitored data. The retained PCs containing dominant variations were selected and defined as correlative PCs (CPCs). The new Hotelling's T2 statistic based on CPCs was then employed to monitor the process. Case studies on the simulated continuous stirred tank reactor and the well-known Tennessee Eastman process demonstrated the feasibility and effectiveness of the CPCs-based fault detection methods.

关键词： Fault detection Principal component analysis (PCA) Correlative principal components (CPCs) Tennessee Eastman process

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Enhancing the Performance of JADE Using Two-phase Parameter Control Scheme and Its Application

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International Journal of Automation and computing 2018年第4期15卷 462-473页

作者： Qin-Qin Fan Yi-Lian Zhang xue-feng yan Zhi-Huan Wang Logistics Research Center Shanghai Maritime UniversityShanghai 201306China Key Laboratory of Advanced Control and Optimization for Chemical Processes of Ministry of Education East China University of Science and Technology Shanghai 200237China Key Laboratory of Marine Technology and Control Engineering Ministry of Communications Shanghai Maritime UniversityShanghai 201306China

The search efficiency of differential evolution （DE） algorithm is greatly impacted by its control parameters. Although many adaptation/self-adaptation techniques can automatically find suitable control parameters for the DE, most techniques are based on pop- ulation information which may be misleading in solving complex optimization problems. Therefore, a self-adaptive DE （i.e., JADE） using two-phase parameter control scheme （TPC-JADE） is proposed to enhance the performance of DE in the current study. In the TPC-JADE, an adaptation technique is utilized to generate the control parameters in the early population evolution, and a well-known empirical guideline is used to update the control parameters in the later evolution stages. The TPC-JADE is compared with four state-of-the-art DE variants on two famous test suites （i.e., IEEE CEC2005 and IEEE CEC2015）. Results indicate that the overall performance of the TPC-JADE is better than that of the other compared algorithms. In addition, the proposed algorithm is utilized to obtain optimal nutrient and inducer feeding for the Lee-Ramirez bioreactor. Experimental results show that the TPC-JADE can perform well on an actual dynamic optimization problem.

关键词： Differential evolution(DE)algorithm evolutionary computation dynamic optimization control parameter adaptation chemical processes.

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Protective Role of Ca Against NaCl Toxicity in Jerusalem Artichoke by Up-Regulation of Antioxidant Enzymes

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Pedosphere 2008年第6期18卷 766-774页

作者： xue yan-feng LIU Ling LIU Zhao-Pu S. K. MEHTA ZHAO Geng-Mao Department of Resources and Environmental Sciences Nanjing Agricultural University Nanjing 210095 （China）. State Key Laboratory Breeding Base Key Laboratory of Food Quality and Safety of Jiangsu Province Nanjing 210014 （China） Department of Life Sciences Nanjing Agricultural University Nanjing 210095 （China）

The ameliorative effect of external Ca^2＋ on Jerusalem artichoke （Helianthus tuberosus L.） under salt stress was studied through biochemical and physiological analyses of Jerusalem artichoke seedlings treated with or without 10 mol L^-1 CaCl2, 150 mmol L^-1 NaCl, and/or 5 mmol L^-1 ethylene-bis（oxyethylenenitrilo）-tetraacetic acid （EGTA） for five days. Exposure to NaC1 （150 mmol L^-1） decreased growth, leaf chlorophyll content, and photosynthetic rate of Jerusalem artichoke seedlings. NaC1 treatment showed 59% and 37% higher lipid peroxidation and electrolyte leakage, respectively, than the control. The activities of superoxide dismutase （SOD）, peroxidase （POD）, and catalase （CAT） were decreased by NaCl, indicating an impeded antioxidant defense mechanism of Jerusalem artichoke grown under salt stress. Addition of 10 mmol L^-1 CaCl2 to the salt solutions significantly decreased the damaging effect of NaC1 on growth and chlorophyll content and simultaneously restored the rate of photosynthesis almost to the level of the control. Ca^2＋ addition decreased the leaf malondialdehyde （MDA） content and electrolyte leakage from NaCl-treated seedlings by 47% and 24%, respectively, and significantly improved the activities of SOD, POD, and CAT in NaCl-treated plants. Addition of EGTA, a specific chelator of Ca2＋, decreased the growth, chlorophyll content, and photosynthesis, and increased level of MDA and electrolyte leakage from NaCl-treated plants and from the control plants. EGTA addition to the growth medium also repressed the activities of SOD, POD, and CAT in NaCl-treated and control seedlings. External Ca2＋ might protect Jerusalem artichoke against NaC1 stress by up-regulating the activities of antioxidant enzymes and thereby decreasing the oxidative stress.

关键词： antioxidant enzymes calcium Jerusalem artichoke lipid peroxidation salt stress

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Self-Powered Flexible Multicolor Electrochromic Devices for Information Displays

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Research 2024年第2期2023卷 529-540页

作者： Wenzhao xue Yun Zhang feng Liu Yao Dou Mei yan Wenshou Wang School of Chemistry and Chemical Engineering University of JinanJinan 250022P.R.China

The development of self-powered flexible multicolor electrochromic(EC)systems that could switch different color without an external power supply has remained extremely ***,a new trilayer film structure for achieving self-powered flexible multicolor EC displays based on self-charging/discharging mechanism is proposed,which is simply assembled by sandwiching an ionic gel film between 2 cathodic nickel hexacyanoferrate(NiHCF)and Prussian blue(PB)nanoparticle films on indium tin oxide *** display exhibits independent self-powered color switching of NiHCF and PB films with fast responsive time and high reversibility by selectively connecting the Al wire as anodes with the 2 EC *** switching is thus achieved through a color overlay effect by superimposing the 2 EC films,including green,blue,yellow,and *** bleaching/coloration process of the displays is driven by the discharging/self-charging mechanism for NiHCF and PB films,respectively,ensuring the self-powered color switching of the displays reversibly without an external power *** is further demonstrated that patterns can be easily created in the self-powered EC displays by the spray-coating method,allowing multicolor changing to convey specific ***,a self-powered ionic writing board is demonstrated based on the self-powered EC displays that can be repeatedly written freehand without the need of an external power *** believe that the design concept may provide new insights into the development of self-powered flexible multicolor EC displays with self-recovered energy for widespread applications.

关键词： connecting repeatedly powered

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Synthesis of ZrSiO_4 and Coesite in SiO_2-ZrO_2 System Under High Pressure

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Chemical Research in Chinese Universities 2008年第2期24卷 135-137页

作者： xue yan-feng XU Da-peng ZHANG Guang-qiang ZHOU Xian-feng DING Zhan-hui LIU Xiao-mei SU Wen-hui College of Physics Jilin University Changchun 130012 P. R. China Center for the Condensed-MatterScience and Technology Harbin Institute of Technology Harbin 150001 P. R. China International Center for Materials Physics Chinese Academy of Sciences Shenyang 110015 P. R. China

ZrSiO4 and coesite were obtained under high-pressure and high-temperature from the nano precursor of a-SiO2 and ZrO2. XRD and Raman measurements indicate that ZrSiO4 was formed at a temperature higher than 920 ℃ under a pressure of 3.6 GPa. As the pressure increased to 3.9 GPa, the ZrSiO4 formation temperature was reduced to 815 ℃. The formation temperature for coesite was 990 ℃ under 3.9 GPa. The lower formation temperature for ZrSiO4, as compared to that for coesite, provided an experimental evidence that the coesite in the Earth＇s surface usually occurs as inclusions in ZrSiO4.

关键词： ZrSiO4 Coesite High pressure synthesis Mechanical ball milling

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Environmental Effects of Groundwater Development in Xuzhou City, China

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Journal of China University of Mining and Technology 2006年第1期16卷 13-16页

作者： HAN Bao-ping LIU Xi-kun ZHU xue-qiang feng Qi-yan SUN Xiao-fei School of Environmental Science and Spatial Informatics China University of Mining ＆ Technology Xuzhou Jiangsu 221008 China

Xuzhou City is located in the most northwestern portion of Jiangsu Province, P. R. China. Karst groundwater in the Ordovician and Cambrian Limestone aquifers is the main source of water supply. There are 527 wells in urban areas to exploit the karst groundwater, yielding up to 35 000 m^3 per day. After 1978, urbanization and industrialization of Xuzhou City have continued at a greatly accelerated pace; the population increased from 670 700 （1978） to 1 645 500 （2002）, its GDP from 0.71 × 10^9 $ to 42.7× 10^9 $ and the urban area from 184 km^2 to 1,038 km^2 （built-up city area from 41.3 km^2 to 81.9 km^2）. The volume of karst groundwater withdrawal increased yearly before the operation of a supply plant of surface water in 1992, from 3.85x 10^7 m^3（1978） to 1.34× 10^8 m^3 （1991） and now maintained at 0.1× 10^9 m^3 （2002）. Intensive overexploitation of karst groundwater has caused a continuous descending of the piezometric level and the area of the depression cone increases year after year. These changes have increased the vulnerability of the karst groundwater system and have induced environmental problems such as depletion of water resources, water quality deterioration, groundwater contamination and karst collapse. The largest buried depth of karst groundwater is up to 100 m in the dry season in some areas, while 66 exhausted wells have been abandoned. A change in the thickness of the unsaturated zone due to the drawdown of the piezometric level has caused a change of the chemical environment which has an impact on the physical state and major chemical compositions in groundwater. The contents of Ca^2＋, Mg^2＋, NO3^-, SO4^2- and C1^- in karst groundwater has increased significantly, total hardness （CaCO3 content） rises annually in most pumping wells and exceeds the Standard of Drinking Water of P.R. China. Point source pollution and belt-like pollution along the rivers has caused water quality deterioration. The sudden loss of buoyant support due to rapid drawdown of

关键词： Xuzhou City karst groundwater vulnerability of groundwater environmental problem

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Anomalous thermal expansion and enhanced magnetocaloric effect in<001>-textured Mn_(x)Fe_(5-x)Si_(3) alloys

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Rare Metals 2024年第5期43卷 2263-2274页

作者： Yong Gong xue-Fei Miao Tapas Samanta Chris Taake Jun Liu feng-Jiao Qian yan-yan Shao Yu-Jing Zhang Qing-Yong Ren Luana Caron feng Xu MIIT Key Laboratory of Advanced Metallic and Intermetallic Materials Technology School of Materials Science and EngineeringNanjing University of Science and TechnologyNanjing210094China Department of Physics Bielefeld University33501BielefeldGermany College of Physics Nanjing University of Aeronautics and AstronauticsNanjing210016China Institute of High Energy Physics Chinese Academy of SciencesBeijing100049China Spallation Neutron Source Science Center Dongguan523803China Guangdong-Hong Kong-Macao Joint Laboratory for Neutron Scattering Science and Technology Dongguan523803China Department of Physics Bielefeld University33501BielefeldGermany Helmholtz-Zentrum Berlin für Materialien und Energie12489BerlinGermany

The development of zero and negative therma expansion(i.e.,ZTE and NTE)materials is of crucial importance to the control of undesirable thermal expansion for high-precision *** the present work,ZTE and NTE were obtained in directionally-solidified Mn_(x)Fe_(5-x)Si_(3)alloys with a strongtexture,in striking contrast to positive thermal expansion in their isotropic counterparts Magnetometry and in-situ X-ray diffraction(XRD)measurements were performed to uncover the origin of the anomalous thermal *** measurements indicate a strong easy-plane magnetocrystalline anisotropy in the textured samples,where the magnetic moments are aligned within the ab plane of the hexagonal structure Temperature-dependent XRD on the x=1 sample reveals a ZTE character in the ab plane that is coupled to a ferromagnetic *** a result,the macroscopic ZTE(~0.22×10^(-6)K^(-1))in the x=1 sample can be attributed to the microscopic magneto volume effect within the ab plane,which is realized by the introduction of the-textured ***,the competition between antiferromagnetic and ferromagnetic exchange coupling leads to NTE in textured x=1.5 and 2 ***,textured x=1 sample displays enhanced magnetocaloric properties as compared to the conventional counterparts with randomly-oriented *** this work demonstrates a new strategy toward the exploration of anomalous thermal expansion properties as well as the enhancement of magnetocaloric properties for materials with a strong magnetocrystalline anisotropy.

关键词： MnFeySis Magnetocaloric effect Magnetic phase transition Negative thermal expansion

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