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High dimensional proteomic mapping of bone marrow immune characteristics in immune thrombocytopenia

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Science China(Life Sciences) 2024年第8期67卷 1635-1647页

作者： Feng-Qi Liu Qing-yuan Qu Ying Lei Qi Chen Yu-Xiu Chen Meng-Lin Li xue-Yan Sun Ye-Jun Wu Qiu-Sha Huang Hai-Xia Fu yuan Kong Yue-Ying Li Qian-Fei wang Xiao-Jun Huang Xiao-Hui Zhang Peking University People’s Hospital Peking University Institute of HematologyBeijing 100044China Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Beijing 100044China National Clinical Research Center for Hematologic Disease Beijing 100044China Collaborative Innovation Centre of Hematology Peking UniversityBeijing 100044China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijing 100074China State Key Laboratory of Natural and Biomimetic Drugs Peking UniversityBeijing 100191China

To investigate the role of co-stimulatory and co-inhibitory molecules on immune tolerance in immune thrombocytopenia(ITP),this study mapped the immune cell heterogeneity in the bone marrow of ITP at the single-cell level using Cytometry by Time of Flight(CyTOF).Thirtysix patients with ITP and nine healthy volunteers were enrolled in the *** soluble immunomodulatory molecules,more sCD25 and sGalectin-9 were detected in ITP *** the cell surface,co-stimulatory molecules like ICOS and HVEM were observed to be upregulated in mainly central memory and effector T *** contrast,co-inhibitory molecules such as CTLA-4 were significantly reduced in Th1 and Th17 cell *** a platelet count of 30×10^(9)L^(−1)as the cutoff value,ITP patients with high and low platelet counts showed different T cell immune ***-presenting cells such as monocytes and B cells may regulate the activation of T cells through CTLA-4/CD86 and HVEM/BTLA interactions,respectively,and participate in the pathogenesis of *** conclusion,the proteomic and soluble molecular profiles brought insight into the interaction and modulation of immune cells in the bone marrow of *** may offer novel targets to develop personalized immunotherapies.

关键词： immune thrombocytopenia autoimmune diseases co-stimulatory co-inhibitory immune checkpoint CTLA4 Cytometry by Time of Flight bone marrow

Protein tyrosine phosphatase non-receptor Ⅱ:A possible biomarker of poor prognosis and mediator of immune evasion in hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2024年第9期16卷 3913-3931页

作者： Hui-yuan Li Yi-Ming Jing xue Shen Ming-Yue Tang Hong-Hong Shen Xin-Wei Li Zi-Shu wang Fang Su Department of Medical Oncology The First Affiliated Hospital of Bengbu Medical UniversityBengbu 233000Anhui ProvinceChina Department of Neurology The First Affiliated Hospital of Bengbu Medical UniversityBengbu 233000Anhui ProvinceChina

BACKGROUND The incidence of primary liver cancer is increasing year by *** 2022 alone,more than 900000 people were diagnosed with liver cancer worldwide,with hepatocellular carcinoma(HCC)accounting for 75%-85%of *** is the most common primary liver *** has the highest incidence and mortality rate of HCC in the world,and it is one of the malignant tumors that seriously threaten the health of Chinese *** onset of liver cancer is occult,the early cases lack typical clinical symptoms,and most of the patients are already in the middle and late stage when ***,it is very important to find new markers for the early detection and diagnosis of liver cancer,improve the therapeutic effect,and improve the prognosis of *** tyrosine phosphatase non-receptor 2(PTPN2)has been shown to be associated with colorectal cancer,triple-negative breast cancer,non-small cell lung cancer,and prostate cancer,but its biological role and function in tumors remain to be further *** To combine the results of relevant data obtained from The Cancer Genome Atlas(TCGA)to provide the first in-depth analysis of the biological role of PTPN2 in *** The expression of PTPN2 in HCC was first analyzed based on the TCGA database,and the findings were then verified by immunohistochemical staining,quantitative real-time polymerase chain reaction(qRT-PCR),and *** value of PTPN2 in predicting the survival of patients with HCC was assessed by analyzing the relationship between PTPN2 expression in HCC tissues and clinicopathological ***,the potential of PTPN2 affecting immune escape of liver cancer was evaluated by tumor immune dysfunction and exclusion and immunohistochemical *** The results of immunohistochemical staining,qRT-PCR,and immunoblotting in combination with TCGA database analysis showed that PTPN2 was highly expressed and associated with a poor prognosis in HCC *** Encyclopedia of Ge

关键词： Protein tyrosine phosphatase non-receptor 2 Hepatocellular carcinoma Immune evasion Biomarker Immunotherapy Prognosis

基于ReliefF算法的钛合金电弧增材沉积层尺寸与光谱特性的相关性分析

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光谱学与光谱分析 2024年第7期44卷 2002-2010页

作者：肖笑王雪晴张弛葛学元李芳河南科技大学材料科学与工程学院河南洛阳471023 中机新材料研究院(郑州)有限公司河南郑州450007 上海交通大学材料科学与工程学院上海200240

电弧增材制造具有沉积效率高、成本低、沉积形状和尺寸不受限制等优点,而目前电弧增材制造成型件的成型精度难以精确保证。沉积层尺寸作为评价构件成型质量的标准之一,对判断加工质量以及缺陷补偿至关重要。实时监测电弧增材制造过程中... 详细信息

电弧增材制造具有沉积效率高、成本低、沉积形状和尺寸不受限制等优点,而目前电弧增材制造成型件的成型精度难以精确保证。沉积层尺寸作为评价构件成型质量的标准之一,对判断加工质量以及缺陷补偿至关重要。实时监测电弧增材制造过程中沉积层尺寸的变化状态,对于优化工艺参数,确保增材制造构件的成型质量具有重要意义。电弧光谱信息可以反映电弧状态,电弧状态与成型质量密切相关,因此研究电弧光谱与沉积层尺寸的关系具有重要意义。以钛合金(TC4)材料作为基板和焊丝,电弧等离子体光谱信号为研究对象,研究GTAW增材电弧光谱特性与沉积层尺寸的相关性。搭建光谱采集系统,采集熔池上方、熔池外围、钨极下方不同位置的电弧光谱信号。基于谱线分离性高原则,分别选取波长为404.20 nm的TiⅠ谱线、波长为416.36 nm的TiⅡ谱线、波长为420.20、434.81、480.50和487.98 nm的ArⅡ谱线以及波长为696.54和794.82 nm的ArⅠ谱线,提取其谱线的峰强特征,结合ReliefF算法分别挖掘不同谱线强度特征与沉积层尺寸的相关性。结果表明,三组位置的所有谱线中熔池上方的波长为404.03 nm的TiⅠ元素谱线、416.36 nm的TiⅡ元素谱线以及794.82 nm的ArⅠ元素谱线谱峰强度特征与沉积层尺寸具有较强的相关性。分别研究相同位置的不同谱线峰强特征与沉积层尺寸的相关性差异,结果表明熔池上方与沉积层尺寸相关性最大特征谱线为波长696.54 nm的ArⅠ谱线、熔池外围和钨极下方与沉积层尺寸相关性最大的特征谱线为波长794.82的ArⅠ谱线。为减小随机误差,采用PCA算法将三个电弧光谱采集位置上与沉积层尺寸相关性最大的谱线对应的强度特征进行融合,获得新的融合特征,结合K近邻算法建立沉积层尺寸预测模型,分别计算这四个特征预测样本类别的准确率,发现融合特征预测样本所属的沉积层尺寸的准确率更高。基于此新特征结合阈值分割法实现动态监测沉积层尺寸变化。

关键词：电弧光谱特征选择特征融合 ReliefF

Short-term displacement prediction for newly established monitoring slopes based on transfer learning

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China Geology 2024年第2期7卷 351-364页

作者： yuan Tian Yang-landuo Deng Ming-zhi Zhang Xiao Pang Rui-ping Ma Jian-xue Zhang Institute of Remote Sensing and Geographical Information Systems Peking UniversityBeijing 100871China Beijing Key Laboratory of Spatial Information Integration and Its Applications Beijing 100871China Institute of Public Safety Research Department of Engineering PhysicsTsinghua UniversityBeijing 100084China China Institute of Geo-Environment Monitoring Beijing 100081China Technology Innovation Center for Geohazard Monitoring and Risk Early Warning Ministry of Natural ResourcesBeijing 100081China

This study makes a significant progress in addressing the challenges of short-term slope displacement prediction in the Universal Landslide Monitoring Program,an unprecedented disaster mitigation program in China,where lots of newly established monitoring slopes lack sufficient historical deformation data,making it difficult to extract deformation patterns and provide effective predictions which plays a crucial role in the early warning and forecasting of landslide hazards.A slope displacement prediction method based on transfer learning is therefore ***,the method transfers the deformation patterns learned from slopes with relatively rich deformation data by a pre-trained model based on a multi-slope integrated dataset to newly established monitoring slopes with limited or even no useful data,thus enabling rapid and efficient predictions for these ***,as time goes on and monitoring data accumulates,fine-tuning of the pre-trained model for individual slopes can further improve prediction accuracy,enabling continuous optimization of prediction results.A case study indicates that,after being trained on a multi-slope integrated dataset,the TCN-Transformer model can efficiently serve as a pretrained model for displacement prediction at newly established monitoring *** three-day average RMSE is significantly reduced by 34.6%compared to models trained only on individual slope data,and it also successfully predicts the majority of deformation *** fine-tuned model based on accumulated data on the target newly established monitoring slope further reduced the three-day RMSE by 37.2%,demonstrating a considerable predictive *** conclusion,taking advantage of transfer learning,the proposed slope displacement prediction method effectively utilizes the available data,which enables the rapid deployment and continual refinement of displacement predictions on newly established monitoring slopes.

关键词： Landslide Slope displacement prediction Transfer learning Integrated dataset Transformer Pre-trained model Universal Landslide Monitoring Program(ULMP) Geological hazards survey engineering

Evaluating the influence of sarcopenia and myosteatosis on clinical outcomes in gastric cancer patients undergoing immune checkpoint inhibitor

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World Journal of Gastroenterology 2024年第8期30卷 863-880页

作者： Gui-Ming Deng Hai-Bin Song Zhong-Ze Du Ying-Wei xue Hong-Jiang Song yuan-Zhou Li Department of Gastrointestinal Surgery Harbin Medical University Cancer HospitalHarbin 150081Heilongjiang ProvinceChina Department of Radiology Harbin Medical University Cancer HospitalHarbin 150081Heilongjiang ProvinceChina

BACKGROUND The development and progression of gastric cancer(GC)are closely linked to the nutritional status of *** immunotherapy has been demonstrated to be clinically effective,the relationships of sarcopenia and myosteatosis with the use of immune checkpoint inhibitors(ICIs)in patients with gastric cancer remain to be *** We performed a retrospective study of patients who were undergoing immuno-therapy for *** the evaluation of sarcopenia,the optimal cut-off value for the skeletal muscle index was established using receiver operating characteristic analysis of data obtained from pre-treatment computed tomography images at the L3 vertebral *** was defined using the mean skeletal muscle density(SMD),with a threshold value of<41 Hounsfield units(HU)for patients with a body mass index(BMI)<25 kg/m^(2)and<33 HU for those with a BMI≥25 kg/m^(2).The log-rank test was used to compare progression-free survival(PFS)and overall survival(OS),and a Cox proportional hazard model was used to identify prognostic *** were developed to predict the PFS and OS of patients on the basis of the results of multivariate *** We studied 115 patients who were undergoing ICI therapy for GC,of whom 27.4%had sarcopenia and 29.8%had *** with sarcopenia or myosteatosis had significantly shorter PFS and OS than those without these ***,both sarcopenia and myosteatosis were found to be independent predictors of PFS and OS in patients with GC administering an *** prediction models created for PFS and OS were associated with C-indexes of 0.758 and 0.781,*** The presence of sarcopenia or myosteatosis is a reliable predictor of the clinical outcomes of patients with GC who are undergoing treatment with an ICI.

关键词： Gastric cancer Sarcopenia Myosteatosis,Immune checkpoint inhibitor Prognostic factor Overall survival Progression-free survival

Traditional Chinese Medicine in colorectal cancer treatment:a bibliometrics study and visualization analysis via CiteSpace

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Cancer Advances 2024年第7期7卷 1-9页

作者： Wen-Kai wang yuan-yuan Feng Yi-Yang Zhao Zi-Wei wang Chao-Wei wang xue-Qing Hu Ling Bi Yan wang Department of Medical Oncology Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai 201203China

Objective:To evaluate the current state of research and areas of interest for traditional Chinese medicine(TCM)in the field of colorectal cancer ***:Related papers published between January 1,2012,and November 27,2021,were found using the Web of Science Core Collection Science Citation Index *** CiteSpace's network map generation capability,we then determined the top writers,organizations,countries,keywords,co-cited writers,journals,references,and research ***:This investigation yielded a total of 336 relevant *** is the most productive *** University of Traditional Chinese Medicine is the leading *** journal with the most popularity and publishing volume is Evidence-based Complementary and Alternative *** author with the most citations and centrality is Lin *** terms"epithelial-mesenchymal transition,""cell cycle arrest,""apoptosis,"and"autophagy"are highly frequent and have a high betweenness ***:According to the results,research on natural products,traditional Chinese medicine(TCM)extracts,and the molecular mechanisms of TCM chemical constituents constitutes the primary focus within TCM cancer treatment *** recent years,there has been a surge of interest in exploring the role of gut microbiota in TCM chemical constituents research,particularly in its ability to induce apoptosis and autophagy in tumor cells,thereby suppressing tumor cell proliferation,metastasis,and ***,due to the intricate composition of TCM and existing technical limitations,the underlying principles guiding TCM's efficacy in treating colorectal cancer remain unclear and warrant further investigation.

关键词： colorectal cancer Traditional Chinese Medicine bibliometrics study visualization analysis CiteSpace

Effect of brazing temperature on microstructure and tensile strength ofγ-TiAl joint vacuum brazed with micro-nano Ti−Cu−Ni−Nb−Al−Hf filler

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Transactions of Nonferrous Metals Society of China 2024年第8期34卷 2563-2574页

作者： Li LI Yu-tong CHEN Lei-xin yuan Fen LUO Zhi-xue FENG Xiao-qiang LI School of Materials Science and Engineering East China Jiaotong UniversityNanchang 330013China State Key Laboratory of Performance Monitoring and Protecting of Rail Transit Infrastructure East China Jiaotong UniversityNanchang 330013China National Engineering Research Center of Near-net-shape Forming for Metallic Materials South China University of TechnologyGuangzhou 510640China

A novel micro-nano Ti−10Cu−10Ni−8Al−8Nb−4Zr−1.5Hf filler was used to vacuum braze Ti−47Al−2Nb−2Cr−0.15B alloy at 1160−1220°C for 30 *** interfacial microstructure and formation mechanism of TiAl joints and the relationships among brazing temperature,interfacial microstructure and joint strength were emphatically *** show that the TiAl joints brazed at 1160 and 1180°C possess three interfacial layers and mainly consist ofα2-Ti3Al,τ3-Al3NiTi2 and Ti2Ni,but the brazing seams are no longer layered and Ti2Ni is completely replaced by the uniformly distributedτ3-Al3NiTi2 at 1200 and 1220°C due to the destruction ofα2-Ti3Al barrier *** transformation at 1200°C obviously improves the tensile strength of the joint and obtains a maximum of 343 ***,the outward diffusion of Al atoms from the dissolution of TiAl substrate dominates the microstructure evolution and tensile strength of the TiAl joint at different brazing temperatures.

关键词： γ-TiAl alloy micro-nano filler vacuum brazing interfacial microstructure tensile strength

Comparison efficacy and safety of total laparoscopic gastrectomy and laparoscopically assisted total gastrectomy in treatment of gastric cancer

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1871-1882页

作者： Long Li Dong-yuan Liu Jing Leng xue-Mei Tao Hui-Qin Wu Yan-Peng Zhu Department of General Surgery The 971^(st)Hospital of Chinese People's Liberation ArmyQingdao 266071Shandong ProvinceChina Department of Surgery Qingdao Municipal HospitalQingdao 266071Shandong ProvinceChina Hyperbaric Oxygen Department The Eighth Peoples Hospital of QingdaoQingdao 266121Shandong ProvinceChina Department of Gastrointestinal Surgery The First Affiliated Hospital of Naval Medical UniversityShanghai 200433China

BACKGROUND The development of laparoscopic technology has provided a new choice for surgery of gastric cancer(GC),but the advantages and disadvantages of laparoscopic total gastrectomy(LTG)and laparoscopic-assisted total gastrectomy(LATG)in treatment effect and safety are still *** purpose of this study is to compare the efficacy and safety of the two methods in the treatment of GC,and to provide a basis for clinical *** To compare the efficacy of totally LTG(TLTG)and LATG in the context of radical gastrectomy for ***,we investigated the safety and feasibility of the total laparoscopic esophagojejunostomy *** Literature on comparative studies of the above two surgical methods for GC(TLTG group and LATG group)published before September 2022 were searched in the PubMed,Web of Science,Wanfang Database,CNKI,and other Chinese and English *** addition,the following search keywords were used:Gastric cancer,total gastrectomy,total laparoscopy,laparoscopy-assisted,esophagojejunal anastomosis,gastric/stomach cancer,total gastrectomy,totally/completely laparoscopic,laparoscopic assisted/laparoscopy assisted/laparoscopically assisted,and esophagojejunostomy/esophagojejunal *** Manager 5.3 software was used for the meta-analysis after two researchers independently screened the literature,extracted the data,and evaluated the risk of bias in the included *** After layer-by-layer screening,258 pieces of literature were recovered,and 11 of those pieces were eventually *** resulted in a sample size of 2421 instances,with 1115 cases falling into the TLTG group and 1306 cases into the LATG *** or sex differences between the two groups were not statistically significant,according to the meta-analysis,however the average body mass index of the TLTG group was considerably higher than that of the LATG group(P=0.01).Compared with those in the LATG group,the incision length in the TLTG

关键词： Total laparoscopic gastrectomy Laparoscopically assisted total gastrectomy Gastric cancer Meta-analysis

Comprehensive analysis of the protein phosphatase 2A regulatory subunit B56ε in pan-cancer and its role and mechanism in hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 475-492页

作者： Hong-Mei Wu yuan-yuan Huang Yu-Qiu Xu Wei-Lai Xiang Chang Yang Ru-yuan Liu Di Li xue-Feng Guo Zheng-Bao Zhang Chun-Hua Bei Sheng-Kui Tan Xiao-Nian Zhu Guangxi Key Laboratory of Environmental Exposomics and Entire Lifecycle Health Guilin Medical UniversityGuilin 541199Guangxi Zhuang Autonomous RegionChina

BACKGROUND B56εis a regulatory subunit of the serine/threonine protein phosphatase 2A,which is abnormally expressed in tumors and regulates various tumor cell *** present,the application of B56εin pan-cancer lacks a comprehensive analysis,and its role and mechanism in hepatocellular carcinoma(HCC)are still *** Cancer Genome Atlas,Genotype-Tissue Expression,Gene Expression Profiling Interactive Analysis,and Tumor Immune Estimation Resource databases were used to analyze B56εexpression,prognostic mutations,somatic copy number alterations,and tumor immune characteristics in 33 *** relationships between B56εexpression levels and drug sensitivity,immuno-therapy,immune checkpoints,and human leukocyte antigen(HLA)-related genes were further *** Set Enrichment Analysis(GSEA)was performed to reveal the role of B56εin *** Cell Counting Kit-8,plate cloning,wound healing,and transwell assays were conducted to assess the effects of B56εinterference on the malignant behavior of HCC *** In most tumors,B56εexpression was upregulated,and high B56εexpression was a risk factor for adrenocortical cancer,HCC,pancreatic adenocarcinoma,and pheochromocytoma and paraganglioma(all P<0.05).B56εexpression levels were correlated with a variety of immune cells,such as T helper 17 cells,B cells,and *** was a positive correlation between B56εexpression levels with immune checkpoint genes and HLA-related genes(all P<0.05).The expression of B56εwas negatively correlated with the sensitivity of most chemotherapy drugs,but a small number showed a positive correlation(all P<0.05).GSEA analysis showed that B56εexpression was related to the cancer pathway,p53 downstream pathway,and interleukin-mediated signaling in *** of B56εexpression in HCC cells inhibited the proliferation,migration,and invasion capacity of tumor *** Tip:The expression of protein phosphatase 2A(PP2A)subunit B56εis up-regulated in most tumors,and its high

关键词： B56ε Prognosis Tumor microenvironment Immune infiltration Immunotherapy Hepatocellular carcinoma