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Cerebral metastasis from hepatoid adenocarcinoma of the stomach

World Journal of Gastroenterology 2007年第43期13卷 5787-5793页

作者： Sheng Zhang Mi Wang Yi-Hui xue yu-Peng chen Department of Pathology The First Affiliated Hospital of FujianMedical University Fuzhou 350005 Fujian Province China

We first report a rare case of metastasis from gastric hepatoid adenocarcinoma (HAC) to cerebral parenchyma, in a 50-year-old Chinese patient. He complained of a one-month history of a paroxysm of headache in the left temple and pars parietalis accompanied with binocular caligation caligo, insensible feeling of limbs and transient anepia. Magnetic resonance (MR) imaging revealed a spherical occupying lesion in the left posterior-temple lobe which was clinically diagnosed as a metastatic tumor. Three years ago, the patient accepted total gastrectomy as he was pathologically diagnosed at gastroscopy having an adenocarcinoma. Eight months after gastrectomy, the occupying lesion in liver was detected by ultrasound and CT, and he accepted transcatheter arterial embolization. Before operation of the brain metastasis, no obvious abnormality was found in liver by ultrasound. Histopathological characteristics of the brain tumor were identical to those of stomach tumor. The growth pattern of both tumors showed solid cell nests. The tumor cells were polygonal, and had abundant eosinophilic cytoplasm and round nuclei with obvious nucleoli. Sinusoid-like blood spaces were located between nodular tumor cells. Immunohistochemistry-stained tumor cells were positive for AFP and negative for Hep-Par-1. According to these histopathological findings, both tumors were diagnosed as HAC and metastatic HAC. The patient remained alive 16 mo after tumorectomy of the cerebral metastasis. The differential diagnosis of brain metastasis from metastatic tumors should use a panel of antibodies to avoid confusing with the brain metastasis of hepatocellular carcinoma (HCC). This paper describes this rare case of metastasis from gastric hepatoid adenocarcinoma to cerebral parenchyma, and provides a review of the literature concerning its histopathological and immunohistochemical characteristics.

关键词： Cerebral metastasis Gastric hepatoidadenocarcinoma Immunohistochemistry

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Venom gland of the ichneumonid Diadromus collaris： morphology, ultrastructure and age-related changes

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Insect Science 2006年第2期13卷 137-143页

作者： WEI-DI LI RUI-XIAN yu xue-XIN chen JUN-HUA HE Institute of Applied Entomology Zhejiang University Hangzhou China

Females of the solitary parasitoid Diadromus collaris （Insecta： Hymenoptera： Ichneumonidae） lay eggs in the pupae of Plutella xylostella （Lepidoptera： Plutellidae）, and the venom is synchronously injected into hosts. The venom apparatus consists of two glandular tubules terminating in a common reservoir, A ductule connects the reservoir with the sting apparatus, by which the reservoir content enters the latter. Secretory units line the two glandular tubules. All secretory cells belong to dermal gland type Ⅲ. Dermal gland cells in glandular tubules are more abundant and developed than those in the reservoir. There are extensive rough endoplasmic reticulum and electrondense vesicles, and the microvilli are well developed. By the cuticle-lined central funnel secretion products of secretory units reach the reservoir. Moreover, the secretory apparatus undergoes age-related changes. The secretory units in the venom gland are better developed and more vigorous 7 days after eclosion than those 1 day after eclosion; autolytic processes occur 15 days after eclosion, and the tissue of the reservoir is more prostrate 15 day after eclosion than those 1 day after eclosion. The ovipostion peak of this parasitoid, about 3-7 days after eclosion, corresponds with the period when the venom gland is highly developed in the life span of the wasp.

关键词： age-related changes Diadromus collaris Ichneumonidae morphology,ultrastructure venom gland

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Jidong cognitive impairment cohort study: objectives, design, and baseline screening

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Neural Regeneration Research 2020年第6期15卷 1111-1119页

作者： Dai-yu Song Xian-Wei Wang Sa Wang Si-Qi Ge Guo-Yong Ding xue-yu chen Yan-Ru chen Hua-Min Liu Xiao-Mei Xie Wei-Jia Xing Dong Li Yong Zhou School of public health Shandong First Medical University&Shandong Academy of Medical SciencesTaianShandong ProvinceChina School of Ophthalmology and Optometry Eye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Neuroepidemiology Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Staff hospital of jidong oilfield Caofeidian districtTangshanHebei ProvinceChina Department of Neurology The Affiliated Wenling Hospital of Wenzhou Medical UniversityWenlingZhejiang ProvinceChina

The risk of dementia increases in patients with cognitive ***,it is not clear what factors contribute to the onset of dementia in those with cognitive *** this prospective cohort study,we will investigate the every-five-year incidence of cognitive impairment and prognostic factors for cognitive *** Jidong cognitive impairment cohort was established from April 2012 to August 2015,during which we recruited 5854 healthy participants(55.1%male)older than 45 years(mean,57 years).Participants received a health examination in the Staff Hospital,Jidong Oilfield Branch,China National Petroleum *** data and blood samples were *** impairment was evaluated using the Mini-Mental State Examination,and was defined as a Mini-Mental State Examination score of less than *** was assessed using the criteria of Diagnostic and Statistical Manual of Mental Disorders(Fourth edition),the International Working Group criteria,and the Mini-Mental State Examination *** follow-up will continue until December 2024,during which a prognostic model will be *** primary outcome is the presence/absence of dementia and the secondary outcome is quality of *** screening results showed the following:(1)Cognitive impairment was apparent in 320 participants(5.5%).These participants will be excluded from the Jidong cohort study,and the remaining participants will be followed up.(2)Of the 320 participants with cognitive impairment,there was a significantly higher prevalence of illiteracy than other education levels(35.9%,P<0.05).Age,arterial hypertension,alcohol consumption,and passive smoking differed significantly between the cognitive impairment and healthy groups(P<0.05).Multivariate logistic regression models showed that age(odds ratio[OR]=1.059,95%confidence interval[CI]:1.044-1.074)and arterial hypertension(OR=1.665,95%CI:1.143-2.427)were risk factors for mild cognitive *** the increase o

关键词： assessment cognitive impairment community dementia follow-up Mini-Mental Status Examination Scale model new basis prevention prognostic factors

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Targeting cholesterol trafficking to mitigate axonal degeneration in hereditary spastic paraplegia

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Neural Regeneration Research 2025年第5期20卷 1397-1398页

作者： Zhenyu chen xue-Jun Li Department of Biomedical Sciences University of Illinois College of Medicine RockfordRockfordILUSA Department of Bioengineering University of Illinois at ChicagoChicagoILUSA

Axonal degeneration underlies many debilitating diseases including hereditary spastic paraplegia(HSP),a genetically and clinically diverse group of disorders characterized by spasticity and weakness of the lower *** is one significant cause of chronic neurodisability due to the lack of effective treatments and a wide range of onset ages from early childhood to 70 years.

关键词： degeneration diseases hereditary

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Mechanistic insight into the synergy between nickel single atoms and nanoparticles on N-doped carbon for electroreduction of CO2

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Journal of Energy Chemistry 2025年第1期100卷 327-336页

作者： Mingdong Sun Wenwen Guan Cailing chen Chao Wu Xiaoling Liu Biao Meng Tao chen yu Han Jun Wang Shibo Xi yu Zhou State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical Engineering Nanjing Tech University Advanced Membranes and Porous Materials Center Physical Sciences and Engineering Division King Abdullah University of Science and Technology Institute of Sustainability for Chemicals Energy and Environment A*STAR (Agency for Science Technology and Research) College of Materials Science and Engineering Sichuan University

The synergy of single atoms （SAs） and nanoparticles （NPs） has demonstrated great potential in promoting the electrocatalytic carbon dioxide reduction reaction （CO2RR）;however,the rationalization of the SAs/NPs proportion remains one challenge for the catalyst ***,a Ni2+-loaded porous poly（ionic liquids）(PIL) precursor synthesized through the free radical self-polymerization of the ionic liquid monomer,1-allyl-3-vinylimidazolium chloride,was pyrolyzed to prepare the Ni,N co-doped carbon materials,in which the proportion of Ni SAs and NPs could be facilely modulated by controlling the annealing *** catalyst Ni-NC-1000 with a moderate proportion of Ni SAs and NPs exhibited high efficiency in the electrocatalytic conversion of CO2into *** Ni K-edge X-ray absorption near-edge structure （XANES） spectra and theoretical calculations were conducted to gain insight into the synergy of Ni SAs and *** charge transfer from Ni NPs to the surrounding carbon layer and then to the Ni SAs resulted in the electron-enriched Ni SAs active *** the electroreduction of CO2,the coexistence of Ni SAs and NPs strengthened the CO2activation and the affinity towards the key intermediate of*COOH,lowering the free energy for the potential-determining*CO2→*COOH step,and therefore promoted the catalysis efficiency.

关键词： Single atom catalyst Synergy effect Carbon catalyst Electrocatalysis

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炼油厂MBR出水回用循环冷却水的试验研究及工业应用

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工业水处理 2009年第1期29卷 74-76页

作者：欧阳志薛育成中石化金陵分公司化肥厂水处理中心江苏南京210033 常州精科霞峰精细化工有限公司江苏常州213022

为实现炼油厂处理后污水可回用于循环冷却水系统,通过旋转挂片腐蚀试验和静态阻垢试验,筛选出适合于炼油厂污水回用循环冷却水条件下的水稳配方,经动态模拟试验和现场应用,该配方具有良好的阻垢缓蚀性能。

关键词：炼油厂污水回用循环冷却水

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Co/Co_(7)Fe_(3)heterostructures with controllable alloying degree on carbon spheres as bifunctional electrocatalyst forrechargeable zinc-air batteries

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 476-487页

作者： Junkang chen Yongyue Zhuang Yanxin Qiao yu Zhang Aihua yuan Hu Zhou School of Materials Science and Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China School of Environmental and Chemical Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China

Exploring efficient and nonprecious metal electrocatalysts of oxygen reduction reaction(ORR)and oxygen evolution reaction(OER)is crucial for developing rechargeable zinc-air batteries(ZABs).Herein,an alloying-degree control strategy was employed to fabricate nitrogen-doped carbon sphere(NCS)decorated with dual-phase Co/Co_(7)Fe_(3)heterojunctions(CoFe@NCS).The phase composition of materials has been adjusted by controlling the alloying *** optimal CoFe_(0.08)@NCS electrocatalyst displays a half-wave potential of 0.80 V for ORR and an overpotential of 283 mV at 10 mA·cm^(-2)for OER in an alkaline *** intriguing bifunctional electrocatalytic activity and durability is attributed to the hierarchically porous structure and interfacial electron coupling of highly-active Co_(7)Fe_(3)alloy and metallic Co *** the CoFe_(0.08)@NCS material is used as air-cathode catalyst of rechargeable liquid-state zinc-air battery(ZAB),the device shows a high peak power-density(157 mW·cm^(-2))and maintains a stable voltage gap over 150 h,outperforming those of the benchmark(Pt/C+RuO_(2))-based *** particular,the as-fabricated solid-state flexible ZAB delivers a reliable compatibility under different bending *** work provides a promising strategy to develop metal/alloy-based electrocatalysts for the application in renewable energy conversion technologies.

关键词： bifunctional electrocatalysts oxygen reduction reaction oxygen evolution reaction zinc-air battery metal/alloy carbon sphere

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A NEW GUANIDINE DERIVATIVE FROM ASTRAGALUS COMPLANATUS ***.

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Chinese Chemical Letters 1991年第9期2卷 691-692页

作者： Zhi xue yu Wu chen Yong Wen Zhang China-Japan Friendship Institute of Clinical Medical Sciences,Beijing 100029 Jing Yang Qi Tai ZHENG Institute of Materia Medica,Chinese Academy of Medical Sciences,Beijing 100050

A new guanidine derivative,complanatin has been isolated from the seeds of Chinese traditional medicine Astragalus complanatus ***..Its structure was established on the basis of spectral data and X-ray crystallographi... 详细信息

关键词： A NEW GUANIDINE DERIVATIVE FROM ASTRAGALUS COMPLANATUS R.Br

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动脉粥样硬化的抗炎靶点ApoB-100的研究进展

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上海交通大学学报（医学版） 2018年第9期38卷 1104-1108页

作者：郭小瑜薛雨晨何斌薛晓梅洪婷尤纱纱上海交通大学医学院附属新华医院麻醉与重症医学科上海200092

动脉粥样硬化是由多种因素共同作用导致的血管壁的免疫炎症性疾病,是众多心血管疾病发生的主要病理基础。目前比较公认的动脉粥样硬化发生机制是"炎症反应"学说,即低密度脂蛋白(low density lipoprotein,LDL)中所包含的载脂蛋白ApoB-10... 详细信息

动脉粥样硬化是由多种因素共同作用导致的血管壁的免疫炎症性疾病,是众多心血管疾病发生的主要病理基础。目前比较公认的动脉粥样硬化发生机制是"炎症反应"学说,即低密度脂蛋白(low density lipoprotein,LDL)中所包含的载脂蛋白ApoB-100的异常增高引起的病理性炎症反应是导致动脉粥样硬化的主要因素。通过免疫疗法抑制ApoB-100导致的病理性炎症反应,有望延缓动脉粥样硬化的发生与发展。该文主要围绕ApoB-100疫苗以及其他ApoB-100抑制剂的最新进展和存在的问题进行综述。

关键词： ApoB-100 动脉粥样硬化免疫疫苗抑制剂

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Literature study on traditional Chinese medicine syndromes after renal transplantation

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World Journal of Transplantation 2025年第1期15卷 150-155页

作者： yun-Peng Guo Ling-xue Bao yu-Yang Wang Quan Wen Gai Hang Bo chen Tongliao Clinical Medical College Inner Mongolia Medical UniversityTongliao 028000Inner Mongolia Autonomous RegionChina Department of Urology Tongliao People's HospitalTongliao 028000Inner Mongolia Autonomous RegionChina

BACKGROUND Kidney transplantation is the most effective means to treat patients with renal failure,but its postoperative problems such as rejection reactions,immunosuppressant poisoning,chronic transplant kidney nephropathy,*** have not been effectively *** study searched for literature on traditional Chinese medicine(TCM)syndromes after kidney transplantation in China,conducted statistical analysis of the results,and sought to identify the underlying *** To understand the TCM syndromes after renal transplantation and associated rules and provide a theoretical basis for further clinical *** The literature pertaining to TCM syndromes in renal transplantation,published in the China National Knowledge Infrastructure,Wanfang database,and WIP database from 1970 to 2021,was meticulously searched and comprehensively and statistically *** Following the established inclusion and exclusion criteria,13 studies were selected for ***-renal transplantation,no significant discrepancy was noted among the groups based on the location of TCM ***,when categorized according to TCM pathogenic factors,the groups with spleen and kidney yang deficiency,as well as liver and kidney yin deficiency,exhibited a statistically significant difference in the *** Currently,the research on TCM syndromes pertaining to renal transplantation is in its nascent *** is imperative to conduct a multicentric,large-scale survey of TCM syndromes subsequent to renal transplantation in the ensuing years.

关键词： Kidney transplantation Syndrome Literature analysis Traditional Chinese medicine Systematic review

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