检索结果-南通市图书馆

The Rainbow Vertex-disconnection in Graphs

在线全文

学校读者我要写书评

暂无评论

Acta Mathematica Sinica,English Series 2021年第2期37卷 249-261页

作者： Xu Qing BAI you CHEN Ping li xue liang li Yin Di WENG Center for Combinatorics and LPMC Nankai UniversityTianjin 300071P.R.China School of Mathematics and Statistics Qinghai Normal UniversityXining 810008P.R.China

Let G be a nontrivial connected and vertex-colored graph. A subset X of the vertex set of G is called rainbow if any two vertices in X have distinct colors. The graph G is called rainbow vertex-disconnected if for any two vertices x and y of G, there exists a vertex subset S of G such that when x and y are nonadjacent, S is rainbow and x and y belong to different components of G-S;whereas when x and y are adjacent, S + x or S + y is rainbow and x and y belong to different components of(G-xy)-S. For a connected graph G, the rainbow vertex-disconnection number of G, denoted by rvd(G), is the minimum number of colors that are needed to make G rainbow vertexdisconnected. In this paper, we characterize all graphs of order n with rainbow vertex-disconnection number k for k ∈ {1, 2, n}, and determine the rainbow vertex-disconnection numbers of some special graphs. Moreover, we study the extremal problems on the number of edges of a connected graph G with order n and rvd(G) = k for given integers k and n with 1 ≤ k ≤ n.

关键词： Vertex-coloring connectivity rainbow vertex-cut rainbow vertex-disconnection number

温度和水分对寒温带典型森林类型土壤有机碳矿化的影响

在线全文

学校读者我要写书评

暂无评论

东北林业大学学报 2025年第2期53卷 127-136页

作者：李雪朱宾宾满秀玲东北林业大学哈尔滨150040 内蒙古呼伦贝尔市林业和草原事业发展中心

通过室内模拟试验,分析寒温带典型森林土壤有机碳矿化随温度和水分的变化特征,揭示土壤有机碳矿化影响机制,以期深入探讨气候变暖背景下,温度和水分对寒温带典型森林类型土壤碳循环的影响。采集白桦林和兴安落叶松林0 详细信息

通过室内模拟试验,分析寒温带典型森林土壤有机碳矿化随温度和水分的变化特征,揭示土壤有机碳矿化影响机制,以期深入探讨气候变暖背景下,温度和水分对寒温带典型森林类型土壤碳循环的影响。采集白桦林和兴安落叶松林0

关键词：寒温带白桦林兴安落叶松林土壤有机碳矿化温度敏感性

Design,synthesis and preliminary biological evaluation of brain targeting L-ascorbic acid prodrugs of ibuprofen

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2013年第2期24卷 117-119页

作者： xue-Ying Wu Xiao-Cen li Jie Mi Jing you li Hai College of Pharmacy Chengdu University of Traditional Chinese Medicine Key Laboratory of Drug Targeting and Drug Delivery System of the Education Ministry Department of Medicinal ChemistryWest China School of PharmacySichuan University

Received 4 November 2012 Received in revised form 17 December 2012 Accepted 31 December 2012 Available online 4 February 2013

关键词： Vitamin CBrain targetProdrugGLUT1 transporterSVCT2 transporterIbuprofen

Estimation of Road Friction Coefficient in Different Road Conditions Based on Vehicle Braking Dynamics

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Mechanical Engineering 2017年第4期30卷 982-990页

作者： you-Qun Zhao Hai-Qing li Fen lin Jian Wang xue-Wu Ji College of Energy&Power Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China School of Automotive Engineering Shandong Jiaotong UniversityJinan 250023China State Key Laboratory of Automotive Safety and Energy Tsinghua UniversityBeijing 100084China

The accurate estimation of road friction coeffi- cient in the active safety control system has become increasingly prominent. Most previous studies on road friction estimation have only used vehicle longitudinal or lateral dynamics and often ignored the load transfer, which tends to cause inaccurate of the actual road friction coef- ficient. A novel method considering load transfer of front and rear axles is proposed to estimate road friction coef- ficient based on braking dynamic model of two-wheeled vehicle. Sliding mode control technique is used to build the ideal braking torque controller, which control target is to control the actual wheel slip ratio of front and rear wheels tracking the ideal wheel slip ratio. In order to eliminate the chattering problem of the sliding mode controller, integral switching surface is used to design the sliding mode sur- face. A second order linear extended state observer is designed to observe road friction coefficient based on wheel speed and braking torque of front and rear wheels. The proposed road friction coefficient estimation schemes are evaluated by simulation in ADAMS/Car. The results show that the estimated values can well agree with the actual values in different road conditions. The observer can estimate road friction coefficient exactly in real-time andresist external disturbance. The proposed research provides a novel method to estimate road friction coefficient with strong robustness and more accurate.

关键词： Road friction coefficient Real timeestimation External disturbance Different roadconditions

Wave Attenuation Performance and the Influencing Factors of A Lower Arc-Plate Breakwater

在线全文

学校读者我要写书评

暂无评论

China Ocean Engineering 2020年第1期34卷 89-98页

作者： li xue-yan WANG Qing you Zai-jin GUO Wei-jun ZHANG Jun-bin ZHAN Chao ZHANG Zhi-chen WANG li-xue li Qin Coast Institute Ludong UniversityYantai 264025China Dalian Maritime University Dalian 116026China Institute of Sea-Crossing Engineering Ludong UniversityYantai 264024China College of Environmental Sciences and Engineering Dalian Maritime UniversityDalian 116026China

Comprehensive experimental and numerical studies have been undertaken to investigate wave energy dissipation performance and main influencing factors of a lower arc-plate breakwater. The numerical model, which considers nonlinear interactions between waves and the arc-plate breakwater, has been constructed by using the velocity wave- generating method, the volume of fluid (VOF) method and the finite volume method. The results show that the relative width, relative height and relative submergence of the breakwater are three main influencing factors and have significant influence on wave energy dissipation of the lower arc-plate open breakwater. The transmission coefficient is found to decrease with the increasing relative width, and the minimum transmission coefficient is 0.15 when the relative width is 0.45. The reflection coefficient is found to vary slightly with the relative width, and the maximum reflection coefficient is 0.53 when the relative width is 0.45. The transmission and reflection coefficients are shown to increase with the relative wave height for approximately 85% of the experimental tests when the relative width is 0.19 0.45. The transmission coefficients at relative submergences of 0.04, 0.02 and 0 are clearly shown to be greater than those at relative submergences of 0.02 and 0.04, while the reflection coefficient exhibits the opposite relationship. After the wave interacts with the lower arc-plate breakwater, the wave energy is mainly converted into transmission, reflection and dissipation energies. The wave attenuation performance is clearly weakened for waves with greater heights and longer periods.

关键词： arc-plate breakwater wave attenuation performance influencing factors VOF method

Development of pharmacological immunoregulatory anticancer therapeutics:current mechanistic studies and clinical opportunities

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第6期9卷 2477-2526页

作者： Nanhao Yin Xintong li Xuanwei Zhang Shaolong xue Yu Cao Gabriele Niedermann you Lu Jianxin xue Division of Thoracic Tumor Multimodality Treatment Cancer Center&State Key Laboratory of Biotherapyand The National Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityNo.37Guoxue LaneChengdu 610041 SichuanPR China Department of Gynecology and Obstetrics West China Second University HospitalSichuan UniversityNo.20Section 3South Renmin RoadChengdu 610041 SichuanPR China Department of Emergency Medicine Laboratory of Emergency MedicineWest China HospitalSichuan UniversityNo.37Guoxue LaneChengdu 610041 SichuanPR China Institute of Disaster Medicine&Institute of Emergency Medicine Sichuan UniversityNo.17Gaopeng AvenueChengdu 610041 SichuanPR China Department of Radiation Oncology Medical Center—University of FreiburgFaculty of MedicineUniversity of FreiburgGerman Cancer Consortium(DKTK)Partner Site DKTK-FreiburgRobert-Koch-Strasse 379106 FreiburgGermany Laboratory of Clinical Cell Therapy West China HospitalSichuan UniversityNo.2222Xinchuan RoadChengdu 610041 SichuanPR China

Immunotherapy represented by anti-PD-(L)1 and anti-CTLA-4 inhibitors has revolutionized cancer treatment,but challenges related to resistance and toxicity still *** to the advancement of immuno-oncology,an increasing number of novel immunoregulatory targets and mechanisms are being revealed,with relevant therapies promising to improve clinical immunotherapy in the foreseeable ***,comprehending the larger picture is *** this review,we analyze and summarize the current landscape of preclinical and translational mechanistic research,drug development,and clinical trials that brought about next-generation pharmacological immunoregulatory anti-cancer agents and drug candidates beyond classical immune checkpoint *** with further clarification of cancer immunobiology and advances in antibody engineering,agents targeting additional inhibitory immune checkpoints,including LAG-3,TIM-3,TIGIT,CD47,and B7 family members are becoming an important part of cancer immunotherapy research and discovery,as are structurally and functionally optimized novel anti-PD-(L)1 and anti-CTLA-4 agents and agonists of co-stimulatory molecules of T *** by bispecific T cell engagers,newly emerging bi-specific and multi-specific antibodies targeting immunoregulatory molecules can provide considerable clinical ***-generation agents also include immune epigenetic drugs and cytokine-based *** therapies,cancer vaccines,and oncolytic viruses are not covered in this *** comprehensive review might aid in further development and the fastest possible clinical adoption of effective immuno-oncology modalities for the benefit of patients.

关键词： clinical immuno landscape

Effects of cerium salts on corrosion behaviors of Si–Zr hybrid sol–gel coatings

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Aeronautics 2015年第2期28卷 600-608页

作者： Yu Mei liu Yuxing liu Jianhua li Songmei xue Bing Zhang you Yin Xiaolin School of Materials Science and Engineering Beihang University

The present work examines the effects of cerium salts on corrosion behaviors of Si-Zr hybrid sol-gel coatings. The Si-Zr hybrid sol-gel coatings on a 2A l2 aluminum substrate were pre- pared through hydrolysis and condensation of glycidoxypropyl-trimethoxy-silane （GTMS） and zirconium（IV） n-propoxide （TPOZ）. Used as inhibitors for corrosion, three types of cerium salts （Co（NO3）3, CeCl3, and Ce（CH3COO）3） were doped into the sol-gel coatings. Fourier transform infrared （FTIR） and scanning electron microscopy （SEM） were employed to investigate the structures and morphologies of various coatings, and the corrosion resistances of the coatings were evaluated by electrochemical methods and neutral salt spray tests. Experimental results indicate that the addition of cerium salts can hinder the process of corrosion due to their self-healing abili- ties. Furthermore, the sol-gel coating doped with Ce（CH3COO）3 has the best corrosion resistance because of the promotions of hydrolysis and condensation provided by CH3COO-.

关键词： Cerium salts Corrosion resistance Hybrid coating Inhibitor

Methylprednisolone inhibits activated CD4^+ T cell survival promoted by toll-like receptor ligands

在线全文

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2010年第4期9卷 376-383页

作者： Lu, you-Sheng Pu, li-Yong li, Xiang-Cheng Wang, xue-Hao Nanjing Med Univ Affiliated Hosp 1 Liver Transplantat Ctr Peoples Hosp Jiangsu Prov Nanjing 210029 Peoples R China

BACKGROUND: Methylprednisolone (MP) can affect the survival of CD4(+) T lymphocytes and plays an important role in adaptive immune responses; however, its mechanism of action is not clear. Recent studies have shown that toll-like receptors (TLRs) on CD4(+) T cells can directly modulate adaptive immune responses by affecting the survival and proliferation of activated CD4(+) T cells. This study aimed to investigate the relationship between MP, TLRs and activated CD4(+) T cells. METHODS: We separated and purified CD4(+) T cells from mice, activated them in vitro, and co-cultured them with TLR ligands, MP or inhibitors of nuclear factor-kappa B (NF-kappa B) and activator protein 1 (AP-1). We then assessed CD4(+) T cell survival and proliferation and the expression of NF-kappa B and AP-1. RESULTS: Activated CD4(+) T cells showed increased TLR-3 and TLR-9 mRNA expression, but polyinosinic-polycytidylic acid (poly I:C) and MP had no effect on the expression of these mRNAs. Still, poly I:C and CpG oligodeoxynucleotides (CpG DNA) increased the survival of activated CD4(+) T cells, whereas MP reduced the survival of activated CD4(+) T cells and could inhibit the survival effects of poly I:C and CpG DNA. The NF-kappa B essential modifier-binding domain (NBD) inhibited the survival of activated CD4(+) T cells induced by poly I:C and CpG DNA, but the AP-1 inhibitor crucumin did not have the same effect. The increased expression of NF-kappa B induced by poly I:C and CpG DNA in activated CD4(+) T cells could be inhibited by MP, but the same was not true for the increased expression of AP-1 induced by poly I:C and CpG DNA. Finally, the proliferation of activated CD4(+) T cells was not affected by poly I:C or MP. CONCLUSION: The survival of activated CD4(+) T cells is promoted by TLR ligands, but this effect is inhibited by MP.

关键词： methylprednisolone toll-like receptor CD4(+) T lymphocytes NF-kappa B

内蒙古达来诺尔湖湖泊沉积物中敏感粒度组分沉积环境及地层分析

在线全文

学校读者我要写书评

暂无评论

沉积与特提斯地质 2016年第3期36卷 77-82页

作者：于瑞雪李畅游李文宝甄志磊赵胜男张帅内蒙古农业大学水利与土木建筑工程学院内蒙古呼和浩特010018 中国中铁投资集团安徽安庆246000

对达来诺尔湖北岸岸边（DL-0）、湖中心（DL-1）和湖南岸（DL-2）3个点的岩心沉积物进行了详细的岩性分析、粒度分析和粒度参数垂向分布序列分析。对沉积环境变化较为敏感的粒度组分的分析发现 DL-0与 DL-1和 DL-2井岩心沉积物敏感粒度... 详细信息

对达来诺尔湖北岸岸边（DL-0）、湖中心（DL-1）和湖南岸（DL-2）3个点的岩心沉积物进行了详细的岩性分析、粒度分析和粒度参数垂向分布序列分析。对沉积环境变化较为敏感的粒度组分的分析发现 DL-0与 DL-1和 DL-2井岩心沉积物敏感粒度组分的峰值有较大差别，其粒度分布范围相差较大，表明湖北岸岸边、湖中心和湖南岸的沉积物来源和沉积环境的时空差异。敏感粒度组分含量随深度变化的初步分析表明，湖北岸岸边（DL-0）和湖中心（DL-1）两个点的沉积环境较为稳定；而位于湖南岸（DL-2）点的沉积环境变化比较大，包含了5个明显的沉积波动旋回，并对达来诺尔湖由北至南进行了沉积地层分析。在达来诺尔湖水下1.5m 内主要是粒径0-200μm 的颗粒，岩性为粘土、粉砂和砂，以粘土和粉砂为主，随着深度的增加，黏土含量增大，粉砂和砂含量减小。

关键词：达来诺尔湖沉积环境粒度分析地层分析