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无创产前基因检测在韶关地区胎儿染色体疾病的临床应用

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湖南师范大学学报（医学版） 2018年第1期15卷 133-135页

作者：李锦昌卢海亮吴新秀黄丽婵曾宪琪杨学煌陈亚军韶关市妇幼保健计划生育服务中心产前诊断中心韶关512026 韶关市始兴县妇幼保健计划生育服务中心检验科始兴512500 韶关市武江区龙归镇中心卫生院妇产科韶关512050

目的:探讨无创产前基因检测技术在胎儿染色体非整倍体疾病诊断中的检出效率及临床应用价值。方法:2014年7月~2017年6月在我院产前诊断中心就诊的因高龄、唐氏筛查高风险等高危因素进行产前诊断,选择无创产前基因检测或介入性产前诊断。... 详细信息

目的:探讨无创产前基因检测技术在胎儿染色体非整倍体疾病诊断中的检出效率及临床应用价值。方法:2014年7月~2017年6月在我院产前诊断中心就诊的因高龄、唐氏筛查高风险等高危因素进行产前诊断,选择无创产前基因检测或介入性产前诊断。对无创产前基因检测高风险患者应进行介入性产前诊断。结果:2014~2015、2015~2016、2016~2017年无创产前基因检测高风险例数分别为5、16、28,阳性三体穿刺例数分别为41、35、30,两者成反比例关系。唐氏产前筛查高风险例数为756、1,101、1,723,介入性产前诊断例数为531、666、986,两者比率为70.24%、60.49%、57.23%,逐年下降。结论:无创产前基因检测可提高产前诊断效率,高准确性和敏感性,可以作为传统产前诊断技术有效辅助手段,具有较高的临床实际应用价值。

关键词：无创产前基因检测染色体非整倍体疾病高通量测序

Pathological BBB Crossing Melanin-Like Nanoparticles as Metal-Ion Chelators and Neuroinflammation Regulators against Alzheimer’s Disease

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Research 2024年第1期6卷 687-706页

作者： Qianqian huang Chaoqing Jiang xue Xia Yufan Wang Chenxing Yan Xiaorong Wang Ting Lei Xiaotong yang Wenqin yang Guo Cheng Huile Gao Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry West China School of PharmacySichuan UniversityChengdu 610041P.R.China Laboratory of Molecular Translational Medicine Center for Translational MedicineKey Laboratory of Birth Defects and Related Diseases of Women and Children(Sichuan University)Ministry of EducationDepartment of PediatricsWest China Second University HospitalSichuan UniversityChengdu 610041P.R.China

Inflammatory responses,manifested in excessive oxidative stress and microglia overactivation,together with metal ion-triggered amyloid-beta(Aβ)deposition,are critical hallmarks of Alzheimer’s disease(AD).The intricate pathogenesis causes severe impairment of neurons,which,in turn,exacerbates Aβaggregation and facilitates AD ***,multifunctional melanin-like metal ion chelators and neuroinflammation regulators(named PDA@K)were constructed for targeted treatment of *** this platform,intrinsically bioactive material polydopamine nanoparticles(PDA)with potent metal ion chelating and ROS scavenging effects were decorated with the KLVFF peptide,endowing the system with the capacity of enhanced pathological blood–brain barrier(BBB)crossing and lesion site accumulation via Aβ*** vitro and in vivo experiment revealed that PDA@K had high affinity toward Aβand were able to hitch a ride on Aβto achieve increased pathological BBB *** engineered PDA@K effectively mitigated Aβaggregate and alleviated neuroinflammation.

关键词： oxidative aggregation chelating

Feature extraction of search product based on multi-feature fusion-oriented to Chinese online reviews

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Data Science and Management 2022年第2期5卷 57-65页

作者： Xunjiang huang Yaqian Liu yang Wang xue Wang School of Business Administration Northeastern UniversityShenyang110169China

The increasing Chinese online reviews contain rich product demand information,especially for search *** study suggests a product feature extraction model from online reviews based on multi-feature fusion named PFEMF(products features extraction based on multi-feature fusion)*** sentence and word characteristics of Chinese online reviews,the model explores the lexical features,frequency features,span features,and semantic similarity features of *** then,they are fused to identify the features that customers are concerned about most by sequential relationship *** identified product feature provides direction for product innovation and facilitates the product selection for ***,the study takes iPad Air as an example to prove this *** results show that the extraction performance of the PFEMF model is superior to the traditional term frequency-inverse document frequency(tf-idf)algorithm,word span algorithm,and semantic similarity algorithm.

关键词： Product feature extraction Chinese online reviews tf-idf Word span Semantic similarity

Linear Quadratic Mean Field Games:Decentralized O(1/N)-Nash Equilibria

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Journal of Systems Science & Complexity 2021年第5期34卷 2003-2035页

作者： huang Minyi yang Xuwei School of Mathematics and Statistics Carleton UniversityOttawaON K1S 5B6Canada.

This paper studies an asymptotic solvability problem for linear quadratic(LQ)mean field games with controlled diffusions and indefinite weights for the state and control in the *** authors employ a rescaling approach to derive a low dimensional Riccati ordinary differential equation(ODE)system,which characterizes a necessary and sufficient condition for asymptotic *** rescaling technique is further used for performance estimates,establishing an O(1/N)-Nash equilibrium for the obtained decentralized strategies.

关键词： Asymptotic solvability decentralized strategies ε-Nash equilibria linear quadratic mean field games Riccati equations

DNA damage response signaling pathways and targets for radiotherapy sensitization in cancer

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Signal Transduction and Targeted Therapy 2020年第1期5卷 1925-1951页

作者： Rui-xue huang Ping-Kun Zhou Department of Occupational and Environmental Health Xiangya School of Public HealthCentral South University410078 ChangshaPeople’s Republic of China Department of Radiation Biology Beijing Key Laboratory for RadiobiologyBeijing Institute of Radiation MedicineAMMS100850 BeijingPeople’s Republic of China Institute for Chemical Carcinogenesis State Key Laboratory of RespiratoryGuangzhou Medical University511436 GuangzhouPeople’s Republic of China

Radiotherapy is one of the most common countermeasures for treating a wide range of ***,the radioresistance of cancer cells is still a major limitation for radiotherapy *** are continuously ongoing to explore sensitizing targets and develop radiosensitizers for improving the outcomes of *** double-strand breaks are the most lethal lesions induced by ionizing radiation and can trigger a series of cellular DNA damage responses(DDRs),including those helping cells recover from radiation injuries,such as the activation of DNA damage sensing and early transduction pathways,cell cycle arrest,and DNA ***,these protective DDRs confer tumor *** DDR signaling pathways has become an attractive strategy for overcoming tumor radioresistance,and some important advances and breakthroughs have already been achieved in recent *** the basis of comprehensively reviewing the DDR signal pathways,we provide an update on the novel and promising druggable targets emerging from DDR pathways that can be exploited for *** further discuss recent advances identified from preclinical studies,current clinical trials,and clinical application of chemical inhibitors targeting key DDR proteins,including DNA-PKcs(DNA-dependent protein kinase,catalytic subunit),ATM/ATR(ataxia–telangiectasia mutated and Rad3-related),the MRN(MRE11-RAD50-NBS1)complex,the PARP(poly[ADP-ribose]polymerase)family,MDC1,Wee1,LIG4(ligase IV),CDK1,BRCA1(BRCA1 C terminal),CHK1,and HIF-1(hypoxia-inducible factor-1).Challenges for ionizing radiation-induced signal transduction and targeted therapy are also discussed based on recent achievements in the biological field of radiotherapy.

关键词： damage radiotherapy injuries

Advanced Functional Electromagnetic Shielding Materials:A Review Based on Micro‑Nano Structure Interface Control of Biomass Cell Walls

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Nano-Micro Letters 2025年第1期17卷 98-134页

作者： yang Shi Mingjun Wu Shengbo Ge Jianzhang Li Anoud Saud Alshammari Jing Luo Mohammed A.Amin Hua Qiu Jinxuan Jiang Yazeed M.Asiri Runzhou huang Hua Hou Zeinhom M.El‑Bahy Zhanhu Guo Chong Jia Kaimeng Xu Xiangmeng Chen Co‑Innovation Center of Efficient Processing and Utilization of Forest Resources College of Materials Science and EngineeringNanjing Forestry UniversityNanjing 210037People’s Republic of China State Key Laboratory of Efficient Production of Forest Resourced Beijing Forestry UniversityQinghua East Road 35Haidian DistrictBeijing 100083People’s Republic of China Department of Physics Faculty of Sciences‑ArarNorthern Border UniversityArar 91431Saudi Arabia Department of Chemistry College of ScienceTaif UniversityP.O.Box 1109921944 TaifSaudi Arabia Shaanxi Key Laboratory of Macromolecular Science and Technology School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’anShaanxi 710072People’s Republic of China Integrated Composites Lab Department of Mechanical and Construction EngineeringNorthumbria UniversityNewcastle Upon Tyne NE18STUK College of Materials Science and Engineering Taiyuan University of Science and TechnologyTaiyuan 030024People’s Republic of China Department of Chemistry Faculty of ScienceAl-Azhar UniversityNasr CityCairo 11884Egypt Yunnan Provincial Key Laboratory of Wood Adhesives and Glued Products International Joint Research Center for Biomass MaterialsSouthwest Forestry UniversityKunming 650224People’s Republic of China School of Science Henan Agricultural UniversityZhengzhou 450002People’s Republic of China

Research efforts on electromagnetic interference(EMI)shielding materials have begun to converge on green and sustainable biomass *** materials offer numerous advantages such as being lightweight,porous,and *** to their porous nature,interfacial compatibility,and electrical conductivity,biomass materials hold significant potential as EMI shielding *** concerted efforts on the EMI shielding of biomass materials have been reported,this research area is still relatively new compared to traditional EMI shielding *** particular,a more comprehensive study and summary of the factors influencing biomass EMI shielding materials including the pore structure adjustment,preparation process,and micro-control would be *** preparation methods and characteristics of wood,bamboo,cellulose and lignin in EMI shielding field are critically discussed in this paper,and similar biomass EMI materials are summarized and *** composite methods and fillers of various biomass materials were *** paper also highlights the mechanism of EMI shielding as well as existing prospects and challenges for development trends in this field.

关键词： Biomass materials Electromagnetic interference shielding Micro-nano structure interface control Conductivity

Boosting C_(2)H_(6)/C_(2)H_(4) separation via the precise electrostatic modulation of synthetic 1D channel at atomic level

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Nano Research 2024年第11期17卷 10083-10087页

作者： Salamanti Ainiwaner Hengcong huang Jia-Jia Zheng Fengting Li xue-Tong yang yang-yang Guo Fangli Yuan Ming-Shui Yao Yifan Gu College of Environmental Science and Engineering State Key Laboratory of Pollution Control and Resource Reuse Tongji University Shanghai 200092 China Laboratory of Theoretical and Computational Nanoscience National Center for Nanoscience and Technology Chinese Academy of Sciences Beijing 100190 China Skate Key Laboratory of Mesoscience and Engineering Institute of Process Engineering Chinese Academy of Sciences Beijing 100190 China Chinese Academy of Sciences University of Chinese Academy of Sciences Beijing 100049 China

The regulation of gas sorption via simple pore modification is crucial to molecular recognition and chemical ***,a rational pore surface electrostatic modulation in synthetic one dimensioned(1-D)channel is demonstrated to boost ethane/ethylene(C_(2)H_(6)/C_(2)H_(4))selectivity for one-step extraction of C_(2)H_(4) from C_(2)H_(6)/C_(2)H_(4) *** the precise modulation of the surface charge arrangement with negatively charged moieties in the 1-D channel of a metal—organic framework(MOF),enhanced C_(2)H_(6)—host framework and decreased C_(2)H_(4)—host framework electrostatic interactions were obtained,which resulted in an obvious improvement in adsorption ***,the breakthrough separation performance rendered the obtained MOF an efficient adsorbent for C_(2)H_(4) purification from C_(2)H_(6)/C_(2)H_(4) *** combined detail theoretical studies prove that the gas sorption selectivity is remarkably sensitive to framework electrostatic change even in the case of pore surface modification at the atomic *** results are of fundamental importance to the design of porous materials for challenging separation tasks.

关键词： metal—organic framework ethane/ethylene separation ethane—selective MOF adsorption electrostatic modulation

Enumeration of Cubic Cayley Graphs on Dihedral Groups

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Acta Mathematica Sinica,English Series 2017年第7期33卷 996-1010页

作者： xue Yi huang Qiong Xiang huang Lu LU College of Mathematics and Systems Science Xinjiang UniversityUrumqi 830046P.R.China

Let p be an odd prime, and D2p = （a,b I aP = b2 = l,bab= a 1） the dihedral group of order 2p. In this paper, we completely classify the cubic Cayley graphs on D2p up to isomorphism by means of spectral method. By the way, we show that two cubic Cayley graphs on D2p are isomorphic if and only if they are cospectral. Moreover, we obtain the number of isomorphic classes of cubic Cayley graphs on D2 by using Gauss＇ celebrated law of quadratic reciprocity.

关键词： Cayley graph dihedral group cospectral isomorphic classes quadratic reciprocity

水泥-蔗渣灰-陶瓷粉三元胶凝材料体系早期水化研究

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三峡大学学报（自然科学版） 2025年第1期47卷 73-80页

作者：王晶杨玉柱黄维蓉广西交通职业技术学院南宁530023 广西大学土木建筑工程学院南宁530004 重庆交通大学交通土建工程材料国家地方联合工程实验室重庆400074

为探究工业固废蔗渣灰、陶瓷粉作为辅助胶凝材料在水泥基材料中的适用性,本文通过单纯型重心设计方法对水泥-蔗渣灰-陶瓷粉三元胶凝体系进行混料设计,并通过凝结时间、水化热与氢核磁共振探究其早期水化性能.研究表明:蔗渣灰与陶瓷粉均... 详细信息

为探究工业固废蔗渣灰、陶瓷粉作为辅助胶凝材料在水泥基材料中的适用性,本文通过单纯型重心设计方法对水泥-蔗渣灰-陶瓷粉三元胶凝体系进行混料设计,并通过凝结时间、水化热与氢核磁共振探究其早期水化性能.研究表明:蔗渣灰与陶瓷粉均会延长水泥浆体的凝结时间,陶瓷粉的延缓幅度更大;水泥浆体水化放热峰会随着蔗渣灰掺量的增加而后移,随陶瓷粉掺量的增加而略微向前移,且蔗渣灰与陶瓷粉的掺入都会使浆体水化放热降低,72h水化程度也会降低;蔗渣灰与陶瓷粉的掺入会增加氢核磁共振信号强度,其中水泥-蔗渣灰组合的信号强度更高.水泥-蔗渣灰-陶瓷粉有较好的协同作用,三元体系可以制备凝结时间符合规范要求、水化热较低的胶凝材料,试验成果为工业固废的绿色应用以及低热混凝土的制备提供参考.

关键词：水泥蔗渣灰陶瓷粉早期水化氢核磁共振水化程度