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Microvascular permeability of brain astrocytoma with contrast- enhanced magnetic resonance imaging： correlation analysis with histopathologic grade

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Chinese Medical Journal 2013年第10期126卷 1953-1956页

作者： JIA Zhong-zheng geng Dao-ying LIU Ying CHEN Xing-rong ZHANG Jun Department of Radiology Affiliated Hospital of Nantong UniversityNantong 226001 China Department of Radiology Huashan Hospital Fudan UniversityShanghai 200040 China Department of Pathology Shanghai Medical Collge FudanUniversity Shanghai 200040 China

Background The degree of pathological microvascular proliferation is an important element in evaluation of the astrocytoma grade. This study was aimed to quantitatively assess the microvascular permeability of brain astrocytoma with the volume transfer constant （Ktrans） and volume of extravascular extracellular space per unit volume of tissue （Ve） from dynamic contrast-enhanced magnetic resonance imaging （DCE-MRI） and to evaluate the effectiveness of the Ktr^n＇ and Ve in the grading of astrocytoma. Methods The highest values of the Kt~~s and Ve of 67 patients with astrocytoma （27 with grade II, 12 with grade III, and 28 with grade IV） were obtained. The comparisons of the differences of the Ktrans and Ve between the different grades were conducted using the Mann-Whitney rank-sum tests. Spearman＇s rank correlation coefficients were determined between Ktrans values, Ve values and astrocytoma grades. Receiver operating characteristic （ROC） curve analyses were performed to determine the cut-off values for the Ktrans and Ve to distinguish between the different grades of astrocytoma. Results There were significant differences （P〈0.001） between the different grades in the Ktrans values and Ve values, except for grades III and IV. The Ktrans values and Ve values were both correlated with astrocytoma grades （both P〈0.001）. The ROC curve analyses showed that the cut-off values for the Ktrans and Ve provided the best combination of sensitivity and specificity in distinguishing between grade II and grade III or IV astrocytomas. Conclusions DCE-MRI can play an important role in assessing the microvascular permeability and the grading of brain astrocytoma.

关键词： astrocytoma, grading, dynamic contrast-enhanced volume transfer constant, extravascular extracellular space

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MIMO系统的多模型预测控制(英文)

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自动化学报 2003年第4期29卷 516-523页

作者：李柠李少远席裕庚上海交通大学自动化研究所上海200030

针对非线性多变量系统提出一种多模型预测控制 (MMPC)策略 .首先给出一种多模型辨识方法 ,利用模糊满意聚类算法将复杂非线性系统划分为若干子系统 ,并获得多个线性模型 ,通过模型变换得出全局系统模型 ,接着对全局MIMO系统设计MMPC ,... 详细信息

针对非线性多变量系统提出一种多模型预测控制 (MMPC)策略 .首先给出一种多模型辨识方法 ,利用模糊满意聚类算法将复杂非线性系统划分为若干子系统 ,并获得多个线性模型 ,通过模型变换得出全局系统模型 ,接着对全局MIMO系统设计MMPC ,并进行了系统的性能分析 ,最后以 pH中和过程为例。

关键词： MIMO系统多模型模型预测控制(MPC) 模糊满意聚类 pH中和过程

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伞型酮类似物的合成及抗菌作用

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有机化学 2010年第2期30卷 254-259页

作者：章维华蒋木庚南京农业大学理学院南京210095

2-甲基间二酚或5-甲基间二酚分别与dl-苹果酸或乙酰乙酸乙酯,在浓硫酸催化下,经Peachmann缩合反应得到伞型酮(7-羟基香豆素)类似物5～7.5～7经甲基化得新化合物5a,6a和7a;经Williamson反应,TBAB(四正丁基溴化铵)相转移催化合成了14个新... 详细信息

2-甲基间二酚或5-甲基间二酚分别与dl-苹果酸或乙酰乙酸乙酯,在浓硫酸催化下,经Peachmann缩合反应得到伞型酮(7-羟基香豆素)类似物5～7.5～7经甲基化得新化合物5a,6a和7a;经Williamson反应,TBAB(四正丁基溴化铵)相转移催化合成了14个新的香豆素类化合物5b～5e,6b～6f,7b～7f.经IR,MS,1HNMR及元素分析对所有化合物的结构进行了表征.初步生物活性实验结果表明,在50μg/mL浓度下,化合物6对辣椒疫霉病菌(Phytophythora capsici)抑制率达58.5%,化合物7c对番茄灰霉病菌(Botrytis cinerea)抑制率为54.0%,化合物6c对水稻纹枯病菌(Rhizoctonia solani)的抑制率达83.7%.

关键词：伞型酮香豆素合成抑菌活性

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Common susceptibility variants of KDR and IGF-1R are associated with poststroke depression in the Chinese population

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General Psychiatry 2023年第1期36卷 36-42页

作者： Yingying Yue Linlin You Fuying Zhao Kezhong Zhang Yanyan Shi Hua Tang Jianxin Lu Shenghua Li Jinxia Cao Deqin geng Aiqin Wu Yonggui Yuan Department of Psychosomatics and Psychiatry ZhongDa HospitalSoutheast UniversityNanjingChina Department of Psychiatry Suzhou High-Tech Development District Yangshan Community HospitalSuzhouChina Department of Neurology The First Affiliated Hospital of Nanjing Medical UniversityNanjingChina Department of Neurology Nanjing First HospitalNangjingChina Department of Neurology The Third People's Hospital of Huai'anHuai'anChina Department of Neurology People's Hospital of Gaochun CountyNanjingChina Department of Neurology The Affiliated Nanjing Jiangning Hospital of Nanjing Medical HospitalNanjingChina Department of Neurology The Second People's Hospital of LianyungangLianyungangChina Department of Neurology The Affiliated Hospital of Xuzhou Medical UniversityXuzhouChina Department of Psychosomatics The Affiliated First Hospital of Soochow UniversitySoochowChina

Background Depression,one of the most frequent complications after stroke,increases the disease’s burden and physical *** depression(PSD)is a multifactorial disease with genetic,environmental and biological factors involved in its *** studies on PSD to date have mainly focused on the monoamine system and brain-derived neurotrophic ***,understanding is still limited about the influence of the single nucleotide polymorphism(SNP)of other neurotrophic factors on *** The present study aimed to investigate the relationship between seven vascular endothelial growth factor(VEGF)family gene variants that occur with *** A multicentre candidate gene study from five hospitals in Jiangsu Province from June 2013 to December 2014 involved 121 patients with PSD and 131 patients with *** characteristics and neuropsychological assessments were ***χ^(2)test was used to evaluate categorical variables,while the independent t-test was applied to continuous *** in seven genes(VEGFA,VEGFB,KDR,FLT-1,IGF-1,IGF-1R and PlGF)were ***-marker association for PSD was analysed byχ^(2)tests and logistic regression using SPSS and PLINK *** Patients with PSD included more women and those with lower education levels,lower body mass indexes,lower Mini-Mental State Examination scores,and higher scores on the 17-item Hamilton Depression Rating Scale than non-PSD ***-two SNPs with seven genes were genotyped and passed quality *** rs7692791 CC genotypes,the C allele of KDR and the rs9282715 T allele of IGF-1R increased the risk for PSD(χ^(2)=7.881,p=0.019;χ^(2)=4.259,p=0.039;χ^(2)=4.222,p=0.040,respectively).In addition,the SNP rs7692791 of KDR was significantly associated with PSD by the logistic regression of an additive model(p=0.015,OR=9.584,95%CI:1.549 to 59.31).Conclusions Patients with rs7692791 C allele carriers or the CC genotype of KDR and the rs9282715 T all

关键词： KDR susceptibility additive

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考虑源-荷时空匹配的农业产业园区分散储能系统优化规划

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供用电 2024年第9期41卷 34-43页

作者：耿光飞勇晔薛溟枫毛晓波牛潇昆中国农业大学信息与电气工程学院北京100083 国网江苏省电力有限公司无锡供电分公司江苏无锡214000

随着可再生能源的快速发展以及农机电能替代技术的不断成熟,农业产业园区供能系统电气化和低碳化已成为发展趋势。考虑本地可再生能源与用电负荷的时空匹配特性,研究农业产业园区分散储能系统优化规划。综合考虑分时电价和碳排放价格,... 详细信息

随着可再生能源的快速发展以及农机电能替代技术的不断成熟,农业产业园区供能系统电气化和低碳化已成为发展趋势。考虑本地可再生能源与用电负荷的时空匹配特性,研究农业产业园区分散储能系统优化规划。综合考虑分时电价和碳排放价格,提出了“等效价格”的概念,有助于在实现峰谷套利的同时提高农业产业园区的减碳效益。以投资运维成本、减碳收益和峰谷套利收益等为目标,建立了计及典型运行模拟的分散储能系统优化配置模型。对仅考虑分时电价、2种价格变化一致、2种价格变化相反3种情形分别进行分散储能的优化配置,分析了2种时变价格的变化趋势对配置储能的影响。算例仿真结果表明,采用“等效价格”制定储能充放电策略能够降低农场用电成本和实现减碳目标;分时电价与碳排放价格曲线变化趋势相同时,配置储能可获得更高的经济效益。

关键词：分散储能优化配置农业产业园区电动农机可再生能源碳排放

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计量经济学与实验经济学的若干新近发展及展望

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中国经济问题 2016年第2期 126-136页

作者：洪永淼方颖陈海强范青亮耿森王云厦门大学王亚南经济研究院厦门大学经济学院教育部厦门大学计量经济学重点实验室

计量经济学与实验经济学是经济学实证分析的重要方法与工具。本文主要概括了近十年来计量经济学与实验经济学领域的主要进展,包括面板数据计量经济学、微观计量经济学、大数据计量经济学、金融计量经济学、宏观计量经济学、新类型实验... 详细信息

计量经济学与实验经济学是经济学实证分析的重要方法与工具。本文主要概括了近十年来计量经济学与实验经济学领域的主要进展,包括面板数据计量经济学、微观计量经济学、大数据计量经济学、金融计量经济学、宏观计量经济学、新类型实验数据、非均衡博弈论框架以及市场机制与政策设计等方向。我们建议重点发展计量经济学与实验经济学在中国社会经济政策评估与分析方面的方法与理论的创新及应用,推动政府决策的科学化。

关键词：计量经济学实验经济学政策评估决策科学化

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极紫外光刻材料研究进展

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红外与激光工程 2014年第6期43卷 1850-1856页

作者：耿永友邓常猛吴谊群中国科学院上海光学精密机械研究所中国科学院强激光材料重点实验室上海201800

极紫外光刻是微电子领域有望用于下一代线宽为22nm及以下节点的商用投影光刻技术,光刻材料的性能与工艺是其关键技术之一。为我国开展极紫外光刻材料研究提供参考,综述了最近几年来文献报道的研究成果,介绍了极紫外光刻技术发展历程、... 详细信息

极紫外光刻是微电子领域有望用于下一代线宽为22nm及以下节点的商用投影光刻技术,光刻材料的性能与工艺是其关键技术之一。为我国开展极紫外光刻材料研究提供参考,综述了最近几年来文献报道的研究成果,介绍了极紫外光刻技术发展历程、现状、光刻特点及对光刻材料的基本要求,总结了极紫外光刻材料的研究领域和具体分类,着重阐述了主要光刻材料的组成、光刻原理,光刻性能所达到的水平和存在的主要问题,最后探讨了极紫外光刻材料未来的主要研究方向。

关键词：极紫外光刻极紫外光刻材料极紫外光刻性能

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Chemical screen identifies a geroprotective role of quercetin in premature aging

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Protein & Cell 2019年第6期10卷 417-435页

作者： Lingling geng Zunpeng Liu Weiqi Zhang Wei Li Zeming Wu Wei Wang Ruotong Ren Yao Su Peichang Wang Liang Sun Zhenyu Ju Piu Chan Moshi Song Jing Qu Guang-Hui Liu Advaneed Innovation Center for Human Brain Protection National Clinical Research Center for Geriatric Disorders Xuanwu Hospital of Capital Medical University Beijing 100053 China National Laboratory of Biomacromolecules CAS Center for Excellenee in Biomacromolecules Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China State Key Laboratory of Stem Cell and Reproductive Biology Institute of Zoology Chinese Academy of Sciences Beijing 100101 China State Key Laboratory of Membrane Biology Institute of Zoology Chinese Academy of Sciences Beijing 100101 China University of Chinese Academy of Sciences Beijing 100049 China Institute of Stem cell and Regeneration Chinese Academy of Sciences Beijing 100101 China Key Laboratory of Regenerative Medicine of Ministry of Education Institute of Aging and Regenerative Medicine Jinan University Guangzhou 510632 China The MOH Key Laboratory of Geriatrics Beijing Hospital National Center of Gerontology Beijing 100730 China

Aging increases the risk of various diseases. The main goal of aging research is to find therapies that attenuate aging and alleviate aging-related diseases. In this study, we screened a natural product library for geroprotective compounds using Werner syndrome (WS) human mesenchymal stem cells (hMSCs), a premature aging model that we recently established. Ten candidate compounds were identified and quercetin was investigated in detail due to its leading effects. Mechanistic studies revealed that quercetin alleviated senescence via the enhancement of cell proliferation and restoration of heterochromatin architecture in WS hMSCs. RNA-sequencing analysis revealed the transcriptional commonalities and differences in the geroprotective effects by quercetin and Vitamin C. Besides WS hMSCs, quercetin also attenuated cellular senescence in Hutchinson-Gilford progeria syndrome (HGPS) and physiological-aging hMSCs. Taken together, our study identifies quercetin as a geroprotective agent against accelerated and natural aging in hMSCs, providing a potential therapeutic intervention for treating age-associated disorders.

关键词： Quercetin Stem cell Aging Werner syndrome Hutchinson-Gilford progeria syndrome

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On the Adverse Selection of P2P Online Lending Market and Its Governance

On the Adverse Selection of P2P Online Lending Market and It...

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作者： ZHOU geng FAN Conglai WANG Yuwei Nanjing University

Information asymmetry has a negative effect on financing efficiency;financing interest rate can ease the impact of information asymmetry on financing efficiency, while financing term can enhance the impact of information asymmetry on financing efficiency. The credit-keeping borrowers should disclose all information as much as possible. When the information disclosure is frustrated, it can be made up by raising interest rates and shortening the time limits. The investors should resist the temptation of high interest rates and choose the financing projects with well-disclosed information. The P2P intermediary platforms should establish smooth channels for information disclosure and improve the degree of intelligence for automated bidding. The regulators should establish a mandatory information disclosure system and strive to reduce the level of equilibrium interest rates in the markets.

关键词： P2P online lending information asymmetry financing efficiency adverse selection

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Behavioral Risk Profile of Men Who Have Sex with Men in Beijing, China： Results from a Cross-sectional Survey with Randomized Response Techniques

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Chinese Medical Journal 2016年第5期129卷 523-529页

作者： Guo-Zhu geng Ge Gao Yu-Hua Ruan Ming-Run Yu Yun-Hua Zhou Department of Epidemiology and Health Statistics School of Public Health Medical College of Soochow University Suzhou Jiangsu 215123 China Chinese Center for Disease Control and Prevention State Key Laboratory of Infectious Disease Prevention and Control Collaborativelnnovation Center for Diagnosis and Treatment of Infectious Diseases Beijing 102206 China Department of STD/AIDS and Dermatology Taizhou City Center for Disease Control and Prevention Taizhou Jiangsu 225300 China

Background：Human immunodeficiency virus （HIV） is spreading rapidly among men who have sex with men （MSM） in *** questionnaires or direct interviews have been frequently used to study their *** aim of the study was to describe the behavioral risk profile of the MSM in Beijing using the randomized response techniques （RRTs）.Methods：A cross-sectional survey of sexual behavior among a sample of MSM was conducted in two HIV counseling and testing clinics in *** survey was carried out with an anonymous questionnaire containing sensitive questions on sexual *** obtain the honest responses to the sensitive questions,three distinctive RRTs were used in the questionnaire：（1） Additive randomized response model for quantitative questions,（2） randomized response model for multiple choice questions,and （3） Simmons randomized response model for binomial *** for the point estimate,variance,and confidence interval （CI） were provided for each specific ***：Using RRTs in a sample of 659 participants,the mean age at first homosexual encounter was estimated to be 21.7 years （95% CI：21.2-22.2）,and each had sex with about three （2.9,95% CI：2.4-3.4） male partners on average in the past *** estimated rate for consistent condom use was 56.4% （95% CI：50.1-62.8%）.In addition,condom was estimated to be used among 80.0% （95% CI：74.1-85.9%） of the population during last anal sex with a male ***：Our study employed RRTs in a survey containing questions on sexual behavior among MSM,and the results showed that RRT might be a useful tool to obtain truthful feedback on sensitive information such as sexual behavior from the respondents,especially in traditional Chinese cultural settings.

关键词： Condom Use, Cross-sectional Survey: Men Who Have Sex with Men Randomized Response Technique, Sexual Behavior

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