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Comparative Study on the Immunogenicity and Efficacy of Different Post-exposure Intramuscular Rabies Vaccination Regimens in China

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Biomedical and Environmental Sciences 2024年第2期37卷 178-186页

作者： SONG Yun HE Ying LU xue Xin ZHANG Xiao Mei JIANG XIAO Lin SONG qing HUANG xue Yong MA Hong Xia YU Peng Cheng ZHU Wu Yang Henan Provincial Center for Disease Control and Prevention Infectious Disease Prevention and Control InstituteHenan Provincial Key Laboratory of Infectious Disease PathogensZhengzhou 450000HenanChina National Institute for Viral Disease Control and Prevention China CDCKey Laboratory of BiosafetyNational Health CommissionBeijing 102206China Shandong Provincial Center for Disease Control and Prevention Jinan 250014ShandongChina qingdao Chengyang District Center for Disease Control and Prevention Qingdao 266108ShandongChina

Objective This study aimed to compare the current Essen rabies post-exposure immunization schedule(0-3-7-14-28)in China and the simple 4-dose schedule(0-3-7-14)newly recommended by the World Health Organization in terms of their safety,efficacy,and *** Mice were vaccinated according to different immunization schedules,and blood was collected for detection of rabies virus neutralizing antibodies(RVNAs)on days 14,21,28,35,and 120after the first ***,different groups of mice were injected with lethal doses of the CVS-11 virus on day 0,subjected to different rabies immunization schedules,and assessed for morbidity and death *** a clinical trial,185 rabies-exposed individuals were selected for post-exposure vaccination according to the Essen schedule,and blood was collected for RVNAs detection on days 28and 42 after the first *** A statistically significant difference in RVNAs between mice in the Essen and 0-3-7-14 schedule groups was observed on the 35th day(P0.05)in RVNAs levels at any time *** post-exposure immune protective test showed that the survival rate of mice in the control group was 20%,whereas that in the immunization groups was 40%.In the clinical trial,the RVNAs positive conversion rates on days 28(14 days after 4 doses)and 42(14 days after 5 doses)were both 100%,and no significant difference in RVNAs levels was observed(P>0.05).Conclusion The simple 4-dose schedule can produce sufficient RVNAs levels,with no significant effect of a delayed fourth vaccine dose(14–28 d)on the immunization potential.

关键词： Rabies Post-exposure immunization Essen regimen RVNAs

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Enhancement of polymyxin B1 production by an artificial microbial consortium of Paenibacillus polymyxa and recombinant Corynebacterium glutamicum producing precursor amino acids

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Synthetic and Systems Biotechnology 2024年第1期9卷 176-185页

作者： Hui-Zhong Sun Si-Yu Wei qiu-Man Xu Wei Shang qing Li Jing-Sheng Cheng Ying-Jin Yuan Frontiers Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering(Ministry of Education) School of Chemical Engineering and TechnologyTianjin UniversityYaguan Road 135Jinnan DistrictTianjin300350PR China Tianjin Key Laboratory of Animal and Plant Resistance College of Life ScienceTianjin Normal UniversityBinshuixi Road 393Xiqing DistrictTianjin300387PR China Department of Pharmaceutical School of Chemical Engineering and TechnologyTianjin UniversityYaguan Road 135Jinnan DistrictTianjin300350PR China

Polymyxin B,produced by Paenibacillus polymyxa,is used as the last line of defense *** this study,exogenous mixture of precursor amino acids increased the level and proportion of polymyxin B1 in the total of polymyxin B analogs of *** CJX518-AC(PPAC)from 0.15 g/L and 61.8%to 0.33 g/L and 79.9%,*** co-culture of strain PPAC and recombinant Corynebacterium glutamicum-leu01,which produces high levels of threonine,leucine,and isoleucine,increased polymyxin B1 production to 0.64 g/*** strains PPAC and ***-leu01 simultaneously inoculated into an optimized medium with 20 g/L peptone,polymyxin B1 production was increased to 0.97 g/***,the polymyxin B1 production in the co-culture of strains PPAC and ***-leu01 increased to 2.21 g/L after optimized inoculation ratios and fermentation medium with 60 g/L *** study provides a new strategy to improve polymyxin B1 production.

关键词： Polymyxin Co-culture Paenibacillus polymyxa Corynebacterium glutamicum Medium optimization Metabolic precursors

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A single degenerated primer significantly improves COX1 barcoding performance in soil nematode community profiling

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Soil Ecology Letters 2024年第2期6卷 31-44页

作者： Yincai Ren Dorota L. Porazinska Quanhui Ma Shuhan Liu Hongmei Li xue qing Department of Plant Pathology Nanjing Agricultural UniversityNanjing210095China Department of Entomology and Nematology University of FloridaGainesvilleFL32611USA Institute of Grassland Science Key Laboratory of Vegetation Ecology of the Ministry of EducationJilin Songnen Grassland Ecosystem National Observation and Research StationNortheast Normal UniversityChangchun130024China

A new COX1 primer for soil nematode metabarcoding was designed,and this primer outperforms other commonly used COX1 primer pairs in species recovery and quantity of PCR products.•The lack of reference database is the main reason that led to the low species recovery in COX1 metabarcoding.•We expanded current NCBI database by adding 51 newly generated COX1 reference *** nematodes play important roles in soil ecosystems and often serve as bioindicators of soil *** identification of soil nematodes is often difficult due to their limited diagnostic characters and high phenotypic *** barcoding and metabarcoding techniques are promising but lack universal primers,especially for mitochondrial COX1 *** this study a degenerated COX1 forward primer COIFGED was *** primer pair(COIFGED/JB5GED)outperforms other four commonly used COX1 primer pairs in species recovery and quantity of polymerase chain reaction(PCR)*** metabarcoding analysis,the reads obtained from the new primer pair had the highest sequencing saturation threshold and amplicon sequence variant(ASV)diversity in comparison to other COX1 as well as 18S rRNA *** annotation of ASVs suggested the new primer pair initially recovered 9 and 6 out of 25 genera from mock communities,respectively,outperformed other COX1 primers,but underperformed the widely used 18S NF1/18Sr2b primers(16 out of 25 genera).By supplementing the COX1 database with our reference sequences,we recovered an additional 6 mock community species bringing the tally closer to that obtained with 18S *** summary,our newly designed COX1 primers significantly improved species recovery and thus can be supplementary or alternative to the conventional 18S metabarcoding.

关键词： degenerated primers DNA metabarcoding mitochondrial cytochrome oxidase c subunit I gene phylogeny ribosomal RNA gene soil nematodes

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Mechanism research progress on transition metal compound electrode materials for supercapacitors

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Rare Metals 2024年第9期43卷 4076-4098页

作者： Zhi-Hui Xu xue-Lei Li qing-Wen Li Kai Lv Jing-Shun Liu Xiu-Kun Hang Aruuhan Bayaguud School of Materials Science and Engineering Inner Mongolia University of TechnologyHohhot 010051China School of Materials Science and Engineering Tianjin University of TechnologyTianjin 300384China College of Chemistry and Chemical Engineering Inner Mongolia UniversityHohhot 010021China

Supercapacitors(SCs)have remarkable energy storage capabilities and have garnered considerable interest due to their superior power densities and ultra-long cycling ***,their comparatively low energy density limits their extensive application in large-scale commercial *** materials directly affect the performance of ***,the development of cutting-edge electrode materials and modification of their morphological and structural properties are vital for advancing the performance of *** metal compounds have a high specific capacity and good cycling durability,making them the most promising electrode active materials for high-energy density ***,their inadequate conductivity,unfavorable ion diffusion rates,substantial volume expansion and phase transitions during charging and discharging are obstacles to their stable and efficient integration into *** address these challenges,this study provides a comprehensive summary of the current advancements in transition metal nanomaterials as electrode materials for SCs,an overview of the current research status,and the prevailing ***,this study highlights synthetic techniques and management strategies for electrode materials derived from transition metal compounds,targeting the resolution of the aforementioned ***,a concise discussion is provided on the future directions of SC development,with an emphasis on the utilization of transition metal compound electrode materials.

关键词： Supercapacitors Transition metal compounds electrode Existing problems Synthetic methods Regulation strategies

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Potassium and calcium channels in different nerve cells act as therapeutic targets in neurological disorders

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Neural Regeneration Research 2025年第5期20卷 1258-1276页

作者： qing qiu Mengting Yang Danfeng Gong Haiying Liang Tingting Chen Department of Pharmacology School of PharmacyNantong UniversityNantongJiangsu ProvinceChina Jiangsu Province Key Laboratory of Inflammation and Molecular Drug Target NantongJiangsu ProvinceChina Department of Pharmacy Longyan First Affiliated Hospital of Fujian Medical UniversityLongyanFujian ProvinceChina

The central nervous system, information integration center of the body, is mainly composed of neurons and glial cells. The neuron is one of the most basic and important structural and functional units of the central nervous system, with sensory stimulation and excitation conduction functions. Astrocytes and microglia belong to the glial cell family, which is the main source of cytokines and represents the main defense system of the central nervous system. Nerve cells undergo neurotransmission or gliotransmission, which regulates neuronal activity via the ion channels, receptors, or transporters expressed on nerve cell membranes. Ion channels, composed of large transmembrane proteins, play crucial roles in maintaining nerve cell homeostasis. These channels are also important for control of the membrane potential and in the secretion of neurotransmitters. A variety of cellular functions and life activities, including functional regulation of the central nervous system, the generation and conduction of nerve excitation, the occurrence of receptor potential, heart pulsation, smooth muscle peristalsis, skeletal muscle contraction, and hormone secretion, are closely related to ion channels associated with passive transmembrane transport. Two types of ion channels in the central nervous system, potassium channels and calcium channels, are closely related to various neurological disorders, including Alzheimer's disease, Parkinson's disease, and epilepsy. Accordingly, various drugs that can affect these ion channels have been explored deeply to provide new directions for the treatment of these neurological disorders. In this review, we focus on the functions of potassium and calcium ion channels in different nerve cells and their involvement in neurological disorders such as Parkinson's disease, Alzheimer's disease, depression, epilepsy, autism, and rare disorders. We also describe several clinical drugs that target potassium or calcium channels in nerve cells and could be u

关键词： astrocytes calcium channels central nervous system extracellular ion concentration microglia neurological disorders neurons potassium channels

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碱木质素的乙酰化及其球形胶束的制备

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高分子学报 2014年第11期24卷 1458-1464页

作者：邱学青李浩邓永红钱勇易聪华华南理工大学化学与化工学院广州510640 华南理工大学制浆造纸工程国家重点实验室广州510640

以造纸制浆废液中的碱木质素(AL)为原料,通过乙酰氯对其进行化学改性,制备出了乙酰化碱木质素(ACAL).红外光谱和核磁共振谱的结果表明乙酰化反应后AL中的羟基被乙酰基取代.ACAL在四氢呋喃(THF)和水的混合溶剂中能够通过自组装形成纳米... 详细信息

以造纸制浆废液中的碱木质素(AL)为原料,通过乙酰氯对其进行化学改性,制备出了乙酰化碱木质素(ACAL).红外光谱和核磁共振谱的结果表明乙酰化反应后AL中的羟基被乙酰基取代.ACAL在四氢呋喃(THF)和水的混合溶剂中能够通过自组装形成纳米级的球形胶束.利用静态光散射测定了胶束形成时的临界含水量,通过动态光散射研究了溶液初始浓度和水的滴加速度对胶束粒径和多分散性的影响,采用透射电镜和原子力显微镜对胶束形貌进行表征.结果表明,碱木质素经乙酰化改性后可用于制备木质素基球形胶束,并且胶束结构具有一定的稳定性,通过改变溶液条件可以在一定范围内调节胶束的粒径大小和多分散性.

关键词：碱木质素乙酰化自组装胶束

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Urgent call for attention to diabetes-associated hospital infections

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World Journal of Diabetes 2024年第8期15卷 1683-1691页

作者： xue-Lu Yu Li-Yun Zhou Xiao Huang Xin-Yue Li qing-qing Pan Ming-Ke Wang Ji-Shun Yang Department of Disease Control and Prevention Naval Medical Center of PLANaval Medical UniversityShanghai 200052China Medical Care Center Naval Medical Center of PLANaval Medical UniversityShanghai 200052China

In this editorial,we discuss the recent article by Zhao et al published in the World Journal of Diabetes,which highlights the importance of recognizing the risk indicators associated with diabetes mellitus(DM).Given the severe implications of healthcare-associated infections(HAIs)in hospitalized individuals-such as heightened mortality rates,prolonged hospitalizations,and increased costs-we focus on elucidating the connection between DM and nosocomial *** patients are susceptible to pathogenic bacterial invasion and subsequent infection,with some already harboring co-infections upon ***,DM is an important risk factor for nosocomial urinary tract infections and surgical site infections,which may indirectly affect the occurrence of nosocomial bloodstream infections,especially in patients with DM with poor glycemic *** evidence regarding the impact of DM on healthcare-associated pneumonias remains inconclusive,attention to this potential association is *** patients with DM should prioritize meticulous blood glucose management,adherence to standard operating procedures,hand hygiene practices,environmental disinfection,and rational use of drugs during *** studies are imperative to explore the main risk factors of HAIs in patients with DM,enabling the development of preventative measures and mitigating the occurrence of HAIs in these patients.

关键词： Diabetes mellitus Healthcare-associated infections Nosocomial urinary tract infections Surgical site infections Nosocomial bloodstream infections

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Performance of Gas-Steam Combined Cycle Cogeneration Units Influenced by Heating Network Terminal Steam Parameters

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Energy Engineering 2024年第6期121卷 1495-1519页

作者： Guanglu Xie Zhimin xue Bo Xiong Yaowen Huang Chaoming Chen qing Liao Cheng Yang Xiaoqian Ma Zhongshan Jiaming Electric Power Co. Ltd.CNOOC Gas&Power GroupZhongshan528403China School of Electric Power South China University of TechnologyGuangzhou510640China

The determination of source-side extracted heating parameters is of great significance to the economic operation of cogeneration *** paper investigated the coupling performance of a cogeneration heating and power system multidimensionally based on the operating characteristics of the cogeneration units,the hydraulic and thermodynamic characteristics of the heating network,and the energy *** a steam network supported by a gas-steam combined cycle cogeneration system as the research case,the interaction effect among the source-side prime movers,the heating networks,and the terminal demand thermal parameters were investigated based on the designed values,the plant testing data,and the validated *** operating maps of the gas-steam combined cycle cogeneration units were obtained using THERMOFLEX,and the minimum source-side steam parameters of the steam network were solved using an inverse solution procedure based on the hydro-thermodynamic coupling *** cogeneration operating maps indicate that the available operating domain considerably narrows with the rise of the extraction steam pressure and flow *** heating network inverse solution demonstrates that the source-side steam pressure and temperature can be optimized from the originally designed 1.11 MPa and 238.8°C to 1.074 MPa and 191.15°C,*** the operating strategy with the minimum source-side heating parameters,the power peak regulation depth remarkably increases to 18.30%whereas the comprehensive thermal efficiency *** operation under the minimum source-side heating steam parameters can be superior to the originally designed one in the economy at a higher price of the heating *** a fuel price of$0.38/kg and the power to fuel price of 0.18 kg/(kW·h),the critical price ratio of heating steam to fuel is 119.1 kg/*** influence of the power-fuel price ratio on the economic deviation appears relatively weak.

关键词： Gas-steam combined cycle cogeneration of heating and power steam network inverse problem operating performance

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Preparation and Structure-Property Regulation Mechanism of Reversible Thermochromic Polydiacetylene

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Chinese Journal of Polymer Science 2024年第8期42卷 1111-1121页

作者： Zhi-qing Ge Shuo Yan Zu-Xiong Pan Shan Lei Xuan-Zhi Mao Chu Zhao Mo-Zhen Wang xue-Wu Ge Key Laboratory of Precision and Intelligent Chemistry Department of Polymer Science and EngineeringUniversity of Science and Technology of ChinaHefei 230026China Marshall Laboratory of Biomedical Engineering International Cancer CenterLaboratory of Evolutionary Theranostics(LET)School of Biomedical EngineeringShenzhen University Medical SchoolShenzhen UniversityShenzhen 518055China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China

The thermochromic mechanism and the structure-property regulation principle of reversible thermochromic polydiacetylene(PDA)materials have always been a challenging *** this work,a series of diacetylene monomers(m-PCDA)containing phenyl and amide or carboxyl groups were synthesized from 10,12-pentacosadiynoic acid(PCDA)through the esterification or amidation *** effects of the number and the distribution of the functional groups in m-PCDA molecules on their solid-state polymerization capability,and the thermochromic mechanism of their corresponding polymers(m-PDA)were investigated and discussed in *** results show that the m-PCDA monomers containing both benzene ring and groups that can form hydrogen bonding interactions have strong intermolecular interaction,and are easy to carry out the solid phase polymerization under 254-nm UV irradiation to obtain the corresponding new thermochromic m-PDA *** thermochromic behavior of m-PDA depends on its melting *** initial color-change temperature(blue to red)is determined by the onset melting tem perature,and the temperature range in which reversible color recovery can be achieved by repeat heating-cooling treatment is determined by its melting *** to the proposed thermochromic mechanism of PDA,various new PDA materials with precise thermochromic temperatu res and reversible thermochromic temperature ra nges can be designed and synthesized through the appropriate introduction of benzene ring and groups that can form hydrogen bonding interactions into the molecular structure of linear diacetylene *** work provides a perspective to the precise molecular structure design and the property regulation of the reversible thermochromic PDA materials.

关键词： Polydiacetylene Thermochromism Hydrogen bonding Chemical modification

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Bibliometric study of sepsis-associated liver injury from 2000 to 2023

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World Journal of Gastroenterology 2024年第30期30卷 3609-3624页

作者： Zheng Zhang Xiao-Jiao Tan Hai-qing Shi Huan Zhang Jian-Bo Li xue-Lian Liao Department of Critical Care Medicine West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Critical Care Medicine West China Tianfu Hospital of Sichuan UniversityChengdu 610200Sichuan ProvinceChina

BACKGROUND Sepsis-associated liver injury(SLI)is a severe and prevalent complication of *** To explore the literature on SLI via a bibliometric *** Reviews and articles correlated with SLI published from January 1,2000 to October 28,2023 were searched from the Web of Science Core ***,the searched data were analyzed using VOSviewer,CiteSpace,and R *** There were 787 publications involved in this paper,comprising 745 articles and 42 ***,the United States,and Germany are the primary publication sources in this *** related to SLI primarily focused on mechanisms of pathogenesis,as evidenced by analyzing keywords,references,and the counting of original *** studies mainly involved tumor necrosis factor alpha,inflammation,oxidative stress,and nuclear factor-kappa *** There is significant growth in the research on *** investigations primarily involve basic experiments that aimed at uncovering pathogenic *** to the analyzed literature,the identified pathogenic mechanisms and potential therapeutic targets serve as the foundation for translating findings from basic research to clinical applications.

关键词： Sepsis Liver injury Bibliometric analysis Cite space VOS viewer

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