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Preparation of 4-and 6-desphenyl analogues of(-)-clausenamide and alternative synthesis of(+)-epi-clausenamide

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Chinese Chemical Letters 2011年第11期22卷 1261-1264页

作者： Jian Jun xue Yu mei zhou Xiao Ming Yu Institute of Materia Medica Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100050 China

4- and 6-desphenyl analogues of（-）-clausenamide,6 and 7,were prepared in optical active form from commercially available D-pyroglutamic acid and the known racemic pyrrolidinone 13,*** order to confirm the absolute s... 详细信息

关键词： (-)-Clausenamide Desphenyl analogue (+)-epi-Clausenamide Synthesis

QTL analysis of flag leaf in barley (Hordeum vulgare L.) for morphological traits and chlorophyll content

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第12期9卷 938-943页

作者： Da-wei xue Ming-can CHEN mei-xue zhou Song CHEN Ying MAO Guo-ping ZHANG Agronomy Department Zhejiang University Hangzhou 310029 China College of Life and Environment Sciences Hangzhou Normal University Hangzhou 310036 China College of Agronomy Henan University of Science and Technology Luoyang 471003 China Tasmanian Institute of Agricultural Research and School of Agricultural Science University of Tasmania Kings Meadows TAS 7249 Australia

To understand genetic patterns of the morphological and physiological traits in flag leaf of barley, a double haploid （DH） population derived from the parents Yerong and Franklin was used to determine quantitative trait loci （QTL） controlling length, width, length/width, and chlorophyll content of flag leaves. A total of 9 QTLs showing significantly additive effect were detected in 8 intervals on 5 chromosomes. The variation of individual QTL ranged from 1.9% to 20.2%. For chlorophyll content expressed as SPAD value, 4 QTLs were identified on chromosomes 2H, 3H and 6H; for leaf length and width, 2 QTLs located on chromosomes 5H and 7H, and 2 QTLs located on chromosome 5H were detected; and for length/width, I QTL was detected on chromosome 7H. The identification of these QTLs associated with the properties of flag leaf is useful for barley improvement in breeding programs.

关键词： Barley (Hordeum vulgare L.) Double haploid (DH) Flag leaf Quantitative trait loci (QTL)

Th–U cycle performance analysis based on molten chloride salt and molten fluoride salt fast reactors

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Nuclear Science and Techniques 2020年第8期31卷 116-128页

作者： Liao-Yuan He Shao-Peng Xia xue-mei zhou Jin-Gen Chen Gui-Min Liu Yang Zou Rui Yan Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China CAS Innovative Academies in TMSR Energy System Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China

The recent development of molten salt fast reactors has generated a renewed interest in them. As compared to traditional solid fuel fast neutron systems, it has many unique advantages, e.g., lower fissile inventory,no initial criticality reserve, waste reduction, and a simplified fuel cycle. It has been recognized as an ideal reactor for achieving a closed Th–U cycle. Based on the carrier salt, molten salt fast reactors could be divided into either a molten chloride salt fast reactor(MCFR) or a molten fluoride salt fast reactor(MFFR);to compare their Th–U cycle performance, the neutronic parameters in a breeding and burning(B&B) transition scenario were studied based on similar core geometry and power. The results demonstrated that the required reprocessing rate for an MCFR to achieve self-breeding was lower than that of an ***, the breeding capability of an MCFR was better than that of an MFFR;at a reprocessing rate of 40 L/day,using LEU and Pu as start-up fissile materials, the doubling time(DT) of an MFFR and MCFR were 88.0 years and 48.0 years, and 16.5 years and 16.2 years, ***, an MCFR has lower radio-toxicity due to lower buildup of fission products(FPs) and transuranium(TRU),while an MFFR has a larger, delayed neutron fraction with smaller changes during the entire operation.

关键词： Th–U cycle Molten salt fast reactor Breeding capability Doubling time

Identification of QTLs for yield and yield components of barley under different growth conditions

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第3期11卷 169-176页

作者： Da-wei xue mei-xue zhou Xiao-qin ZHANG Song CHEN Kang WEI Fan-rong ZENG Ying MAO Fei-bo WU Guo-ping ZHANG College of Life and Environment Sciences Hangzhou Normal University Hangzhou 310036 China Department of Agronomy Zhejiang University Hangzhou 310029 China Tasmanian Institute of Agricultural Research University of Tasmania Kings Meadows TAS 7249 Australia

Waterlogging is a major abiotic stress limiting barley (Hordeum vulgare L.) yield and its stability in areas with excessive *** of genomic regions influencing the response of yield and its components to waterlogging stress will enhance our understanding of the genetics of waterlogging tolerance and the development of more tolerant barley *** trait loci (QTLs) for grain yield and its components were identified using 156 doubled haploid (DH) lines derived from a cross between the cultivars Yerong (waterlogging-tolerant) and Franklin (waterlogging-sensitive) grown under different conditions (waterlogged and well drained).A total of 31 QTLs were identified for the measured characters from two experiments with two growth *** phenotypic variation explained by individual QTLs ranged from 4.74% to 55.34%.Several major QTLs determining kernel weight (KW),grains per spike (GS),spikes per plant (SP),spike length (SL) and grain yield (GY) were detected on the same region of chromosome 2H,indicating close linkage or pleiotropy of the gene(s) controlling these *** different QTLs were identified under waterlogging conditions,and thus different markers may have to be used in selecting cultivars suitable for high rainfall areas.

关键词： Barley (Hordeum vulgare L.) Waterlogging tolerance Yield Quantitative trait locus (QTL)

Blocking　effect　of　tanshinone　Ⅱ－Aon　L－type　Ca2＋　curent　of　single　ventricular 　myocyte　from　guinea　pig

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中国药理学与毒理学杂志 1996年第2期 2-5页

作者： XU Chang-Qing, FAN Jin-Song 2, HAO xue-mei 2, zhou Ying-Ying 2, WANG Xiao-Ming, LIU Tai-Feng 2 (Department of Pathophysiology, Harbin Medical University, Harbin 150086 2Laboratory of Biological Membrane and Membrane Engineering, Departm

本实验采用全细胞膜片钳技术，观察了丹参酮Ⅱ－Ａ对分离的豚鼠单个心室肌细胞Ｌ－型钙电流及跨膜电位的影响．使用Ｌａｎｇｅｎｄｏｒｆ装置和蛋白酶循环消化（０．２ｇ·Ｌ－１）的方法，获取了７０％～８０％的横纹清晰，呈杆状的耐... 详细信息

本实验采用全细胞膜片钳技术，观察了丹参酮Ⅱ－Ａ对分离的豚鼠单个心室肌细胞Ｌ－型钙电流及跨膜电位的影响．使用Ｌａｎｇｅｎｄｏｒｆ装置和蛋白酶循环消化（０．２ｇ·Ｌ－１）的方法，获取了７０％～８０％的横纹清晰，呈杆状的耐钙心肌细胞．并使用ｐＣＬＡＭＰ５．５１微机程序和ＥＬＰ－７膜片钳放大器记录心肌细胞膜电流和跨膜电位的变化．丹参酮采用累积加药法，所有的观察指标均在同一细胞完成．数据分析采用配对ｔ检验．当使心肌细胞的保持电压为－４０ｍＶ，除极到０ｍＶ，刺激电压的时程为２５０ｍｓ，频率为０．５Ｈｚ时，１０，２０和４０μｍｏｌ·Ｌ－１的丹参酮Ⅱ－Ａ可使维拉帕米敏感的钙内向电流分别减少３５．２％，５７．７％和７４．７％（Ｐ＜０．０５），并能使动作电位时程亦呈剂量依赖性缩短，冲洗后两指标均部分恢复．该药的三种不同浓度，对不同电压最大激活的钙电流的电压依赖曲线均无影响．结果表明，丹参酮Ⅱ－Ａ具有类似维拉帕米样Ｌ－型钙通道阻断剂作用，其阻断作用呈非电压依赖性．

关键词：丹参酮Ⅱ-A L-型钙电流动作电位膜片钳心肌

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基于OFDM的子载波加权技术研究

计算机工程 2018年第6期44卷 57-61页

作者：薛梅周杰邵根富南京信息工程大学电子与信息工程学院南京210044 杭州电子科技大学自动化学院杭州310000

针对正交频分复用(OFDM)系统中固有的高旁瓣问题,结合子载波加权方法,提出一种OFDM系统旁瓣抑制算法。根据若干优化限制进行优化运算,使得传输信号的旁瓣达到最小值,从而确定载波权重。在子载波加权的基础上引入时域加窗,将发射信号与... 详细信息

针对正交频分复用(OFDM)系统中固有的高旁瓣问题,结合子载波加权方法,提出一种OFDM系统旁瓣抑制算法。根据若干优化限制进行优化运算,使得传输信号的旁瓣达到最小值,从而确定载波权重。在子载波加权的基础上引入时域加窗,将发射信号与不同于传统矩形窗的窗函数做相乘运算,最终对带外辐射进行有效抑制。仿真结果表明,在无需传输任何边信息的情况下,子载波加权方法平均能够抑制辐射强度不低于10 dB的OFDM旁瓣,对加权后的OFDM信号采取加窗处理,则可以抑制辐射强度约为25 dB的旁瓣。

关键词：正交频分复用带外辐射旁瓣抑制子载波加权优化限制加窗

microRNA在动脉硬化闭塞症中调控血管平滑肌的作用机制

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中国动脉硬化杂志 2017年第2期25卷 210-216页

作者：王雪琴何雪梅周翔宇何延政西南医科大学附属第一医院血管甲状腺外科四川省泸州市646000

动脉硬化闭塞症已成为周围血管疾病的首要病症,严重危害人们身心健康,早期诊断及治疗尤为迫切和必要。近年来,随着非蛋白机制和转录后机制研究的逐渐清晰,部分研究聚焦于探索microRNA与动脉硬化闭塞症之间的关系。文章依据microRNA在动... 详细信息

动脉硬化闭塞症已成为周围血管疾病的首要病症,严重危害人们身心健康,早期诊断及治疗尤为迫切和必要。近年来,随着非蛋白机制和转录后机制研究的逐渐清晰,部分研究聚焦于探索microRNA与动脉硬化闭塞症之间的关系。文章依据microRNA在动脉硬化闭塞症细胞模型、动物模型和患者水平中调控血管平滑肌细胞的增殖、迁移、分化、表型转换和凋亡等方面来进行学习和研究。microRNA的研究从基因调控方面更好地解释了动脉硬化闭塞症的发生与发展,但由于其中复杂的调控机制以及缺乏药代学和药效学研究数据、作用靶基因众多等因素,其临床应用仍然受到制约。展望未来,应用microRNA治疗药剂治疗血管疾病特别是下肢动脉硬化闭塞症将有效减少其带来的损害。

关键词：动脉硬化闭塞症 microRNA 细胞模型动物模型动脉硬化闭塞症

A bipartite molecular module controls cell death activation in the basal cell lineage of plant embryos

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A bipartite molecular module controls cell death activation ...

细胞—生命的基础——中国细胞生物学学会2013年全国学...

作者： Peng Zhao xue-mei zhou Li-yao Zhang Wei Wang Li-gang Ma Li-bo Yang Xiong-bo Peng Vemonica EFranklin-Tong Peter VBozhkov Meng-xiang Sun Department of Cell and Developmental Biology College of Life ScienceWuhan University School of Biosciences University of Birmingham Department of Plant Biology and Forest Genetics Uppsala BioCenterSwedish University of Agricultural Sciences and Linnean Center for Plant Biology

An intriguing feature of plant embryogenesis is that only one part(apical domain)of the embryo gives rise to a plant,whereas another part(basal domain)is eliminated by programmed cell death(PCD)at certain time point,once its function is *** basal domain is called "suspensor" and it serves an important role of a conduit of nutrients and growth factors to the embryo *** has long been

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果蝇在药理学研究中的应用

中国药学杂志 2016年第19期51卷 1638-1642页

作者：段丹丹高丽秦雪梅周玉枝杜冠华山西大学中医药现代研究中心太原030006 山西大学化学化工学院太原030006 中国医学科学院北京协和医学院药物研究所北京100050

果蝇作为一种模式生物,具有生命周期短、繁殖力强、基因保守性高等特点。目前,果蝇已广泛应用于药理学和疾病机制研究中,涵盖衰老、神经退行性疾病、失眠、肿瘤等领域,在加快药物筛选速度和靶点发现等方面显示出潜在的应用价值。笔者就... 详细信息

果蝇作为一种模式生物,具有生命周期短、繁殖力强、基因保守性高等特点。目前,果蝇已广泛应用于药理学和疾病机制研究中,涵盖衰老、神经退行性疾病、失眠、肿瘤等领域,在加快药物筛选速度和靶点发现等方面显示出潜在的应用价值。笔者就果蝇作为模式生物的优势、在药理学研究中的应用及局限性3个方面展开综述。

关键词：果蝇衰老神经退行性疾病失眠肿瘤药物发现