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The First Total Synthesis of(±)-3',7-Dihydroxy-4'-methoxyflavan

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Chinese Chemical Letters 2003年第5期14卷 443-444页

作者： ji Jun xue Xian Shu ZHANG Xi Zhou liang Ying LI National Laboratory of Applied Organic Chemistry and Institute of Organic Chemistry Lanzhou UniversityLanzhou 730000

The first total synthesis of (?-3, 7-dihydroxy-4-methoxyflavan, a naturally occurring flavan, was described. The key step is the cyclization of 1, 3-diaryl-1-propanol by BF3稥t2O.

关键词： (±)-3′ 7-Dihydroxy-4′-methoxyflavan Total synthesis

Salvianolic Acid A Protects Neonatal Cardiomyocytes against Hypoxia/Reoxygenation-Induced Injury by Preserving Mitochondrial Function and Activating Akt/GSK-3β Signals

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Chinese Journal of Integrative Medicine 2019年第1期25卷 23-30页

作者： LI xue-li FAN ji-ping LIU jian-xun liang Li-na Institute of Basic Medical Sciences Xiyuan Hospital China Academy of Chinese Medical Sciences Experimental Research Center China Academy of Chinese Medical Sciences Post-doctoral Research Station China Academy of Chinese Medical Sciences China Academy of Chinese Medical Sciences Eye Function Laboratory Yanke Hospital China Academy of Chinese Medical Sciences

Objective: To investigate the effects of salvianolic acid A(SAA) on cardiomyocyte apoptosis and mitochondrial dysfunction in response to hypoxia/reoxygenation(H/R) injury and to determine whether the Akt signaling pathway might play a role. Methods: An in vitro model of H/R injury was used to study outcomes on primary cultured neonatal rat cardiomyocytes. The cardiomyocytes were treated with 12.5, 25, 50 μg/m L SAA at the beginning of hypoxia and reoxygenation, respectively. Adenosine triphospate(ATP) and reactive oxygen species(ROS) levels were assayed. Cell apoptosis was evaluated by flow cytometry and the expression of cleavedcaspase 3, Bax and Bcl-2 were detected by Western blotting. The effects of SAA on mitochondrial dysfunction were examined by determining the mitochondrial membrane potential(△Ψm) and mitochondrial permeability transition pore(m PTP), followed by the phosphorylation of Akt(p-Akt) and GSK-3β(p-GSK-3β), which were measured by Western blotting. Results: SAA significantly preserved ATP levels and reduced ROS production. Importantly, SAA markedly reduced the number of apoptotic cel s and decreased cleaved-caspase 3 expression levels, while also reducing the ratio of Bax/Bcl-2. Furthermore, SAA prevented the loss of △Ψm and inhibited the activation of m PTP. Western blotting experiments further revealed that SAA significantly increased the expression of p-Akt and p-GSK-3β, and the increase in p-GSK-3β expression was attenuated after inhibition of the Akt signaling pathway with LY294002. Conclusion: SAA has a protective effect on cardiomyocyte H/R injury; the underlying mechanism may be related to the preservation of mitochondrial function and the activation of the Akt/GSK-3β signaling pathway.

关键词： salvianolic acid A cardiomyocyte hypoxia/reoxygenation injury mitochondria Akt/GSK-3β

Chinese Medicine Treatment of Refractory Ascites with Pleural Effusion Caused by Alcoholic Liver Disease: A Case Report

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Chinese Journal of Integrative Medicine 2021年第3期27卷 225-228页

作者： LIU Hong-liang YUAN ji-li xue jing-bo LIU Cheng-hai Institute of Liver Diseases Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China Shanghai Key Laboratory of Traditional Chinese Clinical Medicine Shanghai 201203China

Alcohol is one of the leading causes of chronic liver disease and liver-related deaths *** particular,an overall high average level of alcohol consumption and heavy drinking binges appear to be critical factors that lead to disease and ***,we report a case who was diagnosed with refractory ascites and pleural ffusion caused by liver cirrhosis due to alcoholic liver *** patient was given diuretic therapy,antibiotics,reinfusion of concentrated ascites,and thoracic close drainage,but the result was ***,he responded well to Chinese medicine(CM)treatment.

关键词： ascites infusion alcohol

Expression of MMP-9 in hepatic sinusoidal obstruction syndrome induced by Gynura segetum

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第1期14卷 68-75页

作者： Xia-zhen YU Tao ji xue-li BAI liang liang Lin-yan WANG Wei CHEN Ting-bo liang Department of Hepatobiliary and Pancreatic Surgery the Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 China Department of Surgery Changhai Hospital the Second Military Medical University Shanghai 200433 China The Children 's Hospital School of Medicine Zhejiang University Hangzhou 310003 China

Background and objective： Hepatic sinusoidal obstruction syndrome （HSOS） is characterized by painful hepatomegaly, ascites, increased body weight, and jaundice. Gynura segetum （Compositae）, a plant widely used in Chinese traditional medicine, often leads to the development of HSOS. However, the mechanism is unclear. The aim was to study the role of matrix metalloproteinase-9 （MMP-9） in the onset of HSOS induced by Gynura segetum. Methods： Twenty-five male Sprague-Dawley rats were randomly divided into two groups. Twenty were exposed to 600 mg/kg daily Gynura segetum extract solution for three weeks; five control rats were exposed to tap water alone. Liver sections were evaluated by light microscopy with a modified scoring system. Routine transmission electron microscopy （TEM） methods were used to evaluate the ultrastructual features of fixed liver tissue, and blood samples were collected to determine liver enzyme concentrations. MMP-9 expression was assessed by both immunohisto- chemical staining and enzyme-linked immunosorbent assay （ELISA） methods. Results： A stable and reproducible rat model of HSOS was achieved by long-term exposure to Gynura segetum extract. The treated rats presented clinical symptoms and the histopathological manifestation of HSOS, including abnormal liver enzyme concentrations （alanine aminotransferase （ALT）：（84.8＋13.62） vs. （167.0±72.63） U/L, P〈0.05; aspartate aminotransferase （AST）：（27.6±6.31） vs. （232.8±108.58） U/L, P〈0.05）. Hematoxylin and eosin （H＆E） staining and TEM together revealed deposition of red blood cells, the damage and destruction of hepatic sinusoidal endothelial cells, collapse of hepatic sinusoids, hem- orrhage of subendothelial cells, atrophy and destruction of hepatocytes, etc. Compared with controls, the expression of MMP-9 in the blood sample, the lung and liver tissues of HSOS rats was increased. Conclusions： MMP-9 may have an important role in early patholoclical chanqes of HSOS, and thus the onset of the disease.

关键词： Hepatic sinusoidal obstruction syndrome Gynura segetum (Compositae) Sinusoidal endothelial cells Matrix metalloproteinase-9

Surface micro-arrays enhancing electromagnetic interference shielding of polydimethylsiloxane/multiwalled carbon nanotubes nanocomposites

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Nano Research 2025年第1期18卷 508-519页

作者： Ke jiang Zhi Chen ji Yu Chen Zheng Shan Huang Ming Wang Chongqing Key Laboratory of Soft-Matter Material Manufacturing School of Chemistry and Chemical EngineeringSouthwest UniversityChongqing 400715China School of Mechanics Civil Engineering and ArchitecturesNorthwestern Polytechnical UniversityXi’an 710072China jieyang Branch of Chemistry and Chemical Engineering Guangdong Laboratory(Rongjiang Laboratory) Jieyang 515200China

Herein,the electromagnetic shielding performance of surface concave-convex(SC)and zig-zag micro-arrays was studied by using a simulation prediction and a three-dimensional(3D)printing custom ***,surface stripe concaveconvex(SSC)and surface cylindrical concave-convex(SCC)micro-arrays with or without zig-zag micro-arrays are designed,and their shielding performance is simulated in multi-bands(C-,X-band).The multiwalled carbon nanotubes/polydimethylsiloxane composites(MWCNT/PDMS)with different SC structures and different electrical conductivity are molded in acrylonitrile-butadiene-styrene copolymer(ABS)molds which are printed by a 3D *** results show that the electromagnetic interference shielding effectiveness(EMI SE)of the samples can be enhanced by constructing the SC micro-arrays with zig-zag micro-arrays,and improving with the increase of conductivity and *** addition,the shielding mechanism of the SC-MWCNT/PDMS composites is investigated and discussed by an electromagnetic simulation.

关键词： surface micro-arrays electrical properties electromagnetic interference(EMI)shielding three-dimensional(3D)printing

A New Holographic Entropy Bound from Conformal Field Theory at the Killing Horizon

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Chinese Physics Letters 2002年第1期19卷 20-22页

作者： jing ji-liang Institute of Physics and Physics Department Hunan Normal University Changsha 410081

A new holographic entropy bound is obtained by using conformal field theory at the Killing horizon. The entropy bound is tighter than the well-known bounds, such as the Bekenstein, Bekenstein-Mayo and 'tHooft bounds. The result shows that the entropy of a system decreases when quantum effects are included. Therefore, the quantum effect will increase the degree of order of the system.

关键词： Holographic Entropy Conformal Field Theory Killing Horizon

The Chemical Composition of the Field Zero-Age Star HD 77407

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Chinese Journal of Astronomy and Astrophysics 2007年第3期7卷 405-414页

作者： xue-liang Zhu jian-Rong Shi Gang Zhao ji Li Qing-Xiang Nie College of Physics and Electronics Shandong Normal University Jinan 250014 National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 Department of Physics Hebei Normal University Shijiazhuang 050016

High-resolution optical spectra of the zero age star HD77407 are analysed and its Li, C, O, Na, Mg, Al, Si, K, Ca, Sc, Ti, V, Co, Ni and Ba contents are determined using spectral synthesis method. The temperature of the star is determined by fitting the Hα line wings. The parameters derived for this star are Teff=5900 K, log g=4.47 and [Fe/H] = ＋0.07. It is found that the derived iron content is slightly higher than what is given in the published literature. This star shows a relative overabundances of Ca and Ba, and underabundances of Na, V and Ni with respect to the solar mix. Activity of the star is indicated by the filled in Hα and Ca Ⅱ triplet line cores. It has been confirmed that our spectroscopic approach yields fairly reliable and consistent results for active stars.

关键词： stars abundances- stars ZAMS - stars individual HD77407

High selective epoxidation of 2-methylpropene over a Mo-based oxametallacycle reinforced nano composite

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Nano Research 2023年第1期16卷 209-218页

作者： Chao Xiong Hao Liu jie Zhou Dejing Xu Yichao liang Xiantai Zhou Can xue Hongbing ji Fine Chemical Industry Research Institute School of ChemistrySun Yat-Sen UniversityGuangzhou 510275China School of Chemical Engineering and Technology Sun Yat-Sen UniversityZhuhai 519082China

Compared with the gas-solid phase reactions,the epoxidation of light olefins in the liquid phase could realize the highly selective preparation of epoxides at a lower ***,the C=C bond of light olefins is more difficult to activate,and it is still a challenge to realize the dual activation of the oxidant and light olefins in one reaction *** this contribution,an oxametallacycle reinforced nanocomposite(Mo(O_(2))_(2)@RT)is prepared via an oxidative pretreatment strategy,and its epoxidation performance to 2-methylpropene in liquid-phase with tert-butyl hydroperoxide(TBHP)as an oxidant is evaluated.A set of advanced characterizations including field emission scanning electron microscopy,X-ray photoelectron spectroscopy,in-situ Fourier transform infrared spectroscopy(FT-IR),electron spin-resonance spectroscopy,and high-resolution mass spectrometer are implemented to confirm the physicochemical properties and the catalytic behaviors of Mo(O_(2))_(2)@*** catalyst has a fast kinetic response and exhibits excellent catalytic activity in 2-methylpropene epoxidation to produce 2-methylpropylene oxide(MPO;select.:99.7%;yield:92%),along with good reusability and ***,the main epoxidation mechanism is deduced that TBHP is activated by Mo(O_(2))_(2)@RT to generate the highly active tert-butyl peroxide radical,which realizes the epoxidation of 2-methylpropene to yield MPO.

关键词： oxidative pretreatment Mo(O_(2))_(2)@RT composite 2-methylpropene epoxidation dual activation radical mechanism

Solitary fibrous tumor of the renal pelvis:A case report

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World Journal of Clinical Cases 2022年第27期10卷 9798-9804页

作者： Min Liu Chao Zheng jin Wang ji-xue Wang liang He Department of Urology The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Department of Neurology and Neuroscience Center The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina

BACKGROUND Solitary fibrous tumor(SFT)is a rare mesenchymal *** derived from the renal pelvis is an exceedingly rare *** this study,we report a case of renal pelvis SFT and review the relevant literature on this rare *** SUMMARY A 76-year-old man was hospitalized due to right lumbar and abdominal *** computed tomography showed a hypervascular space-occupying renal lesion,sized 2.3 cm×1.8 *** on the computed tomography findings,the patient was diagnosed with right renal pelvis tumor and underwent *** immunohistochemical results confirmed the *** of the 3-year follow-up,there were no signs of recurrence,and the patient has recovered *** We report a rare case of SFT derived from the renal pelvis and discuss the imaging and histopathological features that distinguish renal pelvis SFT from other renal pelvis tumors.

关键词： Renal pelvis Solitary fibrous tumor Surgery Computed tomography Case report