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Role of nutrition in diabetes mellitus and infections

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World Journal of Clinical Cases 2025年第3期13卷 1-8页

作者： xue-Lu Yu Li-Yun Zhou Xiao Huang Xin-yue Li Ming-Ke Wang Ji-Shun Yang Naval Medical Center of PLA Naval Medical UniversityShanghai 200052China

In this editorial,we have commented on the article that has been published in the recent issue of World Journal of Clinical *** authors have described a case of unilateral thyroid cyst and have opined that the acute onset of infection may be linked to diabetes mellitus(DM).We have focused on the role of nutrition in the association between DM and *** with DM are at a high risk of infection,which could also be attributed to nutrition-related *** interventions for patients with diabetes are mainly based on a low-calorie diet,which can be achieved by adhering to a low-carbohydrate ***,dietary fiber supplementation is recommended to maintain the diversity of the gut ***,high-quality protein can prevent the increased risk of infection due to *** of vitamins C,vitamins A,vitamins D,and folic acid improves blood sugar control and facilitates immune *** deficiencies augment the risk of infection,but the relationship with diabetes is mostly U-shaped and a good intake should be maintained.

关键词： Diabetes mellitus Infection Macronutrients Vitamins Minerals

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World Journal of Clinical Cases 2025年第6期13卷 24-29页

作者： Wen-Jin Yuan Yi-Juan Zheng Bing-Rong Zhang Yi-jie Lin You Li Yan-Yan Qiu xue-Ping Yu Department of Infection Disease Clinical Medical Research Center for Bacterial and Fungal Infectious Diseases of Fujian provinceFujian Medical University Affiliated First Quanzhou HospitalQuanzhou 362000Fujian ProvinceChina

BACKGROUND Hydroxyurea,an antimetabolite,is frequently prescribed for various hemato-logical disorders,and its common side effects include gastrointestinal problems,cutaneous or mucosal lesions and pyrexia/*** SUMMARY This study reports the case of a 67-year-old woman who developed recurrent abdominal pain after 10 years of continuous hydroxyurea therapy for primary *** revealed an ileocecal *** discontinuing hydroxyurea therapy for 6 months,follow-up colonoscopy showed a significant reduction in the *** We consider cecal ulcers as a rare complication of hydroxyurea therapy which typically resolves upon stopping the drug.

关键词： Hydroxyurea Ulcer Abdominal pain Thrombocythemia Colonoscopy Case report

Pharmacological targeting cGAS/STING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3287-3301页

作者： Ziwei Fan Mengxian Jia Jian Zhou Zhoule Zhu Yumin Wu Xiaowu Lin Yiming Qian Jiashu Lian Xin Hua Jianhong Dong Zheyu Fang Yuqing Liu Sibing Chen Xiumin xue Juanqing yue Minyu Zhu Ying Wang Zhihui Huang Honglin Teng Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Neurology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina

The M1/M2 phenotypic shift of microglia after spinal cord injury plays an important role in the regulation of neuroinflammation during the secondary injury phase of spinal cord *** of shifting microglia polarization from M1(neurotoxic and proinflammatory type)to M2(neuroprotective and anti-inflammatory type)after spinal cord injury appears to be *** possesses an anti-inflammatory biological ***,its roles and the underlying molecular mechanisms in spinal cord injury remain *** this study,we found that tryptanthrin inhibited microglia-derived inflammation by promoting polarization to the M2 phenotype in *** promoted M2 polarization through inactivating the cGAS/STING/NF-κB ***,we found that targeting the cGAS/STING/NF-κB pathway with tryptanthrin shifted microglia from the M1 to M2 phenotype after spinal cord injury,inhibited neuronal loss,and promoted tissue repair and functional recovery in a mouse model of spinal cord ***,using a conditional co-culture system,we found that microglia treated with tryptanthrin suppressed endoplasmic reticulum stress-related neuronal *** together,these results suggest that by targeting the cGAS/STING/NF-κB axis,tryptanthrin attenuates microglia-derived neuroinflammation and promotes functional recovery after spinal cord injury through shifting microglia polarization to the M2 phenotype.

关键词： cGAS/STING functional recovery microglia neuroinflammation neuroprotection nuclear factor-κB polarization spinal cord injury tryptanthrin

同辈心理健康病耻感量表中文版测评中学生的效度与信度

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中国心理卫生杂志 2025年第1期39卷 63-67页

作者：彭彪韩雪王慧杨棋凯罗杰长沙民政职业技术学院马克思主义学院长沙410004 贵州医科大学马克思主义学院贵阳550025 贵州师范大学附属中学贵阳550001 清镇市广大实验学校贵阳551499 岳阳市康复医院精神科湖南岳阳414022 贵州师范大学心理学院贵阳550025

目的:检验同辈心理健康病耻感量表(PMHSS-R)中文版在中学生中的效度与信度。方法:选取1 099名中学生,随机分为样本1 (n=549)和样本2(n=550),分别进行探索性因子分析和验证性因子分析;总样本(n=1 099)用于考察内部一致性信度,2周后选取其... 详细信息

目的:检验同辈心理健康病耻感量表(PMHSS-R)中文版在中学生中的效度与信度。方法:选取1 099名中学生,随机分为样本1 (n=549)和样本2(n=550),分别进行探索性因子分析和验证性因子分析;总样本(n=1 099)用于考察内部一致性信度,2周后选取其中87名中学生进行重测;另外选取259名中学生(样本3),采用抑郁症病耻感量表(DSS)、专业心理支持求助态度量表简版(ATSPPHSF)进行效标效度检验。结果:探索性因子分析共提取出2个公因子,命名为病耻感意识、病耻感认同,累计方差贡献率为66.86%;验证性因子分析表明2因子模型拟合指数较好(χ~2/df=3.70,CFI=0.97,TLI=0.96,SRMR=0.03,RMSEA=0.07);PMHSS-R中文版得分与DSS得分正相关(ICC=0.58,P<0.01),与ATSPPH-SF得分负相关(ICC=-0.40,P<0.01);总量表及2个因子的Cronbachα系数分别为0.90、0.92和0.85,重测信度(ICC)分别为0.84、0.76和0.78。结论:同辈心理健康病耻感量表(PMHSS-R)中文版评估中学生的心理健康病耻感具有良好效度与信度。

关键词：心理健康病耻感效度信度中学生

Rare earth monosilicates as oxidation resistant interphase for SiCf/SiC CMC:Investigation of SiC_(f)/Yb_(2)SiO_(5)model composites

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Journal of Advanced Ceramics 2022年第5期11卷 702-711页

作者： Xirui LV Mengkun yue xue FENG Xiaoyan LI Yumin WANG jiemin WANG jie ZHANG Jingyang WANG Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China AML Department of Engineering MechanicsTsinghua UniversityBeijing 100084China Center for Mechanics and Materials Tsinghua UniversityBeijing 100084China Institute of Metal Research Chinese Academy of SciencesShenyang 110016China

Model composites consisting of SiC fiber and Yb_(2)SiO_(5)were processed by the spark plasma sintering(SPS)*** mechanical compatibility and chemical stability between Yb_(2)SiO_(5)and SiC fiber were studied to evaluate the potential application of Yb monosilicate as the interphase of silicon carbide fiber reinforced silicon carbide ceramic matrix composite(SiC_(f)/SiC CMC).Two kinds of interfaces,namely mechanical and chemical bonding interfaces,were achieved by adjusting sintering ***_(f)/Yb_(2)SiO_(5)interfaces prepared at 1450 and 1500℃exhibit high interface strength and debond energy,which do not satisfy the crack deflection criteria based on He-Hutchison *** spectrum analyzation indicates that the thermal expansion mismatch between Yb_(2)SiO_(5)and SiC contributes to high compressive thermal stress at interface,and leads to high interfacial *** layer at interface in model composite sintered at 1550℃is related to the diffusion promoted by high temperature and DC electric filed during *** is inspired that the interfacial parameters could be adjusted by introducing Yb_(2)Si_(2)O_(7)-Yb_(2)SiO_(5)interphase with controlled composition to optimize the mechanical fuse mechanism in SiC_(f)/SiC CMC.

关键词： silicon carbide fiber reinforced silicon carbide ceramic matrix composite(SiCf/SiC CMC) interphase rare earth(RE)silicates interfacial parameters

Overcoming drug efflux-based multidrug resistance in cancer with nanotechnology

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Chinese Journal of Cancer 2012年第2期31卷 100-109页

作者： xue, xue Liang, Xing-jie Natl Ctr Nanosci & Technol China CAS Key Lab Biomed Effects Nanomat & Nanosafety Beijing 100190 Peoples R China

Multidrug resistance(MDR),which significantly decreases the efficacy of anticancer drugs and causes tumor recurrence,has been a major challenge in clinical cancer treatment with chemotherapeutic drugs for *** mechanisms of overcoming drug resistance have been *** known P-glycoprotein(P-gp) and other drug efflux transporters are considered to be critical in pumping anticancer drugs out of cells and causing chemotherapy *** theranostic(therapeutic and diagnostic) strategies with nanoparticles are rapidly evolving and are anticipated to offer opportunities to overcome these *** this review,we discuss the mechanisms of drug efflux-mediated resistance and the application of multiple nanoparticle-based platforms to overcome chemoresistance and improve therapeutic outcome.

关键词：抗癌药物多药耐药纳米技术外排癌症 P-糖蛋白临床治疗化疗药物

Cylindrical KP-Burgers Equation for Two-Temperature Ions in Dusty Plasma with Dissipative Effects and Transverse Perturbations

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Communications in Theoretical Physics 2006年第2X期46卷 313-318页

作者： WANG yue-yue ZHANG jie-Fang Institute of Nonlinear Physics Zhejiang Normal University Jinhua 321004 China

In this paper, the cylindrical KP-Burgers equation with variable coefficient for two-temperature ions in unrsagnified dusty plasma with dissipative effects and transverse perturbations in cylindrical geometry is derived by using the standard reductive perturbation technique. With the help of variable-coeiffcient generalized projected Ricatti equation expansion method, the cylindrical KP-Burgers equation is solved and shock wave solution is obtained. The effecta of some important parameters to the shock wave solution are illustrated from the wave evolution figures. The effects caused by dissipation and transverse perturbations are also discussed.

关键词： dusty plasma KP-Burgers equation shock wave

State transfer on two-fold Cayley trees via quantum walks

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Chinese Physics B 2021年第2期30卷 196-202页

作者： Xi-Ling xue yue Ruan School of Computer Science and Technology Anhui University of TechnologyMaanshan 243032China

Perfect state transfer(PST)has great significance due to its applications in quantum information processing and quantum *** main problem we study in this paper is to determine whether the two-fold Cayley tree,an extension of the Cayley tree,admits perfect state transfer between two roots using quantum *** show that PST can be achieved by means of the so-called nonrepeating quantum walk[***.A 89042332(2014)]within time steps that are the distance between the two roots;while both the continuous-time quantum walk and the typical discrete-time quantum walk with Grover coin approaches *** results suggest that in some cases the dynamics of a discrete-time quantum walk may be much richer than that of the continuous-time quantum walk.

关键词： perfect state transfer two-fold Cayley tree quantum walk

An efficient data-driven global sensitivity analysis method of shale gas production through convolutional neural network

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Petroleum Science 2024年第4期21卷 2475-2484页

作者： Liang xue Shuai Xu jie Nie Ji Qin Jiang-Xia Han yue-Tian Liu Qin-Zhuo Liao State Key Laboratory of Petroleum Resources and Engineering China University of Petroleum(Beijing)Beijing102249China Department of Oil-Gas Field Development Engineering College of Petroleum EngineeringChina University of Petroleum(Beijing)Beijing102249China Chuanqing Drilling Engineering Co.Ltd. China National Petroleum CorporationChengdu610051SichuanChina

The shale gas development process is complex in terms of its flow mechanisms and the accuracy of the production forecasting is influenced by geological parameters and engineering ***,to quantitatively evaluate the relative importance of model parameters on the production forecasting performance,sensitivity analysis of parameters is *** parameters are ranked according to the sensitivity coefficients for the subsequent optimization scheme design.A data-driven global sensitivity analysis(GSA)method using convolutional neural networks(CNN)is proposed to identify the influencing parameters in shale gas *** CNN is trained on a large dataset,validated against numerical simulations,and utilized as a surrogate model for efficient sensitivity *** approach integrates CNN with the Sobol'global sensitivity analysis method,presenting three key scenarios for sensitivity analysis:analysis of the production stage as a whole,analysis by fixed time intervals,and analysis by declining *** findings underscore the predominant influence of reservoir thickness and well length on shale gas ***,the temporal sensitivity analysis reveals the dynamic shifts in parameter importance across the distinct production stages.

关键词： Shale gas Global sensitivity Convolutional neural network Data-driven