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Secondary diabetes due to different etiologies:A problem worthy of attention

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World Journal of Clinical Cases 2024年第33期12卷 6647-6649页

作者： Zhao Wei xue-jian wang Department of Neurosurgery Affiliated Hospital 2 of Nantong UniversityNantong 226000Jiangsu ProvinceChina

There are many factors in the occurrence of diabetes,which can result in insufficient insulin secretion and insulin receptor *** pituitary tumors,can also lead to the occurrence of diabetes,if the primary disease can not be well controlled in time,such secondary diabetes control is more *** the process of clinical diagnosis and treatment,these factors need to be taken into account,timely detection and treatment of primary diseases,so as to reduce the possibility of clinical missed diagnosis.

关键词： Editorial Secondary diabetes Different etiologies Pituitary tumors

A new detection method in studying penetration depth of low-energy heavy ions in botanic samples

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Nuclear Science and Techniques 2001年第3期12卷 169-176页

作者： LIU Feng, wang Yu-Gang, xue jian-Ming, wang Si-xue ZHAO Wei-jiang (Ion Beam Group, Institute of Heavy Ion Physics, Peking University, Beijing 100871) 北京大学重离子物理所北京 100871

A new detection method has been applied to study the penetration depth of low-energy heavy ions in botanic samples. Highly oriented pyrolytic graphite (HOPG) pieces were placed behind the target samples with certain thickness to receive energetic penetrated ions during the irradiation. After irradiation, statistic number density of protrusion-like damage induced by energetic penetrated ions can be ob- tained through scanning tunneling microscope (STM) observation on the surfaces of HOPG. The results of test indicate that the detection limit can be as low as 1.0×109 protrusions/cm2. With the method, the penetration depth of at least 60μm can be detected in kidney bean slices irradiated by N+ ions with dose of 0.3-3×1017ions/cm2.

关键词：低能重离子植物样品贯穿深度探测法

Mesospheric tide comparisons at low latitudes observed by two collocated meteor radars

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Earth and Planetary Physics 2025年第1期9卷 54-68页

作者： jian Li Wen Yi XiangHui xue Jie Zeng HaiLun Ye jianYuan wang JinSong Chen Na Li TingDi Chen Chinese Academy of Sciences(CAS)Key Laboratory of Geospace Environment Department of Geophysics and Planetary SciencesUniversity of Science and Technology of ChinaHefei 230026China CAS Center for Excellence in Comparative Planetology Anhui Mengcheng Geophysics National Observation and Research StationUniversity of Science and Technology of ChinaHefei 230026China Hefei National Laboratory University of Science and Technology of ChinaHefei 230026China Collaborative Innovation Center of Astronautical Science and Technology Harbin 150001China National Key Laboratory of Electromagnetic Environment China Research Institute of Radiowave PropagationQingdao 266107China Yunnan Kunming Electromagnetic Environment National Observation and Research Station Qujing Kunming 655000China

Accurate knowledge of mesospheric winds and waves is essential for studying the dynamics and climate in the mesosphere and lower thermosphere(MLT)*** this study,we conduct a comparative analysis of the mesosphere tidal results obtained from two adjacent meteor radars at low latitudes in Kunming,China,from November 2013 to December *** two radars operate at different frequencies of 37.5 MHz and 53.1 MHz,***,overall good agreement is observed between the two radars in terms of horizontal winds and tide *** results show that the dominant tidal waves of the zonal and meridional winds are diurnal and semidiurnal ***,we conduct an exhaustive statistical analysis to compare the tidal amplitudes and vertical wavelengths recorded by the dual radar systems,which reveals a high degree of alignment in tidal *** investigation includes variances and covariances of tidal amplitudes,which demonstrate remarkable consistency across measurements from both *** finding highlights clear uniformity in the mesospheric tidal patterns observed at low latitudes by the two neighboring meteor *** of the comparative analysis specifically underscore the significant correlation in vertical wavelength measurements,validating the robustness of radar observations for tidal research.

关键词： mesosphere and lower thermosphere region meteor radar mesospheric winds tides

Enhancing microbial superoxide generation and conversion to hydroxyl radicals for enhanced bioremediation using iron-binding ligands

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Journal of Environmental Sciences 2025年第1期147卷 597-606页

作者： Yuhan wang xue Ning Jinsong Liang Aijie wang Jiuhui Qu School of Civil and Environmental Engineering Harbin Institute of TechnologyShenzhen 518055China SFI MaREI Centre for Energy Climate and MarineEnvironmental Research InstituteUniversity College CorkCorkIreland Center for Water and Ecology Tsinghua UniversityBeijing 100084China

Harnessing bacteria for superoxide production in bioremediation holds immense promise,yet its practical application is hindered by slow production rates and the relatively weak redox potential of *** study delves into a cost-effective approach to amplify superoxide production using an Arthrobacter strain,a prevalent soil bacterial *** research reveals that introducing a carbon source along with specific iron-binding ligands,including deferoxamine(DFO),diethylenetriamine pentaacetate(DTPA),citrate,and oxalate,robustly augments microbial superoxide ***,our findings suggest that these iron-binding ligands play a pivotal role in converting superoxide into hydroxyl radicals by modulating the electron transfer rate between Fe(Ⅲ)/Fe(Ⅱ)and ***,among the tested ligands,only DTPA emerges as a potent promoter of this conversion process when complexed with Fe(Ⅲ).We identify an optimal Fe(Ⅲ)to DTPA ratio of approximately 1:1 for enhancing hydroxyl radical production within the Arthrobacter *** research underscores the efficacy of simultaneously introducing carbon sources and DTPA in facilitating superoxide production and its subsequent conversion to hydroxyl radicals,significantly elevating bioremediation ***,our study reveals that DTPA augments superoxide production in cultures of diverse soils,with various soil microorganisms beyond Arthrobacter identified as contributors to superoxide *** emphasizes the universal applicability of DTPA across multiple bacterial *** conclusion,our study introduces a promising methodology for enhancing microbial superoxide production and its conversion into hydroxyl *** findings hold substantial implications for the deployment of microbial reactive oxygen species in bioremediation,offering innovative solutions for addressing environmental contamination challenges.

关键词： Superoxide Hydroxyl radical Iron-binding ligand Bioremediation DTPA

Advances in the mechanism of action of metformin in pituitary tumors

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World Journal of Meta-Analysis 2023年第5期11卷 144-150页

作者： Long-Yao Zhang Yu-Hua Yin xue-jian wang Department of Neurosurgery The Affiliated Hospital 2 to Nantong UniversityNantong 226000Jiangsu ProvinceChina Department of Neurosurgery Renji HospitalShanghai Jiao Tong UniversityShanghai 226000China

Pituitary tumors are common intracranial tumors,but when faced with drugresistant or aggressive tumors,existing medical measures may not provide good control,leading to progression and ***,a traditional hypoglycemic drug,has recently been discovered to have multiple functions including antitumor *** have been studies on the mechanism of metformin for the treatment of pituitary tumors,but it is uncertain whether it will provide new adjuvant or alternative therapies for the treatment of these *** analyzed the potential mechanisms of action of metformin with respect to the inhibition of pituitary tumor growth and hormone secretion by reviewing the available literature.

关键词： Metformin Pituitary tumor Mechanism Treatment Study Review

Advancing gravitational theory through the tetrahedral constellation gravitational wave observatory

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Science China(Physics,Mechanics & Astronomy) 2025年第2期68卷 197-198页

作者： Yun-Yong wang Zhou-jian Cao Institute for Frontiers in Astronomy and Astrophysics Beijing Normal UniversityBeijing102206China

The Tetrahedral Constellation Gravitational Wave Observatory(TEGO)[1]represents a significant leap forward in gravitational wave detection,advancing our understanding of gravitational *** introducing a fourth spacecraft to form a tetrahedral configuration,TEGO enhances traditional triangular setups,enabling the simultaneous sensitivity to all six gravitational wave polarization modes,including those not predicted by general relativity.

关键词： wave polarization theory

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Efficacy and Safety of Juan Bi Pill with Add-on Methotrexate in Active Rheumatoid Arthritis:A 48-Week,Multicentre,Randomized,Double-Blind,and Placebo-Controlled Trial

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Chinese Journal of Integrative Medicine 2025年第2期31卷 99-107页

作者： JIA Qing-yun wang Yi-ru SUN Da-wei MAO jian-chun xue Luan GU Xiao-hua YU Xiang PIAO xue-mei XU Hao LIANG Qian-qian Spine Institute Longhua Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai(200032)China Spine Institute Shanghai University of Traditional Chinese MedicineShanghai(200032)China Key Laboratory of Theory and Therapy of Muscles and Bones Ministry of Education(Shanghai University of Traditional Chinese Medicine)Shanghai(201203)China Department of Orthopedics Linyi People's HospitalLinyiShandong Province(273000)China Department of Orthopedics Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese MedicineShanghai(200437)China Department of Orthopedics the Seventh People's Hospital of Shanghai University of Traditional Chinese MedicineShanghai(200137)China

Objective:To explore the efficacy and safety of Juan Bi Pill(JBP)in treatment of active rheumatoid arthritis(RA).Methods:From February 2017 to May 2018,115 participants from 4 centers were randomly divided into JBP group(57 cases)and placebo group(58 cases)in a 1:1 ratio using a random number table *** received a dose of JBP(4 g,twice a day,orally)combined with methotrexate(MTX,10 mg per week)or placebo(4 g,twice a day,orally)combined with MTX for 12 *** were required with follow-up visits at 24 and 48 weeks,attending 7 assessment *** were undergo disease activity assessment 7 times(at baseline and 2,4,8,12,24,48 weeks)and safety assessments 6 times(at baseline and 4,8,12,24,48 weeks).The primary endpoint was 28-joint Disease Activity Score(DAS28-ESR and DAS28-CRP).The secondary endpoints included American College of Rheumatology(ACR)criteria for 20%and 50%improvement(ACR20/50),Health Assessment Questionnaire Disability Index(HAQ-DI),clinical disease activity index(CDAI),visual analog scale(VAS),Short Form-36(SF-36)score,Medial Outcomes Study(MOS)sleep scale score,serum erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),tender joint count,swollen joint count,and morning *** adverse reactions were observed during the ***:After 12 weeks of treatment,DAS28-ESR and DAS28-CRP scores in both groups were lower than before treatment(both P<0.01),while the remission rate of DAS28-ESR and DAS28-CRP and low disease activity of JBP group were higher than those in the placebo group(both P<0.01).JBP demonstrated better efficacy on ACR20 and ACR50 compliance rate at 12 and 48 weeks comparing to placebo(all P<0.05).The CDAI and HAQ-DI score,pain VAS and global VAS change of RA patients and physicians,the serum ESR and CRP levels,and the number of tenderness and swelling joints were lower than before treatment at 4,8,12,24,48 weeks in both groups(P<0.05 or P<0.01),while the reduction of above indices in

关键词： Chinese medicine Juan Bi Pill methotrexate active rheumatoid arthritis randomized controlled trial

Spatiotemporal evolution of wildfire activity during the Paleocene-Eocene Thermal Maximum in China

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Science China Earth Sciences 2025年第2期68卷 509-522页

作者： xue-Ting wang Zuoling CHEN Linlin CUI Xu wang State Key Laboratory of Lithospheric and Environmental Coevolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China University of Chinese Academy of Sciences College of Earth and Planetary SciencesBeijing 100049China Institute of Geology and Geophysics Chinese Academy of SciencesBeijing 100029China

The Paleocene-Eocene Thermal Maximum(PETM)was the most prominent warming event in the Cenozoic and serves as a geological analog for the current global warming driven by anthropogenic CO_(2)emissions from burning fossil *** a primary disruptor of Earth's ecosystems,wildfire activity affects the balance of ecosystems,the global carbon cycle,and climate ***,studying the evolution and driving mechanisms of wildfires during the PETM is essential for predicting wildfire activity under global warming scenarios and for understanding the carbon cycle in the context of wildfire *** research on wildfires during the PETM has mainly focused on the Northern Hemisphere,particularly Europe and North America,whereas studies on Chinese mainland remain *** this study,we analyzed black carbon(BC)concentration and carbon isotope(δ13C)in the Beigou section of the Nanyang Basin and the Xilutian section of the Fushun Basin to reconstruct the spatiotemporal evolution of wildfires in arid/semi-arid and humid *** integrated these findings with those of previous studies on the paleoclimate of the research area to elucidate the driving mechanisms behind wildfire *** results indicate that wildfire activity weakened at the onset of the PETM,with the negative carbon isotope period characterized by low wildfire activity,except for a brief resurgence in the Nanyang *** the recovery phase of the PETM,wildfire activity gradually increased,returning to the pre-PETM *** prolonged low wildfire state was likely caused by extremely high temperatures and precipitation as well as the resulting vegetation *** the PETM recovery phase,increased wildfire activity transformed“short-term carbon sinks”of the biological-atmospheric carbon cycle into“long-term carbon sinks”through the burial of *** process of carbon sink conversion may have acted as a negative feedback mechanism,contributing to carbon sequestration and the e

关键词： PETM Wildfire Carbon cycle Nanyang Basin Fushun Basin

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Multiple Intussusceptions in Peutz-Jeghers Syndrome： Detection through Multidetector Computerized Tomography Enterography

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Chinese Medical Journal 2016年第12期129卷 1511-1512页

作者： Hui Yu Wei Pu Jing Liu Ming-Ming Huang xue-jian wang Department of Radiology Affiliated Hospital of Guizhou Medical University Guiyang Guizhou 550004 China Department of Radiology Affiliated People'sHospital of Guizhou Medical Universityl Guiyang Guizhou 550002 China Department of Radiology~ Affiliated Guihang 300 Hospital of Zunyi Medical UniversiiY Guiyang Guizhou 550009 China

To the Editor： Peutz-Jeghers syndrome （PJS） is an autosomal dominant inherited disease, characterized by mucocutaneous pigmentation and hamartomatous gastrointestinal polyps. Due to the possible association between PJS and cancer, multidetector computed tomography （MDCT） enterography is regularly used for the surveillance of the small bowel to reduce polyp-related complications, particularly of intussusceptions. Given rare conditions of multiple intussusceptions in PJS, the study investigated a case of a 15-year-old girl who was diagnosed with concurrent intestinal intussusception and colon intussusception due to relatively large polyps by MDCT enterography. In this case, MDCT enterography was enabled to provide information of polyps and complicated intussusceptions in PJS for the consequent endoscopic enteroscopy or surgery.

关键词： Peutz-Jeghers综合征肠套叠结肠色素沉着世界卫生组织体层摄影术息肉胰岛素