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A deep kernel method for lithofacies identification using conventional well logs

Petroleum Science 2023年第3期20卷 1411-1428页

作者： Shao-Qun Dong Zhao-hui Zhong xue-hui cui Lian-Bo Zeng Xu Yang Jian-jun Liu Yan-Ming Sun jing-Ru Hao State Key Laboratory of Petroleum Resources and Prospecting China University of PetroleumBeijing102249China Collge of Science China University of PetroleumBeijing102249China College of Geoscience China University of PetroleumBeijing102249China

How to fit a properly nonlinear classification model from conventional well logs to lithofacies is a key problem for machine learning *** methods(e.g.,KFD,SVM,MSVM)are effective attempts to solve this issue due to abilities of handling nonlinear features by kernel *** mining of log features indicating lithofacies still needs to be improved for kernel ***,this work employs deep neural networks to enhance the kernel principal component analysis(KPCA)method and proposes a deep kernel method(DKM)for lithofacies identification using well *** includes a feature extractor and a *** feature extractor consists of a series of KPCA models arranged according to residual network structure.A gradient-free optimization method is introduced to automatically optimize parameters and structure in DKM,which can avoid complex tuning of parameters in *** test the validation of the proposed DKM for lithofacies identification,an open-sourced dataset with seven con-ventional logs(GR,CAL,AC,DEN,CNL,LLD,and LLS)and lithofacies labels from the Daniudi Gas Field in China is *** are eight lithofacies,namely clastic rocks(pebbly,coarse,medium,and fine sand-stone,siltstone,mudstone),coal,and carbonate *** comparisons between DKM and three commonly used kernel methods(KFD,SVM,MSVM)show that(1)DKM(85.7%)outperforms SVM(77%),KFD(79.5%),and MSVM(82.8%)in accuracy of lithofacies identification;(2)DKM is about twice faster than the multi-kernel method(MSVM)with good *** blind well test in Well D13 indicates that compared with the other three methods DKM improves about 24%in accuracy,35%in precision,41%in recall,and 40%in F1 score,*** general,DKM is an effective method for complex lithofacies *** work also discussed the optimal structure and classifier for *** re-sults show that(m_(1),m_(2),O)is the optimal model structure and linear svM is the optimal classifier.(m_(1),m_(2),O)means there

关键词： Lithofacies identification Deepkernel method Well logs Residual unit Kernel principal component analysis Gradient-free optimization

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以铁调素为靶点的新药研发

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中国药学杂志 2018年第6期53卷 405-410页

作者：王晓雪崔慧斐山东大学药学院济南250012

铁是人体必不可少的微量元素之一,机体会对自身铁含量进行调节维持体内铁平衡。体内铁平衡遭到破坏使体内的铁缺失或过载便会引发多种疾病。铁调素作为一种小分子多肽类激素,对铁代谢调节起负调控作用,也已成为治疗铁代谢相关疾病一个... 详细信息

铁是人体必不可少的微量元素之一,机体会对自身铁含量进行调节维持体内铁平衡。体内铁平衡遭到破坏使体内的铁缺失或过载便会引发多种疾病。铁调素作为一种小分子多肽类激素,对铁代谢调节起负调控作用,也已成为治疗铁代谢相关疾病一个新靶点。笔者综述铁调素的结构,其对铁代谢的调节作用与调控机制,机体对铁调素的调控机制,铁调素失衡导致的相关疾病等;同时,综述了以铁调素为靶点的新药研究类型与进展。由于对铁调素研究的不断深入,逐渐发展出针对铁调素信号转导途径中特定分子的特异性靶向治疗方法,通过铁调素的激活剂或拮抗剂,促进或抑制铁调素的表达,从而从分子水平上改善或治疗铁代谢紊乱的相关疾病。铁调素本身、以小化合物与siRNA为代表的铁调素激活剂、以肝素衍生物为代表的铁调素拮抗剂等都有望成为纠正铁稳态紊乱相关疾病的新药。

关键词：铁调素铁代谢调节机制慢性病贫血肝素及其衍生物

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CaH2-promoted activity of Ni-carbonate interface for CO2 methanation

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Journal of Energy Chemistry 2025年第1期100卷 522-532页

作者： Jin-Peng Wang Guo-cui Mao hui-Lin Jiang Bao-Xia Dong Yun-Lei Teng School of Chemistry and Chemical Engineering Yangzhou University

Transition metal-carbonate interfaces often act as active sites in heterogeneous catalytic *** interface between transition metal and metal carbonate exhibits a dynamic equilibrium during the CO2hydrogenation reaction,involving surface carbonate hydrogenation and ***,there have been few reports on engineering the activity of the interface between transition metal and alkaline earth metal carbonate for catalytic *** work demonstrated that the incorporation of CaH2in Ni/CaCO3enhances the CO2methanation activity of the *** CO2conversion for Ni/CaH2-CaCO3reached 68.5%at 400°C,which was much higher than that of the Ni/CaCO3（31.6%） and Ni/CaH2-CaO （42.4%） ***,the Ni/CaH2-CaCO3catalysts remained stable during the stability test for 24 h at 400°C and 8 *** research revealed that CaH2played a crucial role in promoting the activity of the Ni-carbonate interface for ***2could modify the electronic structure of Ni and tune the structural properties of CaCO3to generate medium basic sites （OH groups）,which are favorable for the activation of H2and ***-situ Fourier transform infrared spectroscopy （FTIR） analysis combined with density functional theory calculations demonstrated that CO2activation occurs at the hydroxyl group （OH） on the CaH2-modified Ni-carbonate surface,leading to the formation of CO3H****,our study has confirmed that CO2methanation over the Ni/CaH2-CaCO3catalysts proceeds via the formate pathway.

关键词： CO 2 methanation Metal hydride Ni catalysts Carbonate Metal-carbonate interface

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The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson's disease

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Neural Regeneration Research 2025年第8期20卷 2361-2372页

作者： Shengyang Zhou Ting Li Wei Zhang Jian Wu hui Hong Wei Quan Xinyu Qiao Chun cui Chenmeng Qiao Weijiang Zhao Yanqin Shen Laboratory of Neurodegenerative and Neuroinjury Diseases Wuxi Medicine SchoolJiangnan UniversityWuxiJiangsu ProvinceChina

Interferon regulatory factor 7 plays a crucial role in the innate immune ***,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains *** we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial *** the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 *** addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and *** together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.

关键词： cyclic guanosine monophosphate adenosine monophosphate synthase H151 interferon regulatory factor 7 M1 phenotype neurodegenerative disease neuroinflammation Parkinson’s disease RU521 STING type I interferon

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高韧性纤维增强水泥基复合材料抗压性能

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土木工程与管理学报 2017年第2期34卷 77-80,86页

作者：薛会青崔宁周明珲王贯明北京市市政工程研究院北京100037

ECC是一种具备应变硬化和多缝开裂特性的新型纤维增强水泥基复合材料,具有良好的韧性、耐久性等。研究表明:水泥品种对ECC同龄期抗压强度的影响较小;纤维种类对ECC同龄期抗压强度影响较大;采用复合水泥配制ECC,以普通水泥为主配制ECC,... 详细信息

ECC是一种具备应变硬化和多缝开裂特性的新型纤维增强水泥基复合材料,具有良好的韧性、耐久性等。研究表明:水泥品种对ECC同龄期抗压强度的影响较小;纤维种类对ECC同龄期抗压强度影响较大;采用复合水泥配制ECC,以普通水泥为主配制ECC,以保证其强度;采用粉煤灰替代部分水泥时,替代比例不宜超过40%,以免影响ECC抗压强度。扫描电镜显示主要水化产物呈小绒毛状,基体内部有好多微气孔,进口PVA纤维在基体内部乱向分布,纤维断裂时呈片层状;国产PVA纤维在基体内部呈同一方向顺向分布,易有结团现象,纤维断裂时呈不规则形状。

关键词：应变硬化多缝开裂抗压强度

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Effects of Ti-and Nb-based transition element from single to multiple compound oxides and carbon-based composite additives on Mg-MgH2 hydrogen storage material

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Tungsten 2025年第1期7卷 32-49页

作者： Li-Rong Xiao Chen Chen Shuo Wang Zi-Yin Dai Hideo Kimura cui Ni Chuan-Xin Hou xue-Qin Sun Si-Jie Guo Wei Du Xiu-Bo Xie School of Environmental and Material Engineering Yantai University Bosch HUAYU Steering Systems (Yantai) Co. Ltd.Ytp/MFE University of Tennessee Knoxville Shandong Key Laboratory of Eco-Environmental Science for the Yellow River Delta Shandong University of Aeronautics

MgH2is considered as a promising hydrogen storage material for its high hydrogen storage capacity,low cost and abundant resource ***,the low kinetics and high enthalpy formation of MgH2limit its wide *** the perspective of adding catalysts to enhance the hydrogen storage properties of Mg-MgH2,this article elaborated the main catalysts based on Ti and Nb transition elements,including single oxide catalysts,binary oxides catalysts（combined with Ni,Na,Sr,V,etc.）,multiple catalysts bound to carbon,and composite catalysts with Ti and Nb elements combined with MXene ***,the main pathways of various catalysts to reduce the reaction activity and broaden the hydrogen desorption channel were also *** Ti-based catalysts can enhance the reactive sites of the matrix by forming multivalent states,while Nb-based catalysts broaden the hydrogen reaction channels by forming tiny *** improving the size structure and enhancing the grain size stability,combined with carbon materials should be the future considerations.

关键词： Catalysts Mg-based hydrogen storage alloys Solid hydrogen storage Transition metal elements

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Research status and prospects of the fractal analysis of metal material surfaces and interfaces

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 20-38页

作者： Qinjin Dai xuefeng Liu Xin Ma Shaojie Tian Qinghe cui Beijing Advanced Innovation Center for Materials Genome Engineering University of Science and Technology BeijingBeijing 100083China Beijing Laboratory of Metallic Materials and Processing for Modern Transportation University of Science and Technology BeijingBeijing 100083China Laboratory for Advanced Materials Processing of Ministry of Education University of Science and Technology BeijingBeijing 100083China School of Mechanical and Electrical Engineering Xinjiang Institute of EngineeringUrumqi 830023China

As a mathematical analysis method,fractal analysis can be used to quantitatively describe irregular shapes with self-similar or self-affine *** analysis has been used to characterize the shapes of metal materials at various scales and *** methods make it difficult to quantitatively describe the relationship between the regular characteristics and properties of metal material surfaces and ***,fractal analysis can be used to quantitatively describe the shape characteristics of metal materials and to establish the quantitative relationships between the shape characteristics and various properties of metal *** the perspective of two-dimensional planes and three-dimensional curved surfaces,this paper reviews the current research status of the fractal analysis of metal precipitate interfaces,metal grain boundary interfaces,metal-deposited film surfaces,metal fracture surfaces,metal machined surfaces,and metal wear *** relationship between the fractal dimensions and properties of metal material surfaces and interfaces is *** from three perspectives of fractal analysis,namely,research scope,image acquisition methods,and calculation methods,this paper identifies the direction of research on fractal analysis of metal material surfaces and interfaces that need to be *** is believed that revealing the deep influence mechanism between the fractal dimensions and properties of metal material surfaces and interfaces will be the key research direction of the fractal analysis of metal materials in the future.

关键词： metal material surfaces and interfaces fractal analysis fractal dimension homogeneity

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The complex effects of miR-146a in the pathogenesis of Alzheimer's disease

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Neural Regeneration Research 2025年第5期20卷 1309-1323页

作者： Yunfan Long Jiajia Liu Yu Wang Haidong Guo Guohong cui Department of Neurology Shanghai No.9 People’s HospitalShanghai Jiaotong University School of MedicineShanghaiChina Academy of Integrative Medicine Shanghai University of Traditional Chinese MedicineShanghaiChina School of Integrative Medicine Shanghai University of Traditional Chinese MedicineShanghaiChina Department of Neurology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghaiChina

Alzheimer's disease is a neurodegenerative disorder characterized by cognitive dysfunction and behavioral *** plaques formed through the extracellular deposition of amyloid-βproteins,as well as neurofibrillary tangles formed by the intracellular deposition of hyperphosphorylated tau proteins,comprise two typical pathological features of Alzheimer's *** symptomatic treatment,there are no effective therapies for delaying Alzheimer's disease ***(miR)are small,non-coding RNAs that negatively regulate gene expression at the transcriptional and translational levels and play important roles in multiple physiological and pathological ***,miR-146a,a NF-κB-regulated gene,has been extensively implicated in the development of Alzheimer's disease through several *** has demonstrated substantial dysregulation of miR-146a both during the initial phases and throughout the progression of this *** R-146a is believed to reduce amyloid-βdeposition and tau protein hyperphosphorylation through the TLR/IRAK1/TRAF6 pathway;however,there is also evidence supporting that it can promote these processes through many other pathways,thus exacerbating the pathological manifestations of Alzheimer's *** has been widely reported that miR-146a mediates synaptic dysfunction,mitochondrial dysfunction,and neuronal death by targeting m RNAs encoding synapticrelated proteins,mitochondrial-related proteins,and membrane proteins,as well as other *** the impact on glial cells,miR-146a also exhibits differential *** one hand,it causes widespread and sustained inflammation through certain pathways,while on the other hand,it can reverse the polarization of astrocytes and microglia,alleviate neuroinflammation,and promote oligodendrocyte progenitor cell differentiation,thus maintaining the normal function of the myelin sheath and exerting a protective effect on *** this review,we provide a

关键词： Alzheimer's disease amyloid-β glial cells microRNAs miR-146a neuroinflammatory

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福建省屏南县健康人群麻疹免疫水平和强化免疫效果监测

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职业与健康 2011年第4期27卷 441-442页

作者：胡云峰薛翠惠福建省屏南县疾病预防控制中心 352300

根据福建省的统一部署,屏南县于2009年3月1—10日对8月龄～14岁儿童进行麻疹疫苗强化免疫活动,为评价此次强化免疫效果,了解健康人群麻疹免疫力,为消除麻疹提供依据,我们开展了健康人群麻疹免疫水平和强化免疫效果监测,现报告如下。

关键词：麻疹疫苗强化免疫麻疹IgG抗体

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A new horizon for neuroscience:terahertz biotechnology in brain research

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Neural Regeneration Research 2025年第2期20卷 309-325页

作者： Zhengping Pu Yu Wu Zhongjie Zhu Hongwei Zhao Donghong cui Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Department of Psychiatry Kangci Hospital of JiaxingTongxiangZhejiang ProvinceChina Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghaiChina Key Laboratory of Interfacial Physics and Technology Shanghai Institute of Applied PhysicsChinese Academy of ScienceShanghaiChina National Facility for Protein Science in Shanghai Shanghai Advanced Research InstituteChinese Academy of SciencesShanghaiChina

Terahertz biotechnology has been increasingly applied in various biomedical fields and has especially shown great potential for application in brain *** this article,we review the development of terahertz biotechnology and its applications in the field of *** evidence indicates promising prospects for the use of terahertz spectroscopy and terahertz imaging techniques in the diagnosis of amyloid disease,cerebrovascular disease,glioma,psychiatric disease,traumatic brain injury,and myelin *** vitro and animal experiments have also demonstrated the potential therapeutic value of terahertz technology in some neuropsychiatric *** the precise underlying mechanism of the interactions between terahertz electromagnetic waves and the biosystem is not yet fully understood,the research progress in this field shows great potential for biomedical noninvasive diagnostic and therapeutic ***,the biosafety of terahertz radiation requires further exploration regarding its two-sided efficacy in practical *** review demonstrates that terahertz biotechnology has the potential to be a promising method in the field of neuropsychiatry based on its unique advantages.

关键词： biological effect brain neuron neuropsychiatry neuroscience non-thermal effect terahertz imaging terahertz radiation terahertz spectroscopy terahertz technology

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