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Diagnosis and management of acute complications in patients with colon cancer:bleeding,obstruction,and perforation

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Chinese Journal of Cancer Research 2014年第3期26卷 331-340页

作者： xue-fei yang Kai Pan Department of Surgery the University of Hong Kong-Shenzhen Hospital Department of Gastrointestinal Surgery Shenzhen People's Hospital Second Clinical Medical College of Jinan University

Among the colorectal cancers, the incidence of colon cancer has obviously increased. As a result, the actual incidence of colon cancer has exceeded that of rectal cancer, which dramatically changed the longexisting epidemiological profile. The acute complications of colon cancer include bleeding, obstruction, and perforation, which were among the common acute abdominal surgical conditions. The rapid and accurate diagnosis of these acute complications was very important, and laparoscopic techniques can be applied in abdominal surgery for management of the complications.

关键词： Colon cancer bleeding obstruction perforation

Synthesis of 2-aryl-5-alkyl-7-methoxylbenzo[b]furan derivatives

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Chinese Chemical Letters 2007年第4期18卷 380-382页

作者： xue fei yang Ling Yi Kong Department of Natural Medicinal Chemistry China Pharmaceutical University Nanjing 210009 China

A series of 2-aryl-5-alkyl-7-methoxylbenzo[b]furan derivatives have been synthesized by utilizing the coupling of methyl 3- methoxy-4hydroxy-5-bromocinnamate with cuprous phenylacetylide as the key step. The structures of the new compounds were confirmed by 1H NMR, IR and MS. The structure of compound 14 was further confirmed by single crystal X-ray. Compound 17 showed cytotoxic activity against human lung carcinoma A549.

关键词： 2-Aryl-5-alkyl-7-methoxylbenzo[b]furan Neolignans Synthesis Cytotoxicity

Sedimentology of reefal buildups of the Xiannüdong Formation(Cambrian Series 2),SW China

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Journal of Palaeogeography 2019年第2期8卷 170-180页

作者： Hao Tang Stephen Kershaw Xiu-Cheng Tan Hong Liu fei Li Cheng Shen fei-Fan Lu xue-fei yang Division of Key Laboratory of Carbonate Reservoir of CNPC Southwest Petroleum University Shandong Provincial Key Laboratory of Depositional Mineralization and Sedimentary Mineral Shandong University of Science and Technology Department of Life Sciences Brunel University

The reefs in the Xiannüdong Formation(Cambrian Series 2) are the oldest archaeocyathan–microbial bioconstructions in China,but the details of their microbial structures have not been previously ***,a new section at Tangjiahe site,northern Sichuan Province,contains very well-preserved microbial fabrics that provide these details,and is described in this *** Tangjiahe section contains three levels of reefal buildups that were constructed by a consortium of archaeocyaths and calcimicrobes in varying *** lowest(oldest) reefal buildup is a calcimicrobial biostrome,possibly in the form of a wide mound with a low relief(unconfirmed due to outcrop limitation),which was formed by Epiphyton with rare small archaeocyaths,and is sandwiched by flat-pebble *** middle reefal buildup is a high-relief calcimicrobial mound,enclosed by oolites,that was built by intergrown Renalcis and *** fossils are uncommon,and were bound into the framework by microbial *** uppermost(youngest) reefal buildup is a low-relief archaeocyathan mound lacking calcimicrobes but partly having microbially-clotted textures attached on *** built or aided archaeocyaths to form the framework of Tangjiahe *** three buildups formed in low-energy lagoons behind ooid shoals,and the environment was nutrient-rich due to terrigenous influx from adjacent *** reefs thus resemble most Early Cambrian reefs,in settings consistent with eutrophic,calm environments,and are characterized by the domination or aid of calcimicrobial components in framework construction.

关键词： Microbialites Archaeocyaths Reefs Cambrian Series 2 Southwest China

CLINICOPATHOLOGICAL SIGNIFICANCE OF PTEN AND CASPASE-3 EXPRESSIONS IN BREAST CANCER

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Chinese Medical Sciences Journal 2008年第2期23卷 95-102页

作者： xue-fei yang Yan Xin Li-li Mao The Fourth Laboratory of Cancer Institute ＆ Department of Tumor Pathology of General Surgery Institute the First Hospital of China Medical University Shenyang 110001

Objective To investigate the expressions of PTEN and Caspase-3 proteins in human breast carcinoma,and to evaluate their clinicopathological implications during the tumorigenesis and progression of breast *** The expressions of PTEN and Caspase-3 proteins in 95 cases of breast cancer and 15 cases of benign breast diseases were investigated *** between the expression of PTEN protein,Caspase-3 protein,and clinicopathological features of breast cancers were *** The loss expression rate of PTEN protein in tumor tissues was significantly higher than that in benign breast diseases(33.7% vs.0,P0.05).In addition,the expression of PTEN protein had significantly positive correlation with the expression of Caspase-3 protein in breast cancer(P<0.01).Conclusion The combination detection of PTEN and Caspase-3 may serve as an important index to estimate the pathobiological behavior and prognosis of breast cancer.

关键词： breast cancer tumor suppressor gene PTEN Caspase-3 prognosis

The response of structure and nitrogen removal function of the biofilm on submerged macrophytes to high ammonium in constructed wetlands

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Journal of Environmental Sciences 2024年第8期142卷 129-141页

作者： xue Jiang Mengmeng Wang Shunqing yang Di He fei Fang Liuyan yang State Key Laboratory of Pollution Control and Resource Reuse School of the EnvironmentNanjing UniversityNanjing 210023China School of Resources and Environment Anqing Normal UniversityAnqing 246133China

The ammonium exceedance discharge from sewage treatment plants has a great risk to the stable operation of subsequent constructed wetlands(CWs).The effects of high ammonium shocks on submerged macrophytes and epiphytic biofilms on the leaves of submerged macrophytes in CWs were rarely mentioned in previous *** this paper,the 16S rRNA sequencing method was used to investigate the variation of the microbial communities in biofilms on the leaves of Vallisneria natans plants while the growth characteristics of *** plants were measured at different initial ammonium *** results demonstrated that the total chlorophyll and soluble sugar synthesis of *** plants decreased by 51.45%and 57.16%,respectively,and malondialdehyde content increased threefold after8 days if the initial NH_(4)^(+)-N concentration was more than 5 mg/*** density,bacterial quantity,dissolved oxygen,and pH increased with high ammonium *** average removal efficiencies of total nitrogen and NH_(4)^(+)-N reached 73.26%and 83.94%,*** heat map and relative abundance analysis represented that the relative abundances of phyla Proteobacteria,Cyanobacteria,and Bacteroidetes *** numbers of autotrophic nitrifiers and heterotrophic nitrification aerobic denitrification(HNAD)bacteria expanded in *** particular,HNAD bacteria of Flavobacterium,Hydrogenophaga,Acidovorax,Acinetobacter,Pseudomonas,Aeromonas,and Azospira had higher abundances than autotrophic nitrifiers because there were organic matters secreted from declining leaves of *** *** analysis of the nitrogen metabolic pathway showed aerobic denitrification was the main nitrogen removal ***,the nitrification and denitrification bacterial communities increased in epiphytic biofilms on submerged macrophytes in constructed wetlands while submerged macrophytes declined under ammonium shock loading.

关键词： Ammonium shock loading Biofilm Autotrophic nitrifiers Heterotrophic nitrification aerobic denitrification bacteria Submerged macrophyte

Three-Center Experience on Patients with Influenza-Associated Acute Respiratory Distress Syndrome in Chongqing, China

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Chinese Medical Journal 2018年第10期131卷 1244-1245页

作者： xue-fei yang Tomer Talmy Peng-fei Li Yao-Rong Zhang Wei-Jun Song Yao-Li Wang Jian Zhou Intensive Care Unit Trauma Center The Daping Hospital and Research Institute of Surgery of Army Medical University Chongqing 400042 China Hadassah Medical Center The Institute of Research in Military Medicine The Hebrew University of Jerusalem Jerusalem 91120 Israel Intensive Care Unit Changan Hospital Chongqing 400021 China Intensive Care Unit Wushan County People's Hospital of Chongqing Chongqing 404700 China

To the Editor：Influenza-associated acute respiratory distress syndrome （ARDS） remains a devastating clinical picture. From December 2017 to January 2018,ten patients with influenza-associated ARDS were admitted to three different hospital＇s Intensive Care Units （ICUs） in Chongqing,with all cases resulting in *** main documented reasons for their admission to the ICU were due to progressive dyspnea and worsening hypoxemia which lead to endotracheal intubation and mechanical ventilation in these *** of influenza viruses was achieved using nucleic-acid testing from venous *** study was approved by the Institutional Review Board of Daping Hospital,Army Medical University.

关键词： A H1N1 ARDS

Alleviation of acute pancreatitis-associated lung injury by inhibiting the p38 mitogen-activated protein kinase pathway in pulmonary microvascular endothelial cells

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World Journal of Gastroenterology 2021年第18期27卷 2141-2159页

作者： Xiao-Xin Zhang Hao-yang Wang xue-fei yang Zi-Qi Lin Na Shi Chan-Juan Chen Lin-Bo Yao Xin-Min yang Jia Guo Qing Xia Ping xue Department of Integrated Traditional Chinese and Western Medicine West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND Previous reports have suggested that the p38 mitogen-activated protein kinase signaling pathway is involved in the development of severe acute pancreatitis(SAP)-related acute lung injury(ALI).Inhibition of p38 by SB203580 blocked the inflammatory responses in ***,the precise mechanism associated with p38 is unclear,particularly in pulmonary microvascular endothelial cell(PMVEC)*** To determine its role in the tumor necrosis factor-alpha(TNF-α)-induced inflammation and apoptosis of PMVECs in *** then conducted in vivo experiments to confirm the effect of SB203580-mediated p38 inhibition on *** In vitro,PMVEC were transfected with mitogen-activated protein kinase kinase 6(Glu),which constitutively activates p38,and then stimulated with TNF-α.Flow cytometry and western blotting were performed to detect the cell apoptosis and inflammatory cytokine levels,*** vivo,SAP-ALI was induced by 5%sodium taurocholate and three different doses of SB203580(2.5,5.0 or 10.0 mg/kg)were intraperitoneally injected prior to SAP ***-ALI was assessed by performing pulmonary histopathology assays,measuring myeloperoxidase activity,conducting arterial blood gas analyses and measuring TNF-α,interleukin(IL)-1βand IL-6 *** microvascular permeability was measured by determining bronchoalveolar lavage fluid protein concentration,Evans blue pulmonary cells was confirmed by performing a terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling analysis and examining the Bcl2,Bax,Bim and cle-caspase3 *** proteins levels of P-p38,NFκB,IκB,P-signal transducer and activator of transcription-3,nuclear factor erythroid 2-related factor 2,HO-1 and Myd88 were detected in the lungs to further evaluate the potential mechanism underlying the protective effect of *** In vitro,mitogen-activated protein kinase(Glu)transfection resulted in higher apoptotic rates and cytokine(IL-1βand IL-6)levels in TNF-α-t

关键词： Acute pancreatitis Acute lung injury Pulmonary microvascular endothelial cells P38 SB203580 Apoptosis

Energy evolution and structural health monitoring of coal under different failure modes:An experimental study

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International Journal of Minerals,Metallurgy and Materials 2024年第5期31卷 917-928页

作者： Yarong xue xueqiu He Dazhao Song Zhenlei Li Majid Khan Taoping Zhong fei yang School of Civil and Resources Engineering University of Science and Technology BeijingBeijing 100083China Zhong-an Academy of Safety Engineering Beijing 100083China

Structural instability in underground engineering,especially in coal-rock structures,poses significant safety ***,the development of an accurate monitoring method for the health of coal-rock bodies is *** focus of this work is on understanding energy evolution patterns in coal-rock bodies under complex conditions by using shear,splitting,and uniaxial compression *** examine the changes in energy parameters during various loading stages and the effects of various failure modes,resulting in an innovative energy dissipation-based health evaluation technique for *** results show that coal bodies go through transitions between strain hardening and softening mechanisms during loading,indicated by fluctuations in elastic energy and dissipation energy *** tensile failure,the energy profile of coal shows a pattern of “high dissipation and low accumulation” before peak *** the other hand,shear failure is described by “high accumulation and low dissipation” in energy *** failure modes correlate with an accelerated increase in the dissipation energy before destabilization,and a significant positive correlation is present between the energy dissipation rate and the stress state of the coal samples.A novel mathematical and statistical approach is developed,establishing a dissipation energy anomaly index,W,which categorizes the structural health of coal into different danger *** method provides a quantitative standard for early warning systems and is adaptable for monitoring structural health in complex underground engineering environments,contributing to the development of structural health monitoring technology.

关键词： energy dissipation structural health monitoring early warning coal-rock mechanics failure mode

Lignin-reinforced PVDF electrolyte for dendrite-free quasi-solid-state Li metal battery

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Rare Metals 2024年第3期43卷 1006-1016页

作者： Xin-yang Chen xue-Jie Gao Han-Yan Wu Yu-Long Liu Xiao-fei yang Run-Cang Sun Center for Lignocellulosic Chemistry and Biomaterials College of Light Industry and Chemical EngineeringDalian Polytechnic UniversityDalian116034China Division of Energy Storage Dalian National Laboratory for Clean EnergyDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian116023China School of Chemistry Northeast Normal UniversityChangchun130024China

Quasi-solid-state lithium metal batteries(QSSLMBs)assembled with polyvinylidene fluoride(PVDF)are a promising class of next-generation rechargeable batteries due to their safety,high energy density,and superior interfacial ***,PVDF has a series of inherent drawbacks such as low ionic conductivity,ease of crystallization,and hydrophobic character that leading to poor cell *** tackle these issues,a lignin-reinforced PVDF electrolyte is proposed in this work to solve these drawbacks of PVDF and enhance the comprehensive performance of *** lithophilic polar groups of lignin can promote uniform deposition of Li on the *** with the improved mechanical properties can efficiently prevent Li dendrites penetration through the *** addition,more active sites provided by lignin can also enhance Li^(+)transport and lead to a faster electrochemical reaction *** from the ingenious design,Li symmetric cells with 5%lignin-PVDF quasi-solid-state electrolyte can operate for 900 h at a high current density/capacity of 5 mA·cm^(-2)/5 mAh·cm^(-2),while shortcircuiting occurs after 56 h for the counterpart(pure PVDF).Moreover,a full cell of Li/5%lignin-PVDF/LFP cell demonstrates a high capacity of 96.2 mAh·g^(-1)after 2000 cycles at 10 *** work is expected to open up promising opportunities to develop other high-energy/power-density QSSLMBs.

关键词： Quasi-solid-state electrolyte Lignin PVDF Dendrite-free Li metal battery