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A correlative study of iron metabolism based on q-Dixon MRI in benign prostatic hyperplasia and prostate cancer

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Asian Journal of Andrology 2022年第6期24卷 671-674页

作者： Zhen Tian Yong-Gang Li Guang-Zheng Li Zhi-Hao Huang Wen-Hao Dail xue-dong wei wei-Jie Zhang Zhen-Yu Fu Yu-Hua Huang Department of Urology The First Affiliated Hospital of Soochow UniversitySuzhou 215000China Department of Radiology The First Affiliated Hospital of Soochow UniversitySuzhou 215000China Department of Urology Changshu No.2 People's HospitalChangshu 215500China

Clinical staging,Gleason score,and prostate-specific antigen(PSA)have been accepted as factors for evaluating the prognosis of prostate cancer(PCa).With the in-depth study of iron metabolism and the development of multiparametric magnetic resonance imaging technology,we used q-Dixon magnetic resonance imaging(MRI)to measure the iron content of the PCa patients'lesions,and used enzyme-linked immunosorbent assay(ELISA)to measure the iron metabolism indicators in the patients'serum samples,combined with the patients'postoperative clinical data for *** found that the serum indexes were correlated with the T2 star values,International Society of Urological Pathology(ISUP)grade,and pathological classification in PCa patients(all PO.05).The utilization of q-Dixon-based MRI and serum indexes allows the noninvasive measurement of iron content in prostate lesions and the assessment of differential iron metabolism between PCa and BPH,which may be helpful for evaluating the prognosis of PCa.

关键词： iron metabolism prostate cancer q-Dixon MRl serum index

First principles study on Mn-doped LiFePO_4 as cathode material for rechargeable lithium batteries

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原子与分子物理学报 2007年第B8期24卷 128-132页

作者：许芳伟薛卫东 College of Physics and Electronic Engineering Sichuan Normal University College of Chemistry and Materials Science Sichuan Normal University

The electronic structure and diffusion energy barriers of Li ions in pure and Mn-doped LiFePO4 have been studied using density functional theory(DFT).The results demonstrate clearly that Fe-O covalent bond is weaker than P-O covalent *** LiFePO4 has band gap of 0.56 eV and diffusion energy barrier of 2.57 eV for Li ions,while the dopant has small band gap of 0.25 eV and low diffusion energy barrier of 2.31 eV,which indicates that the electronic and ionic conductivity of LiFePO4 have been improved owing to doping.

关键词：锂电池 DFT 密度函数电子结构阴极材料

Anti-HBV effect of TAT-HBV targeted ribonuclease

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World Journal of Gastroenterology 2003年第7期9卷 1525-1528页

作者： Jin Ding Jun Liu Cai-Fang xue wei-dong Gong Ying-Hui Li Ya Zhao Department of Etiology,Fourth Military Medical University,Xi’an 710032,Shaanxi Province,China Department of Etiology Fourth Military Medical University Xi'an 710032 Shaanxi Province China.

AIM: To prepare and purify TAT-HBV targeted ribonuclease fusion protein, evaluate its transduction activity and investigate its effect on HBV replication in 2.2.15 ***: The prokaryotic expression vector pTAT containing TR gene was used in transforming E. coli BL21(DE3) LysS and TR was expressed with the induction of IPTG. The TAT-TR fusion protein was purified using Ni-NTA-agrose and PD-10 desalting columns, and analyzed by SDSPAGE. Transduction efficiency of TAT-TR was detected with immunofluorescence assay and the concentration of HBeAg in the supernatant of the 2.2.15 cells was determined via solid-phase radioimmunoassay (spRIA). MTT assay was used to detect the cytotoxicity of ***: The SDS-PAGE showed that the TAT-TR fusion protein was purified successfully, and the purity of TAT-TR was 90 %. The visualization of TAT-TR by immunofiuorescence assay indicated its high efficiency in transducing 2.2.15 *** result suggests that TAT-TR could inhibit the replication of HBV effectively, it didn′t affect cell growth and had no ***: TAT-TR possesses a significant anti-HBV activity and the preparation of TAT-TR fusion protein has laid the foundation for the use of TR in the therapeutic trial of HBV infection.

关键词：乙型肝炎病毒核糖核酸酶 TAT融合蛋白蛋白纯化

New model of PIRADS and adjusted prostatespecific antigen density of peripheral zone improves the detection rate of initial prostate biopsy:a diagnostic study

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Asian Journal of Andrology 2023年第1期25卷 126-131页

作者： Chen Huang Zong-Qiang Cai Feng Qiu Jin-Xian Pu Qi-Lin Xi xue-dong wei Xi-Ming Wang Xiao-Jun Zhao Lin-Chuan Guo Jian-Quan Hou Yu-Hua Huang Department of Urology The First Affiliated Hospital of Soochow UniversitySuzhou 215006China Department of Radiology The First Affiliated Hospital of Soochow UniversitySuzhou 215006China Department of Pathology The First Affiliated Hospital of Soochow UniversitySuzhou 215006China

This study explored a new model of Prostate Imaging Reporting and Data System(PIRADS)and adjusted prostate-specific antigen density of peripheral zone(aPSADPZ)for predicting the occurrence of prostate cancer(PCa)and clinically significant prostate cancer(csPCa).The demographic and clinical characteristics of 853 patients were ***-specific antigen(PSA),PSA density(PSAD),PSAD of peripheral zone(PSADPZ),aPSADPZ,and peripheral zone volume ratio(PZ-ratio)were calculated and subjected to receiver operating characteristic(ROC)curve *** calibration and discrimination abilities of new nomograms were verified with the calibration curve and area under the ROC curve(AUC).The clinical benefits of these models were evaluated by decision curve analysis and clinical impact *** AUCs of PSA,PSAD,PSADPZ,aPSADPZ,and PZ-ratio were 0.669,0.762,0.659,0.812,and 0.748 for PCa diagnosis,while 0.713,0.788,0.694,0.828,and 0.735 for csPCa diagnosis,*** nomograms displayed higher net benefit and better overall calibration than the scenarios for predicting the occurrence of PCa or *** new model significantly improved the diagnostic accuracy of PCa(0.945 vs 0.830,P<0.01)and csPCa(0.937 vs 0.845,P<0.01)compared with the base *** addition,the number of patients with PCa and csPCa predicted by the new model was in good agreement with the actual number of patients with PCa and csPCa in high-risk *** study demonstrates that aPSADPZ has a higher predictive accuracy for PCa diagnosis than the conventional *** aPSADPZ with PIRADS can improve PCa diagnosis and avoid unnecessary biopsies.

关键词： adjusted prostate-specific antigen density of peripheral zone biopsy diagnosis Prostate Imaging Reporting and Data System prostate cancer

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无压给料三产品重介质旋流器

煤炭科学技术 2001年第4期29卷 4-6页

作者：薛维东煤炭科学研究总院唐山分院河北唐山063000

介绍了无压给料三产品重介质旋流器工作原理和推广应用情况。

关键词：重介质旋流器选煤工艺精煤中煤矸石分选原理

四方相BaTiO_3铁电性的第一性原理研究

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物理学报 2005年第2期54卷 857-862页

作者：薛卫东陈召勇杨春李言荣电子科技大学微电子与固体电子学院四川师范大学化学系成都610066

在广义梯度近似下 ,利用超软赝势对立方相和四方相BaTiO3晶胞中Ti原子沿c轴位移时体系的能量、原子间电子云重叠布局数和各原子上的净电荷等进行了自洽计算 .结果显示 ,当Ti原子沿c轴位移 0 0 12nm时 ,四方相BaTiO3体系能量最低 ,其自... 详细信息

在广义梯度近似下 ,利用超软赝势对立方相和四方相BaTiO3晶胞中Ti原子沿c轴位移时体系的能量、原子间电子云重叠布局数和各原子上的净电荷等进行了自洽计算 .结果显示 ,当Ti原子沿c轴位移 0 0 12nm时 ,四方相BaTiO3体系能量最低 ,其自发极化强度为 0 2 6 1C m2 ,该结果与实验数据相符合 ;同时表明 ,O原子的 2p轨道和Ti原子的 3d轨道的杂化是BaTiO3晶体出现铁电性的重要原因 .

关键词：原子第一性原理自洽广义梯度近似赝势电子云四方相 BaTiO3 铁电性

8-羟基喹啉铁配合物对锐钛矿型TiO2(101)表面的敏化机理

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物理化学学报 2009年第5期25卷 947-952页

作者：苏荣薛卫东冯勇王建华易丹四川师范大学化学与材料科学学院成都610068 电子科技大学微电子与固体电子学院成都610054

用密度泛函理论和DMol3程序包对锐钛矿型TiO2(101)表面复合三(8-羟基喹啉-5-羧酸)铁的敏化机理进行了研究.计算结果表明,该染料敏化剂经式结构的HOMO(最高占据分子轨道)-LUMO(最低未占据分子轨道)能隙非常小,很容易受到激发;TiO2纳米晶... 详细信息

用密度泛函理论和DMol3程序包对锐钛矿型TiO2(101)表面复合三(8-羟基喹啉-5-羧酸)铁的敏化机理进行了研究.计算结果表明,该染料敏化剂经式结构的HOMO(最高占据分子轨道)-LUMO(最低未占据分子轨道)能隙非常小,很容易受到激发;TiO2纳米晶吸附染料后,HOMO、LUMO和费米能级都升高,导致吸附染料后开路电压VOC升高.并进一步探讨了三(8-羟基喹啉-5-羧酸)铁在TiO2(101)表面复合过程及作用机理.

关键词：密度泛函理论 TiO2 三(8-羟基喹啉-5-羧酸)铁敏化机理

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工业控制机在选煤厂的应用

计算机自动测量与控制 2000年第6期8卷 30-31页

作者：薛维东煤炭科学研究总院唐山分院河北唐山063012

将工控机成功的应用于“浮选工艺参数自动测控系统”中 ,其最大优势在于非常容易将企业管理与工业自动化系统融合为一体。在工业性试验中 ,其抗干扰性能经受了恶劣环境的严峻考验并取得了较好的经济效益。本文详细介绍了该项目的研究情况。

关键词：选煤厂工业控制机 STD总线抗干扰

左半结肠切除Ⅰ期吻合术治疗结肠癌并发肠梗阻的临床效果

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中外医学研究 2016年第20期14卷 25-27页

作者：董雪伟常州市第一人民医院江苏常州213003

目的:探讨用左半结肠切除Ⅰ期吻合术治疗结肠癌并发肠梗阻的临床效果。方法:选取2009年1月-2014年12月在笔者所在医院接受治疗的结肠癌并发肠梗阻患者44例,将患者随机分为治疗组与对照组,每组22例。其中对照组患者以结肠次全切除术进行... 详细信息

目的:探讨用左半结肠切除Ⅰ期吻合术治疗结肠癌并发肠梗阻的临床效果。方法:选取2009年1月-2014年12月在笔者所在医院接受治疗的结肠癌并发肠梗阻患者44例,将患者随机分为治疗组与对照组,每组22例。其中对照组患者以结肠次全切除术进行治疗,治疗组患者以左半结肠切除Ⅰ期吻合术进行治疗,对两组患者的治疗效果进行观察比较。结果:治疗组指标均优于对照组,如手术时间、术中出血量、住院时间,组间比较差异均有统计学意义(P<0.05)。且治疗组患者术后生活质量高于对照组,组间比较差异均有统计学意义(P<0.05)。结论:左半结肠切除Ⅰ期吻合术治疗结肠癌并发肠梗阻具有较好的效果,临床上可进行广泛使用。

关键词：左半结肠切除 Ⅰ期结肠癌肠梗阻