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Causal association between 731 immunocyte phenotypes and liver cirrhosis: A bidirectional two-sample mendelian randomization analysis

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World Journal of Hepatology 2024年第8期16卷 1156-1166页

作者： Ying Li Xin Quan Yang tai Yu-Tong Wu Bo Wei Hao Wu Department of Gastroenterology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Clinical Medicine Chongqing Medical UniversityChongqing 400016China

BACKGROUND Liver cirrhosis is a progressive hepatic disease whose immunological basis has attracted increasing ***,it remains unclear whether a concrete causal association exists between immunocyte phenotypes and liver *** To explore the concrete causal relationships between immunocyte phenotypes and liver cirrhosis through a mendelian randomization(MR)*** Data on 731 immunocyte phenotypes were obtained from genome-wide assoc-iation *** cirrhosis data were derived from the Finn Gen dataset,which included 214403 individuals of European *** used inverse variable weighting as the primary analysis method to assess the causal *** analyses were conducted to evaluate heterogeneity and horizontal *** The MR analysis demonstrated that 11 immune cell phenotypes have a positive association with liver cirrhosis[P1]and that 9 immu-nocyte phenotypes were negatively correlated with liver cirrhosis(P1)and negatively linked to 10 immune cell phenotypes(P0.05).CONCLUSION This bidirectional two-sample MR study demonstrated a concrete causal association between immunocyte phenotypes and liver *** findings offer new directions for the treatment of liver cirrhosis.

关键词： Liver cirrhosis Immune cell Immunocyte phenotype Mendelian analysis Causal association

Evolution and function of residual solvent in polymer-Li_2B_(12)H_(12) composite solid electrolyte

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Rare Metals 2024年第8期43卷 3748-3757页

作者： Xiang-Yang Ye Ke-Pan Bao Sai-Nan Luo Xin Li tai-Qiang Chen Shui-Xin Xia Tao Yuan Yue-Peng Pang Shi-You Zheng School of Materials and Chemistry University of Shanghai for Science and TechnologyShanghai 200093China Department of Materials Science and Engineering National University of SingaporeSingapore 119077Singapore

Composite solid electrolytes(CSEs) containing polymer matrices and inorganic fillers hold promise for the next generation of solid-state ***,the role of residual solvents in CSEs remains *** study investigated the evolution and function of the residual solvent in a polymer-Li_2B_(12)H_(12) CSE.A partial reaction occurred between Li_2B_(12)H_(12) and solvent N,N-dimethylformamide(DMF),which produced dimethylaminomethanol(DMAM) in the *** functional theory calculations have revealed that DMA M forms stronger hydrogen bonds with polyvinylidene fluoride chains than DMF,which can have a plasticizing effect on the polymer matrix,leading to lower crystallinity and quicker segment ***,this CSE exhibited improved Li-ion conducting properties,enabling the stable cycling of Li‖LiFePO_(4) solid-state *** study provided insights into the role of residual solvents in CSEs.

关键词： Composite solid electrolyte Residual solvent Lithium borohydride Plasticizing effect

Discrete Choice Analysis of Temporal Factors on Social Network Growth

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Intelligent Information Management 2024年第1期16卷 21-34页

作者： Kwok-Wai Cheung Yuk tai Siu School of Communication The Hang Seng University of Hong Kong Hong Kong China

Social networks like Facebook, X (Twitter), and LinkedIn provide an interaction and communication environment for users to generate and share content, allowing for the observation of social behaviours in the digital world. These networks can be viewed as a collection of nodes and edges, where users and their interactions are represented as nodes and the connections between them as edges. Understanding the factors that contribute to the formation of these edges is important for studying network structure and processes. This knowledge can be applied to various areas such as identifying communities, recommending friends, and targeting online advertisements. Several factors, including node popularity and friends-of-friends relationships, influence edge formation and network growth. This research focuses on the temporal activity of nodes and its impact on edge formation. Specifically, the study examines how the minimum age of friends-of-friends edges and the average age of all edges connected to potential target nodes influence the formation of network edges. Discrete choice analysis is used to analyse the combined effect of these temporal factors and other well-known attributes like node degree (i.e., the number of connections a node has) and network distance between nodes. The findings reveal that temporal properties have a similar impact as network proximity in predicting the creation of links. By incorporating temporal features into the models, the accuracy of link prediction can be further improved.

关键词： Discrete Choice Models Temporal Factors Social Network Link Prediction Network Growth

NOX4 promotes tumor progression through the MAPK-MEK1/2-ERK1/2 axis in colorectal cancer

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1421-1436页

作者： Yu-Jie Xu Ya-Chang Huo Qi-tai Zhao Jin-Yan Liu Yi-Jun Tian Lei-Lei Yang Yi Zhang Biotherapy Center and Cancer Center The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Department of Oncology Henan Provincial People’s HospitalPeople’s Hospital of Zhengzhou UniversityPeople’s Hospital of Henan UniversityZhengzhou 450003Henan ProvinceChina

BACKGROUND Metabolic reprogramming plays a key role in cancer progression and clinical outcomes;however,the patterns and primary regulators of metabolic reprogramming in colorectal cancer(CRC)are not well *** To explore the role of nicotinamide adenine dinucleotide phosphate oxidase 4(NOX4)in promoting progression of *** We evaluated the expression and function of dysregulated and survival-related metabolic genes using Gene Ontology and Kyoto Encyclopedia of Genes and *** clustering was used to cluster CRC based on dysregulated metabolic genes.A prediction model was constructed based on survival-related metabolic *** formation,migration,invasion,proliferation,apoptosis and clone formation was used to evaluate the biological function of NOX4 in *** sequencing was utilized to explore the alterations of gene expression NOX4 over-expression tumor *** vivo subcutaneous and lung metastasis mouse tumor model was used to explore the effect of NOX4 on tumor *** We comprehensively analyzed 3341 metabolic genes in CRC and identified three clusters based on dysregulated metabolic *** these genes,NOX4 was highly expressed in tumor tissues and correlated with worse *** vitro,NOX4 overexpression induced clone formation,migration,invasion,and stemness in CRC ***,RNA-sequencing analysis revealed that NOX4 overexpression activated the mitogen-activated protein kinase-MEK1/2-ERK1/2 signaling ***,a MEK1/2 inhibitor,abolished the NOX4-mediated tumor *** vivo,NOX4 overexpression promoted subcutaneous tumor growth and lung metastasis,whereas trametinib treatment can reversed the *** Our study comprehensively analyzed metabolic gene expression and highlighted the importance of NOX4 in promoting CRC metastasis,suggesting that trametinib could be a potential therapeutic drugs of CRC clinical therapy targeting NOX4.

关键词： Colorectal cancer Metabolic reprogramming Metastasis Nicotinamide adenine dinucleotide phosphate oxidase 4 Mitogen-activated protein kinase signaling

Search for an exotic vectorlike X-quark in same-sign dilepton final states at the future 3 TeV CLIC

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Chinese Physics C 2024年第7期48卷 67-74页

作者：张艳菊常金龙刘太刚 School of Medical Engineering Xinxiang Medical UniversityXinxiang 453003China

Vectorlike quarks(VLQs)with masses at the TeV-scale have been predicted in many new physics scenarios beyond the Standard Model(SM).Based on a simplified(X,T)doublet model including the exotic vectorlike X quark(VLQ-X)with an electric charge 5/3,we study the production of the VLQ-X decaying into tW at the future Compact Linear Collider(CLIC)with■TeV including the initial state radiation and beamstrahlung *** focus on the final signals,including same-sign dileptons(electrons or muons),at least one b-tagged jet,and large missing transverse *** performing detailed signal-to-background analyses and detector simulations,we obtain the 2σexclusion capabilities and discovery reaches,respectively,on the mass of the VLQ-Xmx as well as the relevant parameters■for mx≥1500GeV and the coupling strengthg*formx≥1500 GeV)for some typical luminosities at the 3 TeV CLIC.

关键词： Vectorlike quarks CLIC same-sign dilepton

Regioselective cation exchange reaction for photoelectrochemical water splitting

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Rare Metals 2024年第7期43卷 3400-3407页

作者： Mo-Yan Chen tai-Song Zhang Zhi Yan Jiang-Nan Lv Xiao-Ting Sun Rui-Xia Yang Mark TSwihart Xiao-Hong Xu Yang Liu Research Institute of Materials Science of Shanxi Normal University&Key Laboratory of Magnetic Molecules and Magnetic Information Materials of Ministry of Education Taiyuan 030031China Department of Chemical and Biological Engineering University at Buffalo(SUNY)NY 14260USA Department of Materials Science Fudan UniversityShanghai 200433China

Engineering copper sulfide-based heterostructures via cation exchange(CE)is an appealing approach,as it allows selective combination of distinct compositions and functions of metal *** heterostructures can play a significant role in photoelectrochemical applications,but the effect of the ratio between two or more domains in such heterostructures on the photoresponse has not been well explored.

关键词： exchange sulfide splitting

Meibomian glands segmentation in infrared images with limited annotation

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 401-407页

作者： Jia-Wen Lin Ling-Jie Lin Feng Lu tai-Chen Lai Jing Zou Lin-Ling Guo Zhi-Ming Lin Li Li College of Computer and Data Science Fuzhou UniversityFuzhou 350108Fujian ProvinceChina Fujian Provincial Key Laboratory of Networking Computing and Intelligent Information Processing Fuzhou UniversityFuzhou 350108Fujian ProvinceChina Shengli Clinical Medical College of Fujian Medical University Fuzhou 350001Fujian ProvinceChina Department of Ophthalmology Fujian Provincial Hospital South BranchFujian Provincial HospitalFuzhou 350001Fujian ProvinceChina

●AIM:To investigate a pioneering framework for the segmentation of meibomian glands(MGs),using limited annotations to reduce the workload on ophthalmologists and enhance the efficiency of clinical diagnosis.●METHODS:Totally 203 infrared meibomian images from 138 patients with dry eye disease,accompanied by corresponding annotations,were gathered for the study.A rectified scribble-supervised gland segmentation(RSSGS)model,incorporating temporal ensemble prediction,uncertainty estimation,and a transformation equivariance constraint,was introduced to address constraints imposed by limited supervision information inherent in scribble *** viability and efficacy of the proposed model were assessed based on accuracy,intersection over union(IoU),and dice coefficient.●RESULTS:Using manual labels as the gold standard,RSSGS demonstrated outcomes with an accuracy of 93.54%,a dice coefficient of 78.02%,and an IoU of 64.18%.Notably,these performance metrics exceed the current weakly supervised state-of-the-art methods by 0.76%,2.06%,and 2.69%,***,despite achieving a substantial 80%reduction in annotation costs,it only lags behind fully annotated methods by 0.72%,1.51%,and 2.04%.●CONCLUSION:An innovative automatic segmentation model is developed for MGs in infrared eyelid images,using scribble annotation for *** model maintains an exceptionally high level of segmentation accuracy while substantially reducing training *** holds substantial utility for calculating clinical parameters,thereby greatly enhancing the diagnostic efficiency of ophthalmologists in evaluating meibomian gland dysfunction.

关键词： infrared meibomian glands images meibomian gland dysfunction meibomian glands segmentation weak supervision scribbled annotation

Efficiency-first spraying mission arrangement optimization with multiple UAVs in heterogeneous farmland with varying pesticide requirements

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Information Processing in Agriculture 2024年第2期11卷 237-248页

作者： Yang Li Yanqiang Wu Xinyu xue xuemei Liu Yang Xu Xinghua Liu Nanjing Institute of Agricultural Mechanization Ministry of Agriculture and Rural AffairsNanjing 210014PR China College of Mechanical&Electronic Engineering Shandong Agricultural UniversityTai'an 271018PR China Key Laboratory of Modern Agricultural Equipment Ministry of Agriculture and Rural AffairsNanjing 210014PR China Shandong Provincial Key Laboratory of Horticultural Machinery and Equipment Tai’an 271018PR China Shandong Provincial Engineering Laboratory of Agricultural Equipment Intellectualization Tai’an 271018PR China

Combining multiple crop protection Unmanned Aerial Vehicles(UAVs)as a team for a scheduled spraying mission over farmland now is a common way to significantly increase ***,given some issues such as different configurations,irregular borders,and especially varying pesticide requirements,it is more important and more complex than other multi-Agent Systems(MASs)in common *** this work,we focus on the mission arrangement of UAVs,which is the foundation of other high-level cooperations,systematically propose Efficiency-first Spraying Mission Arrangement Problem(ESMAP),and try to construct a united problem framework for the mission arrangement of crop protection ***,to characterise the differences in sub-areas,the varying pesticide requirement per unit is well considered based on Normalized Difference Vegetation Index(NDVI).Firstly,the mathematical model of multiple crop-protection UAVs is established and ESMAP is ***,an acquisition method of a farmland’s NDVI map is proposed,and the calculation method of pesticide volume based on NDVI is ***,an improved Genetic Algorithm(GA)is proposed to solve ESMAP,and a comparable combination algorithm is *** simulations for algorithm analysis are carried out within MATLAB,and it is determined that the proposed GA is more efficient and accurate than the ***,a mission arrangement tested with three UAVs was carried out to validate the effectiveness of the proposed GA in spraying *** results illustrated that it performed well,which took only 90.6%of the operation time taken by the combination algorithm.

关键词： Efficiency-first optimization Mission arrangement Multi-UAVs Heterogeneous farmland

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盐渍土环境下纤维锂渣混凝土柱恢复力模型

吉林大学学报（工学版） 2024年第7期54卷 1944-1957页

作者：张广泰周乘孝刘诗拓新疆大学建筑工程学院乌鲁木齐830017 新疆大学新疆建筑结构与抗震重点实验室乌鲁木齐830017 重庆市万州区市政设施维护管理中心重庆404100

为研究聚丙烯纤维锂渣混凝土(PLiC)柱在盐渍土环境下的抗震性能,对6根试验柱进行低周反复荷载试验。基于试验结果,得到四折线骨架曲线,并在众学者的研究基础上考虑纤维和锂渣的作用,通过回归分析得到各特征点修正系数计算公式。结合侵... 详细信息

为研究聚丙烯纤维锂渣混凝土(PLiC)柱在盐渍土环境下的抗震性能,对6根试验柱进行低周反复荷载试验。基于试验结果,得到四折线骨架曲线,并在众学者的研究基础上考虑纤维和锂渣的作用,通过回归分析得到各特征点修正系数计算公式。结合侵蚀时间的影响,引入刚度退化指数μ和损伤因子D,采用适用于PLiC柱承载力衰减、刚度退化的滞回规则,建立了盐渍土环境作用下的PLiC柱力-位移恢复力模型。结果表明,加入聚丙烯纤维和锂渣可一定程度上提高混凝土柱的极限承载力、延性等力学性能及耐久性。由本文恢复力模型得到的骨架曲线、滞回曲线与试验结果吻合度良好,可为盐渍土环境下聚丙烯纤维锂渣混凝土柱抗震性能非线性分析提供参考。

关键词：结构工程盐渍土环境聚丙烯纤维锂渣混凝土滞回规则恢复力模型