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Interleukin-17A facilitates tumor progression via upregulating programmed death ligand-1 expression in hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 176-198页

作者： Zhong-Xia Yang Li-Ting Zhang Xiao-Jun Liu xue-Bin peng Xiao-Rong Mao The First School of Clinical Medicine Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Infectious Diseases The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Radiotherapy Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)is an inflammation-associated tumor with a dismal *** has become an important treatment strategy for HCC,as immunity is closely related to inflammation in the tumor *** regulates the expression of programmed death ligand-1(PD-L1)in the immunosuppressive tumor microenvironment and affects im-munotherapy ***-17A(IL-17A)is involved in the remodeling of the tumor microenvironment and plays a protumor or antitumor role in different *** hypothesized that IL-17A participates in tumor progression by affe-cting the level of immune checkpoint molecules in *** upregulation of PD-L1 expression in HCC cells by IL-17A was assessed by reverse transcription PCR,western blotting,and flow *** studies were conducted with gene knockout models and pathway *** function of IL-17A in immune evasion was explored through coculture of T cells and HCC *** effects of IL-17A on the malignant biological behaviors of HCC cells were evaluated in vitro,and the antitumor effects of an IL-17A inhibitor and its synergistic effects with a PD-L1 inhibitor were studied in *** IL-17A upregulated PD-L1 expression in HCC cells in a dose-dependent manner,whereas IL-17A receptor knockout or treatment with a small mothers against decapentaplegic 2 inhibitor diminished the PD-L1 expression induced by ***-17A enhanced the survival of HCC cells in the coculture ***-17A increased the viability,G2/M ratio,and migration of HCC cells and decreased the apoptotic *** D1,VEGF,MMP9,and Bcl-1 expression increased after IL-17A treatment,whereas BAX expression *** combination of IL-17A and PD-L1 inhibitors showed synergistic antitumor efficacy and increased cluster of differentiation 8+T lymphocyte infiltration in an HCC mouse *** IL-17A upregulates PD-L1 expression via the IL-17A receptor/phosphorylation-small mothers against

关键词： Interleukin-17A Programmed death ligand-1 Interleukin-17A receptor Small mothers against decapentaplegic 2 Hepatocellular carcinoma Immunotherapy

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Scapular metastasis from acinic cell carcinoma of parotid gland:A case report

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World Journal of Clinical Cases 2025年第9期13卷 41-46页

作者： Deng-Qun Sun Chang-Chun Chen Duo-An Zheng Hai-Yan Xing xue peng Department of General Surgery The Chinese People’s Armed Police Forces Anhui Provincial Corps HospitalHefei 230001Anhui ProvinceChina Department of Radiology The Chinese People’s Armed Police Forces Anhui Provincial Corps HospitalHefei 230001Anhui ProvinceChina Department of Pathology The Chinese People’s Armed Police Forces Anhui Provincial Corps HospitalHefei 230001Anhui ProvinceChina

BACKGROUND Acinic cell carcinoma(ACC)is a malignant epithelial neoplasm that commonly occurs in the parotid *** is known to have a high recurrence rate and the potential to metastasize to the lung or cervical lymph ***,few cases of ACC with bone metastasis have been reported in the medical *** SUMMARY The clinical significance of this case report lies in the unique site of occurrence of the metastasis:To the best of our knowledge,this report is the only literature documenting ACC arising in a shoulder *** Unusual presentations of uncommon malignancies can present diagnostic challenges for both surgeons and *** is important to be aware of these rare occurrences in order to provide the best possible treatment for patients.

关键词： Acinic cell carcinoma Shoulder mass Scapular Metastasis Case report

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A Controlled Phase Gate with Nitrogen-Vacancy Centers in Nanocrystal Coupled to a Silica Microsphere Cavity

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Chinese Physics Letters 2010年第6期27卷 5-8页

作者： xue peng Department of Physics Southeast University Nanjing 211189

We show how a controlled phase gate, induced by adiabatic passage of dark states, can be implemented with the nitrogen-vacancy defects in nanocrystal coupled to the optical whispering gallery mode in a silica microsphere cavity. The gate presented is robust to the fluctuations of the experimental parameters compared to the dynamical and geometric phases gates. The feasibility of this scheme is characterized by exact numerical simulations that incorporate various sources of experiment noise. The results demonstrate the practicality by way of current experimental technologies.

关键词： GATE array circuits NITROGEN POINT defects NANOCRYSTALS SILICA NUMERICAL analysis SIMULATION methods & models

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Entangling Gate of Dipolar Molecules Coupled to a Photonic Crystal

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Chinese Physics Letters 2011年第5期28卷 38-41页

作者： xue peng Department of Physics Southeast UniversityNanjing 211189

A hybrid entangling gate is proposed by using the coherent interaction between dipolar molecules and a photonic crystal microcavity,which is effected by virtual electric dipole *** is included in the present model and... 详细信息

关键词： transitions coherent dipole

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Quantum Memory via Wigner Crystals of Polar Molecules

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Chinese Physics Letters 2011年第12期28卷 32-35页

作者： xue peng Department of Physics Southeast UniversityNanjing 211189

Collective excitations of rotational and spin states of an ensemble of polar molecules as a candidate for a high-fidelity quantum memory are *** dipolar crystals are formed in the high-density limit of cold clouds of polar molecules under one-dimensional trapping *** lifetime of quantum memory is calculated by identifying the dominant decoherence mechanisms,and we estimate their effects on gate operations,when a molecular ensemble qubit is transferred to a superconducting microwave cavity.

关键词： ensemble quantum operations

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Quantum Computing via Singlet-Triplet Spin Qubits in Nanowire Double Quantum Dots

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Chinese Physics Letters 2011年第7期28卷 31-34页

作者： xue peng Department of Physics Southeast UniversityNanjing 211189

We propose a new structure for quantum computing via spin qubits with high *** spin qubit corresponds to two electrons in a nanowire double quantum dot,with the singlet and one of the triplets as the logical qubit *** entangling gate is effected by virtual charge dipole *** include noise to show the feasibility of this scheme under current experimental conditions.

关键词： conditions states quantum

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Disorder in parity-time symmetric quantum walks

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Chinese Physics B 2022年第1期31卷 69-73页

作者： peng xue Beijing Computational Science Research Center Beijing 100084China

We experimentally investigate the impact of static disorder and dynamic disorder on the non-unitary dynamics of parity-time(PT)-symmetric quantum *** temporally alternating photon losses in an interferometric network,we realize the passive PT-symmetric quantum dynamics for single *** coin operations allow us to simulate different environmental influences,which result in three different behaviors of quantum walkers:a standard ballistic spread,a diffusive behavior,and a localization,respectively,in a PT-symmetric quantum walk architecture.

关键词： parity-time symmetry quantum walks disorder

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Uniform nonintegrability of random variables

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Frontiers of Mathematics in China 2018年第1期13卷 41-53页

作者： Zechun HU xue peng College of Mathematics Sichuan University Chengdu 610064 China

Recently, T. K. Chandra, T. -C. Hu and A. Rosalsky [Statist. Probab. Lett., 2016, 116： 27-37] introduced the notion of a sequence of random variables being uniformly nonintegrable, and presented a list of interesting results on this uniform nonintegrability. We introduce a weaker definition on uniform nonintegrability （W-UNI） of random variables, present a necessary and sufficient condition for W-UNI, and give two equivalent characterizations of W- UNI, one of which is a W-UNI analogue of the celebrated de La Vall6e Poussin criterion for uniform integrability. In addition, we give some remarks, one of which gives a negative answer to the open problem raised by Chandra et al.

关键词： Nonintegrable random variables uniformly nonintegrable randomvariables

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Saturation phenomenon of Ce and Ti in the modification of Al–Zn–Si filler metal

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International Journal of Minerals,Metallurgy and Materials 2015年第2期22卷 184-189页

作者： Jin-long Yang Song-bai xue Wei Dai peng xue College of Materials Science and Technology Nanjing University of Aeronautics and Astronautics Zhejiang Xinrui Welding Material Co. Ltd.

Cerium and titanium were added to an A1-42Zn-5.5Si brazing alloy, and the subsequent microstructures of the brazing alloy and the 6061 AI alloy brazing seam were investigated. The microstructures of filler metals and brazed joints were characterized by scanning elec- tron microscopy and X-ray energy dispersion spectrometry. A new Ce-Ti phase formed around the silicon phase in the modified filler metal and this saturation phenomenon was analyzed. Interestingly, following brazing of the 6061 alloy, there is no evidence of the Ce--Ti phase in the brazing seam. Because of the mutual solubility of the brazing alloy and base metal, the quantity of the solvent increases, and the solute Ce and Ti atoms assume an undersaturated state.

关键词： filler metals aluminum alloys brazing cerium titanium saturation

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Study of giant magnetoresistance and giant electroresistance of carbon based thin film

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Rare Metals 2006年第z1期25卷 617-620页

作者： ZHANG Xiaozhong TIAN peng xue Qingzhong Laboratory of Advanced Materials Department of Materials Science and Engineering Tsinghua University Beijing 100084 China Laboratory of Advanced Materials Department of Materials Science and Engineering Tsinghua University Beijing 100084 China Laboratory of Advanced Materials Department of Materials Science and Engineering Tsinghua University Beijing 100084 China College of Physics Science and Technology China University of Petroleum Dongying 257061 China

Using pulsed laser deposition, Fex-C1-x films on Si (100) substrates were prepared. At T=300 K and B=5 T a large positive MR of 138% was found in Fe0.011-C0.989 film. It is also found that when T<258 K, the MR of Fe0.... 详细信息

关键词： magnetoresistance electroresistance carbon based film

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