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Effect of ostholon memory and tau protein phosphorylation in brain of AD mice

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中国药理学与毒理学杂志 2019年第10期 852-853页

作者： XU li HOU xue-qin College of Pharmacy Shandong First Medical University & Shangdong Academy of Medical Sciences

OBJECTIVE To investigate the effects of osthole on learning and memory impairment of AD mice induced by injection of Aβ25-35and effects of aspartate proteolytic enzymes（caspase 3, 6, 8） containing cysteine on the phosphorylation of tau protein. METHODS Mice were randomly assigned to sham operation, Aβ25-35, Aβ25-35+Ost-L, Aβ25-35+Ost-M, and Aβ25-35+Ost-H group. The learning ability of mice was evaluated by behavioral dark avoidance experiment. The protein expression of tau and p-tau in brain tissue of AD rats was detected by Western *** levels of apoptotic proteins in brain tissues were detected by the kit. HE staining was used to detect the pathological changes of neurons in brain ***（1） Effects of osthole on learning and memory:the results of behavior avoidance experiments showed that: compared with the model group, the dark avoidance latency of osthole（OST） increased in the low, medium and high dose groups. The difference was statistically significant（P<0.05）. The dark incubation period of mice in the low-dose OST group was the longest, followed by those in the medium-dose OST group, and was the shortest in the high-dose OST group.（2） Effects on tau and p-tau expression in AD mice: the main pathological features of AD are senile plaque deposition with Aβ as the core,neuronal fiber tangles formed by tau protein phosphorylation, and neuronal death. Western blotting was used to detect the protein expression of tau and p-tau in brain tissue of AD rats. The test results show that: compared with the sham group, tau and p-tau expression in the model group were significantly increased. Compared with the model group, tau and p-tau expression of OST decreased significantly in brain tissues of the low, medium and high dose groups. In addition, the decreased expression of tau and p-tau in brain tissues of mice in the low-dose group of OST was the most significant, followed by the mice in the medium-dose group of OST, and the decreased expression of tau an

关键词： osthole Alzheimer disease Aβ25-35 protein tau

Solution chemistry of carbonate minerals and its effects on the flotation of hematite with sodium oleate

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International Journal of Minerals,Metallurgy and Materials 2017年第7期24卷 736-744页

作者： Dong li Wan-zhong Yin Ji-wei xue Jin Yao Ya-feng Fu Qi liu School of Resources and Civil Engineering Northeastern University College of Zijin Mining Fuzhou University Department of Chemical and Materials Engineering University of Alberta

The effects of carbonate minerals（dolomite and siderite） on the flotation of hematite using sodium oleate as a collector were investigated through flotation tests, supplemented by dissolution measurements, solution chemistry calculations, zeta-potential measurements, Fourier transform infrared（FTIR） spectroscopic studies, and X-ray photoelectron spectroscopy（XPS） analyses. The results of flotation tests show that the presence of siderite or dolomite reduced the recovery of hematite and that the inhibiting effects of dolomite were stronger. Dissolution measurements, solution chemistry calculations, and flotation tests confirmed that both the cations（Ca^（2＋） and Mg^（2＋）） and CO_3^（2＋）ions dissolved from dolomite depressed hematite flotation, whereas only the 23CO-ions dissolved from siderite were responsible for hematite depression. The zeta-potential, FTIR spectroscopic, and XPS analyses indicated that Ca^（2＋）, Mg^（2＋）, and CO_3^（2-）（HCO_3^-） could adsorb onto the hematite surface, thereby hindering the adsorption of sodium oleate, which was the main reason for the inhibiting effects of carbonate minerals on hematite flotation.

关键词： hematite carbonate minerals solution chemistry sodium oleate flotation

Banded structure control of low carbon microalloyed steel based on oxide metallurgy

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Journal of Iron and Steel Research International 2023年第11期30卷 2242-2253页

作者： Yong-kun Yang Jia-yu Zhu Xiao-ming li Yang Wang Dong-ping Zhan School of Metallurgical Engineering Xi’an University of Architecture and TechnologyXi’an710055ShaanxiChina School of Metallurgy Northeastern UniversityShenyang110819LiaoningChina

Banded structure is a common harmful microstructure for low carbon microalloyed steel,which seriously shortens the service life of processed *** order to study the effect of oxide metallurgy on improving banded structure,the Ti-Zr deoxidized low carbon microalloyed steel that can play the oxide metallurgical role of inclusion was chosen as the research object,and the inclusion characteristics,microstructure and transverse and longitudinal mechanical properties after hot rolling were *** results showed the inclusion number density increased in all experimental steels after hot rolling,and a large number of long strip inclusions with aspect ratio greater than 3 appeared along the rolling *** addition,after hot rolling,there were element segregation bands in the experimental steels,and granular bainite bands were formed in the element enrichment ***,the intragranular ferrite generated in the cooling process destroyed the continuity of granular bainite bands,so that the microstructure anisotropy indexes of experimental steels were *** mechanical properties analysis showed that the anisotropy of performance was mainly reflected in plasticity and toughness in the experimental *** them,the difference ratio of elongation,section shrinkage and impact energy of No.2 steel was 1.69%,3.87% and 1.69%,respectively,which were less than those of No.1 steel and No.3 *** anisotropy of microstructure and mechanical properties of No.2 steel that full played the role of oxide metallurgy were improved,and the banded structure control of low carbon microalloyed steel can be realized by oxide metallurgy technology.

关键词： Low carbon microalloyed steel Hot rolling Banded structure Oxide metallurgy Intragranular ferrite

Kinetic Monte Carlo Simulation of EB-PVD Film:Effects of Substrate Temperature

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Chinese Journal of Aeronautics 2006年第B12期19卷 86-90页

作者： SHAN Ying-chun HE Xiao-dong li ming-wei li Yao XU Jiu-jun Electromechanics and Materials Engineering College Dalian Maritime University Dalian 116026 China Center for Composite Materials Harbin Institute of Technology Harbin 150001 China ChengDu Aircraft Design ＆ Research Institute Chengdu 610041 China

The 2D kinetic Monte Carlo （KMC） simulation was used to study the effects of different substrate temperatures on the microstructure of Ni-Cr films in the process of deposition by the electron beam physical vapor deposition （EB-PVD）. In the KMC model, substrate was assumed to be a ＂surface＂ of tight-packed rows, and the simulation includes two phenomena： adatom-surface collision and adatom diffusion. While the interaction between atoms was described by the embedded atom method, the jumping energy was calculated by the molecular static （MS） calculation. The initial location of the adatom was defined by the Momentum Scheme. The results reveal that there exists a critical substrate temperature which means that the lowest packing density and the highest surface roughness structure will be achieved when the temperature is lower than the smaller critical value, while the roughness of both surfaces and the void contents keep decreasing with the substrate temperature increasing until it reaches the higher critical value. The results also indicate that the critical substrate temperature rises as the deposition rate increases.

关键词： substrate temperature film kinetic Monte Carlo EB-PVD

Effect of Danshao Huaxian capsule on Gremlin and bone morphogenetic protein-7 expression in hepatic fibrosis in rats

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World Journal of Gastroenterology 2014年第40期20卷 14875-14883页

作者： xue-Ke Zhao ming-liang Cheng Rong-Min Wu Yu-Mei Yao Mao Mu Juan-Juan Zhu Bao-Fang Zhang ming-Yu Zhou Department of Infectious Diseases Affiliated Hospital of Guiyang Medical College Department of B Ultrasound Maternal and Child Health Hospital of Guizhou Province

AIM: To observe the effect of Danshao Huaxian capsule (DHC) on the expression of Gremlin and bone morphogenetic protein-7 (BMP-7) in the liver of hepatic fibrosis rats.

关键词： Hepatic fibrosis Bone morphogenetic protein Gremlin Transforming growth factor Traditional Chinese herbs

Application of Grain Boundary Engineering to Improve Intergranular Corrosion Resistance in a Fe–Cr–Mn–Mo–N High-Nitrogen and Nickel-Free Austenitic Stainless Steel

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Acta Metallurgica Sinica(English Letters) 2020年第6期33卷 789-798页

作者： Feng Shi Ruo-Han Gao Xian-Jun Guan Chun-ming liu Xiao-Wu li Department of Materials Physics and Chemistry School of Materials Science and EngineeringNortheastern UniversityShenyang 110819China Key Laboratory for Anisotropy and Texture of Materials(Ministry of Education) Northeastern UniversityShenyang 110819China

Optimization of grain boundary engineering(GBE) process is explored in a Fe–20Cr–19Mn–2Mo–0.82N high-nitrogen and nickel-free austenitic stainless steel, and its intergranular corrosion(IGC) property after GBE treatment is experimentally evaluated. The proportion of low Σ coincidence site lattice(CSL) boundaries reaches 79.4% in the sample processed with 5% cold rolling and annealing at 1423 K for 72 h;there is an increase of 32.1% compared with the solution-treated sample. After grain boundary character distribution optimization, IGC performance is noticeably improved. Only Σ3 boundaries in the special boundaries are resistant to IGC under the experimental condition. The size of grain cluster enlarges with increasing fraction of low ΣCSL boundaries, and the amount of Σ3 boundaries interrupting the random boundary network increases during growth of the clusters, which is the essential reason for the improvement of IGC resistance.

关键词： High-nitrogen and nickel-free austenitic stainless steel Grain boundary engineering Electron backscatter diffraction(EBSD) LowΣcoincidence site lattice boundary Intergranular corrosion

Cell deaths:Involvement in the pathogenesis and intervention therapy of COVID-19

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Signal Transduction and Targeted Therapy 2022年第7期7卷 2272-2292页

作者： xue li Ziqi Zhang Zhenling Wang Pedro Gutiérrez-Castrellón Huashan Shi Department of Biotherapy State Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan UniversityNo.17Block 3Southern Renmin RoadChengduSichuan 610041People’s Republic of China Laboratory of Aging Research and Cancer Drug Target State Key Laboratory of BiotherapyNational Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityNo.17Block 3Southern Renmin RoadChengduSichuan 610041People’s Republic of China State Key Laboratory of Biotherapy and Cancer Center West China HospitalSichuan Universityand Collaborative Innovation Center of BiotherapyKe Yuan 4th RoadGao Peng StreetChengduSichuan 610041People’s Republic of China Center for Translational Research on Health Science Hospital General Dr.Manuel Gea Gonzalez.Ministry of HealthCalz.Tlalpan 4800Col.Secc.XVI14080Mexico cityMexico

The current pandemic of coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARSCoV-2)infection has dramatically influenced various aspects of the *** is urgent to thoroughly study pathology and underlying mechanisms for developing effective strategies to prevent and treat this threatening *** is universally acknowledged that cell death and cell autophagy are essential and crucial to maintaining host homeostasis and participating in disease *** present,more than twenty different types of cell death have been discovered,some parts of which have been fully understood,whereas some of which need more *** studies have indicated that cell death and cell autophagy caused by coronavirus might play an important role in virus infection and ***,the knowledge of the interactions and related mechanisms of SARS-CoV-2 between cell death and cell autophagy lacks systematic ***,in this review,we comprehensively delineate how SARS-CoV-2 manipulates diverse cell death(including apoptosis,necroptosis,pyroptosis,ferroptosis,and NETosis)and cell autophagy for itself benefits,which is simultaneously involved in the occurrence and progression of COVID-19,aiming to provide a reasonable basis for the existing interventions and further development of novel therapies.

关键词： pathogenesis thoroughly urgent

Auxin regulation and MdPIN expression during adventitious root initiation in apple cuttings

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Horticulture Research 2020年第1期7卷 955-966页

作者： ling Guan Yingjun li Kaihui Huang Zong-ming(Max)Cheng College of Horticulture Nanjing Agricultural University210095 NanjingChina Institute of Pomology Jiangsu Academy of Agricultural SciencesJiangsu Key Laboratory for Horticultural Crop Genetic Improvement210014 NanjingChina Department of Plant Sciences University of TennesseeKnoxvilleTN 37831USA

Adventitious root(AR)formation is critical for the efficient propagation of elite horticultural and forestry *** decades of research,the cellular processes and molecular mechanisms underlying AR induction in woody plants remain *** examined the details of AR formation in apple(Malus domestica)M.9 rootstock,the most widely used dwarf rootstock for intensive production,and investigated the role of polar auxin transport in postembryonic *** formation begins with a series of founder cell divisions and elongation of the interfascicular cambium adjacent to vascular *** process is associated with a relatively high indole acetic acid(IAA)content and hydrolysis of starch *** auxin treatment promoted this cell division,as well as the proliferation and reorganization of the endoplasmic reticulum and Golgi *** contrast,treatment with the auxin transport inhibitor N-1-naphthylphthalamic acid(NPA)inhibited cell division in the basal region of the cuttings and resulted in abnormal cell divisions during the early stage of AR *** addition,PIN-FORMED(PIN)transcripts were differentially expressed throughout the whole AR development *** also detected upregulation of MdPIN8 and MdPIN10 during induction;upregulation of MdPIN4,MdPIN5,and MdPIN8 during extension;and upregulation of all MdPINs during AR *** research provides an improved understanding of the cellular and molecular underpinnings of the AR process in woody plants.

关键词： hydrolysis elite dwarf

PEN/BADCy Interlayer Dielectric Films with Tunable Microstructures via an Assist of Temperature for Enhanced Frequency Stability

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Chinese Journal of Polymer Science 2020年第11期38卷 1258-1266,I0009页

作者： Xi-Ting Lei li-Fen Tong ming-Zhen Xu Yong You Xiao-Bo liu School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu 610054China

Low dielectric in terlayer films have become an important element to ensure the development of the microelectr onics industry.A kind of flexible interlayer dielectrics,polyarylene ether nitrile/bisphenol A cyanate ester(PEN/BADCy)film,with good thermal stability and low frequency dependence,has been developed by solution casting ***,materials were designed to incorporate bisphenol A cyanate ester as a part of blend,contributing to the frequency stability and structural *** morphological study combined with electron microscopy revealed the uniform and flexible microstructure information with controllable morphology through self-polymerization of cyanate esters with different prepolymerization time and curing *** dielectric films could present high thermal stability with Tg>180℃.Significant improvement in the dielectric properties was achieved for the dielectric constant and loss was much stabler than neat PEN over the frequency range from 100 Hz to 5 *** the prepolymerization time was 3h and final curing temperature reached 230℃,the dielectric constant and dielectric loss of the films were 3.36 and 0.013 at 100 kHz,*** dimensional stability(CTE=53.67×10^-6 K^-1)was confirmed and con sidered beneficial to use as an in terlayer dielectrics.

关键词： Polyarylene ether nitrile Bisphenol A cyanate ester Interlayer dielectrics Tunable microstructures