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Variability of the Pacific subtropical cells under global warming in CMIP6 models

Journal of Oceanology and Limnology 2024年第1期42卷 24-40页

作者： xue han Junqiao FENG Yunlong LU Dunxin HU Key Laboratory of Ocean Circulation and Waves Chinese Academy of SciencesQingdao 266071China Institute of Oceanology Chinese Academy of SciencesQingdao 266071China University of Chinese Academy of Sciences Beijing 100049China Center for Ocean Mega-Science Chinese Academy of SciencesQingdao 266071China Laboratory for Ocean Dynamics and Climate Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China

The Pacific subtropical cells(STCs)are shallow meridional overturning circulations connecting the tropics and subtropics,and are assumed to be an important driver of the tropical Pacific decadal *** variability of STCs under global warming is investigated using multimodal outputs from the latest phase of the Coupled Model Inter-comparison Project(CMIP6)and ocean reanalysis ***,the volume transport diagnostic analysis is employed to evaluate how coupled models and ocean reanalysis products reproduce interior STC *** variation of heat transport by the interior STC under the high-emissions warming scenarios is also *** results show that the multimodal-mean linear trends of the interior STC transport along 9°S and 9°N are-0.02 Sv/a and 0.04 Sv/a under global warming,respectively,which is mainly due to the combined effect of the strengthened upper oceanic stratification and the weakening of wind *** is a compensation relationship between the interior STC and the western boundary transport in the future climate,and the compensation relationship of 9°S is more significant than that of 9°*** addition,compared with ocean reanalysis products,the coupled models tend to underestimate the variability of the interior STC transport convergence,and thus may lose some sea surface temperature(SST)driving force,which may be the reason for the low STC-SST correlation simulated by the *** future scenario simulation shows that the heat transport of interior STC is weakened under global warming,with a general agreement across models.

关键词： interior subtropical cell(STC) global warming Coupled Model Inter-comparison Project(CMIP6) western boundary transport

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Low-temperature graphitization of lignin via Co-assisted electrolysis in molten salt

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Green Energy & Environment 2024年第9期9卷 1449-1458页

作者： Shijie Li Wei-Li Song xue han Qingqing Cui Yan-li Zhu Shuqiang Jiao Institute of Advanced Structure Technology Beijing Institute of Technology State Key Laboratory of Advanced Metallurgy University of Science and Technology Beijing State Key Laboratory of Explosion Science and Technology Beijing Institute of Technology

The ever-growing energy demand and environmental issues have stimulated the development of sustainable energy ***,an efficient and environmentally friendly electrochemical transformation technology was proposed to prepare highly graphitized carbon materials from an abundant natural resource-lignin （LG）.The preparation process mainly includes pyrolytic carbonization of raw LG material and electrochemical conversion of amorphous carbon ***,with the assistance of Co catalyst,the graphitization degree of the products was significantly improved,in which the mechanism was the removal of heteroatoms in LG and the rearrangement of carbon atoms into graphite ***,tunable microstructures （nanoflakes） under catalytic effects could also be observed by controlling the electrolytic *** with the products CN1 （without catalyst） and CN5 （with 10%catalyst）,the specific surface area are 158.957 and202.246 m2g-1,*** used as the electrode material for lithium-ion batteries,CN5 delivered a competitive specific capacity of～350 m Ah g-1（0.5 C） compared with commercial *** strategy proposed in this work provides an effective way to extract value-added graphite materials from lignin and can be extended to the graphitization conversion of any other amorphous carbon precursor materials.

关键词： Lignin Graphitic carbon Electrochemical conversion Lithium-ion batteries

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Arginine methylation of ALKBH5 by PRMT6 promotes breast tumorigenesis via LDHA-mediated glycolysis

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Frontiers of Medicine 2024年第2期18卷 344-356页

作者： xue han Chune Ren Aifang Jiang Yonghong Sun Jiayi Lu Xi Ling Chao Lu Zhenhai Yu Department of Reproductive Medicine Affiliated Hospital of Weifang Medical UniversityWeifang261053China Department of Pathology Affiliated Hospital of Weifang Medical UniversityWeifang261053China

ALKBH5 is a master regulator of N6-methyladenosine(m6A)modification,which plays a crucial role in many biological ***,we show that ALKBH5 is required for breast tumor ***,PRMT6 directly methylates ALKBH5 at R283,which subsequently promotes breast tumor ***,arginine methylation of ALKBH5 by PRMT6 increases LDHA RNA stability via m6A demethylation,leading to increased aerobic ***,PRMT6-mediated ALKBH5 arginine methylation is confirmed in PRMT6-knockout ***,these findings identify a PRMT6-ALKBH5-LDHA signaling axis as a novel target for the treatment of breast cancer.

关键词： PRMT6 ALKBH5 N6-methyladenosine glycolysis tumor growth

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Fatigue and Corrosion Fatigue Properties of Mg-Zn-Zr-Nd Alloys in Glucose-Containing Simulated Body Fluids

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Acta Metallurgica Sinica(English Letters) 2024年第9期37卷 1533-1550页

作者： xue han Dan Zhang Song Zhang Mohammed R.I.Abueida Lili Tan Xiaopeng Lu Qiang Wang Huanye Liu School of Materials Science and Engineering Shenyang University of TechnologyShenyang110870China School and Hospital of Stomatology China Medical UniversityShenyang110001China Shi-Changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang110016China Shenyang National Laboratory for Materials Science Northeastern UniversityShenyang110819China

Medical bone implant magnesium(Mg)alloys are subjected to both corrosive environments and complex loads in the human *** increasing number of hyperglycemic and diabetic patients in recent years has brought new challenges to the fatigue performance of Mg ***,it is significant to study the corrosion fatigue(CF)behavior of medical Mg alloys in glucose-containing simulated body fluids for their clinical ***,the corrosion and fatigue properties of extruded Mg-Zn-Zr-Nd alloy in hank’s balanced salt solution(HBSS)containing different concentrations(1 g/L and 3 g/L)of glucose were *** average grain size of the alloy is about 5μm,which provides excellent overall mechanical *** conditional fatigue strength of the alloy was 127 MPa in air and 88 MPa and 70 MPa in HBSS containing 1 g/L glucose and 3 g/L glucose,*** crack initiation points for alloys in air are oxide inclusions and in solution are corrosion *** corrosion rate of the alloy is high at the beginning,and decreases as the surface corrosion product layer thickens with the increase of immersion *** corrosion products of the alloy are mainly Mg(OH)_(2),MgO and a small amount of Ca-P *** electrochemical results indicated that the corrosion rate of the alloys gradually decreased with increasing immersion time,but the corrosion tendency of the alloy was greater in HBSS containing 3 g/L *** the one hand,glucose accelerates the corrosion process by adsorbing large amounts of aggressive Cl^(-)*** the other hand,glucose will be oxidized to form gluconic acid,and then reacts with Mg(OH)_(2) and MgO to form Mg gluconate,which destroys the corrosion product film and leads to the aggravation of corrosion and the accumulation of fatigue damage.

关键词： Mg alloys Corrosion fatigue Glucose Gluconic acid Corrosion product

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High-rate metal-free MXene microsupercapacitors on paper substrates

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Carbon Energy 2024年第5期6卷 94-104页

作者： han xue Po‐han Huang Lee‐Lun Lai Yingchun Su Axel Strömberg Gaolong Cao Yuzhu Fan Sergiy Khartsev Mats Göthelid Yan‐Ting Sun Jonas Weissenrieder Kristinn BGylfason Frank Niklaus Jiantong Li School of Electrical Engineering and Computer Science KTH Royal Institute of TechnologyStockholmSweden School of Engineering Sciences KTH Royal Institute of TechnologyStockholmSweden

MXene is a promising energy storage material for miniaturized microbatteries and microsupercapacitors(MSCs).Despite its superior electrochemical performance,only a few studies have reported MXene-based ultrahigh-rate(>1000 mV s^(−1))on-paper MSCs,mainly due to the reduced electrical conductance of MXene films deposited on ***,ultrahigh-rate metal-free on-paper MSCs based on heterogeneous MXene/poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate)(PEDOT:PSS)-stack electrodes are fabricated through the combination of direct ink writing and femtosecond laser *** a footprint area of only 20 mm^(2),the on-paper MSCs exhibit excellent high-rate capacitive behavior with an areal capacitance of 5.7 mF cm^(−2)and long cycle life(>95%capacitance retention after 10,000 cycles)at a high scan rate of 1000 mV s^(−1),outperforming most of the present on-paper ***,the heterogeneous MXene/PEDOT:PSS electrodes can interconnect individual MSCs into metal-free on-paper MSC arrays,which can also be simultaneously charged/discharged at 1000 mV s^(−1),showing scalable capacitive *** heterogeneous MXene/PEDOT:PSS stacks are a promising electrode structure for on-paper MSCs to serve as ultrafast miniaturized energy storage components for emerging paper electronics.

关键词： direct ink writing femtosecond laser scribing MXene on-paper microsupercapacitors PEDOT:PSS ultrahigh rate capability

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Single-nucleus RNA and ATAC sequencing analyses provide molecular insights into early pod development of peanut fruit

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Plant Communications 2024年第8期5卷 50-68页

作者： Yuanyuan Cui Yanning Su Jianxin Bian xue han Haosong Guo Zhiyuan Yang Yijun Chen Lihui Li Tianyu Li Xing Wang Deng Xiaoqin Liu Peking University Institute of Advanced Agricultural Sciences Shandong Laboratory for Advanced Agricultural Sciences at WeifangShandong 261325China School of Advanced Agricultural Sciences Peking UniversityBeijing 100083China

Peanut(Arachis hypogaea L.)is an important leguminous oil and economic crop that produces flowers aboveground and fruits *** fruit-pod development,which significantly affects peanut production,involves complex molecular mechanisms that likely require the coordinated regulation of multiple genes in different *** investigate the molecular mechanisms that underlie peanut fruitpod development,we characterized the anatomical features of early fruit-pod development and integrated single-nucleus RNA-sequencing(snRNA-seq)and single-nucleus assay for transposase-accessible chromatin with sequencing(snATAC-seq)data at the single-cell *** identified distinct cell types,such as meristem,embryo,vascular tissue,cuticular layer,and stele cells within the shell *** specific cell types were used to examine potential molecular changes unique to each cell type during pivotal stages of fruit-pod ***-seq analyses of differentially expressed genes revealed cell-type-specific insights that were not previously obtainable from transcriptome analyses of bulk *** instance,we identified MADS-box genes that contributes to the formation of parenchyma cells and gravity-related genes that are present in the vascular cells,indicating an essential role for the vascular cells in peg ***,our single-nucleus analysis provides comprehensive and novel information on specific cell types,gene expression,and chromatin accessibility during the early stages of fruit-pod *** information will enhance our understanding of the mechanisms that underlie fruit-pod development in peanut and contribute to efforts aimed at improving peanut production.

关键词： peanut pod development single-nucleus RNA-seq single-nucleus ATAC-seq in situ RNA hybridization

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嗜冷菌耐热蛋白酶AprX对乳制品的危害与控制

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中国食品学报 2024年第7期24卷 425-437页

作者：王宇韩雪哈尔滨工业大学化工与化学学院哈尔滨150001

嗜冷菌分泌的耐热蛋白酶能够降低乳制品品质而受到广泛关注。嗜冷菌分泌的蛋白酶具有耐热性,能够在超高温瞬时灭菌处理后仍保持部分活性。原料乳中常见的外源耐热蛋白酶是假单胞菌分泌的胞外蛋白酶AprX,全面了解蛋白酶AprX的生物学特性... 详细信息

嗜冷菌分泌的耐热蛋白酶能够降低乳制品品质而受到广泛关注。嗜冷菌分泌的蛋白酶具有耐热性,能够在超高温瞬时灭菌处理后仍保持部分活性。原料乳中常见的外源耐热蛋白酶是假单胞菌分泌的胞外蛋白酶AprX,全面了解蛋白酶AprX的生物学特性、蛋白水解潜力和调控途径,有助于寻找抑制嗜冷菌蛋白酶的方法。本文概述蛋白酶AprX的最新研究进展和控制手段,为蛋白酶AprX的控制提供新思路。

关键词：嗜冷菌蛋白酶AprX 腐败潜力控制策略

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Developing a diagnostic model for predicting prostate cancer: a retrospective study based on Chinese multicenter clinical data

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Asian Journal of Andrology 2024年第1期26卷 34-40页

作者： Chang-Ming Wang Lei Yuan xue-han Liu Shu-Qiu Chen Hai-Feng Wang Qi-Fei Dong Bin Zhang Ming-Shuo Huang Zhi-Yong Zhang Jun Xiao Tao Tao Department of Urology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Department of Radiology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Core Facility Center for Medical Sciences The First Affiliated Hospital of USTcDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Department of Urology Affiliated Zhongda Hospital of Southeast UniversityNanjing 210009China Department of Urology Shanghai East HospitalTongji University School of MedicineShanghai 200120China Department of Urology Shanghai Changhai HospitalSecond Military Medical UniversityShanghai 200000China Department of Urology Affiliated Anhui Provincial Hospital of Anhui Medical UniversityHefei 230001China

The overdiagnosis of prostate cancer(PCa)caused by nonspecific elevation serum prostate-specific antigen(PSA)and the overtreatment of indolent PCa have become a global problem that needs to be solved *** aimed to construct a prediction model and provide a risk stratification system to reduce unnecessary *** this retrospective study,clinical data of 1807 patients from three Chinese hospitals were *** final model was built using stepwise logistic regression *** apparent performance of the model was assessed by receiver operating characteristic curves,calibration plots,and decision curve ***,a risk stratification system of clinically significant prostate cancer(csPCa)was created,and diagnosis-free survival analyses were *** multivariable screening and evaluation of the diagnostic performances,a final diagnostic model comprised of the PSA density and Prostate Imaging-Reporting and Data System(PI-RADS)score was *** validation in the development cohort and two external cohorts showed excellent discrimination and ***,we created a risk stratification system using risk thresholds of 0.05 and 0.60 as the cut-off *** follow-up results indicated that the diagnosis-free survival rate for csPCa at 12 months and 24 months postoperatively was 99.7%and 99.4%,respectively,for patients with a risk threshold below O.05 after the initial negative prostate biopsy,which was significantly better than patients with higher *** diagnostic model and risk stratification system can achieve a personalized risk calculation of *** provides a standardized tool for Chinese patients and physicians when considering thenecessity of prostatebiopsy.

关键词： nomogram prostate biopsy prostate cancer Prostate Imaging-Reporting and Data System prostate-specific antigen density

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金纳米圆孔阵列异常光学透射模拟研究

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大连理工大学学报 2024年第3期64卷 221-227页

作者：陈琳韩雪大连理工大学光电工程与仪器科学学院辽宁大连116024

利用COMSOL Multiphysics对金纳米圆孔阵列的物理场进行模拟,分析不同金属膜厚度、孔径、周期下阵列的光谱和电场分布,探究异常光学透射(extraordinary optical transmission,EOT)的成因.通过分析发现透射峰主要有3个成因:一是材料本身... 详细信息

利用COMSOL Multiphysics对金纳米圆孔阵列的物理场进行模拟,分析不同金属膜厚度、孔径、周期下阵列的光谱和电场分布,探究异常光学透射(extraordinary optical transmission,EOT)的成因.通过分析发现透射峰主要有3个成因:一是材料本身的带间跃迁特性会导致透射峰;二是金属阵列产生的表面波会激发金属膜背侧的局域表面等离激元,通过散射形成透射峰;三是耦合的表面等离激元转化成波导模式,沿着圆孔传输造成透射峰,该透射峰的频率低于表面等离激元的频率.

关键词：异常光学透射(EOT) 表面波局域表面等离激元波导

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Ocular rosacea without facial erythema involvement manifesting as bilateral multiple recurrent chalazions:A case report

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World Journal of Clinical Cases 2024年第17期12卷 3253-3258页

作者： xue-Mei han Yi-Mai Zhou Lu-Sha Cen Department of Ophthalmology The First Affiliated Hospital of Zhejiang Chinese Medical University(Zhejiang Provincial Hospital of Chinese Medicine)Hangzhou 310006Zhejiang ProvinceChina The First Clinical Medical College Zhejiang Chinese Medicine UniversityHangzhou 310053Zhejiang ProvinceChina

BACKGROUND In addition to the non-specific symptomatology of ocular rosacea,currently,there are no reliable diagnostic tests for the disease,which may lead to its ***,we report a case of ocular rosacea presenting with multiple recurrent chalazion on both *** SUMMARY A 63-year-old female patient presented with multiple chalazion and dry eyes in both eyes,with no facial *** management done were application of steroid eye ointment on both eyelids,hot compresses,and eyelid margin cleaning;noting that there was no relief of *** excision of the chalazion was done on both eyes,however,bilateral recurrence occurred *** pathological studies showed infiltration of a small amount of fibrous tissue with many chronic inflammatory *** studies were positive for *** of the chalazion occurred after oral administration of doxycycline and *** Our findings show that ophthalmologists should recognize the ocular manifestations of skin diseases.

关键词： Ocular rosacea Rosacea Recurrent chalazion Bilateral chalazion Multiple chalazion Case report

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