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The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons

Neural Regeneration Research 2025年第1期20卷 209-223页

作者： Shi-Yan Sun Lingyun Nie Jing Zhang xue fang Hongmei Luo Chuanhai Fu Zhiyi Wei Ai-Hui Tang Hefei National Research Center for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseMinistry of Education Key Laboratory for Membrane-less Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina CAS Center for Excellence in Molecular Cell Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Neurobiology School of Life SciencesSouthern University of Science and TechnologyShenzhenGuangdong ProvinceChina Brain Research Center Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina

Morphological alterations in dendritic spines have been linked to changes in functional communication between neurons that affect learning and ***-4 KIF21A helps organize the microtubule-actin network at the cell cortex by interacting with KANK1;however,whether KIF21A modulates dendritic structure and function in neurons remains *** this study,we found that KIF21A was distributed in a subset of dendritic spines,and that these KIF21A-positive spines were larger and more structurally plastic than KIF21A-negative ***,the interaction between KIF21A and KANK1 was found to be critical for dendritic spine morphogenesis and synaptic *** of either KIF21A or KANK1 inhibited dendritic spine morphogenesis and dendritic branching,and these deficits were fully rescued by coexpressing full-length KIF21A or KANK1,but not by proteins with mutations disrupting direct binding between KIF21A and KANK1 or binding between KANK1 and *** down KIF21A in the hippocampus of rats inhibited the amplitudes of long-term potentiation induced by high-frequency stimulation and negatively impacted the animals’cognitive *** together,our findings demonstrate the function of KIF21A in modulating spine morphology and provide insight into its role in synaptic function.

关键词： actin cytoskeleton dendrite KANK1 KIF21A microtubule spine morphology spine synaptic plasticity talin1

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Heterostructure Intervalley Transferred Electron Effects

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Chinese Physics Letters 2001年第2期18卷 263-265页

作者： xue fang-Shi National Laboratory for Superlattices and Microstructures Institute of SemiconductorsChinese Academy of SciencesBeijing 100083 Nanjing Electronic Devices Institute Nanjing 210016(mailing address)

A Gunn active layer is used as an X electron probe to detect the X tunnelling current in the GaAs--AlAs heterostructure,from which a new heterostructure intervalley transferred electron(HITE)device is *** the 8 mm band,the highest pulse output power of these diodes is 2.65 W and the highest conversion efficiency is 18%.The dc and rf performance of the HITE devices was simulated by the band mixing resonant tunnelling theory and Monte Carlo transport *** HITE effect has transformed the transit-time dipole-layer mode in the Gunn diode into a relaxation oscillation mode in the HITE *** the comparison of simulated results to the measured data,the HITE effect is demonstrated straightforwardly.

关键词： Electron effect straight

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Quantum Well Controller

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Chinese Physics Letters 1999年第7期16卷 535-537页

作者： xue fang-shi National Laboratory for Superlattices and Microstructures Institute of SemiconductorsChinese Academy of SciencesBeijing 100083 Nanjing Electronic Devices Institute Nanjing 210016

A quantum well controller(QWC)consisting of a direct-gap/indirect-gap quantum well and a doping interface is proposed to control the dynamic operation of the Gunn active *** the Monte Carlo simulation a new relaxation mode for this new device is *** oscillation and amplification behavior of the Gunn active layer under the control of the QWC is investigated theoretically and *** work demonstrates the great control capacity of the QWC and provides a new way to improve the performance of semiconductor devices.A new oscillation diode made of the QWC and a Gunn active layer has been designed and *** the 8 mm band the highest pulse output power of these diodes is 2.55 W and the highest conversion efficiency is 18%.

关键词： layer. oscillation quantum

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Sb nanoparticles encapsulated in N-doped carbon nanotubes as freestanding anodes for high-performance lithium and potassium ion batteries

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Rare Metals 2023年第2期42卷 449-458页

作者： Xiao-Ping Lin fang-fang xue Zhi-Gang Zhang Qiu-Hong Li Pen-Tung Sah Institute of Micro-Nano Science and Technology Xiamen UniversityXiamen361005China

Sb-based materials with high specific capacity have targeted as an alternative anode material for alkali metal ion ***,Sb nanoparticles embedded in hollow porous N-doped carbon nanotubes(Sb@N-C nanotubes)are used as freestanding anode for Li-ion batteries(LIBs)and K-ion batteries(PIBs).The Sb@N-C nanotubes demonstrate exceptional reversible capacity of643 mAh·g^(-1)at 0.1 A·g^(-1)with long cycle stability,as well as outstanding rate performance(219.6 mAh·g^(-1)at10 A·g^(-1))in *** the anode material of PIBs,they reveal impressive capacity of 325.4 mAh·g^(-1)at 0.1 A·g^(-1).The superior electrochemical properties mainly originate from the novel *** be specific,the obtained 3D connected network allows for quick ion and electron migration,and prevents the aggregation of Sb *** hollow porous nanotubes can not only accommodate the volume expansion of Sb nanoparticles during cycling,but also facilitate the infiltration of the electrolyte and reduce the ion diffusion *** work provides a new insight for designing advanced Sb-based anodes for alkali metal ion batteries.

关键词： Alkali metal ion batteries Freestanding electrode Hollow porous nanotube Sb@N-C nanotubes

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Construction,Expression and Purification of SUMO1-GST Fusion Protein

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Chemical Research in Chinese Universities 2011年第2期27卷 245-248页

作者： QIAO Xiao-fang fang xue-dong LIU Jun The Second Hospital of Jilin University Changchun 130041 P. R.China

Sumoylation is an important protein modification discovered recently. SUMO（small ubiquitin-related modifier） pathway regulates the protein stability and transcriptional activity with a 12-kDa small molecular protein, SUMO, ligated to the target protein. The purification of SUMO proteins is a key step to reveal their function. The purpose of this study was to construct the recombinant SUMO1 gene cloned to a pGEX-4T-1 vector to express and purify the SUMO1-GST fusion protein in Escherichia coli. First, the full length DNA sequence of SUMO1 gene was amplified by PCR and was ligated to pMD18-T vector. Then the SUMO1 gene was subcloned to pGEX-4T-1 prokaryotic expression vector between BamHI and XhoI sites, and transformed in Escherichia coli DH5α cells. The right colonies were identified by restrictive enzyme digestion and sequencing. The correct rebombinant plasmid of pGEX-4T-1-SUMO1 was transformed in Escherichia coli BL21 cells and then induced by IPTG（isopropyl- β-D-1- thiogalacto-pyranoside） to express the SUMO1-GST fusion protein. The highly purified SUMO1-GST（glutathione S-transferase） fusion protein was obtained by affinity chromatography. Finally, the properties of SUMO1-GST fusion protein were confirmed by Coomassie brilliant blue strain and Western blot analysis. The recombinant plasmid of pGEX-4T-1-SUMO1 was successfully constructed, and SUMO1-GST fusion proteins were successfully expressed.

关键词： Small ubiquitin-related modifier 1 (SUMO1) Gutathione S-transferase(GST) fusion protein Affinity chromatography

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Lifted System Framework for Learning Control with Different Trial Lengths

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International Journal of Automation and computing 2015年第3期12卷 273-280页

作者： xue-fang Li Jian-Xin Xu Department of Electrical and Computer Engineering National University of Singapore

This paper addresses an iterative learning control(ILC) design problem for discrete-time linear systems with randomly varying trial lengths. Due to the variation of the trial lengths, a stochastic matrix and an iteration-average operator are introduced to present a unified expression of ILC scheme. By using the framework of lifted system, the learning convergence condition of ILC in mathematical expectation is derived without using λ-norm. It is shown that the requirement on classic ILC that all trial lengths must be identical is mitigated and the identical initialization condition can be also removed. In the end, two illustrative examples are presented to demonstrate the performance and the effectiveness of the proposed ILC scheme for both time-invariant and time-varying linear systems.

关键词： Iterative learning control average operator randomly varying trial lengths identical initialization condition lifted sys-tem.

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Thickness-Dependent Microstructure and its Effect on Anisotropic Mechanical Properties of Duplex Stainless Steel 2205 Multi-pass Welded Joints

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Acta Metallurgica Sinica(English Letters) 2023年第11期36卷 1883-1892页

作者： Zhilong Dong xue-fang Xie Jingwen Li Yu Wan State Key Laboratory of Heavy Oil Processing College of New EnergyChina University of Petroleum(East China)Qingdao266580China China National Offshore Oil Corporation Petrochemical Engineering Company Limited Jinan250000China

In this study,the thickness-dependent microstructural characteristics of duplex stainless steel 2205 multi-pass welded joints were first investigated by the combination of optical microscope and electron back-scattered diffraction ***,a series of tensile tests of miniature samples cut from different passes and directions were performed to analyze the thickness-dependent and anisotropic mechanical *** results demonstrate that the microstructure changed with the welded passes,i.e.,a large number of grain boundary austenite,Widmanstätten austenite and a small number of tiny intragranular austenite existed at the surface passes,while a mass of intragranular austenite were found at the middle ***,the Kurdjumov–Sachs orientation relationship was widespread at the welded *** addition,the yield and tensile strengths of the middle passes were greater than that of the surface passes due to the grain-boundary strengthening by tiny intragranular ***,due to the existence of Kurdjumov–Sachs orientation relationship,the longitudinal yield and tensile strength were greater than transverse values,particularly for the middle passes.

关键词： Duplex stainless steel Multi-pass welded joints Thickness-dependent microstructure Anisotropic mechanical properties

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建设健康社会的催化剂:健康社会工作者与全科医生在基层的合作

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中国全科医学 2025年第4期28卷 516-520页

作者：李奕桦赵艾杨曾飞方雪张旺王欣武汉大学中南医院创伤与显微骨科湖北省武汉市430071 巴东县人民医院骨科湖北省恩施土家族苗族自治州444300

以“健康中国”战略为导向,从优势互补专业知识、共同连接医院社区、拓展研究社会健康三个方面去探讨健康社会工作者与全科医生在基层卫生环境中的合作价值,尤其在完善公共卫生应急体系和构建医联体上,健康社会工作者与全科医生的合作... 详细信息

以“健康中国”战略为导向,从优势互补专业知识、共同连接医院社区、拓展研究社会健康三个方面去探讨健康社会工作者与全科医生在基层卫生环境中的合作价值,尤其在完善公共卫生应急体系和构建医联体上,健康社会工作者与全科医生的合作可以发挥必不可少的作用,能有效推动健康社会的建设进程。同时文章也指明了目前健康社会工作面临的主要挑战,并提出相应的对策。

关键词：健康社会健康社会工作者全科医生基层卫生公共卫生应急医联体

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Bromate removal by gamma irradiation in aqueous solutions

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Nuclear Science and Techniques 2016年第1期27卷 44-49页

作者： Zhao-Lian Ye xue-Hui fang Hui-Qi Hou College of Chemistry and Environmental Engineering Jiangsu University of Technology Department of Environmental Science and Engineering Fudan University

Bromate(BrO_3) is a disinfection by-product in drinking water, and its removal is very difficult especially at low levels.60 Co gamma rays were used to remove BrO_3in aqueous solution in this study. The effects of absorbed doses, BrO_3initial concentration, gas saturation, p H value and coexisting anions(Cl, NO 3, SO2 4and HCO 3=CO_3^(2 -))on BrO_3reduction were evaluated. After 4.0-k Gy irradiation of air-equilibrated solution of 30.7 lg/L BrO_3, the residual BrO_3was 8.3 lg/L, which is below the maximum contaminant level of drinking water. The BrO_3reduction rate increased with the dose, in the order of N2[ air [ O_2[ N_2O atmosphere under similar conditions. The results also show that high p H favored the BrO_3removal. According to the experimental results, it can be concluded that the efficiency of decomposing BrO_3by reactive species followed the order of e aq[ H [ HO_2 [ O_2. Coexisting Cl, HCO 3=CO_3^(2 -)and SO2 4ions have little effect on BrO_3removal, whereas NO_3can inhibit its removal as a result of competition with BrO_3for e aq.

关键词： γ射线照射水溶液溴酸盐吸收剂量二氧化碳高pH值消毒副产物含气饱和度

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Mallat Algorithm of Wavelet for Time-Varying System Parametric Identification

Mallat Algorithm of Wavelet for Time-Varying System Parametr...

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第25届中国控制与决策会议

作者： Lv xue-fang Ping Tao Shandong Foreign Trade Vocational College Qingdao Institute of Bioenergy and Bioprocess Technology Chinese Academy of Sciences

ISBN: (纸本)9781467355339

This paper presents a mallat algorithm of wavelet for identifying time-varying parameter method. Expand the time-varying parameters used mallat algorithm, then the identification of the time-varying parameters is converted to the problem of identifying invariant coefficients. Select the filter banks which make the most of the energy of time-varying parameters concentrated in low-resolution part, then select multi resolution depths, on which gives the wavelet expansions of time-varying parameters. Finally invariant coefficients are identified through least-square method, then reconstruct them and get the time-varying parameters we needed. Simulation results show the wavelet analysis method is accurate and timely tracking of mutations in the signal, showing the superiority of the algorithm.

关键词： Mallat Algorithm of Wavelet Time-Varying System Parametric Identification

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