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International Journal of Mining Science and Technology 2017年第5期27卷 883-887页

作者： Liu Chao Li Shugang Cheng Cheng xue junhua School of Safety Science and Engineering Xi’an University of Science and TechniqueXi’an 710054China State Key Laboratory of Deep Coal Mining&Environment Protection Huainan 710054China

In order to effectively monitor the concealed fault activation process in excavation activities, based on the actual condition of a working face containing faults with high outburst danger in Xin Zhuangzi mine in Huainan, China, we carried out all-side tracking and monitoring on the fault activation process and development trend in excavation activities by establishing a microseismic monitoring system. The results show that excavation activities have a rather great influence on the fault activation. With the working face approaching the fault, the fault activation builds up and the outburst danger increases; when the excavation activities finishes, the fault activation tends to be stable. The number of microseismic events are corresponding to the intensity of fault activation, and the distribution rules of microseismic events can effectively determine the fault occurrence in the mine. Microseismic monitoring technique is accurate in terms of detecting geologic tectonic activities, such as fault activations lying ahead during excavation activities. By utilizing this technique, we can determine outburst danger in excavation activities in time and accordingly take effective countermeasures to prevent and reduce the occurrence of outburst accidents.

关键词： Excavation roadway Fault Microseismic monitoring technique Coal and gas outburst Activation characteristics

Numerical simulation of gas flow process in mining-induced crack network

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International Journal of Mining Science and Technology 2012年第6期22卷 793-799页

作者： Zhou Hongwei Liu Jinfeng xue Dongjie Yi Haiyang xue junhua State Key Laboratory of Coal Resources and Safe Mining China University of Mining & Technology State Key Laboratory of Deep Coal Mining and Environmental Protection Huainan Mining Group Corporation

The exploitation of coal bed methane or coal gas is one of the most effective solutions of the problem of coal gas hazard.A better understanding of gas flow in mining-induced cracks plays an important role in comprehensive development and utilization of coal gas as well as prevention of coal gas *** paper presents a case study of gas flow in mining-induced crack network regarding the situation of low permeability of coal seam.A two-dimensional physical model is constructed on the basis of geological background of mining face No.1122(1) in coal seam No.11-2,Zhangji Coal Mine,Huainan Mining Group *** mining-induced stress and cracks in overburden rocks are obtained by simulating an extraction in physical *** evolution of mining-induced cracks in the process of advancing of coal mining face is characterized and three typical crack networks are taken from digital photos by means of image ***,the numerical software named COMSOL Multiphysics is employed to simulate the process of gas flow in three representative crack *** of gas pressure at various times in mining-induced crack networks are plotted,suggesting a shape and dimension of gas accumulation area.

关键词： Gas flow Gas pressure Physical modeling Mining-induced cracks COMSOL

Application of deep borehole blasting on fully mechanized hard top-coal pre-splitting and gas extraction in the special thick seam

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International Journal of Mining Science and Technology 2015年第5期25卷 755-760页

作者： Liu Jian Liu Zegong xue junhua Gao Kui Zhou Wei State Key Laboratory of Deep Coal Mining & Environmental Protection School of Energy and Safety Anhui University of Science & Technology Key Laboratory of Safety and High-efficiency Coal Mining Ministry of EducationAnhui University of Science & Technology

In order to solve the problems of top-coal inadequate destruction and large amounts of gas emission in mining extra thick and hard coal seam,this study investigated the pre-splitting for deep borehole blasting and gas pre-draining technologies on top *** mechanism of the technologies was systematically expounded based on hard top-coal cracks development obtained by numerical simulation and theoretical *** results show that explosive blasting in the hard rock results in a large number of cracks and large displacement in the rock mass due to the effect of explosion ***,the thick top-coal caves,and desorbing gas flows along the cracks improve gas ***,the pre-splitting for deep borehole blasting and gas pre-draining technologies was applied in No.3802 working face of Shui Liandong Coal Mine,which increases monthly output in the face to 67.34 kt and the drained gas concentration to 86.2%.The drained gas average concentration from each borehole reaches 40%,and the effect is remarkable.

关键词： Deep borehole blasting Fully mechanized mining Hard thick coal seam Top-coal pre-splitting Gas extraction

基于CT扫描技术的煤样三维重构及气体表观渗透率研究

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矿业安全与环保 2024年第1期51卷 27-35页

作者：石钰马玉华李树刚薛俊华赵鹏翔詹可亮西安科技大学安全科学与工程学院陕西西安710054 西安科技大学西部矿井开采及灾害防治教育部重点实验室陕西西安710054 淮南师范学院机械与电气工程学院安徽淮南232038

基于CT扫描技术对煤样扫描成像,并进行滤波和二值化处理,获取孔裂隙尺寸、孔隙率等特征参数。通过盒维法计算煤样的分形维数,推导煤样孔裂隙的平均迂曲度及迂曲度维数。结合分形理论和克努森数,推导煤体中经滑移修正的气体表观渗透率模... 详细信息

基于CT扫描技术对煤样扫描成像,并进行滤波和二值化处理,获取孔裂隙尺寸、孔隙率等特征参数。通过盒维法计算煤样的分形维数,推导煤样孔裂隙的平均迂曲度及迂曲度维数。结合分形理论和克努森数,推导煤体中经滑移修正的气体表观渗透率模型并进行验证。通过ANASY有限元软件研究煤体中的瓦斯渗流规律。结果表明,瓦斯在孔裂隙弯折处压力变化剧烈,渗流速度在孔裂隙弯折处达到最大,瓦斯在个别孔隙发生凝滞、不流通。采用经过滑移修正的气体表观渗透率模型计算瓦斯表观渗透率,并与通过Forchheimer公式拟合得到的瓦斯表观渗透率及通过FT模型计算得到的瓦斯表观渗透率相比较,发现经过滑移修正后的气体表观渗透率模型适用于微尺度介质中气体表观渗透率研究。

关键词：煤 CT扫描三维重构分形理论滑脱效应气体表观渗透率

Experimental research on overlying strata movement and fracture evolution in pillarless stress-relief mining

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International Journal of Coal Science & Technology 2015年第1期2卷 38-45页

作者： junhua xue Hanpeng Wang Wei Zhou Bo Ren Changrui Duan Dongsheng Deng State Key Laboratory of Deep Coal Mining & Environment Protection Huainan 232001 China Geotechnical & Structural Engineering Research Center Shandong University Jinan 250012 China

In multiple seams mining, the seam with relatively low gas content （protective seam） is often extracted prior to mining its overlying and/or underlying seams of high gas content and low permeability to minimize the risk of high gas emission and outbursts of coal and gas. A key to success with this mining sequence is to gain a detailed understanding of the movement and fracture evolution of the overlying and underlying strata after the protective seam in extracted. In Zhuji mine, the No. 11-2 seam is extracted as a protective seam with the pillarless mining method by retaining goal-side roadways prior to its overlying No. 13-1 seam. An investigation has been undertaken in the panel 1111 （1） of Zhuji mine to physically simulate the movement and fracture evolution of the overlying strata alter the No. 1 I-2 seam is extracted. In the physical simulation, the displacement, strain, and deformation and failure process of the model for simulation were acquired with various means such as grating displacement meter, strain gauges, and digital photography. The simulation result shows that：（1） Initial caving interval of the immediate roof was 21.6 m, the first weighting interval was 23.5-37.3 m with the average interval of 33.5 m, and the periodic weighting interval of the main roof was in a range of 8.2-20.55 m and averaged at 15.2 m. （2） The maximum height of the caving zone after the extraction of No. 11-2 seam was 8.0 m, which was 4 times of the seam mining height and the internal strata of the caving zone collapsed irregularly. The mining-induced fractures developed 8-30 m above the mined No. 11-2 seam, which was 7.525 times of the seam mining height, the fracture zone was about 65° upward from the seam open-off cut toward the goaf, the height of longitudinal joint growth was 4-20 times of the mining seam height, and the height of lateral joint growth was 20-25 times of the mining seam height. （3） The ＂arch-in-arch＂ mechanical structure of the internal goaf was bounded by

关键词： Low-permeability coal seam Pillarless stress-relief mining Overburden movement Fracture evolution Physical simulation

Gas drainage from different mine of drainage systems for deep coal areas： optimal placement seams with high gas emissions

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International Journal of Coal Science & Technology 2015年第1期2卷 84-90页

作者： Ping Lu Ping Li Jian Chen Chuijin Zhang junhua xue Tao Yu Xi'an University of Science and Technology Xi'an 710054China Anhui Jianzhu University Hefei 230022 China Huainan Mining Group Co. Ltd. Huainan 232001 China

The techniques of stress relief mining in low-permeability coal seams and pillarless gob side retained roadway entry using Y-type ventilation and gas drainage systems were developed to control gas outbursts and applied successfully. However, as the mining depth increasing, parts of the gas drainage system are not suitable for mines with high gas emissions. Because larger mining depths cause higher ground stresses, it becomes extremely difficult to maintain long gob side roadways. The greater deformation suffered by the roadway is not favorable lor borehole drilling for continuous gas drainage. To solve these problems, Y-type ventilation and gas drainage systems installed from a roof roadway were designed for drainage optimization. This system was designed based on a gas-enrichment zone analysis developed from mining the 11-2 coal seam in the Zhuji Mine at Huainan, Anhui Province, China. The method of Y-type gas extraction from different mine areas was applied to the panel 1112（1） in the Zhuji Mine. The absolute gas emission rate was up to 116.3 m^3/min with an average flow of 69.1 m^3/min at an average drainage concentration of nearly 85 %. After the Y-type method was adopted, the concentration of gas in the return air was 0.15 %-0.64 %, averaging 0.39 % with a ventilation rate of 2100-2750 m^3/min. The gas management system proved to be efficient, and the effective gas control allowed safe production to continue .

关键词： Gas drainage Different gas sources Y-type ventilation Gob side retained roadway Gas emission Gas-enrichment zone

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断层带破碎煤巷围岩锚注预强化技术

采矿与安全工程学报 2018年第3期35卷 509-516页

作者：周波袁亮薛生薛俊华安徽理工大学能源与安全学院安徽淮南232001 淮南职业技术学院能源工程系安徽淮南232001 深部煤炭开采与环境保护国家重点实验室安徽淮南232001

为解决张集煤矿17246工作面回采断层带破碎煤巷支护困难、变形大等工程问题,将断层带内的破碎围岩视为弱结构体,采用数值模拟和现场实验的方法,模拟浆液在弱结构体内的扩散规律以及锚杆支护压应力的扩散效应,确定出合理的注浆钻孔参数... 详细信息

为解决张集煤矿17246工作面回采断层带破碎煤巷支护困难、变形大等工程问题,将断层带内的破碎围岩视为弱结构体,采用数值模拟和现场实验的方法,模拟浆液在弱结构体内的扩散规律以及锚杆支护压应力的扩散效应,确定出合理的注浆钻孔参数和锚杆支护参数,开展回采巷道局部弱结构体锚注安全控制工程试验,提出锚杆基础支护+注浆加固对试验巷道弱结构煤岩体的预强化工程控制技术。结果表明:1)注浆和锚杆支护可强化浅部弱结构体围岩强度和围压,确定出试验巷道合理的注浆参数为:注浆压力4.0 MPa、注浆时间>600 s、黏滞性系数0.14 Pa·s、注浆孔间排距1.8 m×2 m、孔深2.5 m、孔径56 mm;2)注浆前后巷道的变形监测数据表明,注浆和提高围压可显著提高弱结构体的承载能力和抗变形能力,保障了巷道围岩稳定。

关键词：煤巷顶板弱结构预强化注浆锚杆支护断层带

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锚固支护深部巷道爆破开挖模型试验研究

岩石力学与工程学报 2016年第9期35卷 1830-1836页

作者：袁璞徐颖薛俊华安徽理工大学矿山地下工程教育部工程研究中心安徽淮南232001 安徽理工大学土木建筑学院安徽淮南232001 淮南矿业(集团)有限责任公司深部煤炭开采与环境保护国家重点实验室安徽淮南232000

为研究锚固支护对钻爆法施工深部巷道围岩分区破裂的影响,采用深部巷道围岩破裂机制与支护技术模拟试验装置,开展高轴地应力条件下锚固支护深部巷道爆破开挖三维相似物理模型试验。爆破开挖、轴向超载完毕,模型巷道洞周围岩径向拉应变... 详细信息

为研究锚固支护对钻爆法施工深部巷道围岩分区破裂的影响,采用深部巷道围岩破裂机制与支护技术模拟试验装置,开展高轴地应力条件下锚固支护深部巷道爆破开挖三维相似物理模型试验。爆破开挖、轴向超载完毕,模型巷道洞周围岩径向拉应变和径向压应力均呈现出波峰与波谷的波浪变化,与未支护模型巷道洞周径向拉应变变化规律相似,表明锚固支护模型巷道依然存在分区破裂的趋势。与未支护模型试验结果对比,锚杆和锚索联合支护的模型巷道在锚固支护部位未出现分区破裂现象,分析得出锚杆和锚索的联合作用可实现围岩应力的转移和重分布。研究结果表明,锚固支护对抑制深部巷道分区破裂具有重要的作用。

关键词：岩石力学深部岩体分区破裂锚固支护爆破开挖模型试验

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液氮溶浸作用对不同煤阶煤样渗流特性的影响

煤炭学报 2020年第5期45卷 1835-1844页

作者：卢硕张磊薛俊华张村陈帅中国矿业大学矿业工程学院江苏徐州221116 西安科技大学安全科学与工程学院陕西西安710054 中国矿业大学(北京)能源与矿业学院北京100083

中国低透气性煤层广泛赋存且煤阶跨度较大。针对不同煤阶、性质煤层如何确定有效的液氮致裂方式是一个亟待解决的难题。为此,分别选择褐煤、烟煤和无烟煤3种煤阶的煤样进行不同条件下的液氮溶浸,并使用摄像机定点拍摄、观察煤样表面宏... 详细信息

中国低透气性煤层广泛赋存且煤阶跨度较大。针对不同煤阶、性质煤层如何确定有效的液氮致裂方式是一个亟待解决的难题。为此,分别选择褐煤、烟煤和无烟煤3种煤阶的煤样进行不同条件下的液氮溶浸,并使用摄像机定点拍摄、观察煤样表面宏观裂隙的演化规律,使用受载煤体注气驱替瓦斯测试实验系统与纯度为99.999%的氮气测试得出煤样渗透率的变化规律。对实验得到的煤样渗流曲线趋势进行简要讨论,对比分析了液氮处理不同阶段煤样的渗透率数值。实验结果表明:①相同围压条件下,煤样的渗透率随着气体压力的增加呈“U”型变化趋势,使用二次函数公式拟合效果良好;②单次液氮处理即可对褐煤煤样产生显著增透效果;③通过增加液氮循环处理次数可有效提升液氮对烟煤的增透效果,一次液氮溶浸处理后的烟煤渗透率增幅最大达到514.89%,两次处理后最大可达到1129.79%;④多次液氮处理对无烟煤透气性的改善不甚明显,只会逐渐降低其抗拉强度,通过增大热冷冲击温度梯度的液氮处理方式可以有效改善无烟煤透气性,在围压-气压为2.00~1.25 MPa时,初始温度50℃的无烟煤液氮处理后的渗透率增幅仅为2.44%,而初始温度100℃的无烟煤处理后的渗透率增幅达到125.43%;⑤基于实验结果讨论、提出适宜于不同煤阶煤层的液氮致裂增透方法。

关键词：煤阶液氮溶浸渗透率处理次数温度梯度

Licorice-saponin A3 is a broad-spectrum inhibitor for COVID-19 by targeting viral spike and anti-inflammation

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Journal of Pharmaceutical Analysis 2024年第1期14卷 115-127页

作者： Yang Yi Wenzhe Li Kefang Liu Heng xue Rong Yu Meng Zhang Yang-Oujie Bao Xinyuan Lai Jingjing Fan Yuxi Huang Jing Wang Xiaomeng Shi junhua Li Hongping Wei Kuanhui Xiang Linjie Li Rong Zhang Xin Zhao xue Qiao Hang Yang Min Ye State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing100191China Yunnan Baiyao International Medical Research Center Peking UniversityBeijing100191China CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing100101China CAS Key Laboratory of Special Pathogens and Biosafety Center for Biosafety Mega-ScienceWuhan Institute of VirologyChinese Academy of SciencesWuhan430071China University of Chinese Academy of Sciences Beijing100049China Department of Microbiology and Infectious Disease Center School of Basic Medical SciencesPeking University Health Science CenterPeking UniversityBeijing100191China Hubei Jiangxia Laboratory Wuhan430000China Shenzhen Children's Hospital ShenzhenGuangdong518036China

Currently,human health due to corona virus disease 2019(COVID-19)pandemic has been seriously *** coronavirus severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)spike(S)protein plays a crucial role in virus transmission and several S-based therapeutic approaches have been approved for the treatment of ***,the efficacy is compromised by the SARS-CoV-2 evolvement and *** we report the SARS-CoV-2 S protein receptor-binding domain(RBD)inhibitor licorice-saponin A3(A3)could widely inhibit RBD of SARS-CoV-2 variants,including Beta,Delta,and Omicron BA.1,XBB and ***,A3 could potently inhibit SARS-CoV-2 Omicron virus in Vero E6 cells,with EC50 of 1.016μ*** mechanism was related to binding with Y453 of RBD determined by hydrogen-deuterium exchange mass spectrometry(HDX-MS)analysis combined with quantum mechanics/molecular mechanics(QM/MM)***,phosphoproteomics analysis and multi fluorescent immunohistochemistry(mIHC)respectively indicated that A3 also inhibits host inflammation by directly modulating the JNK and p38 mitogen-activated protein kinase(MAPK)pathways and rebalancing the corresponding immune *** work supports A3 as a promising broad-spectrum small molecule drug candidate for COVID-19.

关键词： COVID-19 Inflammation Licorice-saponin A3 Receptor-binding domain(RBD) SARS-CoV-2