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A study on the correlation between function motivation and professional identity among nursing volunteers

Journal of Integrative Nursing 2021年第4期3卷 165-169页

作者： Juan XU Wenjun HAO Hui YANG xuanxuan li Department of Inpatient Shanxi Provincial People’s HospitalYingze DistrictTaiyuan CityShanxi ProvinceChina School of Nursing Shanxi University of Chinese MedicineTaiyuan CityShanxi ProvinceChina Department of Nursing First Hospital of Shanxi Medical UniversityTaiyuan CityShanxi ProvinceChina

Objective:The objective of this study is to understand the status quo of function motivation and professional identity among nursing volunteers and explore the correlation between the *** and Methods:A total of 3375 nursing volunteers from Nightingale Volunteer Service Group in Shanxi Province were investigated by using Occupational Identity Scale and Volunteer Functional Motivation ***:A total of 3375 questionnaires were issued and 3330 were recovered,among which 3324 were valid,with an effective recovery rate of 99.82%(3324/3330).The overall score of professional identity of nurses was 110.31±18.71,and the score of each dimension was 32.17±6.62 for professional cognitive evaluation dimension,22.77±3.74 for professional social support,21.31±4.09 for professional social skills,22.78±3.79 for professional frustration coping,and 11.32±2.03 for professional *** total score of function motivation was 157.12±*** above five dimensions of nurse’s professional identity scale were positively correlated with the total score of function motivation of nursing volunteers(r=0.044,0.035,0.034,0.035,and 0.042,respectively,all P<0.05).Conclusion:The functional motivation and professional identity of nursing volunteers in Shanxi Province are in the middle level in ***,it is necessary for the hospital to stimulate nursing staff’s enthusiasm about participation by carrying out multi-channel and multi-form volunteer service projects,enhance their professional identity,and make them better give back nursing professional skills to the society.

关键词： Functional motivation nurse professional identity volunteers

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Computational simulations reveal the binding dynamics between human ACE2 and the receptor binding domain of SARS-CoV-2 spike protein

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Quantitative Biology 2021年第1期9卷 61-72页

作者： Cecylia SLupala xuanxuan li Jian Lei Hong Chen Jianxun Qi Haiguang liu Xiao-Dong Su Complex Systems Division Beijing Computational Science Research CenterBeijing 100193China Engingeering Physics Department Tsinghua UniversityBeijing 100084China State Key Laboratory of Biotherapy and Cancer Center National Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityChengdu 610041China School of life Sciences State Key Laboratory of Protein and Plant Gene Research and Biomedical Pioneering Innovation Center(BIOPIC)Peking UniversityBeijing 100871China CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China Physics Department Beijing Normal UniversityBeijing 100875China

Background:A novel coronavirus(the SARS-CoV-2)has been identified in January 2020 as the causal pathogen for COVID-19,a pandemic started near the end of *** Angiotensin converting enzyme 2 protein(ACE2)utilized by the SARS-CoV as a receptor was found to facilitate the infection of SARS-CoV-2,initiated by the binding of the spike protein to human ***:Using homology modeling and molecular dynamics(MD)simulation methods,we report here the detailed structure and dynamics of the ACE2 in complex with the receptor binding domain(RBD)of the SARS-CoV-2 spike ***:The predicted model is highly consistent with the experimentally determined structures,validating the homology modeling *** the binding interface reported in the crystal structures,novel binding poses are revealed from all-atom MD *** simulation data are used to identify critical residues at the complex interface and provide more details about the interactions between the SARS-CoV-2 RBD and human ***:Simulations reveal that RBD binds to both open and closed state of *** human ACE2 mutants and rat ACE2 are modeled to study the mutation effects on RBD binding to *** simulations show that the N-terminal helix and the K353 are very important for the tight binding of the complex,the mutants are found to alter the binding modes of the CoV2-RBD to ACE2.

关键词： SARS-CoV-2 COVID-19 ACE2 mutation molecular dynamics simulations

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Gadolinium-based contrast agents built of DO3A-pyridine scaffold:Precisely tuning carboxylate group for enhanced magnetic resonance imaging

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Chinese Chemical Letters 2023年第6期34卷 537-540页

作者： Yongyin Geng Tianze Wu Qiuyue Han Yongtai Yang Zhenxia Chen xuanxuan li Bo Yin Yaming Zhou Yun ling Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Department of ChemistryFudan UniversityShanghai 200438China Department of Radiology Huashan Hospital NorthFudan UniversityShanghai 201907China

It is greatly desired to develop novel gadolinium-based contrast agents(GBCAs)as improved platforms for magnetic resonance imaging(MRI).Herein,we report the syntheses of a series of nonionic cyclenbased GBCAs by precisely tuning carboxylate group on DO3A-pyridine scaffold.[Gd-DO3A-4cp]is isolated which adopts an octadentate coordination mode with a free carboxylate group at 4-position of *** shows the r_(1)relaxivity of 5.8(mmol/L)^(-1)s^(-1)(3 T,25℃),which is 75%higher than 3.3(mmol/L)^(-1)s^(-1)of the clinic used[Gd-DOTA].The possible mechanisms behind the enhanced relaxivity are investigated and proposed by structure-property relationship *** validation of low cytotoxicity and considerable kinetic inertness,in-vivo studies are further examined,demonstrating its good MRI performance,biodistribution as well as the way of excretion.

关键词： Gadolinium-based contrast agents Cyclen-based ligand Structure-property relationship Relaxivity Magnetic resonance imaging

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Genetic characteristics of H1N1 influenza virus outbreak in China in early 2023

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Virologica Sinica 2024年第3期39卷 520-523页

作者： xuanxuan li Zefeng Dong Jiaming li Chuanran Dou Deyu Tian Zhenghai Ma Wenjun liu George F.Gao Yuhai Bi College of life Science and Technology Xinjiang UniversityUrumchi830046China CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyCenter for Influenza Research and Early-warning(CASCIRE)CAS-TWAS Center of Excellence for Emerging Infectious Diseases(CEEID)Chinese Academy of SciencesBeijing100101China Suzhou Center for Disease Control and Prevention Suzhou215004China Lafayette College EastonPA 18042USA University of Chinese Academy of Sciences Beijing100049China D.H.Chen School of Universal Health Zhejiang UniversityHangzhou 310058China

Dear Editor,Influenza A virus(IAV)exhibits rapid mutability and antigenic *** the 20th century,IAV has caused at least four pandemics(Yang et al.,2022).Presently,seasonal H_(3)N_(2)and H1N1 are the prevailing human-adaptive IAV subvariants responsible for human *** implementation of public health interventions since the commencement of the COVID-19 pandemic has effectively curtailed global influenza circulation(Olsen et al.,2021).Following the downregulation of the prevention and control strategies against COVID-19,global influenza activity is showing a recovery.

关键词： influenza prevention H1N1

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Effects of PM_(2.5)and Its Components on Disease Severity in Patients with Schizophrenia and the Mediating Role of Thyroid Hormones

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Environment & Health 2024年第5期2卷 290-300页

作者： Jintao liu Rong Song xuanxuan li li liu Ning Wei Jiajun Yuan Weizhuo Yi Rubing Pan Jian Cheng Xulai Zhang Hong Su Department of Epidemiology and Health Statistics School of Public HealthAnhui Medical UniversityHefeiAnhui 230032China Inflammation and Immune Mediated Diseases Laboratory of Anhui Province HefeiAnhui 230032China Center for Big Data and Population Health of IHM HefeiAnhui 230032China Anhui Mental Health Center(Affiliated Psychological Hospital of Anhui Medical University) HefeiAnhui 230032China

Studies have indicated the different effects of PM_(2.5)components on human ***,specific components that influence the severity of disease in schizophrenia patients and their underlying mechanisms remain ***,a repeated measures study for schizophrenia was constructed based on Anhui Mental Health *** collected information,including demographics and thyroid hormones(TH)levels,on repeat admissions of schizophrenia patients during 2017−2020,assessing their illness severity by positive and negative symptom scales(PANSS).Concentrations from the nearest component monitoring station in the 3 months before admission were assigned as the participant’s exposure *** assessed the effects of PM_(2.5)components individually and in combination on schizophrenia and explored the mediating role of *** indicated that benzo[a]pyrene,sulfate,nitrate,chloride,ammonia,cadmium,chromium,lead,selenium,and thallium exposure were associated with increased PANSS scores,with more significant results observed in *** exposure to PM_(2.5)components was found to be associated with increased PANSS scores and decreased free triiodothyronine(FT3).Mediation analysis suggested that the reduction in FT3 might mediate the association between the PM_(2.5)components and PANSS *** findings emphasize the impacts of PM_(2.5)components on schizophrenia and the potential value of focusing on changes in THs.

关键词： PM_(2.5)components Schizophrenia Thyroid hormones Mediation analysis

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A computational study of the chemokine receptor CXCR1 bound with interleukin-8

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Chinese Physics B 2018年第3期27卷 534-543页

作者： Yang Wang Cecylia Severin Lupala Ting Wang xuanxuan li Ji-Hye Yun Jae-hyun Park Zeyu Jin Weontae Lee Leihan Tan Haiguang liu Complex Systems Division Beijing Computational Science Research Center Beijing 100193 China Genome Center University of California Davis 451 East Health Science Drive Davis CA 95616 USA Department of Engineering physics Tsinghua University Beijing 100086 China Department of Biochemistry College of Life Science ＆ Biotechnology Yonsei University Seou103722 South Korea Department of Physics and Institute of Computational and Theoretical Studies Hong Kong Baptist University Hong Kong China

CXCR1 is a G-protein coupled receptor, transducing signals from chemokines, in particular the interleukin-8 （1L8） molecules. This study combines homology modeling and molecular dynamics simulation methods to study the structure of CXCRI-IL8 complex. By using CXCR4-vMIP-II crystallography structure as the homologous template, CXCRI-IL8 complex structure was constructed, and then refined using all-atom molecular dynamics simulations. Through extensive simulations, CXCRI-IL8 binding poses were investigated in detail. Furthermore, the role of the N-terminal of CXCR1 receptor was studied by comparing four complex models differing in the N-terminal sequences. The results indicate that the receptor N-terminal affects the binding of IL8 significantly. With a shorter N-terminal domain, the binding of IL8 to CXCR1 becomes unstable. The homology modeling and simulations also reveal the key receptor-ligand residues involved in the electrostatic interactions known to be vital for complex formation.

关键词： CXCRI-IL8 complex homology modeling ligand binding molecular dynamics

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Association of Di(2-ethylhexyl)Phthalate Exposure with Reproductive Hormones in the General Population and the Susceptible Population:A Systematic Review and Meta-Analysis

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Environment & Health 2024年第11期2卷 750-765页

作者： xuanxuan li Changchun Xiao Jintao liu Ning Wei Jian Song Jiajun Yuan li liu Rong Song Weizhuo Yi Rubing Pan Jian Cheng Shusi Wang Hong Su Department of Epidemiology and Health Statistics School of Public HealthAnhui Medical UniversityHefeiAnhui 230032China Center for Big Data and Population Health of IHM HefeiAnhui 230032China Inflammation and Immune Mediated Diseases Laboratory of Anhui Province HefeiAnhui 230032China Hefei Center for Disease Control and Prevention HefeiAnhui 230032China Department of Healthcare-associated Infection Management Hefei Stomatological HospitalAnhui Medical University Hefei Oral Clinic CollegeHefei 230032China

Di(2-ethylhexyl)phthalate(DEHP),an environ-mental endocrine disruptor,has hormone-like activity and endocrine-disrupting ***,the types of reproductive hormones associated with DEHP vary across the ***,we conducted a systematic review and meta-analysis to pool existing epidemiological *** searched three databases up to January 31,2024,for eligible original studies to ultimately include 37 studies from eight countries with a total of 28911 *** exposure was evaluated with urinary *** the main types,production sites,blood concentrations,and functions of reproductive hormones differ between men and women,we reported the combined effect values by *** analyses were conducted by age,subfertility status,and the national sociodemographic index(SDI)***,the effect of maternal exposure during pregnancy on children’s reproductive hormone levels was analyzed ***,in general,in men,DEHP was positively correlated with sex hormone binding-globulin(SHBG)and adversely correlated with total testosterone(TT),free androgen index(FAI),and follicle-stimulating hormone(FSH).Results indicated that among men of reproductive age,DEHP exposure was associated with more significant hormonal suppression in infertile men compared with fertile ***,age subgroup analysis among women revealed that postmenopausal women were more vulnerable to DEHP,which was related to lower TT and estradiol(E2).However,this study did not observe a significant association between prenatal DEHP metabolites and reproductive hormone levels in *** research identifies the most susceptible hormones(androgen suppression)after DEHP exposure and suggests that infertile men and postmenopausal women are in great need of more attention as sensitive populations.

关键词： Di(2-ethylhexyl)phthalate DEHP Reproductive hormones Endocrine disruptors Meta-analysis

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基于贝叶斯网络和关联规则的航电系统故障诊断

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计算机应用与软件 2023年第3期40卷 45-51,148页

作者：王凯李玄玄中国民航大学电子信息与自动化学院天津300300

为了提高机载航线维修的效率,提出利用贝叶斯网络结合关联规则来构建航电系统故障诊断模型。有效利用航电系统的故障树转化为以贝叶斯网络为架构的故障诊断模型结构,并将BITE信息作为节点扩展到结构中,采用Leak Noisy-Or模型简化故障诊... 详细信息

为了提高机载航线维修的效率,提出利用贝叶斯网络结合关联规则来构建航电系统故障诊断模型。有效利用航电系统的故障树转化为以贝叶斯网络为架构的故障诊断模型结构,并将BITE信息作为节点扩展到结构中,采用Leak Noisy-Or模型简化故障诊断模型条件概率的计算,利用关联规则算法挖掘历史维修数据包含的强关联规则,并综合专家经验完成条件概率参数的学习。以VHF系统为例,使用GeNIe2.3软件对故障诊断模型进行仿真,通过对具体案例的推理、诊断分析,实现了机载航线维修的动态化诊断过程。

关键词：航电系统贝叶斯网络关联规则 BITE Leak Noisy-Or 条件概率故障诊断

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轴流转桨水轮机多指标非线性调速器设计

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电网技术 2013年第7期37卷 1874-1879页

作者：骆武宁肖明李啸骢李绚绚孔繁镍广西诺斯贝电气有限公司广西壮族自治区南宁市530004 广西大学电气工程学院广西壮族自治区南宁市530004 广西民族大学物理与电子工程学院广西壮族自治区南宁市530006

为了改善轴流转桨水轮机调速器的控制性能,在考虑调速系统非线性因素的基础上,提出了一种多指标非线性控制策略。通过分析轴流转桨水轮机机械特性,给出了水轮机调速系统各环节数学模型,在此基础上建立了轴流转桨水轮机调速系统的非线性... 详细信息

为了改善轴流转桨水轮机调速器的控制性能,在考虑调速系统非线性因素的基础上,提出了一种多指标非线性控制策略。通过分析轴流转桨水轮机机械特性,给出了水轮机调速系统各环节数学模型,在此基础上建立了轴流转桨水轮机调速系统的非线性模型。并基于多指标非线性控制理论,针对轴流转桨水轮机的刚性水锤效应,设计了非线性控制器。仿真结果表明,文中所建立的调速系统模型,能有效反映轴流转桨水轮机非线性特征;所提出的控制策略与工程实际中应用的PID策略相比,能更好地改善系统的稳定性和运行特性,控制目标品质更为优秀,使得系统具有很高的可靠性和抗干扰能力。

关键词：轴流转桨水轮机多指标非线性控制刚性水锤效应非线性控制器

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安徽庐枞盆地黄竹园银多金属矿床地质特征和关键金属赋存状态研究

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岩石学报 2021年第9期37卷 2805-2820页

作者：刘杰添陈静范裕刘军李旋旋合肥工业大学资源与环境工程学院矿床成因与勘查技术研究中心(ODEC)合肥230009 安徽省矿产资源与矿山环境工程技术研究中心合肥230009

黄竹园银多金属矿床位于长江中下游成矿带庐枞矿集区东南缘,是成矿带断凹区火山岩盆地内首次发现的浅成低温热液型银多金属矿床,亟待开展矿床地质特征、金属元素特别是关键金属的赋存状态和矿床成因研究。黄竹园矿床矿体主要赋存于下白... 详细信息

黄竹园银多金属矿床位于长江中下游成矿带庐枞矿集区东南缘,是成矿带断凹区火山岩盆地内首次发现的浅成低温热液型银多金属矿床,亟待开展矿床地质特征、金属元素特别是关键金属的赋存状态和矿床成因研究。黄竹园矿床矿体主要赋存于下白垩统砖桥组、双庙组火山岩及断裂破碎带中,呈层状、似层状产出;矿石类型主要有脉状、浸染状、细网脉状。本次工作基于矿床地质特征研究,通过对矿床中采集样品进行手标本及室内镜下观察、短波红外分析测试(SWIR)、扫描电子显微镜(SEM-EDS)、电子探针分析(EPMA)和自动矿物综合分析(TIMA)等方法,阐明了矿床中的主要蚀变矿化特征和成矿期次,重点开展银和关键金属赋存状态及矿床成因类型研究。研究结果表明,黄竹园矿床总体表现出靠近矿体部位发育绢云母-伊利石化,向外围矿化较弱部位变为蒙脱石-高岭石化;根据不同的矿物共生组合及其相互关系,将矿床的成矿过程从早到晚分为无矿化石英脉阶段、石英-银矿物-硫化物脉阶段和石英-碳酸盐脉阶段,其中石英-银矿物-硫化物脉阶段为该矿床最重要的银、铜成矿阶段。主要的银矿物为自然银、硫铜银矿和硫汞铜银矿。矿床中的主要关键金属矿物为辉砷钴矿和铁硫砷钴矿,呈不规则粒状镶嵌在辉铜矿和黄铁矿边缘。通过黄竹园矿床与国内外其他浅成低温热液矿床地质特征对比,本次工作认为黄竹园矿床是高硫型浅成低温热液矿化叠加于斑岩型矿化之上的复合成矿的典型实例。通过与矿区北部钱铺酸性蚀变岩帽(<1km)之间对比研究,提出黄竹园-钱铺酸性蚀变岩帽地区可能存在一大型“斑岩-浅成低温热液成矿系统”,为庐枞盆地下一步深部找矿提供了方向。

关键词：庐枞火山岩盆地黄竹园银多金属矿床蚀变及矿化特征关键矿产高硫-斑岩复合型矿床

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