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Effect of low anterior resection syndrome on quality of life in colorectal cancer patients:A retrospective observational study

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World Journal of Gastrointestinal Surgery 2023年第10期15卷 2123-2132页

作者： Dong-Ai Jin Fang-Ping Gu Tao-Li Meng xuan-xuan zhang Department of Nursing Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016Zhejiang ProvinceChina Department of Ultrasound The Fourth Affiliated Hospital of Zhejiang University School of MedicineYiwu 322000Zhejiang ProvinceChina

BACKGROUND Low anterior resection syndrome(LARS)is a common complication of anuspreserving surgery in patients with colorectal cancer,which significantly affects patients'quality of *** To determine the relationship between the incidence of LARS and patient quality of life after colorectal cancer surgery and to establish a LARS prediction model to allow perioperative precision *** We reviewed the data from patients who underwent elective radical resection for colorectal cancer at our institution from April 2013 to June 2020 and completed the LARS score questionnaire and the European Organization for Research and Treatment of Cancer Core Quality of Life and Colorectal Cancer Module *** to the LARS score results,the patients were divided into no LARS,mild LARS,and severe LARS *** incidence of LARS and the effects of this condition on patient quality of life were *** and multivariate analyses were performed to identify independent risk factors for the occurrence of *** on these factors,we established a risk prediction model for LARS and evaluated its *** Among the 223 patients included,51 did not develop LARS and 171 had mild or severe *** following quality of life indicators showed significant differences between patients without LARS and those with mild or severe LARS:Physical,role,emotional,and cognitive function,total health status,fatigue,pain,shortness of breath,insomnia,constipation,and *** size,partial/total mesorectal excision,colostomy,preoperative radiotherapy,and neoadjuvant chemotherapy were identified to be independent risk factors for LARS.A LARS prediction model was successfully established,which demonstrated an accuracy of 0.808 for predicting the occurrence of *** The quality of life of patients with LARS after colorectal cancer surgery is significantly reduced.

关键词： Colorectal cancer Low anterior resection syndrome Precision nursing Quality of life Prediction model Risk factors

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Recent progress in carbene-catalyzed fluoroalkylation

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Science China Chemistry 2024年第8期67卷 2448-2460页

作者： Bei zhang xuan zhang Jian Wang Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control Collaborative Innovation Center of Atmospheric Environment and Equipment TechnologySchool of Environmental Science and EngineeringNanjing University of Information Science and TechnologyNanjing 210044China School of Pharmaceutical Sciences Tsinghua UniversityBeijing 100084China

The fluoroalkyl fragment plays a vital role in various fields such as pharmaceuticals and materials science, and has a significant impact on human life not only on the present but also in the future. The insertion of fluoroalkyl groups into the chemical skeletons can cause considerable alternations in the chemical, physical and biological properties of molecules, which has attracted numerous scientists from different fields. This review focuses on N-heterocyclic carbene(NHC)-catalyzed fluoroalkylation reactions, providing a detailed analysis and summary of the achievements in the past two decades. Many successful examples clearly indicate that NHCs can catalyze the tranformation of fluoroalkylation reagents with various electronic characteristics, whether electrophilic, nucleophilic, or radical precursors. Herein, the fluoroalkylation reactions are classified based on different catalytic modes of NHCs: Lewis base catalysis, Umploung catalysis, radical catalysis and others. Meanwhile, by refining and systematically studying the contribution of NHC catalysis in fluoroalkylation reactions, this review is expected to provide valuable insights and enlightenment for related fields.

关键词： N-heterocyclic carbene fluoroalkylation radical catalysis

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Hollow Carbon Microspheres/MnO_2 Nanosheets Composites:Hydrothermal Synthesis and Electrochemical Behaviors

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Nano-Micro Letters 2015年第1期7卷 59-67页

作者： Hui-li Fan Fen Ran xuan-xuan zhang Hai-ming Song Xiao-qin Niu Ling-bin Kong Long Kang School of Materials Science and Engineering Lanzhou University of Technology State Key Laboratory of Advanced Processing and Recycling of Non-ferrous Metals Lanzhou University of Technology

This article reported the electrochemical behaviors of a novel hollow carbon microspheres/manganese dioxide nanosheets(micro-HC/nano-MnO2) composite prepared by an in situ self-limiting deposition method under hydrothermal condition. The results of scanning electron microscopy reveal that MnO2 nanosheets homogeneously grow onto the surface of micro-HC to form a loose-packed microstructure. The quantity of MnO2 required in the electrode layer has thereby been reduced significantly, and higher specific capacitances have been achieved. The micro-HC/nano-MnO2 electrode presents a high capacitance of 239.0 F g-1 at a current density of 5 m A cm-2, which is a strong promise for high-rate electrochemical capacitive energy storage applications.

关键词： Manganese oxide Hollow carbon microspheres Composite electrode Supercapacitor

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Successful treatment of plasma exchange-refractory thrombotic thrombocytopenic purpura with rituximab:A case report

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World Journal of Clinical Cases 2020年第12期8卷 2617-2622页

作者： Jian Chen Jing-Xia Jin Xiao-Fei Xu xuan-xuan zhang Xing-Nong Ye Jian Huang Department of Ultrasonography The Fourth Affiliated Hospital of Zhejiang University School of MedicineYiwu 322000Zhejiang ProvinceChina Department of Hematology The Fourth Affiliated Hospital of Zhejiang University School of MedicineYiwu 322000Zhejiang ProvinceChina

BACKGROUND Thrombotic thrombocytopenic purpura(TTP),a subtype of thrombotic microangiopathy,has a very high fatality rate if there is no timely diagnosis or ***,we report a case of TTP refractory to high displacement plasma exchange,which was later successfully treated with *** SUMMARY Here we report a case of refractory TTP in a 63-year-old woman with a low platelet count and decreased ADAMTS13 *** platelet count was 9×109/L,hemoglobin level was 81 g/L,and ADAMTS13 was<5%.She was diagnosed with thrombotic thrombocytopenic *** 8 d of daily plasma exchange(PEX),her platelet levels were still ***,after 6 d of treatment with rituximab,her platelet count increased and ADAMTS13 activity returned to *** PEX can cure most patients,but the relapse rate can be up to 50%-60%.This case suggested that rituximab can improve the curative efficiency of PEX and prevent disease relapse in TTP.

关键词： Thrombotic thrombocytopenic purpura ADAMTS13 Plasma exchange Rituximab Case report

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Three-dimensional echocardiographic assessment of left ventricular volume in different heart diseases using a fully automated quantification software

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World Journal of Clinical Cases 2022年第13期10卷 4050-4063页

作者： Chen-Ke Pan Bo-Wen Zhao xuan-xuan zhang Mei Pan Yan-Kai Mao Yuan Yang Department of Diagnostic Ultrasound and Echocardiography Sir Run Run Shaw HospitalZhejiang University College of MedicineHangzhou 310016Zhejiang ProvinceChina Department of Ultrasound The Fourth Affiliated Hospital of Zhejiang University College of MedicineYiwu 322200Zhejiang ProvinceChina

BACKGROUND HeartModel(HM)is a fully automated adaptive quantification software that can quickly quantify left heart volume and left ventricular *** study used HM to quantify the left ventricular end-diastolic(LVEDV)and end-systolic volumes(LVESV)of patients with dilated cardiomyopathy(DCM),coronary artery heart disease with segmental wall motion abnormality,and hypertrophic cardiomyopathy(HCM)to determine whether there were differences in the feasibility,accuracy,and repeatability of measuring the LVEDV,LVESV,LV ejection fraction(LVEF)and left atrial end-systolic volume(LAESV)and to compare these measurements with those obtained with traditional twodimensional(2D)and three-dimensional(3D)*** To evaluate the application value of HM in quantifying left heart chamber volume and LVEF in clinical *** A total of 150 subjects who underwent 2D and 3D echocardiography were divided into 4 groups:(1)42 patients with normal heart shape and function(control group,Group A);(2)35 patients with DCM(Group B);(3)41 patients with LV remodeling after acute myocardial infarction(Group C);and(4)32 patients with HCM(Group D).The LVEDV,LVESV,LVEF and LAESV obtained by HM with(HM-RE)and without regional endocardial border editing(HM-NE)were compared with those measured by traditional 2D/3D echocardiographic methods to assess the correlation,consistency,and repeatability of all ***(1)The parameters measured by HM were significantly different among the groups(P<0.05 for all).Compared with Groups A,C,and D,Group B had higher LVEDV and LVESV(P<0.05 for all)and lower LVEF(P<0.05 for all);(2)HM-NE overestimated LVEDV,LVESV,and LAESV with wide biases and underestimated LVEF with a small bias;contour adjustment reduced the biases and limits of agreement(bias:LVEDV,28.17 mL,LVESV,14.92 mL,LAESV,8.18 mL,LVEF,-0.04%).The correlations between HM-RE and advanced cardiac 3D quantification(3DQA)(r_(s)=0.91-0.95,P<0.05 for all)were higher than those between HM-NE(

关键词： HeartModel Three-dimensional echocardiography Left ventricular volume Left ventricular ejection function Left atrial volume

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Retroperitoneal parasitic fetus: A case report

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World Journal of Clinical Cases 2021年第36期9卷 11482-11486页

作者： Bin Xia Dan-Dan Li Hua-Xing Wei xuan-xuan zhang Ru-Mei Li Jian Chen Department of Ultrasonography The Fourth Affiliated Hospital of Zhejiang University School of MedicineYiwu 322000Zhejiang ProvinceChina Department of Cardiothoracic Surgery The Fourth Affiliated Hospital of Zhejiang University School of MedicineYiwu 322000Zhejiang ProvinceChina

BACKGROUND Fetus-in-fetu(FIF)is an extremely rare congenital abnormal mass,in which a normal fetus’s vertebral axis frequently connected with malformed fetus around this ***,we report the case of a male infant aged 26 d presenting with retroperitoneal parasitic *** SUMMARY In a prenatal examination,we first detected an abdominal mass measuring 7.8 cm×5.1 cm×6.8 cm in a mother’s abdomen at 25 gestational weeks and teratoma was *** the fetal was born,we did a magnetic resonance imaging(MRI)and ultrasonography on him and saw a distinctive limb with *** to the result of MRI,ultrasonography and postoperative pathology,he finally was diagnosed with *** A laparotomy was performed at 26 d of age with excision of the retroperitoneal cystic tumor,which measured about 10 cm in *** to the result of imaging and histological test,FIF was confirmed.

关键词： Ultrasound Abdominal mass Teratoma Fetus-in-fetu Case report

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Influence of ecological function protection zone on the water conservation in Gansu-Qinghai Contiguous Region of the upper Yellow River

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Journal of Mountain Science 2024年第4期21卷 1345-1357页

作者： TONG Huali CHEN Qingbo zhang xuan College of Geography and Environmental Science Northwest Normal UniversityLanzhou 730070China Gansu Province Land Use and Comprehensive Improvement Engineering Research Center Lanzhou 730070China

The implementation of Ecological Function Protection Zone(EFPZ)policy is significant for the ecological restoration and conservation of soil and water in the territory *** manuscript analyzed and quantified the impact of EFPZ on the regional water conservation function,based on land use data from 2005,2008,2010,2015 and 2020,by conducting a counterfactual simulation along with the GeoSOS-FLUS model and the InVEST *** results demonstrate that the delineation of EFPZ can significantly influence the water conservation.(1)From 2010 to 2020,as the EFPZ was implemented,the water conservation in the study area was increasing year by year,with a growth rate of 0.03×10^(8) m^(3)∙a^(-1).On the other hand,the simulated water conservation capacity without the implementation of EFPZ decreased year by year,with a decrease rate of 0.01×10^(8) m^(3)∙a^(-1).(2)The EFPZ accounts for only 23%of the total area,but the contribution rate of water conservation reaches 80%.The actual values of water conservation and average water yield per unit pixel in the EFPZ show an increasing trend both internally and externally,while the counterfactual simulation values exhibit a decreasing trend.(3)The water conservation is much higher within the EFPZ than without *** implementation of EFPZ has a significant effect on the improvement of the water conservation capacity in Maqu EFPZ and Yellow River Source *** protection effectiveness should be enhanced in Qilian Mountain EFPZ and afforestation activities need to be carefully considered in Loess Plateau EFPZ.

关键词： Water conservation function Ecological Function Protection Zone Counterfactual simulation Geo SOS-FLUS model InVEST model

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Endochondral ossification of hindlimbs in embryonic development of Japanese Quail(Coturnix japonica)

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Avian Research 2024年第1期15卷 123-132页

作者： xuan Li Yuxin zhang Hongfeng Zhao College of Life Sciences Shaanxi Normal UniversityXi’an710119China

The endochondral ossification of hindlimb is essential to a bird’s ability to stand,walk and *** hindlimb is ossified in the embryos before hatching in precocial ***,the molecular mechanisms of hindlimb ossification in birds is still ***,we tried to examine the process of hindlimb ossification and its molecular regulation by using an animal model—Japanese Quail(Coturnix japonica).We selected four critical stages(Embryo Day:E6,E8,E12 and E16) of skeletal development of embryonic quails for hindlimb skeleton staining to show the process of endochondral ossification and to examine the molecular regulation of endochondral osteogenesis by RNA-Seq *** results showed that ossification became increased with embryonic development and most hindlimb was ossified before ***-Seq analysis revealed that various signaling pathways were involved with endochondral ossification with thyroid hormone signaling and WNT signaling pathway particularly ***,the expression levels of 42 genes were continuously upregulated and 14 genes were continuously downregulated from E6 to *** present study might provide new insights into complex molecular mechanisms in regulation of endochondral ossification.

关键词： Embryos Hindlimb Ossification Precocial Transcriptomics

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Optimising multi-vent module-based adaptive ventilation using a novel parameter for improved indoor air quality and health protection

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Building Simulation 2024年第1期17卷 113-130页

作者： Haotian zhang Xiaoxiao Ding Weirong zhang Weijia zhang Yingli xuan Key Laboratory of Green Built Environment and Energy Efficient Technology Beijing University of TechnologyBeijing 100124China Department ofArchitecture TokyoPolytechnic UniversityTokyoJapan

As infectious respiratory diseases are highly transmissible through the air,researchers have improved traditional total volume air distribution systems to reduce infection ***-vent module-based adaptive ventilation(MAV)is a novel ventilation type that facilitates the switching of inlets and outlets to suit different indoor scenarios without changing ductwork ***,little research has evaluated MAV module sizing and air velocity selection,both related to MAV system efficiency in removing contaminants and the corresponding level of protection for occupants in the ventilated ***,the module-source offset ratio(MSOR)is proposed,based on the MAV module size and its distance from an infected occupant,to inform selection of optimal MAV module *** fluid dynamics simulations illustrated contaminant distribution in a two-person MAV equipped *** phase particles modelled respiratory contaminants from the infected occupant,and contaminant concentration distributions were compared under four MAV air distribution layouts,three air velocities,and three module sizes considered using the *** indicate that lower air velocities favour rising contaminant levels,provided the ventilation rate is *** contaminant discharge can be achieved when the line of outlets is located directly above the infected *** this parameter to guide MAV system design,85.7% of contaminants may be rendered harmless to the human body within 120 s using the default air vent layout.A more appropriate supply air velocity and air vent layout increases this value to 91.4%.These results are expected to inform the deployment of MAV systems to reduce airborne infection risk.

关键词： multi-vent module-based adaptive ventilation computational fluid dynamics indoor air quality infection control

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Design and tailoring of patterned ZnO nanostructures for perovskite light absorption modulation

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International Journal of Minerals,Metallurgy and Materials 2024年第5期31卷 855-861页

作者： Haonan Si xuan Zhao Qingliang Liao Yue zhang Academy for Advanced Interdisciplinary Science and Technology Beijing Advanced Innovation Center for Materials Genome EngineeringUniversity of Science and Technology BeijingBeijing 100083China Key Laboratory of Advanced Materials and Devices for Post-Moore Chips Ministry of EducationBeijing Key Laboratory for Advanced Energy Materials and TechnologiesSchool of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing 100083China

Lithography is a pivotal micro/nanomanufacturing technique,facilitating performance enhancements in an extensive array of devices,encompassing sensors,transistors,and photovoltaic *** key to creating highly precise,multiscale-distributed patterned structures is the precise control of the lithography ***,high-quality patterned ZnO nanostructures are constructed by systematically tuning the exposure and development times during *** optimizing these parameters,ZnO nanorod arrays with line/hole arrangements are successfully *** ZnO nanostructures with highly controllable morphology and structure possess discrete three-dimensional space structure,enlarged surface area,and improved light capture ability,which achieve highly efficient energy conversion in perovskite solar *** lithography process management for these patterned ZnO nanostructures provides important guidance for the design and construction of complex nanostructures and devices with excellent performance.

关键词： lithography patterned ZnO nanorod arrays light absorption perovskite solar cell

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