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A three-dimensional matrix system containing melatonin and neural stem cells repairs damage from traumatic brain injury in rats

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Neural Regeneration Research 2022年第11期17卷 2512-2517页

作者： xuan-yu fang Da-Wei Zhao Chao Zhang Hong-Fei Ge Xu-Yang Zhang Feng-Chun Zhao Yi-Bin Jiang Hua Feng Rong Hu Department of Neurosurgery and Key Laboratory of Neurotrauma Southwest HospitalArmy Medical UniversityChongqingChina

Brain lesions can cause neural stem cells to activate,proliferate,diffe rentiate,and migrate to the injured ***,after traumatic brain injury,brain tissue defects and microenvironment changes greatly affect the survival and growth of neural stem cells;the resulting reduction in the number of neural stem cells impedes effective repair of the injured *** can promote the survival,proliferation,and differentiation of neural stem cells under adverse conditions such as oxidative stress or hypoxia that can occur after traumatic brain ***,we investigated the therapeutic effects of melatonin combined with neural stem cells on traumatic brain injury in ***,in vitro studies confirmed that melatonin promoted the survival of neural stem cells deprived of oxygen and ***,we established a three-dimensional Matrigel-based transplantation system containing melatonin and neural stem cells and then used it to treat traumatic brain injury in *** found that treatment with the Matrigel system containing melatonin and neural stem cells decreased brain lesion volume,increased the number of surviving neuro ns,and improved recove ry of neurological function compared with treatment with Matrigel alone,neural stem cells alone,Matrigel and neural stem cells combined,and Matrigel and melatonin *** findings suggest that the three-dimensional Matrigelbased transplantation system containing melatonin and neural stem cells is a potential treatment for traumatic brain injury.

关键词： cell therapy magnetic resonance imaging Matrigel melatonin neural stem cells neurological function recovery three-dimensional transplantation traumatic brain injury

The gut microbiome modulate response to immunotherapy in cancer

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Science China(Life Sciences) 2025年第2期68卷 381-396页

作者： Shan-Shan Jiang Zi-Ran Kang Ying-xuan Chen Jing-yuan fang Division of Gastroenterologyand Hepatology Shanghai Instituteof Digestive DiseaseNHC KeyLaboratoryof Digestive DiseasesState KeyLaboratoryfor Oncogenesand Related GenesRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200001China

Gut microbiota have been reported to play an important role in the occurrence and development of malignant ***,clinical studies have identified specific gut microbiota and its metabolites associated with efficacy of immunotherapy in multiple types of *** investigations have elucidated that gut microbiota modulate the antitumor immunity and affect the efficacy of cancer *** microbiota and its metabolites may favorably remodel the tumor microenvironment by engaging innate and/or adaptive immune *** how the gut microbiome interacts with cancer immunotherapy opens new avenues for improving treatment *** microbial transplants,probiotics,dietary interventions,and other strategies targeting the microbiota have shown promise in preclinical studies to enhance the *** clinical trials are evaluating these *** review presents the recent advancements in understanding the dynamic interplay among the host immunity,the microbiome,and cancer immunotherapy,as well as strategies for modulating the microbiome,with a view to translating into clinical applications.

关键词： cancer immunotherapy gut microbiota intratumoral microbiota microbiota-derived metabolites innate and adaptive immunity

Foliar-applied zinc promotes cadmium allocation from leaf surfaces to grains in rice

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Journal of Environmental Sciences 2025年第5期151卷 582-593页

作者： Ya-Ting Liu Bo-fang Yan xuan Cai Hong-Xiang Zheng Rong-Liang Qiu Ye-Tao Tang School of Environmental Science and Engineering Sun Yat-sen UniversityGuangzhou 510006China Institute of Facility Agriculture Guangdong Academy of Agricultural SciencesGuangzhou 510640China Guangdong Provincial Key Laboratory of Environmental Pollution Control and Remediation Technology Sun Yat-sen UniversityGuangzhou 510006China Guangdong Provincial Key Laboratory of Agricultural&Rural Pollution Abatement and Environmental Safety College of Natural Resources and EnvironmentSouth China Agricultural UniversityGuangzhou 510642China

The accumulation of Cd by rice poses significant health *** fertilizationwith Zn can reduce grain Cd contents in rice grown in Cd-contaminated ***,atmospheric deposition on leaves is another vector of Cd contamination,and it remains unclear how Zn application affects the allocation of such *** conducted an experiment where the flag leaves of rice plants were treated with solutions with various Zn concentrations and a constant Cd *** 111Cd stable isotope was used to trace the flux of foliarapplied *** levels of foliar-applied Zn enhanced Cd efflux and grain *** is attributed to limited sequestration of foliar-applied Cd in the leaf cell symplasm and increased Cd desorption from leaf cell walls when a high Zn^(2+)concentration occurs in the *** Zn oxide nanoparticlesmitigated these ***,the expressions of OsLCT1 and OsZIP7 in flag leaves and OsHMA2 and OsZIP7 in the uppermost nodes were upregulated under high-Zn^(2+)treatment,which may facilitate Cd phloem loading and grain *** is advised in using foliar Zn in areas with high atmospheric Cd due to potential grain-contamination risks.

关键词： Atmospheric deposition Isotope labelling Metal interaction Phloem Cell wall

On load dependence of detachment rate of kinesin motor

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Chinese Physics B 2025年第1期34卷 498-505页

作者： Xiao-xuan Shi Yao Wang yu-Ru Liu Ping Xie School of Pharmaceutical Engineering Chongqing Chemical Industry Vocational CollegeChongqing 401220China Laboratory of Soft Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China

Kinesin is an archetypal microtubule-based molecular motor that can generate force to transport cargo in cells. The load dependence of the detachment rate is an important factor of the kinesin motor, the determination of which is critically related to the chemomechanical coupling mechanism of the motor. Here, we use three models for the load dependence of the detachment rate of the kinesin motor to study theoretically and numerically the maximal force generated and microtubuleattachment duration of the motor. By comparing the theoretical and numerical results with the available experimental data,we show that only one model can explain well the available experimental data, indicating that only this model can be applicable to the kinesin motor.

关键词： kinesin detachment rate generated force chemomechanical coupling mechanism optical trapping

Mechanism of AsperosaponinⅥRelated to EGFR/MMP9/AKT/PI3K Pathway in Treatment of Rheumtoid Arthritis

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Chinese Journal of Integrative Medicine 2025年第2期31卷 131-141页

作者： LUO Jin-fang yu Yang LIU Jian-xin School of Basic Medicine Guizhou University of Traditional Chinese MedicineGuiyang(550025)China Sino-Pakistan Center on Traditional Chinese Medicine China-Pakistan International Science and Technology Innovation Cooperation Base for Ethnic Medicine Development in Hunan ProvinceSchool of Pharmaceutical SciencesHunan University of MedicineHuaihua CityHunan Province(418000)China

Objective:To explore the mechanism of action of asperosaponinⅥ(AⅥ)in the treatment of rheumatoid arthritis(RA)and validate it in ex vivo experiments using network pharmacology and molecular docking ***:The predicted targets of AⅥwere obtained from PharmMaper,UniProt and Swiss Target Prediction platforms,the disease targets were collected from Online Mendelian Inheritance in Man,Therapeutic Target Database and Gene Cards databases,the intersection targets of AⅥand RA were obtained from Venny 2.1.0,and the protein-protein interaction(PPI)network was obtained from STRING database,which was analyzed by Cytoscape software and screened to obtain the core *** software was used to analyze PPI network and screen the core *** on the Database for Annotation,Visualization and Integrated Discovery database,Gene Ontology functional and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis were performed,and Cytoscape software was used to construct the"DiseasePathway-Target-Drug"network,which was finally verified by molecular docking and animal ***:Network pharmacological studies showed that AⅥwas able to modulate 289 targets,with 102 targets for the potential treatment of RA,with the core pathway being the AKT/PI3K signaling pathway,and the core targets being the epidermal growth factor receptor(EGFR)and matrix metalloproteinase 9(MMP9).Molecular docking results showed that AⅥcould produce strong binding with both of the 2 core *** vitro cellular experiments showed that AⅥreduced nitric oxide,prostaglandin E_2,tumor necrosis factor-alpha(TNF-α),interleukin-6(IL-6),and IL-1βlevels(P<0.05)and inhibited cyclooxygenase-2,nitric oxide synthase,EGFR,MMP9,phosphorylated phosphoinositide 3-kinase(p-PI3K),and phosphorylated serine-threonine kinase(p-AKT)proteins(P<0.05).The results of in vivo studies showed that AⅥimproved RA score and foot swelling thickness and decreased TNF-α,IL-6,p-PI3K and p-AKT levels in RA rat

关键词： inflammation rheumatoid arthritis network pharmacology asperosaponinⅥ EGFR/MMP9/AKT/PI3K pathway

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商品林可持续经营问题探析

浙江林学院学报 2005年第3期22卷 322-325页

作者：宣裕方周伯煌浙江大学法学院浙江杭州310028 浙江林学院浙江临安311300

在分析商品林可持续经营现实意义的基础上,指出了目前制约我国商品林可持续经营的主要因素:投入政策不宽松;现有的限额采伐政策与市场经济条件下商品林经营规律相悖;林业税费繁重,经营者负担过重;商品林经营管理体制与社会生产力发展不... 详细信息

在分析商品林可持续经营现实意义的基础上,指出了目前制约我国商品林可持续经营的主要因素:投入政策不宽松;现有的限额采伐政策与市场经济条件下商品林经营规律相悖;林业税费繁重,经营者负担过重;商品林经营管理体制与社会生产力发展不相适应等。提出了完善商品林可持续经营的主要对策:①加强对商品林发展的金融支持,创造良好的投资环境;②改革商品林的采伐管理制度,促进商品林建设;③改革林业税费制度,减轻商品林经营者的负担;④构建新型商品林经营管理体制。

关键词：商品林可持续经营采伐管理制度税费制度

Hyperbranched Poly(α-aminonitrile)s Constructed via Catalyst-Free Multicomponent Polymerization of Trialdehydes, Diamines and Trimethylsilyl Cyanide

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CHINESE JOURNAL OF POLYMER SCIENCE 2025年第2期43卷 341-349页

作者： Cheng, Tian-yu Ding, Jian-Qing Tong, yu-Xin fang, Jun-Guo Wang, Jia Anhui Polytech Univ Sch Chem & Environm Engn Wuhu 241000 Peoples R China Songshan Lake Mat Lab Dongguan 523808 Peoples R China

Functional hyperbranched polymers, as an important class of materials, are widely applied in diverse areas. Therefore, the development of simple and efficient reactions to prepare hyperbranched polymers is of great significance. In this work, trialdehydes, diamines, and trimethylsilyl cyanide could easily undergo multicomponent polymerization under mild conditions, producing hyperbranched poly(alpha-aminonitrile)s with high molecular weights (Mw up to 4.87x104) in good yields (up to 85%). The hyperbranched poly(alpha-aminonitrile)s have good solubility in commonly used organic solvents, high thermal stability as well as morphological stability. Furthermore, due to the numerous aldehyde groups in their branched chains, these hb-poly(alpha-aminonitrile)s can undergo one-pot, two-step, four-component post-polymerization with high efficiency. This work not only confirms the efficiency of our established catalyst-free multicomponent polymerization of aldehydes, amines and trimethylsilyl cyanide, but also provides a versatile and powerful platform for the preparation of functional hyperbranched polymeric materials.

关键词： Catalyst-free Multicomponent polymerization Hyperbranched polymer Post-polymerization

Reveal short range interactions between u/d quarks in the NN, D03, and D30 systems

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Science China(Physics,Mechanics & Astronomy) 2025年第3期Mechanics & Astronomy) .卷 106-115页

作者： Qi-fang Lü yu-Bing Dong Peng-Nian Shen Zong-Ye Zhang Department of Physics Hunan Normal University Key Laboratory of Low-Dimensional Quantum Structures and Quantum Control of Ministry of Education Key Laboratory for Matter Microstructure and Function of Hunan Province Hunan Normal University Institute of High Energy Physics Chinese Academy of Sciences School of Physical Sciences University of Chinese Academy of Sciences

The dynamic mechanism of short range interactions between u/d quarks remains an open and challenging problem. In order to reveal this quark dynamics, we perform a systematic analysis of N N, D03, and D30systems in the（extended） chiral SU（3） constituent quark models. By comparing results calculated with different models and different parameter sets, the effects of one gluon exchange and vector meson exchange terms are carefully examined. The results indicate that the vector meson exchange interactions dominate the short range interactions between u/d quarks, whereas the small residual one gluon exchange coupling strength is also allowed.

关键词： short range interactions dibaryons constituent quark models

New Insights on Gamma-Ray Burst Radiation Mechanisms from Multiwavelength Observations

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Research in Astronomy and Astrophysics 2025年第2期25卷 3-12页

作者： yu-Hua Yao fang-Sheng Min Shi Chen Yi-Qing Guo College of Physics Chongqing University Key Laboratory of Particle Astrophysics Institute of High Energy Physics Chinese Academy of Sciences Wisconsin Ice Cube Particle Astrophysics Center University of Wisconsin–Madison University of Chinese Academy of Sciences School of Physics and Astronomy Yunnan University Tianfu Cosmic Ray Research Center

The study of high-energy gamma-ray emission from gamma-ray bursts(GRBs) involves complex synchrotron radiation and synchrotron self-Compton(SSC) scattering mechanisms with multiple parameters exhibiting a wide distribution. Recent advancements in GRB research, particularly the observation of very high energy(VHE,>100 Ge V) radiation, have ushered in a new era of multiwavelength exploration, offering fresh perspectives and limitations for understanding GRB radiation mechanisms. This study aimed to leverage VHE observations to refine constraints on synchrotron + SSC radiation from electrons accelerated by forward shocks. By analyzing two external environments—the uniform interstellar medium and stratified stellar wind medium, we conducted spectral and variability fitting for five specific bursts(GRB 180720B, GRB 190114C, GRB 190829A, GRB 201216C, and GRB 221009A) to identify the optimal parameters characterizing these events. A comparative analysis of model parameter distributions with and without VHE radiation observations reveals that the magnetic energy equipartition factor εBis more concentrated with VHE emissions. This suggests that VHE emissions may offer greater constraints on this microphysical parameter. Additionally, we found that the energy budget between VHE and ke V–Me V γ-ray emissions under the SSC radiation exhibits an almost linear relationship, which may serve as a tool to differentiate radiation mechanisms. We anticipate future statistical analyses of additional VHE bursts to validate our findings.

关键词： (transients:) gamma-ray bursts gamma-rays: ISM radiation mechanisms: non-thermal