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Hemoglobin integrated red blood cell membrane-coated metalorganic framework nano-platform for improving the self-adaptive blood glucose management

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Nano Research 2025年第1期18卷 618-627页

作者： Shuai Wu Li Zhu Sheng Ni Xiong Zhao Meng Yan Yuan Zhong Karissa Kusuma Yi liang Kaiwen Bao Kai Qu Xian Qin kun Zhang Wuquan Deng Da Sun Wei Wu Key Laboratory of Biorheological Science and Technology Ministry of EducationCollege of BioengineeringChongqing UniversityChongqing 400044China Chongqing University Three Gorges Hospital Chongqing Municipality Clinical Research Center for Endocrinology and Metabolic DiseasesChongqing 404000China Institute of Life Sciences&Biomedical Collaborative Innovation Center of Zhejiang Province Wenzhou UniversityWenzhou 325035China Department of Endocrinology School of MedicineChongqing Emergency Medical CenterChongqing University Central HospitalChongqing 400014China

Diabetes,a prevalent chronic metabolic disorder,often leads to severe ***,existing treatment methods may pose life-threatening risks due to poor patient compliance and inaccurate dosing of subcutaneous insulin ***,a biomimetic red blood cell(RBC)membrane-coated glucose-responsive nanoplatform is developed for controlling insulin *** nanoplatforms with RBC membrane can prolong the half-life of nano-formulation in vivo mediated by the biomimetic immune ***,the cascade catalytic effect of glucose oxidase(GOx)encapsulated in metal-organic frameworks(MOFs)and hemoglobin(Hb)in the RBC membrane are able to not only facilitate glucose-responsive insulin release,but also eliminate the detrimental by-product hydrogen peroxide(H_(2)O_(2))resulting from the Hb mediated H_(2)O_(2)*** in vitro and in vivo studies have demonstrated the favorable glucose-responsive performances of this advanced nano-platform with a single intravenous injection maintaining blood glucose balance in Type 1 Diabetes(T1D)mice for an extended duration without the hypoglycemia ***,this biomimetic insulin delivery system is poised to function as a strategy for the intravenous insulin administration,offering a promising drug candidate for the self-adaptive long-term T1D treatment.

关键词： glucose-responsive metal-organic frameworks red blood cell membrane insulin delivery glucose oxidase hemoglobin

Experimental investigation of evolutive mode-I and mode-II fracture behavior of fiber-reinforced cemented paste backfill:Effect of curing temperature and curing time

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Frontiers of Structural and Civil Engineering 2023年第2期17卷 256-270页

作者： kun FANG liang CUI School of Mines China University of Mining&TechnologyXuzhou 221116China Department of Civil Engineering Lakehead UniversityOntario P7B 5E1Canada

The curing temperature-dependent cement hydration causes the nonlinear evolution of fracture behavior and properties of fiber-reinforced cemented paste backfill(CPB)and thus influences the stability of mine backfill materials in deep ***,the coupled effect of curing temperature(20,35,and 45℃)and cement hydration at different curing times(3,7,and 28 d)on the mode-I and mode-II fracture behavior and properties of fiber-reinforced CPB is investigated.A comprehensive experimental testing program consisting of semicircular bend tests,direct shear tests,measurement of volumetric water content and matric suction,TG/DTG tests,and SEM observation is carried *** results show that the coupled thermochemical effect results in strongly nonlinear development of pre-and post-peak behavior of fiber-reinforced ***,the results discover a positive linear correlation between fracture toughness and shear strength parameters and also reveal the vital role played by matric suction in the formation of fracture ***,predictive functions are developed to estimate the coupled thermochemical effect on the development of KIc and ***,the findings and the developed mathematical tools have the potential to promote the successful application of fiber-reinforced CPB technology in deep underground mines.

关键词： fiber reinforcement cemented paste backfill fracture behavior underground mine cement hydration

Thermal Feature Analysis of a New Hot-Air Anti-Icing Structure

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Journal of Thermal Science 2023年第3期32卷 911-921页

作者： liang Jiuli xuan Yimin LIAN Wenlei School of Energy and Power Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China Key Laboratory of Thermal Management and Energy Utilization of Aviation Vehicles Ministry of Industry and Information TechnologyNanjing 210016China

Ice accretion on surfaces of the aircraft and engine is a serious threat to the flight *** this paper,a novel hot air anti-icing method is proposed based on the porous *** the NACA0012 airfoil as an example,the traditional thermal protection structure is proved to exist the deficiency in balancing the heat exchange caused by route loss of the *** dividing the hot chamber into multiple regions to fill with various foam metal,flow resistance characteristics and heat transfer characteristics for this protection mode are analyzed in order to derive the maximized benefit in anti-icing *** calculation results reveal that,under the same condition,the region filled with foamed copper not only improves the temperature uniformity on the anti-icing area,but also achieves a better protection effect for enhancing heat transfer between the tube and the hot gas,averagely above 20℃higher than it without porous foam filling in surface ***,the minimum mass flow rate of the protection hot air is reduced by 16.7%.The gratifying efficiency of the porous filler in fortifying heat transfer confirms the potential of replacing the efficient but complex heat transfer design with simple structure filled with foam metal.

关键词： ice accretion hot air anti-icing foam metal heat transfer

Full-endoscopic spine surgery treatment of lumbar foraminal stenosis after osteoporotic vertebral compression fractures:A case report

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World Journal of Clinical Cases 2022年第2期10卷 656-662页

作者： Quan-Lai Zhao kun-Peng Hou Zhong-xuan Wu liang Xiao Hong-Guang Xu Department of Spine Surgery Wannan Medical CollegeWuhu 241001Anhui ProvinceChina

BACKGROUND Few reports have described lumbar foraminal stenosis-induced radiculopathy after treatment by full-endoscopic spine surgery(FESS)combined with percutaneous vertebroplasty(PVP)in patients with vertebral compression *** herein report such a case,including the patient’s treatment process and doctor’s surgical *** SUMMARY A 79-year-old man presented with symptoms of radiculopathy after sustaining L4 vertebral compression *** and physical examination revealed L4 vertebral compression fractures combined with L3/4 Lumbar foraminal stenosis(LFS).The patient’s symptoms were low back pain with pain in the lateral left *** many reports have described radiculopathy induced by osteoporotic vertebral compression fractures,the use of FESS combined with PVP has rarely been *** case report indicates that the combination of FESS and PVP is a safe and effective approach for the treatment of LFS-induced radiculopathy after vertebral compression *** minimally invasive technique has great potential to replace traditional lumbar fixation and decompression ***,we suggest the continued accumulation of similar cases to discuss the wider application of *** For patients with osteoporotic vertebral compression fracture(OVCF)and LFS,PVP and FESS can be used to restore the vertebral height and reduce the pressure around the intervertebral ***,the combination of FESS and PVP can treat the pain or numbness of the low back and lower limbs and allow for recovery in a short time with excellent postoperative *** general,FESS is a good treatment for radiculopathy caused by foraminal stenosis after OVCF.

关键词： Osteoporotic vertebral compression fracture Lumbar foraminal stenosis Percutaneous vertebroplasty Full-endoscopic spine surgery Radiculopathy Case report

Comparison of Fifth-OrderWENO Scheme and Finite Volume WENO-Gas-Kinetic Scheme for Inviscid and Viscous Flow Simulation

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Communications in Computational Physics 2013年第8期14卷 599-620页

作者： Jun Luo Lijun xuan kun Xu Mathematics Department Hong Kong University of Science and TechnologyClear Water BayKowloonHong Kong

The development of high-order schemes has been mostly concentrated on the limiters and high-order reconstruction *** this paper,the effect of the flux functions on the performance of high-order schemes will be *** on the same WENO reconstruction,two schemes with different flux functions,i.e.,the fifthorderWENO method and the WENO-Gas-kinetic scheme(WENO-GKS),will be *** fifth-order finite difference WENO-SW scheme is a characteristic variable reconstruction based method which uses the Steger-Warming flux splitting for inviscid terms,the sixth-order central difference for viscous terms,and three stages Runge-Kutta time stepping for the time *** the other hand,the finite volume WENO-GKS is a conservative variable reconstruction based method with the same WENO ***,it evaluates a time dependent gas distribution function along a cell interface,and updates the flow variables inside each control volume by integrating the flux function along the boundary of the control volume in both space and *** order to validate the robustness and accuracy of the schemes,both methods are tested under a wide range of flow conditions:vortex propagation,Mach 3 step problem,and the cavity flow at Reynolds number *** study shows that both WENO-SW and WENO-GKS yield quantitatively similar results and agree with each other very well provided a sufficient grid resolution is *** the reduction of mesh points,the WENO-GKS behaves to have less numerical dissipation and present more accurate solutions than those from the WENO-SW in all test *** the Navier-Stokes equations,since theWENO-GKS couples inviscid and viscous terms in a single flux evaluation,and the WENO-SW uses an operator splitting technique,it appears that theWENO-SWismore sensitive to theWENO reconstruction and boundary *** terms of efficiency,the finite volume WENO-GKS is about 4 times slower than the finite differenceWENO-SW in two dimensional simulat

关键词： WENO scheme gas-kinetic scheme Euler equations Navier-Stokes equations highorder methods

Spatiotemporal evolution of thermo-hydro-mechanical-chemical processes in cemented paste backfill under interfacial loading

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International Journal of Mining Science and Technology 2022年第6期32卷 1207-1217页

作者： Sai Pramod Singalreddy liang Cui kun Fang Department of Civil Engineering Lakehead UniversityThunder BayOntario P7B 5E1Canada

Cemented paste backfill(CPB)and rock interface interaction causes the formation of an interfacial loading and affects the thermal,hydraulic,mechanical,and chemical processes in bulk CPB and thus its in-situ *** this study,a new meter-sized column model is developed to systematically investigate the multiphysics processes in CPB under interfacial *** obtained results discover that for the mechanical process,the interfacial loading leads to a reduced settlement and a weakened stress level in *** the hydraulic process,lower matric suction and smaller moisture content coexist in CPB under interfacial *** the thermal process,the interfacial loading weakens the porosity-dependent thermal conduction and causes retardation in temperature variation relative to the ambient *** the chemical process,weakened cement hydration with smaller electrical conductivity was observed in CPB under interfacial ***,the obtained results reveal the linkage between the interfacial loading and multiphysics processes in CPB and thus contribute to an in-depth understanding of the multiphysics behavior of CPB in underground mines.

关键词： Spatiotemporal evolution Multiphysics processes Interfacial loading Cemented paste backfill Underground mine

Monoclinicβ-AgVO_(3) coupled with CdS formed a 1D/1D p-n heterojunction for efficient photocatalytic hydrogen evolution

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Rare Metals 2023年第5期42卷 1494-1507页

作者： xuan-Pu Wang Zhi-liang Jin Xin Li School of Chemistry and Chemical Engineering North Minzu UniversityYinchuan750021China Institute of Biomass Engineering Key Laboratory of Energy Plants Resource and UtilizationMinistry of Agriculture and Rural AffairsSouth China Agricultural UniversityGuangzhou510642China

Improving the separation of photogenerated carriers and suppressing the rapid complication of electron-hole pairs are essential ways to improve photocatalytic hydrogen production *** high recombination rate of the photogenerated carriers is an issue encountered when developing CdS as a promising photocatalytic *** work allowed to accelerate the separation of photogenerated electrons and holes by loading monoclinicβ-AgVO_(3)on hexagonal CdS nanorods to construct a one-dimensional(1D)/1D p-n *** introduction of monoclinicβ-AgVO_(3)with a narrow band gap effectively improves the light absorption of CdS,which is conducive to improving the use of visible *** integrated electric field of the p-n heterojunction can effectively transfer electrons and holes in the direction suitable to hydrogen *** photoluminescence and electrochemical characterization of the catalysts showed that the p-n heterojunction formed after loadingβ-AgVO_(3)greatly improved the separation efficiency of *** hydrogen evolution experiments show that the composite catalyst has good photocatalytic hydrogen evolution capability and *** composite catalyst with the best photocatalytic performance was obtained by studyingβ-AgVO_(3)with different *** composite catalyst reached 581.5μmol of hydrogen amount within 5 h,which is 3.8 times higher than that of CdS alone and its apparent quantum efficiency reaches8.02%.The present work provides a possible solution for the development of perovskite and the extensiveness of CdS in photocatalytic hydrogen evolution.

关键词： Photocatalysis Hydrogen evolution p-n heterojunction AgVO_(3)

Distributed Real-time Temperature and Energy Control of Energy Efficient Buildings via Geothermal Heat Pumps

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CSEE Journal of Power and Energy Systems 2023年第6期9卷 2289-2300页

作者： Xiaotian Wang Lei liang xuan Zhang Hongbin Sun Tsinghua-Berkeley Shenzhen Institute Tsinghua UniversityShenzhenChina Department of Electrical Engineering Tsinghua UniversityBeijingChina

Geothermal heat pumps(GHPs)are a type of heating ventilation and air conditioning(HVAC)systems that use low-temperature resources from soil and groundwater for heating/*** recent years,there has been an increasing interest in GHP systems due to their high energy efficiency and abundant geothermal ***,the optimization and control design of the GHP system has become a hot *** the other hand,as the GHP system is an ideal respon-sive load,mechanism design for the GHP system to realize demand response(DR)in a virtual power plant(VPP)without affecting user comfort is particularly *** this paper,we propose a distributed real-time temperature and energy management method via GHP systems for multi-buildings,where both floor and radiator heating/cooling distribution subsystems in multiple thermal zones are *** design an energy demand response mechanism for a single GHP to track the given energy consumption command for participating in VPP aggregation/***,a coordination mechanism for multiple GHPs is designed for the community-level oper-ator in joining VPP aggregation/*** designed schemes are scalable and do not need to measure or predict any exogenous disturbances such as outdoor temperature and heating disturbances from external sources,e.g.,user activity and device ***,four numerical examples for the simulation of two different scenarios demonstrate the effectiveness of the proposed methods.

关键词： Building temperature and energy management disaggregation distributed control GHP HVAC VPP

Numerical Studies of Estimation of Fracture Parameters for Mismatched Welded Joints with HAZ Cracks

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Journal of Iron and Steel Research International 2015年第9期22卷 846-851页

作者： kun LING Zheng-dong WANG Fu-zhen xuan Key Laboratory of Pressure Systems and Safety Ministry of EducationEast China University of Science and Technology

An idealized tri-material assumption is established to describe the constitutive relationship of mismatched welded joints by considering the influence of heat affected zone（HAZ）.The fracture parameters Jand C＊are estimated for mismatched welded joints with HAZ cracks by finite element analysis with ABAQUS.A middle crack tension（M（T））specimen is utilized in the analysis for different material properties and geometries of the *** influence of mechanical property and geometry on the fracture parameters Jand C＊of the specimen is discussed for the welded joints with HAZ *** results suggest that the HAZ property is a significant factor in the estimation of Jand C＊for the mismatched welded joint with HAZ crack.

关键词： mismatched welded joint tri-material assumption heat affected zone(HAZ) J-integral C*parameter