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Repeatability and agreement of CCT measurement in myopia using entacam and ultrasound pachymetry

International Journal of Ophthalmology(English edition) 2012年第3期5卷 329-333页

作者： Yong-Heng Luo, xuan-chu duan Department of Ophthalmology the Second Xiangya Hospital Central South University Changsha 410011 Hunan Province China Department of Ophthalmology Rikang Hospital Guangxi Traditional Chinese Medical College Nanning 530011 Guangxi Zhuang Autonomous Region China

AIM: To evaluate the repeatability of central corneal thickness (CCT) measurement by entacam, and agreement of CCT measured by Pentacam and ultrasound pachymetry (USP) in Chinese myopia. Thereby investigate the possibility of Pentacam as a substitute for USP in CCT measurement before refractive surgery. The effects of corneal curvature measured by Pentacam on CCT were also evaluated. METHODS: One hundred and forty-eight right eyes of 148 individual with myopia were included in this study. Three successive Pentacam CCT measurements followed by 10 successive ultrasound pachymetry were carried out in the 148 eyes. Mean of CCT taken by each device was calculated for comparison. According to the CCT measured by USP, all the 148 eyes were divided into 3 groups: 560 mu m. For all eyes and each group the CCT obtained by Pentacam and USP were compared. Anterior corneal curvature of the 148 eyes was also adopted for correlation analysis with CCT obtained by ultrasound pachymetry. In addition, CCT measurement using 60 random selected Scheimpflug images was performed by 3 skilled investigators at different time, and this was repeated for 3 times by a forth investigator to assess repeatability of Pentacam CCT measurement using Scheimpflug images. RESULTS: Intraclass correlation coefficient (ICC) analysis revealed high intraobserver repeatability (ICC=0.994, F=158.60, P<0.001) for CCT measurement by Pentacam. The interobserver (ICC=0.998, F =494.73, P <0.001) and intraobserver (ICC=0.997, F=383.98, P<0.001) repeatability for Pentacam CCT measurements using Scheimpflug images were also excellent. There was high positive correlation between the CCT values measured by Pentacam and ultrasound pachymetry (r=0.963, P<0.001). Bland-altman plots showed that the Pentacam underestimate the CCT by 8.02 mu m compared with ultrasouond *** differences between Pentacam and USP increased as the CCT readings by USP increased (Pentacam vs USP: slope=-0.04, P< 0

关键词： pentacam central corneal thickness ultrasound pachymetry repeatability agreement

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Diagnosis and treatment of myopic traction maculopathy

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International Journal of Ophthalmology(English edition) 2012年第6期5卷 754-758页

作者： Ping-Bo Ouyang xuan-chu duan Xiao-Hua Zhu Department of Ophthalmology the Second Xiangya Hospital of Central South University

In recent years, the broad application of optical coherence tomography and vitrectomy, combined with research efforts in maculopathy in high myopia have provided many achievements, such as the new classification of myopic traction maculopathy (MTM). Here, we review the latest developments in the diagnosis and treatment of MTM, including its conception, clinical characteristics, pathogenesis, clinical stages, and the options for surgical treatment.

关键词： myopic traction maculopathy optical coherence tomography high myopia vitrectomy

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Biomechanics of the sclera and effects on intraocular pressure

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International Journal of Ophthalmology(English edition) 2016年第12期9卷 1824-1831页

作者： Xu Jia Juan Yu Sheng-Hui Liao xuan-chu duan Department of Ophthalmology the Second Xiangya Hospital Central South University Changsha 410011 Hunan Province China Department of Ophthalmology the First Hospital of Hunan University of Chinese Medicine Changsha 410011 Hunan Province China School of Information Science and Engineering Central South University Changsha 410011 Hunan Province China

Accumulating evidence indicates that glaucoma is a multifactorial neurodegenerative disease characterized by the loss of retinal ganglion cells （RGC）, resulting in gradual and progressive permanent loss of vision. Reducing intraocular pressure （IOP） remains the only proven method for preventing and delaying the progression of glaucomatous visual impairment. However, the specific role of IOP in optic nerve injury remains controversial, and little is known about the biomechanical mechanism by which elevated IOP leads to the loss of RGC. Published studies suggest that the biomechanical properties of the sclera and scleral lamina cribrosa determine the biomechanical changes of optic nerve head, and play an important role in the pathologic process of loss of RGC and optic nerve damage. This review focuses on the current understanding of biomechanics of sclera in glaucoma and provides an overview of the possible interactions between the sclera and IOP. Treatments and interventions aimed at the sclera are also discussed.

关键词： biomechanics glaucoma sclera intraocular pressure finite element models

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A case of 9p deletion syndrome with congenital infantile glaucoma,effective method of diagnosis,and treatment

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International Journal of Ophthalmology(English edition) 2017年第2期10卷 318-320页

作者： Xu Jia Xu-Yang Liu xuan-chu duan Department of Ophthalmology the Second Xiangya HospitalCentral South University Department of Ophthalmology Shenzhen Eye Hospital of Jinan University

Dear Editor,I am *** X from the Department of Ophthalmology,Second Xiangya Hospital,Central South University,Changsha,China.I write to present a rare case report of 9p deletion syndrome with congenital infantile glauc... 详细信息

关键词： case A case of 9p deletion syndrome with congenital infantile glaucoma,effective method of diagnosis,and treatment IOP

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Therapeutic effect of Keap1-Nrf2-ARE pathway-related drugs on age-related eye diseases through anti-oxidative stress

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International Journal of Ophthalmology(English edition) 2021年第8期14卷 1260-1273页

作者： Zi-Yan Cai Meng-Die Fu Ke Liu xuan-chu duan Department of Ophthalmology the Second Xiangya Hospital of Central South UniversityChangsha 410011Hunan ProvinceChina Department of Ophthalmology Changsha Aier Eye HospitalChangsha 410011Hunan ProvinceChina

Age-related eye diseases,including cataract,glaucoma,diabetic retinopathy(DR),and age-related macular degeneration(AMD),are the leading causes of vision loss in the *** studies have shown that the occurrence and development of these diseases have an important relationship with oxidative stress in the *** Keap1-Nrf2-ARE pathway is a classical pathway that resists oxidative stress and inflammation in the *** pathway is also active in the development of age-related eye diseases.A variety of drugs have been shown to treat agerelated eye diseases through the Keap1-Nrf2-ARE(Kelch-like ECH-Associating protein 1-nuclear factor erythroid 2 related factor 2-antioxidant response element)*** review describes the role of oxidative stress in the development of age-related eye diseases,the function and regulation of the Keap1-Nrf2-ARE pathway,and the therapeutic effects of drugs associated with this pathway on age-related eye diseases.

关键词： oxidative stress Keap1-Nrf2-ARE pathway age-related eye diseases

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Changes of optic nerve head microcirculation in high myopia

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International Journal of Ophthalmology(English edition) 2023年第1期16卷 102-107页

作者： Wen-Quan Tang Yu-Lin Luo Xi-Lang Wang xuan-chu duan Department of Ophthalmology Hunan Children’s HospitalChangsha 410007Hunan ProvinceChina Changsha Aier Eye Hospital Changsha 410011Hunan ProvinceChina Aier School of Ophthalmology Central South UniversityChangsha 410011Hunan ProvinceChina

AIM:To analyze the correlation of age,spherical equivalent(SE),and axial length(AL)with the microcirculation of optic nerve head(ONH)in high myopia(HM).METHODS:In this cross-sectional clinical study,164 right eyes were *** coherence tomography angiography(OCTA)was used to detect ONH vessel *** were classified based on age,SE,and *** of Age1,Age2,and Age3 were denoted for age classification(Age10.05)and the SE1,SE2,and SE3 groups(all P>0.05).No significant difference was observed in the intrapapillary vascular density(IVD)among AL1,AL2,AL3,and AL4 groups(P>0.05).However,a significant decrease was found in the peripapillary vascular density(PVD)in the AL1,AL2,AL3,and AL4 groups(F=3.605,P=0.015),especially in the inferotemporal(IT;F=6.25,P0.05).The PVD was correlated with AL(r=-0.236,P0.05).CONCLUSION:With the increase of AL,the IVD remains stable while the PVD decreases,especially in the three directions of temporal(IT,TI,and TS).The main cause of microcirculation reduction may be related to AL elongation rather than an increase in age or SE.

关键词： high myopia optic nerve head optical coherence tomography angiography vascular density axial length

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Assessment of intraocular pressure measured by Reichert Ocular Response Analyzer,Goldmann Applanation Tonometry,and Dynamic Contour Tonometry in healthy individuals

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International Journal of Ophthalmology(English edition) 2012年第1期5卷 102-107页

作者： Ping-Bo Ouyang Cong-Yi Li Xiao-Hua Zhu and xuan-chu duan Department of Ophthalmology the Second Xiangya Hospital of Central South University Changsha 410011 Hunan Province China

AIM: To investigate the accuracy of intraocular pressure (IOP) as measured by a Reichert Ocular Response Analyzer (ORA), as well as the relationship between central corneal thickness (CCT) and IOP as measured by ORA, Goldmann applanation tonometry (GAD, and dynamic contour tonometry (DCT). METHODS: A total of 158 healthy individuals (296 eyes) were chosen randomly for measurement of IOP. After CCT was measured using A-ultrasound (A-US), IOP was measured by ORA, GAT, and DCT devices in a randomized order. The IOP values acquired using each of the three tonometries were compared, and the relationship between CCT and IOP values were analyzed separately. Two IOP values, Goldmann-correlated IOP value (IOPg) and corneal-compensated intraocular pressure (IOPcc), were got using ORA. Three groups were defined according to CCT: 1) thin cornea (CCT580 mu m) groups. RESULTS: In normal subjects, IOP measurements were 14.95 2.99mmHg with ORA (IOPg), 15.21+/- 2.77mmHg with ORA(IOPcc),1522+/- 2.77mmHg with GAT,and 15.49+/- 2.56mmHg with DCT. Mean differences were 0.01+/- 2.29mmHg between IOPcc and GAT (P >0.05) and 0.28+/- 2.20mmHg between IOPcc and DC (P >0.05). There was a greater correlation between IOPcc and DCT (r =0.946, P =0.000) than that between IOPcc and GAT (r=0.845, P=0.000). DCT had a significant correlation with GAT (r=0.854, P=0.000). GAT was moderately correlated with CCT (r=0.296, P580 mu m) showed the least significant correlation between IOPcc and GAT (r=0.859, 0.000); while the thin cornea group (CCT< 520 mu m) had the most significant correlation between IOP

关键词： intraocular pressure tonometry central corneal thickness

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Efficacy and necessity of prophylactic vitrectomy for acute retinal necrosis syndrome

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International Journal of Ophthalmology(English edition) 2012年第4期5卷 482-487页

作者： Yong-Heng Luo xuan-chu duan Bai-Hua Chen Luo-Sheng Tang and Xiao-Jian Guo Department of Ophthalmology the Second Xiangya Hospital Central South University Changsha 410011 Hunan Province China

AIM: To compare the efficacy of prophylactic vitrectomy for acute retinal necrosis syndrome(ARN) with routine treatment in Chinese patients, thereby investigate the necessity of prophylactic vitrectomy for ARN. METHODS: Thirty patients (37 eyes) were retrospectively included in this study. The eyes were divided into 2 groups by treatment, including routine treatment, which consisted of antiviral medication and vitrectomy after retinal detachment (RD) (n=21), and prophylactic vitrectomy, which consisted of antiviral medication and vitrectomy for the prevention of RD performed during the active inflammatory phase (n=16). The extent of necrosis was determined by fundus photographs at the time of presentation (for eyes with mild vitreous opacity) or the drawings in the operation records. Necrosis of the 37 eyes was divided into 3 grades, including peripheral, middle-peripheral and extensive. The follow-up period ranged from 8 to 57 months. Differences in visual acuity and necrosis between groups were identified using independent samples t-test. RESULTS: Necrosis was more extensive in the routine treatment group than in the prophylactic vitrectomy group (P<0.05). In the routine treatment group, conservative treatment improved necrosis and prevented RD in 6 eyes (29%). Seven eyes (33%) obtained anatomical success, but retinal redetachment occurred in 8 eyes (57%). There were also 5 eyes (24%) developed ocular hypotony or atrophy. Ten eyes (48%) achieved equal or increased visual acuity. In the prophylactic vitrectomy group, RD occurred in 2 eyes (13%). Twelve eyes (75%) were completely anatomically successful, and 10 eyes underwent silicone oil removal. Only one eye (6%) became ocular hypotony. Fourteen eyes (88%) achieved equal or increased visual acuity. The prophylactic vitrectomy group achieved better vision trends than the routine treatment group (P<0.05). Eyes with peripheral necrosis had better visual outcomes than those with mid-peripheral (P<0.05) or extensive (P

关键词： acute retinal necrosis prophylactic vitrectomy retinal detachment visual acuity

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Descemet membrane detachment after trabeculectomy

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International Journal of Ophthalmology(English edition) 2012年第4期5卷 527-529页

作者： Yue-Hua Li Jing-Ming Shi Fang Fan xuan-chu duan Song-Bai Jia Department of Ophthalmology the 2^nd Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina

Descemet's membrane detachment (DMD) can be a potentially serious complication of intraocular surgery or ocular trauma. The cause is not very clear. We are trying to remind an awareness of the spectrum of DMD resultin... 详细信息

关键词： Descemet membrane detachment trabeculectomy glaucoma cornea

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滤过道瘢痕化相关信号传导通路及其干扰靶位

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国际眼科杂志 2009年第3期9卷 542-545页

作者：樊芳段宣初中南大学湘雅二医院眼科中国湖南省长沙市410011

青光眼滤过性手术后滤过道的瘢痕化是手术失败的主要原因,它以Tenon’s囊成纤维细胞转化为肌成纤维细胞持续存在并产生大量的细胞外基质为主要特征。多种细胞因子通过TGF-β/Smad,Rho-ROCK,MAPK以及NF-κB等信号通路调控瘢痕化的进程,利... 详细信息

青光眼滤过性手术后滤过道的瘢痕化是手术失败的主要原因,它以Tenon’s囊成纤维细胞转化为肌成纤维细胞持续存在并产生大量的细胞外基质为主要特征。多种细胞因子通过TGF-β/Smad,Rho-ROCK,MAPK以及NF-κB等信号通路调控瘢痕化的进程,利用RNA干扰技术和其它方法调节信号传导途径中的关键分子,如Smad,ROCK,P38MAPK等可以减轻或预防滤过道瘢痕化,提高手术成功率。本文综述影响滤过道瘢痕化的主要信号传导通路以及针对不同通路进行干预的化学药物和基因治疗的研究进展。

关键词：青光眼滤过性手术瘢痕化信号传导

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