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Cancer Communications 2020年第8期40卷 355-369页

作者： Zhong-Guo Zhou Jin-Bin Chen Rong-Xin Zhang Ling Ye Jun-ChengWang Yang-Xun Pan xiao-HuiWang Wen-xuan Li Yao-Jun Zhang Li Xu Min-Shan Chen State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhouGuangdong 510060P.R.China Department of Liver Surgery Sun Yat-sen University Cancer CenterGuangzhouGuangdong 510060P.R.China Department of Colorectal Cancer Sun Yat-sen University Cancer CenterGuangzhouGuangdong 510060P.R.China Department of Oncology The First Affiliated Hospital of Jinan UniversityGuangzhouGuangdong 510630P.R.China

Background:Hepatocellular carcinoma(HCC)is a major health problem and a primary cause of cancer-related death *** great advances have achieved recently by large-scale high-throughput analysis,the precise molecular mechanism underlying HCC progression remains to be clearly *** investigated the relationship between Tescalcin(TESC),a candidate oncogene,and clinicopathological features of HCC patients and explored the role of TECS in HCC ***:To identify new genes involved in HCC development,we analyzed The Cancer Genome Atlas liver cancer database,and TESC was selected for further *** tissue microarray analysis for TESC and its association with clinicopathological features were performed to investigate its clinical *** was knocked down by using short-hairpin *** proliferation was analyzed by WST-1 assay and cell *** apoptosis was tested by fluorescence-activated cell sorting.A subcutaneous xenograft tumor model in nude mice was established to determine the in vivo function of *** microarray was used to identify its molecular ***:TESC was significantly increased in HCC tissues compared with the adjacent normal liver *** expression of TESC was detected in 61 of 172 HCC patients by tissue *** tumor(>5 cm)and elevated total bilirubin were associated with high TESC expression(both P<0.050).In multivariate analysis,TESC was identified as an independent prognostic factor for short overall survival of HCC *** knockdown impaired HCC cell growth in vitro and in *** knockdown significantly increased cell apoptosis in HCC cell ***,Affymetrix microarray analysis revealed that TESC knockdown inhibited tumor proliferation-related pathways while activated cell death-related ***:TESC was identified as an independent prognostic factor for short overall survival of HCC patients,and was critical for HCC cell proli

关键词： Apoptosis Cell proliferation Hepatocellular carcinoma Oncogene Tescalcin

The association analysis polymorphism of CDKAL1 and diabetic retinopathy in Chinese Han population

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International Journal of Ophthalmology(English edition) 2016年第5期9卷 707-712页

作者： Nai-Jia Liu Qian Xiong Hui-Hui Wu Yan-Liang Li Zhen Yang xiao-Ming Tao Yan-Ping Du Bin Lu Ren-Ming Hu xuan-Chun Wang Jie Wen Department of Endocrinology and Metabolism Huashan Hospital Affiliated to Fudan University Department of Endocrinology and Metabolism Jing'an District Center Hospital of Shanghai Department of Endocrinology and Metabolism Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Department of Endocrinology and Metabolism Hua Dong Hospital Affiliated to Fudan University

AIM： To identify the contribution of CDKAL1 to the development of diabetic retinopathy（DR） in Chinese population.·METHODS： A case-control study was performed to investigate the genetic association between DR and polymorphic variants of CDKAL1 in Chinese Han population with type 2 diabetes mellitus（T2DM）. A welldefined population with T2 DM, consisting of 475 controls and 105 DR patients, was recruited. All subjects were genotyped for the genetic variant（rs10946398） of CDKAL1. Genotyping was performed by i PLEX technology. The association between rs10946398 and T2 DM was assessed by univariate and multivariate logistic regression（MLR） analysis.· RESULTS： There were significant differences in C allele frequencies of rs10946398（CDKAL1） between control and DR groups（45.06% versus 55.00%, P 〈0.05）.The rs10946398 of CDKAL1 was found to be associated with the increased risk of DR among patients with diabetes.·CONCLUSION： Our findings suggest that rs10946398 of CDKAL1 is independently associated with DR in a Chinese Han population.

关键词： CDKAL1 polymorphism association analysis diabetic retinopathy Chinese Han population

Experimental Investigation of Reflectometry as a Density Fluctuation Diagnostic

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Chinese Physics Letters 1996年第5期13卷 374-377页

作者： XU Hong-liang CAO Jin-xiang DING Wei-xing YU Chang-xuan Department of Modem Physics University of Science and Technology of ChinaHefei 230026

In this paper,a controlled laboratory experiment to investigate the response properties of reflec-tometry to the density fluctuations is *** reflectometer signal is observed to be highly spatially localized in the *** quantitative measurement has demonstrated that the signal originates about one free space wavelength of the probe•wave in front of the critical layer and this position is independent of the fluctuation *** is also found that the sensitivity of transverse response to wavenumbers is different from that of longitudinal response.

关键词： number. wave spatially

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三孩孕产妇妊娠及分娩体验的质性研究

中华护理杂志 2025年第1期60卷 24-30页

作者：夏家爱蒲丛珊单春剑顾璇张翔娣单艳吕明英王莹谢琳琳周晖南京医科大学附属妇产医院产科南京市210004 南京医科大学附属妇产医院护理部南京市210004 浙江省中医药大学护理学院

目的深入了解三孩孕产妇妊娠及分娩体验,为医护人员提供更系统、安全、针对性的三孩孕产妇围产期保健服务及护理措施提供依据。方法采用目的抽样法,选取2022年8月—2023年6月于南京市某三级甲等妇幼保健院建档并分娩的17名三孩孕产妇进... 详细信息

目的深入了解三孩孕产妇妊娠及分娩体验,为医护人员提供更系统、安全、针对性的三孩孕产妇围产期保健服务及护理措施提供依据。方法采用目的抽样法,选取2022年8月—2023年6月于南京市某三级甲等妇幼保健院建档并分娩的17名三孩孕产妇进行半结构式访谈,采用Colaizzi 7步分析法归纳并提炼主题。结果共提炼出4个主题,包括妊娠意愿的确立、感知生育风险、自身及家庭获益感、支持需求多样化。结论三孩孕妇妊娠意愿的建立受多方面因素影响,建议相关部门积极落实三孩生育政策相关配套措施;医护人员应强化三孩孕产妇围产期保健服务,降低生育风险,积极强化其妊娠相关获益感,建立全程支持体系,促进母婴健康。

关键词：三孩孕产妇妊娠分娩质性研究产科护理

Astudy on flooding scenario simulation of future extreme precipitation in Shanghai

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Frontiers of Earth Science 2018年第4期12卷 834-845页

作者： xiaoting WANG Zhan'e YIN xuan WANG Pengfei TIAN Yonghua HUANG Department of Geography Shanghai Normal UniversityShanghai 200234China

In the context of climate warming and urbanization, predictions and inundation simulations for future extreme precipitation have become highly active research topics. In this paper, using daily precipitation recorded at 10 meteorological stations in Shanghai for the period 1961-2010, the daily precipitation of each station during the period 2011-2099 was simulated by the statistical downscaling model (SDSM). And we examined the varying tendencies of future precipitation by the Mann- Kendall test. Further, the Soil Conservation Service (SCS) model and Pearson-III distribution curve were used to simulate the waterlogging duration and depth of future extreme precipitation in different scenarios with 3-, 5-, 10-, 20-, 50-, and 100-year return periods. The results show that: 1) Precipitation in Shanghai before the 2050s shows a trend of increasing and decreasing alternations, followed by a trend of decreasing and a marked decrease in about the 2070s. 2) In the 21st century, the waterlogging duration with return periods of 3, 5, and 10 years in Shanghai is predicted to last for less than 30 minutes, while the return periods of 20, 50, and 100 years last for less than 45 minutes. From the spatial distribution, the waterlogging duration to the east and south of the Huangpu River is predicted to be shorter than that of the west and north. 3) With the increase of the return periods, the depth of waterlogging is predicted to increase. The deepest inundated areas are Jinshan to the south-west of Shanghai, the east side of the Huangpu River, and Chongming Island.

关键词： flooding scenario simulation future extreme precipitation Shanghai

A novel transposable Mu-like prophage in Bacillus alcalophilus CGMCC 1.3604(ATCC 27647)

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Virologica Sinica 2015年第1期30卷 63-65页

作者： Junjie Yang Yimeng Kong xuan Li Sheng Yang Key Laboratory of Synthetic Biology Institute of Plant Physiology and Ecology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai Research and Development Center of Industrial Biotechnology Shanghai Collaborative Innovation Center for Biomanufacturing Technology University of the Chinese Academy of Sciences

Dear Editor,Transposable phages,which are reproduced by transposition(Harshey,2012;Taylor,1963),have been widely applied in the field of biotechnology to manipulate operon/gene fusions,in vivo cloning,randomion mutagenesis,and integration of DNA into bacterial genomes(Abalakina et al.,2008;Akhverdyan et al.,2011).One of the best-studied transposable phages is

关键词： cloning biotechnology reproduced mutagenesis phage sequencing DNA http Sanger chromosome

Superior performance in visible-light-driven hydrogen evolution reaction of three-dimensionally ordered macroporous SrTiO_(3) decorated with Zn_(x)Cd_(1−x)S

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Frontiers of Chemical Science and Engineering 2021年第6期15卷 1561-1571页

作者： Huiying Quan Kejiang Qian Ying xuan Lan-Lan Lou Kai Yu Shuangxi Liu MOE Key Laboratory of Pollution Processes and Environmental Criteria Tianjin Key Laboratory of Environmental Technology for Complex Transmedia PollutionCollege of Environmental Science and EngineeringNankai UniversityTianjin300350China Institute of New Catalytic Materials Science and MOE Key Laboratory of Advanced Energy Materials Chemistry School of Materials Science and EngineeringNational Institute of Advanced MaterialsNankai UniversityTianjin300350China

It is of broad interest to develop emerging photocatalysts with excellent light-harvesting capacity and high charge carrier separation efficiency for visible light photocatalytic hydrogen evolution ***,achieving satisfying hydrogen evolution efficiency under noble metal-free conditions remains *** this study,we demonstrate the fabrication of three-dimensionally ordered macroporous SrTiO_(3)decorated with Zn_(x)Cd_(1−x)S nanoparticles for hydrogen production under visible light irradiation(λ>420 nm).Synergetic enhancement of photocatalytic activity is achieved by the slow photon effect and improved separation efficiency of photogenerated charge *** obtained composites could afford very high hydrogen production efficiencies up to 19.67 mmol·g^(−1)·h^(−1),with an apparent quantum efficiency of 35.9%at 420 nm,which is 4.2 and 23.9 times higher than those of pure Zn_(0.5)Cd_(0.5)S(4.67 mmol·g^(−1)·h^(−1))and CdS(0.82 mmol·g^(−1)·h^(−1)),*** particular,under Pt-free conditions,an attractive hydrogen production rate(3.23 mmol·g^(−1)·h^(−1))was achieved,providing a low-cost and high-efficiency strategy to produce hydrogen from water ***,the composites showed excellent stability,and no obvious loss in activity was observed after five cycling tests.

关键词： three-dimensionally ordered macroporous SrTiO_(3) Zn_(x)Cd_(1−x)S visible light hydrogen production promotion mechanism

Viromes of Haemaphysalis longicornis reveal different viral abundance and diversity in free and engorged ticks

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Virologica Sinica 2024年第2期39卷 194-204页

作者： Jian xiao xuan Yao Xuhua Guan Jinfeng Xiong Yaohui Fang Jingyuan Zhang You Zhang Abulimiti Moming Zhengyuan Su Jiayin Jin Yingying Ge Jun Wang Zhaojun Fan Shuang Tang Shu Shen Fei Deng Key Laboratory of Virology and Biosafety and National Virus Resource Center Wuhan Institute of VirologyChinese Academy of SciencesWuhan430071China Hubei Provincial Center for Disease Control and Prevention Wuhan430070China University of Chinese Academy of Sciences Beijing101408China Hubei Jiangxia Laboratory Wuhan430200China Xinjiang Key Laboratory of Vector-borne Infectious Diseases Urumqi830002China Current address:Department of Medical Laboratory The Second Affiliated HospitalHainan Medical UniversityHaikou57000China

Haemaphysalis longicornis ticks,commonly found in East Asia,can transmit various pathogenic viruses,includingthe severe fever with thrombocytopenia syndrome virus(SFTSV)that has caused febrile diseases among humansin Hubei ***,understanding of the viromes of *** was limited,and the prevalence ofviruses among *** ticks in Hubei was not well *** study investigates the viromes of bothengorged(fed)and free(unfed)*** ticks across three mountainous regions in Hubei Province from 2019to ***-sequencing analysis identified viral sequences that were related to 39 reference viruses belonging tounclassified viruses and seven RNA viral families,namely Chuviridae,Nairoviridae,Orthomyxoviridae,Parvoviridae,Phenuiviridae,Rhabdoviridae,and *** abundance and diversity in these ticks were analysed,andphylogenetic characteristics of the Henan tick virus(HNTV),Dabieshan tick virus(DBSTV),Okutama tick virus(OKTV),and Jingmen tick virus(JMTV)were elucidated based on their full genomic *** demonstrated that DBSTV was the most common virus found in individual *** ticks(12.59%),followed by HNTV(0.35%),whereas JMTV and OKTV were not *** results improve our understanding of *** tick viromes in central China and highlight the role of tick feeding status and geographyin shaping the viral *** findings of new viral strains and their potential impact on public health raisethe need to strengthen surveillance efforts for comprehensively assessing their spillover potentials.

关键词： Ticks Virome Haemaphysalis longicornis Phylogenetic analysis Viral abundance and diversity

A comprehensive review of bioactive compounds and processing technology of sesame seed

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Oil Crop Science 2022年第2期7卷 88-94页

作者： xuan Ma Zhi Wang Chang Zheng Changsheng Liu Oil Crops Research Institute of the Chinese Academy of Agricultural Sciences Oil Crops and Lipids Process Technology National&Local Joint Engineering LaboratoryKey Laboratory of Oilseeds ProcessingMinistry of Agriculture and Rural AffairsHubei Key Laboratory of Lipid Chemistry and NutritionWuhan430062China

Sesame seeds are promulgated as traditional high-quality edible oil crops,rich in lipid(40–65%),protein(19–35%),and bioactive *** review starts with bioactive components(fatty acid,tocopherol,phytosterol,sesamin,sesamolin,and sesamol)of sesame *** considers processing techniques for extracting oil(aqueous extraction and pressing)from *** technologies,such as enzyme-assisted aqueous,supercritical CO_(2),and microwave-assisted solvent extraction,are also *** methods of utilization of sesame seed cake are also *** the future,the processing technology of sesame seed will be further developed in the direction of improving comprehensive utilization rate to meet new consumption demand.

关键词： Sesame seed Bioactive compound Nutritional properties Processing technology By-product