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Multistate circularly polarized luminescence switches based on dual stimuli-responsive chiral[2]rotaxanes

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Science China Chemistry 2024年第12期67卷 4202-4211页

作者： Wei-Tao xu xue Li Xiao-Qin xu xu-qing wang Hai-Bo Yang Wei wang Wuhu Hospital East China Normal University(The Second People’s HospitalWuhu)Wuhu 241001China Shanghai Key Laboratory of Green Chemistry and Chemical Processes State Key Laboratory of Petroleum Molecular and Process EngineeringSchool of Chemistry and Molecular EngineeringEast China Normal UniversityShanghai 200062China Shanghai Center of Brain-inspired Intelligent Materials and Devices East China Normal UniversityShanghai 200241China

Aiming at the construction of novel multistate circularly polarized luminescence(CPL)switches,dual stimuli-responsive chiral[2]rotaxanes towards anions and light have been designed and *** the light-controlled on/off F?rster resonance energy transfer(FRET)switching between the emissive stoppers and anion-induced controllable motions of the chiral wheel for the precise regulations of chirality information transfer from the chiral wheel to the emissive stoppers,precisely switching between four CPL emission states with varied emission wavelengths and dissymmetry factors has been successfully realized,making them a promising platform for practical uses such as information storage and *** proof-of-concept study not only provides a novel design strategy for multistate CPL switching but also contributes excellent candidates for the construction of novel smart chiral luminescent materials.

关键词： mechanically interlocked molecules Förster resonance energy transfer aggregation-induced emission pillararene spiropyran

Characterization of Interfacial Bonding Mechanism for Graphene-Modified Powder Metallurgy Nickle-Based Superalloy

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Acta Metallurgica Sinica(English Letters) 2018年第7期31卷 753-760页

作者： Jin-Wen Zou Xiao-Feng wang Jie Yang Chuan-Bo Ji xu-qing wang Xian-Qiang Fan Zhi-Peng Guo AECC Beijing Institute of Aeronautical Materials Beijing 100089China Science and Technology on Advanced High Temperature Structural Materials Laboratory Beijing Institute of Aeronautical MaterialsBeijing 100089China School of Materials Science and Engineering Tsinghua UniversityBeijing 100089China

A modified FGH96 superalloy using 0.1 wt% graphene was successfully prepared using the wet mixing method. The interracial bonding mechanism between the graphene and the superalloy matrix was characterized using optical micro- scope, scanning electronic microscope, transmission electronic microscope and X-ray tomography. The results revealed that the graphene could be dispersed uniformly inside the matrix of the superalloy, and the bonding interface between graphene and the superalloy showed a rather diffusion instead of abrupt distinction, suggesting that the interface was formed via chemical fusion rather than a mechanical combination. The uniform dispersity of the graphene inside the superalloy matrix could improve the tensile properties significantly, including tensile strength, plasticity and yield strength. The existence of the graphene at the fracture surface further verified that the graphene could increase the effective bearing force of the material during the tensile test.

关键词： Powder metallurgical(PM)superalloy Graphene Interfacial binding mechanism Mechanical propertiesCharacterization

Sequence Engineering in Tuning the Circularly Polarized Luminescence of Aggregation-Induced Emission-Active Hetero[3]rotaxanes

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CCS Chemistry 2024年第10期6卷 2489-2501页

作者： Zhiyong Peng Pei-Pei Jia xu-qing wang Xiao-Li Zhao Hai-Bo Yang Wei wang Shanghai Key Laboratory of Green Chemistry and Chemical Processes State Key Laboratory of Petroleum Molecular&Process EngineeringSchool of Chemistry and Molecular EngineeringEast China Normal UniversityShanghai 200062 Shanghai Center of Brain-Inspired Intelligent Materials and Devices East China Normal UniversityShanghai 200241

Based on a[2]rotaxane precursor with exchangeable pentafluorophenyl ester stoppers,a new wheelassembling approach has been successfully developed for the precise sequence control of hetero[3]rotaxanes,leading to the facile and efficient synthesis of both sequence isomers of hetero[3]*** importantly,taking advantage of the chirality retention along with the wheel-assembling process,corresponding sequence isomers of chiral AIEgenfunctionalized hetero[3]rotaxanes were further precisely ***,the resultant hetero[3]rotaxanes revealed remarkable sequencedependent aggregation-induced emission(AIE)behavior and circularly polarized luminescence performance with large dissymmetry factors up to 0.012,highlighting the great power of the newly coined sequence engineering concept in developing novel AIE-active chiroptical *** proof-ofconcept study lays the foundation for investigation of the structure-property relationships of heterorotaxanes that can further direct the rational design and precise synthesis of sequence-defined heterorotaxanes with desirable properties for practical applications.

关键词： mechanically interlocked molecules rotaxanes sequence isomerism aggregationinduced emission circularly polarized luminescence

Dynamic changes of IL-2/IL-10, sFas and expression of Fas in intestinal mucosa in rats with acute necrotizing pancreatitis

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World Journal of Gastroenterology 2008年第14期14卷 2246-2250页

作者： Sheng-Chun Dang Jian-Xin Zhang Jian-Guo Qu Zheng-Fa Mao xu-qing wang Bei Zhu Department of General Surgery The Affiliated Hospital of Jiangsu University Zhenjiang 212001 Jiangsu Province China

AIM:To investigate dynamic changes of serum IL-2, IL-10, IL-2/IL-10 and sFas in rats with acute necrotizing pancreatitis. To explore the expression of Fas in intestinal mucosa of rats with acute necrotizing pancreatitis (ANP). METHODS:A total of 64 Sprague-Dawley (SD) rats were randomly divided into two groups:normal control group (C group), ANP group (P group). An ANP model was induced by injection of 50 g/L sodium taurocholate under the pancreatic membrane. Normal control group received isovolumetric injection of 9 g/L physiological saline solution using the same method. The blood samples of the rats in each group were obtained via superior mesenteric vein to measure levels of IL-2, IL-10, sFas and calculate the value of IL-2/IL-10. The levels of IL-2, IL-10 and sFas were determined by ELISA. The severity of intestinal mucosal injury was evaluated by pathologic score. The expression of Fas in intestinal mucosal tissue was determined by immunohistochemistry staining. RESULTS:Levels of serum IL-2 were significantly higher in P group than those of C group (2.79 ± 0.51 vs 3.53 ± 0.62, 2.93 ± 0.89 vs 4.35 ± 1.11, 4.81 ± 1.23 vs 6.94 ± 1.55 and 3.41 ± 0.72 vs 4.80 ± 1.10, respectively, P 0.05). In sFas assay, there was no significant difference between P group and C group (3.16 ± 0.75 vs 3.31 ± 0.80,

关键词： Acute necrotizing pancreatitis Fas Intestinal mucosal injury T helper cell

Seeing Is Believing:Directly Imaging Contractions of Artificial Molecular Muscles with Platinum Atom Markers

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CCS Chemistry 2024年第9期6卷 2162-2174页

作者： Dan-Yang Zhang Yonghui Zheng Yefei Jiang Wei-Jian Li xu-qing wang Lianrui Hu Wei wang Hai-Bo Yang Shanghai Key Laboratory of Green Chemistry and Chemical Processes State Key Laboratory of Petroleum Molecular&Process EngineeringSchool of Chemistry and Molecular EngineeringEast China Normal UniversityShanghai 200062 Key Laboratory of Polar Materials and Devices(MOE) Department of ElectronicsEast China Normal UniversityShanghai 200241 Shanghai Center of Brain-Inspired Intelligent Materials and Devices East China Normal UniversityShanghai 200241

Artificial molecular muscles undergo well-controlled contractile and extensile motions upon external stimulation,leading to remarkable length *** such length changes at the molecular level is essential to the design of integrated artificial molecular muscles that mimic biological *** advantage of the strong contrast of platinum(Pt)atoms in high-angle annular dark-field scanning transmission electron microscopy images,we imaged Pt-containing molecular[c2]daisy chains directly by employing metal atom *** length changes and associated conformational transformations of these newly developed artificial molecular muscles have been measured experimentally in combination with theoretical *** contraction ratios of these two molecular muscles with the TEMPO or pyrene anchoring group were calculated to be 21.0%or 15.7%respectively,suggesting a substantial anchoring *** study demonstrates the experimental measurement of the length changes of artificial molecular muscles and provides a new avenue for investigating the motion of artificial molecular machines.

关键词： mechanically interlocked molecules molecular[c2]daisy chain artificial molecular machines high-angle annular dark-field scanning transmission electron microscopy stimuli responsiveness

Dyeing bacterial cellulose pellicles for energetic heteroatom doped carbon nanofiber aerogels

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Nano Research 2014年第12期7卷 1861-1872页

作者： Zhen-Yu Wu Hai-Wei Liang Chao Li Bi-Cheng Hu Xing-Xing xu qing wang Jia-Fu Chen Shu-Hong Yu Division of Nanomaterials and Chemistry Hefei National Laboratory for Physical Sciences at Microscale Collaborative InnovationCenter of Suzhou Nano Science and Technology Department of Chemistry University of Science and Technology of China HefeiAnhui 230026 China

The energy crisis and environmental pollution are serious challenges that humanity will face for the long-term. Despite tremendous efforts, the development of environmentally friendly methods to fabricate new energy materials is still challenging. Here we report, for the first time, a new strategy to fabricate various doped carbon nanofiber （CNF） aerogels by pyrolysis of bacterial cellulose （BC） pellicles which had adsorbed or were dyed with different toxic organic dyes. The proposed strategy makes it possible to remove the toxic dyes from waste-water and then synthesize doped CNF aerogels using the dyed BC pellicles as precursors. Compared with other reported processes for preparing heteroatom doped carbon （HDC） nanomaterials, the present synthetic method has some significant advantages, such as being green, general, low-cost and easily scalable. Moreover, the as-prepared doped CNF aerogels exhibit great potential as electrocatalysts for the oxygen reduction reaction （ORR） and as electrode materials for supercapacitors.

关键词： doped carbon nanofiberaerogels electrocatalysts oxygen reduction reaction supercapacitors organic dyes bacterial cellulose

Characteristic changes in astrocyte properties during astrocyte-to-neuron conversion induced by NeuroD1/Ascl1/Dlx2

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Neural Regeneration Research 2025年第6期20卷 1801-1815页

作者： qing He Zhen wang Yuchen wang Mengjie Zhu Zhile Liang Kanghong Zhang Yuge xu Gong Chen GHM Institute of CNS Regeneration Jinan UniversityGuangzhouGuangdong ProvinceChina

Direct in vivo conversion of astrocytes into functional new neurons induced by neural transcription factors has been recognized as a potential new therapeutic intervention for neural injury and degenerative disorders. However, a few recent studies have claimed that neural transcription factors cannot convert astrocytes into neurons, attributing the converted neurons to pre-existing neurons mis-expressing transgenes. In this study, we overexpressed three distinct neural transcription factors––NeuroD1, Ascl1, and Dlx2––in reactive astrocytes in mouse cortices subjected to stab injury, resulting in a series of significant changes in astrocyte properties. Initially, the three neural transcription factors were exclusively expressed in the nuclei of astrocytes. Over time, however, these astrocytes gradually adopted neuronal morphology, and the neural transcription factors was gradually observed in the nuclei of neuron-like cells instead of astrocytes. Furthermore,we noted that transcription factor-infected astrocytes showed a progressive decrease in the expression of astrocytic markers AQP4(astrocyte endfeet signal), CX43(gap junction signal), and S100β. Importantly, none of these changes could be attributed to transgene leakage into preexisting neurons. Therefore, our findings suggest that neural transcription factors such as NeuroD1, Ascl1, and Dlx2 can effectively convert reactive astrocytes into neurons in the adult mammalian brain.

关键词： aquaporin-4 Ascl1 astrocyte cortex Dlx2 gap junction glia-to-neuron conversion neural regeneration NeuroD1 reprogramming

Association between inflammatory mediators and angiographic morphologic features indicating thrombus formation in patients with acute myocardial infarction

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Chinese Medical Journal 2009年第15期122卷 1738-1742页

作者： LI Dong-bao HUA Qi LIU Zhi LI Jing xu Li-qing wang Shan JIN Wei-ying Department of Cardiology Xuanwu Hospital of Capital Medical University Beijing 100053 China

Background Inflammatory mechanisms had played an important role in the occurrence and prognosis of acute myocardial infarction, inflammatory mediators was associated with adverse outcomes of acute myocardial infarction. This study tested the hypothesis that in the acute phase of myocardial infarction with ST-segment elevation, neutrophil count and high-sensitivity C-reactive protein are predictive of angiographic morphologic features that indicate thrombus formation in the infarct-related artery. Methods This retrospective study included 182 consecutive patients with acute myocardial infarction and ST-segment elevation. Patients were assigned to a thrombus-formation group （n=77） and a non-thrombus-formation group （n=-106）. All patients had a Killip＇s classification 〈3 and onset 〈12 hours prior to presentation. All the cases were going to undergo coronary angiography, including primary percutaneous coronary intervention, simple coronary angiography, or thrombolysis in a coronary artery （or arteries） or coronary artery bypass graft（s）. Blood samples for measurement of high-sensitivity C-reactive protein and for routine blood laboratory studies were collected prior to coronary angiography. Results The levels of high-sensitivity C-reactive protein, total leukocyte counts, neutrophil counts, and neutrophil/ lymphocyte ratios were substantially higher in the thrombus-formation group than in the non-thrombus-formation group patients （for each, P 〈0.05）. Stepwise Logistic regression analyses identified high-sensitivity C-reactive protein, neutrophil count, and neutrophil/lymphocyte ratio as independent predictors of thrombus formation in the infarct-related artery （for each, P 〈0.05）. Conclusions In patients with acute myocardial infarction levels of high-sensitivity C-reactive protein are predictors to higher neutrophil counts, neutrophil/lymphocyte ratio, and ndicate thrombus formation

关键词： acute myocardial infarction thrombosis neutrophil percutaneous coronary intervention C-reactive protein

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基于自适应形态学滤波的红外小目标检测算法

激光与红外 2017年第1期47卷 108-113页

作者：徐文晴王敏华中科技大学自动化学院湖北武汉430074

针对低对比度下小目标常被大量背景杂波和噪声干扰,检测结果不理想的问题,提出了一种基于视觉注意机制与自适应双结构元素形态学滤波的红外小目标检测方法。根据人类视觉对比机制对图像进行感兴趣区域(ROI)提取以确定候选目标,通过提取... 详细信息

针对低对比度下小目标常被大量背景杂波和噪声干扰,检测结果不理想的问题,提出了一种基于视觉注意机制与自适应双结构元素形态学滤波的红外小目标检测方法。根据人类视觉对比机制对图像进行感兴趣区域(ROI)提取以确定候选目标,通过提取轮廓获得候选目标的尺寸,并由获取的尺寸自适应构造双结构元素。运用双结构元素形态学滤波抑制噪声和杂波信号,用中值滤波对形态学滤波后的杂点噪声进一步抑制。实验表明本文提出的算法能有效抑制噪声干扰,显著提高目标信杂比,准确检测弱小红外目标,算法具有很好的鲁棒性和实时性。

关键词：视觉注意机制感兴趣区域双结构元素自适应形态学滤波中值滤波