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双掺杂LiNbO3晶体光谱和光折变特性

山东大学学报(自然科学版) 2001年第4期36卷 400-404页

作者：许心光杨旭东王正平刘均海王东邵宗书徐玉恒山东大学晶体材料国家重点实验室哈尔滨工业大学山东济南250100 山?

报道了双掺杂Ce :Fe ,Ce :Mn ,Mn :Fe生长态LiNbO3(LN)的光谱及光折变效应二波耦合增益特性 .研究表明 ,双掺杂浓度较高时 ,生长态的LiNbO3晶体的透过率光谱范围较小 ,光折变效应二波耦合增益较低 .几种双掺杂晶体都比单掺Fe晶体的光折... 详细信息

报道了双掺杂Ce :Fe ,Ce :Mn ,Mn :Fe生长态LiNbO3(LN)的光谱及光折变效应二波耦合增益特性 .研究表明 ,双掺杂浓度较高时 ,生长态的LiNbO3晶体的透过率光谱范围较小 ,光折变效应二波耦合增益较低 .几种双掺杂晶体都比单掺Fe晶体的光折变效应二波耦合增益低 ,表现出较强的抗光折变特性

关键词：铌酸锂晶体光谱光折变效应二波耦合

Perfluoropentane-based oxygen-loaded nanodroplets reduce microglial activation through metabolic reprogramming

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Neural Regeneration Research 2025年第4期20卷 1178-1191页

作者： Wanxian Luo Chuanhui xu Linxi Li Yunxiang Ji Yezhong wang Yingjia Li Yongyi Ye Department of Medicine Ultrasonics Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina Institute of Neuroscience Department of NeurosurgeryThe Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina

Microglia,the primary immune cells within the brain,have gained recognition as a promising therapeutic target for managing neurodegenerative diseases within the central nervous system,including Parkinson’s *** perfluorocarbon droplets have been reported to not only possess a high oxygen-carrying capacity,but also exhibit remarkable anti-inflammatory ***,the role of perfluoropentane in microglia-mediated central inflammatory reactions remains poorly *** this study,we developed perfluoropentane-based oxygen-loaded nanodroplets(PFP-OLNDs)and found that pretreatment with these droplets suppressed the lipopolysaccharide-induced activation of M1-type microglia in vitro and in vivo,and suppressed microglial activation in a mouse model of Parkinson’s *** suppression led to a reduction in the inflammatory response,oxidative stress,and cell migration capacity in ***,the neurotoxic effects were mitigated,which alleviated neuronal ***,ultrahigh-performance liquid chromatography–tandem mass spectrometry showed that the anti-inflammatory effects of PFP-OLNDs mainly resulted from the modulation of microglial metabolic *** further showed that PFP-OLNDs regulated microglial metabolic reprogramming through the AKT-mTOR-HIF-1α***,our findings suggest that the novel PFP-OLNDs constructed in this study alleviate microglia-mediated central inflammatory reactions through metabolic reprogramming.

关键词： metabolic reprogramming microglia microglial migration nanotherapy neurodegenerative diseases neuroinflammation oxygen-loaded nanodroplets Parkinson’s disease perfluoropentane ultra-performance liquid chromatography–mass spectrometry

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基于生态城市的立体绿化构建系统研究

建筑与文化 2018年第3期 167-169页

作者：许东王雪英辽宁工业大学艺术设计与建筑学院

随着城市建设的发展,生态环境不断恶化。针对城市用地紧张与增加绿化面积二者之间矛盾问题,从生态城市建设的大背景出发,侧重从立体绿化的角度,通过分析立体绿化的概念及在生态城市建设中的效益,提出在城市不同空间内不同立体绿化的构... 详细信息

随着城市建设的发展,生态环境不断恶化。针对城市用地紧张与增加绿化面积二者之间矛盾问题,从生态城市建设的大背景出发,侧重从立体绿化的角度,通过分析立体绿化的概念及在生态城市建设中的效益,提出在城市不同空间内不同立体绿化的构建方式,从而形成一个完整的立体绿化系统,旨在为探索城市建筑与绿化的结合方式提供参考。

关键词：生态城市平面绿化立体绿化建筑绿化

Progress of research in the application of ultrasound technology for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2823-2837页

作者： Qiuquan Cai Lianghui Meng Meina Quan Ling wang Jing Ren Chenguang Zheng Jiajia Yang dong Ming Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Innovation Center for Neurological Disorders Xuanwu HospitalCapital Medical UniversityBeijingChina Brain-Computer Interaction and Human-Machine Fusion Haihe Laboratory Tianjin UniversityTianjinChina Tianjin Key Laboratory of Brain Science and Neural Engineering Tianjin UniversityTianjinChina

Alzheimer’s disease is a common neurodegenerative disorder defined by decreased reasoning abilities,memory loss,and cognitive *** presence of the blood-brain barrier presents a major obstacle to the development of effective drug therapies for Alzheimer’s *** use of ultrasound as a novel physical modulation approach has garnered widespread attention in recent *** a safe and feasible therapeutic and drug-delivery method,ultrasound has shown promise in improving cognitive *** article provides a summary of the application of ultrasound technology for treating Alzheimer’s disease over the past 5 years,including standalone ultrasound treatment,ultrasound combined with microbubbles or drug therapy,and magnetic resonance imaging-guided focused ultrasound *** is placed on the benefits of introducing these treatment methods and their potential *** found that several ultrasound methods can open the blood-brain barrier and effectively alleviate amyloid-βplaque *** believe that ultrasound is an effective therapy for Alzheimer’s disease,and this review provides a theoretical basis for future ultrasound treatment methods.

关键词： Alzheimer’s disease blood-brain barrier drugs magnetic resonance imaging-guided focused ultrasound microbubbles scanning ultrasound ultrasound ultrasound stimulation

Microglia lactylation in relation to central nervous system diseases

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Neural Regeneration Research 2025年第1期20卷 29-40页

作者： Hui Yang Nan Mo Le Tong Jianhong dong Ziwei Fan Mengxian Jia Juanqing Yue Ying wang School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Clinical Laboratory The Fourth Clinical Medical College of Zhejiang University of Traditional Chinese Medicine(Hangzhou First People’s Hospital)HangzhouZhejiang ProvinceChina College of Medical Veterinary and Life SciencesUniversity of GlasgowGlasgowUK Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina

The development of neurodegenerative diseases is closely related to the disruption of central nervous system ***,as innate immune cells,play important roles in the maintenance of central nervous system homeostasis,injury response,and neurodegenerative *** has been considered a metabolic waste product,but recent studies are revealing ever more of the physiological functions of *** is an important pathway in lactate function and is involved in glycolysis-related functions,macrophage polarization,neuromodulation,and angiogenesis and has also been implicated in the development of various *** review provides an overview of the lactate metabolic and homeostatic regulatory processes involved in microglia lactylation,histone versus non-histone lactylation,and therapeutic approaches targeting ***,we summarize the current research on microglia lactylation in central nervous system diseases.A deeper understanding of the metabolic regulatory mechanisms of microglia lactylation will provide more options for the treatment of central nervous system diseases.

关键词： brain central nervous system glycolysis immune response inflammation lactate metabolism lactate lactylation microglia neurodegenerative diseases

泸州市青少年膳食模式与超重肥胖的相关性研究

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中华疾病控制杂志 2022年第3期26卷 280-284页

作者：刘小燕邱明康家豪许望东马玲西南医科大学公共卫生学院泸州646000

目的探讨泸州市青少年膳食模式与超重和肥胖的关系,为青少年的膳食干预提供理论依据。方法通过多阶段分层整群抽样,于泸州市抽取3869名青少年作为调查对象;通过问卷调查收集调查对象的基本信息、膳食习惯,并通过膳食频率法获取调查对象... 详细信息

目的探讨泸州市青少年膳食模式与超重和肥胖的关系,为青少年的膳食干预提供理论依据。方法通过多阶段分层整群抽样,于泸州市抽取3869名青少年作为调查对象;通过问卷调查收集调查对象的基本信息、膳食习惯,并通过膳食频率法获取调查对象近1年内摄取各种食物的频率以及每次的摄入量;采用因子分析法提取泸州市青少年的膳食模式,并通过多因素Logistic回归分析模型探讨青少年膳食模式与超重肥胖发生风险的相关性。结果泸州市青少年存在3种膳食模式,分别为蔬菜水果膳食模式,速食食品膳食模式以及主食肉类膳食模式。Logistic回归分析模型分析结果显示,在调整混杂因素后,与速食食品膳食模式高分组相比,随着分值的降低,肥胖发生的风险增加(中高分组OR=0.59,95%CI:0.36~0.97,P=0.041;中低分组OR=0.60,95%CI:0.36~0.99,P=0.046)。结论青少年的膳食模式和肥胖之间有相关性,相关部门应加强健康教育和膳食干预,优化青少年膳食模式,促进青少年健康成长。

关键词：膳食模式超重肥胖因子分析

Dielectric-ion-conductive ZnNb2O6 layer enabling rapid desolvation and diffusion for dendrite-free Zn metal batteries

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Journal of Energy Chemistry 2025年第1期100卷 693-701页

作者： Haifeng Yang Jian wang Panpan Zhang Xiaomin Cheng Qinghua Guan Jing dong Bixian Chen Lujie Jia Jing Zhang Yongzheng Zhang Yunjian Liu Hongzhen Lin School of Materials Science and Engineering Jiangsu University i-Lab & CAS Key Laboratory of Nanophotonic Materials and Devices Suzhou Institute of Nano-Tech and Nano-Bionics Chinese Academy of Sciences Helmholtz Institute Ulm (HIU) Karlsruhe Institute of Technology (KIT) School of Materials Science and Engineering Xi'an University of Technology State Key Laboratory of Chemical Engineering East China University of Science and Technology

Rechargeable aqueous zinc-metal batteries （AZMBs） are promising candidates for large-scale energy storage systems due to their low cost and high ***,their performance and sustainability are significantly hindered by the sluggish desolvation kinetics at the electrode/electrolyte interface and the corresponding hydrogen evolution reaction where active water molecules tightly participate in the Zn（H2O）62+solvation ***,learnt from self-generated solid electrolyte interphase （SEI） in anodes,the dielectric but ion-conductive zinc niobate nanoparticles artificial layer is constructed on metallic Zn surface （ZNB@Zn）,acting as a rapid desolvation *** zincophilic and dielectric-conductive properties of ZNB layer accelerate interfacial desolvation/diffusion and suppress surface corrosion or dendrite formation,achieving uniform Zn plating/stripping behavior,as confirmed by electronic/optical microscopies and interface spectroscopical measurements together with theoretical ***,the as-prepared ZNB@Zn electrode exhibits excellent cycling stability of over 2000 h and robust reversibility （99.54%） even under high current density and depth of discharge ***,the assembled ZNB@Zn-based full cell displays high capacity-retention rate of 80.21%after 3000 cycles at 5 A g-1and outstanding rate performance up to 10 A *** large-areal pouch cell is stabilized for hundreds of cycles,highlighting the bright prospects of the dielectric but ion-conductive layer in further application of AZMBs.

关键词： Zn metal battery Dielectric artificial layer Rapid ion diffusion Zincophilic diffusion Active water inhibition

Small modifications of endo-functionalized cavities lead to large changes in molecular interaction in water

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Science China Chemistry 2025年第1期 369-376页

作者： Song-Meng wang Hao Nian Yan-Fang wang Li-Shuo Zheng Yu-Tao Zheng Yi-Wei dong Liping Huang Xiaoping wang Wei Jiang Liu-Pan Yang Department of Chemistry Southern University of Science and Technology School of Chemistry and Pharmaceutical Sciences State Key Laboratory for Chemistry and Molecular Engineering of Medicinal ResourcesGuangxi Normal University School of Pharmaceutical Science Hengyang Medical School University of South China

Studying molecular recognition in aqueous environments is crucial for understanding biological processes. Herein, we present a series of N-doped endo-functionalized anthracene-based cavities by introducing inward-directed pyridine units. The subtle modifications can significantly affect the binding properties of these receptors, which is similar to the mutations in biological systems. Combining theoretical calculations and molecular recognition experiments demonstrated that these “mutations” have an impact on the hydrophobicity and charge distribution of the hosts, consequently significantly influencing molecular *** is crucial for understanding the intricate mechanisms of molecular-level interactions in biological receptors.

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La对Pd/Al/蜂窝陶瓷催化剂高温活性与耐热稳定作用的研究

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燃料化学学报 2001年第Z1期29卷 134-136页

作者：田东旭王浩静王心葵中国科学院山西煤炭化学研究所山西太原030001

应用溶胶—凝胶技术对蜂窝陶瓷基体进行涂层 ,以CO氧化作模型反应 ,并应用BET、XRD和TEM技术考察了La的加入对催化剂高温活性和耐热稳定性的影响。热老化和活性评价实验表明La的加入显著提高了催化剂的抗烧结性能。催化剂BET、XRD和TEM... 详细信息

应用溶胶—凝胶技术对蜂窝陶瓷基体进行涂层 ,以CO氧化作模型反应 ,并应用BET、XRD和TEM技术考察了La的加入对催化剂高温活性和耐热稳定性的影响。热老化和活性评价实验表明La的加入显著提高了催化剂的抗烧结性能。催化剂BET、XRD和TEM表征结果表明 :加入La的催化剂生成了LaAlO3 新晶相 ,此化合物抵消了Al2 O3 表面的空位阻止了Al2 O3 载体的烧结。

关键词：热稳定性 La2O3 LaAlO3 BET XRD和TEM