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Brain plasticity after peripheral nerve injury treatment with massage therapy based on resting-state functional magnetic resonance imaging

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Neural Regeneration Research 2021年第2期16卷 388-393页

作者： Xiang-Xin Xing Mou-Xiong Zheng xu-yun hua Shu-Jie Ma Zhen-Zhen Ma Jian-Guang xu School of Rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghaiChina Department of Rehabilitation Medicine Yueyang HospitalShanghai University of Traditional Chinese MedicineShanghaiChina Department of Traumatology and Orthopedics Yueyang HospitalShanghai University of Traditional Chinese MedicineShanghaiChina Yangzi Rehabilitation Hospital Tongji UniversityShanghaiChina

Massage therapy is an alternative treatment for chronic pain that is potentially related to brain ***,the underlying mechanism remains *** established a peripheral nerve injury model in rats by unilateral sciatic nerve transection and direct *** experimental rats were treated over the gastrocnemius muscle of the affected hindlimb with a customized massage instrument(0.45 N,120 times/min,10 minutes daily,for 4 successive weeks).Resting-state functional magnetic resonance imaging revealed that compared with control rats,the amplitude of low-frequency fluctuations in the sensorimotor cortex contralateral to the affected limb was significantly lower after sciatic nerve ***,amplitudes were significantly higher in the massage group than in a sham-massage *** findings suggest that massage therapy facilitated adaptive change in the somatosensory cortex that led to the recovery of peripheral nerve injury and *** study was approved by the Animal Ethics Committee of Shanghai University of Traditional Chinese Medicine of China(approval No.201701001)on January 12,2017.

关键词： injury massage model neuron peripheral nerve plasticity rat repair

Structural remodeling in related brain regions in patients with facial synkinesis

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Neural Regeneration Research 2021年第12期16卷 2528-2533页

作者： Jia-Jia Wu Ye-Chen Lu Mou-Xiong Zheng xu-yun hua Chun-Lei Shan Wei Ding Jian-Guang xu Center of Rehabilitation Medicine Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Wound Healing Center Ruijin HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Trauma and Orthopedics Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina School of Rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghaiChina Department of Plastic and Reconstructive Surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghaiChina

Facial synkinesis is a troublesome sequelae of facial nerve *** is difficult to recover from synkinesis,despite improved surgical techniques for isolating the peripheral facial nerve ***,it remains unclear whether long-term dysfunction of motor control can lead to irreversible plasticity-induced structural brain *** case-control study thus investigated the structural brain alterations associated with facial *** study was conducted at Shanghai Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine,*** patients with facial synkinesis(2 male and 18 female,aged 33.35±6.97 years)and 19 healthy volunteers(2 male and 17 female,aged 33.21±6.75 years)underwent magnetic resonance imaging,and voxel-based and surface-based morphometry techniques were used to analyze *** was no significant difference in brain volume between patients with facial synkinesis and healthy *** with facial synkinesis exhibited a significantly reduced cortical thickness in the contralateral superior and inferior temporal gyri and a reduced sulcal depth of the ipsilateral precuneus compared with healthy *** addition,sulcal depth of the ipsilateral precuneus was negatively correlated with the severity of *** findings suggest that there is a structural remodeling of gray matter in patients with facial synkinesis after facial nerve *** study was approved by the Ethics Review Committee of the Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine,China(approval No.2017-365-T267)on September 13,2017,and was registered with the Chinese Clinical Trial Registry(registration number:ChiCTR1800014630)on January 25,2018.

关键词： brain plasticity cortical thickness depression facial nerve paralysis facial synkinesis peripheral nerve injury sulcal depth structural remodeling surface-based morphometry voxel-based morphometry

Surface-based map plasticity of brain regions related to sensory motor and pain information processing after osteonecrosis of the femoral head

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Neural Regeneration Research 2022年第4期17卷 806-811页

作者： Jie Ma xu-yun hua Mou-Xiong Zheng Jia-Jia Wu Bei-Bei Huo Xiang-Xin Xing Sheng-Yi Feng Bo Li Jian-Guang xu School of Rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghaiChina Department of Traumatology and Orthopedics Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Yangzhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center) Tongji UniversityShanghaiChina Center of Rehabilitation Medicine Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina

Pain is one of the manifestations of hip disorder and has been proven to lead to the remodeling of somatotopic map plasticity in the ***,most studies are volume-based which may lead to inaccurate anatomical positioning of functional *** methods that work on the cortical surface may be more sensitive than those using the full brain volume and thus be more suitable for map plasticity *** this prospective cross-sectional study performed in Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,China,20 patients with osteonecrosis of the femoral head(12 males and 8 females,aged 56.80±13.60 years)and 20 healthy controls(9 males and 11 females,aged 54.56±10.23 years)were included in this *** of resting-state functional magnetic resonance imaging were *** results revealed that compared with healthy controls,compared with the healthy controls,patients with osteonecrosis of the femoral head(ONFH)showed significantly increased surface-based regional homogeneity(Re Ho)in areas distributed mainly in the left dorsolateral prefrontal cortex,frontal eye field,right frontal eye field,and the premotor cortex and decreased surface-based Re Ho in the right primary motor cortex and primary sensory *** showing significant differences in surfacebased Re Ho values between the healthy controls and patients with ONFH were defined as the regions of ***-based functional connectivity was performed to investigate interregional functional *** the areas with decreased surface-based Re Ho in the frontal eye field and right premotor cortex were used as the regions of interest,compared with the healthy controls,the patients with ONFH displayed increased functional connectivity in the right middle frontal cortex and right inferior parietal cortex and decreased functional connectivity in the right precentral cortex and right middle occipital ***

关键词： cortical thickness functional connectivity hip disorder osteonecrosis of the femoral head Re Ho sensorimotor cortex surface-based map plasticity volume of subcortical gray matter nuclei

Effects of paired associative magnetic stimulation between nerve root and cortex on motor function of lower limbs after spinal cord injury:study protocol for a randomized controlled trial

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Neural Regeneration Research 2022年第11期17卷 2459-2464页

作者： Ting-Ting Sun Guang-Yue Zhu Ya Zheng Ye-Ran Mao Qi-Long Hu Gong-Ming Song Rong xu Qi Yang Dan Zhao xu-yun hua Dong-Sheng xu Shanghai Yangzhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center) School of MedicineTongji UniversityShanghaiChina Rehabilitation Medical Center Tongji Hospital Affiliated to Tongji University School of MedicineShanghaiChina School of Rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghaiChina Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation Ministry of EducationShanghaiChina Department of Traumatology and Orthopedics Yueyang HospitalShanghai University of Traditional Chinese MedicineShanghaiChina Department of Rehabilitation Medicine Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghaiChina

Classic paired associative stimulation can improve synaptic plasticity,as demonstrated by animal expe riments and human clinical trials in spinal cord injury *** associative magnetic stimulation(dual-target peripheral and central magnetic stimulation)has been shown to promote neurologic recove ry after ***,it remains unclear whether paired associative magnetic stimulation can promote recovery of lower limb motor dysfunction after spinal cord *** hypothesize that the curre nt caused by central and peripheral magnetic stimulation will conve rge at the synapse,which will promote synapse function and improve the motor function of the relevant ***,this study aimed to examine the effects of paired associative magnetic stimulation on neural circuit activation by measuring changes in motor evoked and somatosensory evoked potentials,motor and sensory function of the lower limbs,functional health and activities of daily living,and depression in patients with spinal co rd *** will recruit 110 thora cic spinal trauma patients treated in the Department of Spinal Cord Injury,China Rehabilitation Hospital and randomly assign them to expe rimental and control groups in a 1:1 *** trial group(n=55)will be treated with paired associative magnetic stimulation and conventional rehabilitation *** control group(n=55)will be treated with sham stimulation and co nventional rehabilitation *** will be measured at four time points:baseline and 4,12,and 24 wee ks after the start of inte rvention(active or sham paired associative magnetic stimulation).The primary outcome measure of this trial is change in lower limb American Spinal Injury Association Impairment Scale motor function score from baseline to last *** outcome measures include changes in lower limb American Spinal Injury Association sensory function sco re,motor evoked potentials,sensory evoked potentials,modified Ashwo rth scale score,Masl

关键词： interstimulus interval motor-evoked potentials Modified Ashworth Scale Maslach Burnout Inventory paired-associative magnetic stimulation plasticity repetitive transcranial magnetic stimulation sensory-evoked potential spinal cord injury spike timing-dependent plasticity

Electroacupuncture treatment improves motor function and neurological outcomes after cerebral ischemia/reperfusion injury

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Neural Regeneration Research 2022年第7期17卷 1545-1555页

作者： Si-Si Li xu-yun hua Mou-Xiong Zheng Jia-Jia Wu Zhen-Zhen Ma Xiang-Xin Xing Jie Ma Chun-Lei Shan Jian-Guang xu School of Rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghaiChina Department of Traumatology and Orthopedics Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Center of Rehabilitation Medicine Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation Ministry of EducationShanghaiChina

Electroacupuncture(EA)has been widely used for functional restoration after ***,its role in post-stroke rehabilitation and the associated regulatory mechanisms remain poorly *** this study,we applied EA to the Zusanli(ST36)and Quchi(LI11)acupoints in rats with middle cerebral artery occlusion and *** found that EA effectively increased the expression of brain-derived neurotrophic factor and its receptor tyrosine kinase B,synapsin-1,postsynaptic dense protein 95,and microtubule-associated protein 2 in the ischemic penumbra of rats with middle cerebral artery occlusion and ***,EA greatly reduced the expression of myelin-related inhibitors Nogo-A and NgR in the ischemic *** kinase B inhibitor ANA-12 weakened the therapeutic effects of *** findings suggest that EA can improve neurological function after middle cerebral artery occlusion and reperfusion,possibly through regulating the activity of the brain-derived neurotrophic factor/tyrosine kinase B signal *** procedures and experiments were approved by the Animal Research Committee of Shanghai University of Traditional Chinese Medicine,China(approval ***200110002)on January 10,2020.

关键词： brain-derived neurotrophic factor dendritic electroacupuncture ischemia/reperfusion motor function neurite outgrowth inhibitor-A neurological outcomes Nogo receptor synapse tyrosine kinase B

Altered intra- and inter-network brain functional connectivity in upper-limb amputees revealed through independent component analysis

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Neural Regeneration Research 2022年第12期17卷 2725-2729页

作者： Bing-Bo Bao Hong-Yi Zhu Hai-Feng Wei Jing Li Zhi-Bin Wang Yue-hua Li xu-yun hua Mou-Xiong Zheng Xian-You Zheng Department of Orthopedic Surgery Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghaiChina Institute of Diagnostic and Interventional Radiology Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghaiChina Department of Traumatology and Orthopedics Yueyang HospitalShanghai University of Traditional Chinese MedicineShanghaiChina

Although cerebral neuroplasticity following amputation has been observed, little is understood about how network-level functional reorganization occurs in the brain following upper-limb amputation. The objective of this study was to analyze alterations in brain network functional connectivity(FC) in upper-limb amputees(ULAs). This observational study included 40 ULAs and 40 healthy control subjects;all participants underwent resting-state functional magnetic resonance imaging. Changes in intra-and inter-network FC in ULAs were quantified using independent component analysis and brain network FC analysis. We also analyzed the correlation between FC and clinical manifestations, such as pain. We identified 11 independent components using independent component analysis from all subjects. In ULAs, intra-network FC was decreased in the left precuneus(precuneus gyrus) within the dorsal attention network and left precentral(precentral gyrus) within the auditory network;but increased in the left Parietal_Inf(inferior parietal, but supramarginal and angular gyri) within the ventral sensorimotor network, right Cerebelum_Crus2(crus Ⅱ of cerebellum) and left Temporal_Mid(middle temporal gyrus) within the ventral attention network, and left Rolandic_Oper(rolandic operculum) within the auditory network. ULAs also showed decreased inter-network FCs between the dorsal sensorimotor network and ventral sensorimotor network, the dorsal sensorimotor network and right frontoparietal network, and the dorsal sensorimotor network and dorsal attention network. Correlation analyses revealed negative correlations between inter-network FC changes and residual limb pain and phantom limb pain scores, but positive correlations between inter-network FC changes and daily activity hours of stump limb. These results show that post-amputation plasticity in ULAs is not restricted to local remapping;rather, it also occurs at a network level across several cortical regions. This observation provides addit

关键词： amputation functional connectivity functional magnetic resonance imaging independent component analysis neuroimaging phantom pain phantom sensation resting-state networks

Modified constraint-induced movement therapy enhances cortical plasticity in a rat model of traumatic brain injury:a resting-state functional MRI study

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Neural Regeneration Research 2023年第2期18卷 410-415页

作者： Cheng-Cheng Sun Yu-Wen Zhang Xiang-Xin Xing Qi Yang Ling-yun Cao Yu-Feng Cheng Jing-Wang Zhao Shao-Ting Zhou Dan-Dan Cheng Ye Zhang xu-yun hua He Wang Dong-Sheng xu Department of Rehabilitation Tongji HospitalSchool of MedicineTongji UniversityShanghaiChina Institute of Science and Technology for Brain-Inspired Intelligence Fudan UniversityShanghaiChina Center of Rehabilitation Medicine Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghaiChina Institute of Rehabilitation Medicine School of Rehabilitation ScienceShanghai University of Traditional Chinese MedicineShanghaiChina Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation Ministry of EducationShanghaiChina Department of Rehabilitation Shanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina Department of Rehabilitation Tongren HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Rehabilitation Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghaiChina Department of Traumatology and Orthopedics Yueyang HospitalShanghai University of Traditional Chinese MedicineShanghaiChina Department of Rehabilitation Yangzhi Rehabilitation HospitalTongji UniversityShanghaiChina Human Phenome Institute Fudan UniversityShanghaiChina Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence(Fudan University) Ministry of EducationShanghaiChina

Modified constraint-induced movement therapy(mCIMT)has shown beneficial effects on motor function improvement after brain injury,but the exact mechanism remains *** this study,amplitude of low frequency fluctuation(ALFF)metrics measured by resting-state functional magnetic resonance imaging was obtained to investigate the efficacy and mechanism of mCIMT in a control co rtical impact(CCI)rat model simulating traumatic brain *** 3 days after control co rtical impact model establishment,we found that the mean ALFF(mALFF)signals were decreased in the left motor cortex,somatosensory co rtex,insula cortex and the right motor co rtex,and were increased in the right corpus *** 3 weeks of an 8-hour daily mClMT treatment,the mALFF values were significantly increased in the bilateral hemispheres compared with those at 3 days *** mALFF signal valu es of left corpus callosum,left somatosensory cortex,right medial prefro ntal cortex,right motor co rtex,left postero dorsal hippocampus,left motor cortex,right corpus callosum,and right somatosensory cortex were increased in the mCIMT group compared with the control cortical impact ***,we identified brain regions with significantly decreased mALFF valu es at 3 days *** correlation coefficients with the right forelimb sliding score indicated that the improvement in motor function of the affected upper limb was associated with an increase in mALFF values in these brain *** findings suggest that functional co rtical plasticity changes after brain injury,and that mCIMT is an effective method to improve affected upper limb motor function by promoting bilateral hemispheric co rtical *** values correlate with behavio ral changes and can potentially be used as biomarkers to assess dynamic cortical plasticity after traumatic brain injury.

关键词： amplitude of low frequency fluctuation cortical plasticity functional magnetic resonance imaging modified constraint-induced movement therapy traumatic brain injury

Supplementary motor area deactivation impacts the recovery of hand function from severe peripheral nerve injury

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Neural Regeneration Research 2016年第4期11卷 670-675页

作者： Ye-chen Lu Han-qiu Liu xu-yun hua yun-dong Shen Wen-dong xu Jian-guang xu Yu-dong Gu Department of Hand Surgery Huashan HospitalFudan University Department of Radiology Huashan HospitalFudan University State Key Laboratory of Medical Neuroscience Fudan University

Although some patients have successful peripheral nerve regeneration,a poor recovery of hand function often occurs after peripheral nerve *** is believed that the capability of brain plasticity is crucial for the recovery of hand *** supplementary motor area may play a key role in brain remodeling after peripheral nerve *** this study,we explored the activation mode of the supplementary motor area during a motor imagery *** investigated the plasticity of the central nervous system after brachial plexus injury,using the motor imagery *** from functional magnetic resonance imaging showed that after brachial plexus injury,the motor imagery task for the affected limbs of the patients triggered no obvious activation of bilateral supplementary motor *** result indicates that it is difficult to excite the supplementary motor areas of brachial plexus injury patients during a motor imagery task,thereby impacting brain *** of the supplementary motor area is likely to be a serious problem for brachial plexus injury patients in terms of preparing,initiating and executing certain movements,which may be partly responsible for the unsatisfactory clinical recovery of hand function.

关键词： nerve regeneration peripheral nerve injury brachial plexus injury neuronal plasticity supplementary motor area premotor area magnetic resonance imaging motor preparation motor imagery clinical restoration of hand function cortical remodeling block design neural regeneration

Application of precise strategy of TMS on stroke rehabilitation: based on mechanism of neural circuit disruption and plasticity

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Application of precise strategy of TMS on stroke rehabilitat...