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Energy-Saving Distributed Flexible Job Shop Scheduling Optimization with Dual Resource Constraints Based on Integrated Q-Learning Multi-Objective Grey Wolf Optimizer

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Computer Modeling in Engineering & Sciences 2024年第8期140卷 1459-1483页

作者： Hongliang Zhang yi chen Yuteng Zhang Gongjie xu School of Management Science and Engineering Anhui University of TechnologyMa’anshan243032China Laboratory of Multidisciplinary Management and Control of Complex Systems of Anhui Higher Education Institutes Anhui University of TechnologyMa’anshan243032China Department of Industrial Engineering School of Mechanical EngineeringNorthwestern Polytechnical UniversityXi’an710072China

The distributed flexible job shop scheduling problem(DFJSP)has attracted great attention with the growth of the global manufacturing *** DFJSP research only considers machine constraints and ignores worker *** one critical factor of production,effective utilization of worker resources can increase ***,energy consumption is a growing concern due to the increasingly serious environmental ***,the distributed flexible job shop scheduling problem with dual resource constraints(DFJSP-DRC)for minimizing makespan and total energy consumption is studied in this *** solve the problem,we present a multi-objective mathematical model for DFJSP-DRC and propose a Q-learning-based multi-objective grey wolf optimizer(Q-MOGWO).In Q-MOGWO,high-quality initial solutions are generated by a hybrid initialization strategy,and an improved active decoding strategy is designed to obtain the scheduling *** further enhance the local search capability and expand the solution space,two wolf predation strategies and three critical factory neighborhood structures based on Q-learning are *** strategies and structures enable Q-MOGWO to explore the solution space more efficiently and thus find better Pareto *** effectiveness of Q-MOGWO in addressing DFJSP-DRC is verified through comparison with four algorithms using 45 *** results reveal that Q-MOGWO outperforms comparison algorithms in terms of solution quality.

关键词： Distributed flexible job shop scheduling problem dual resource constraints energy-saving scheduling multi-objective grey wolf optimizer Q-learning

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榄香烯脂质体结合超声空化技术对裸鼠异位瘤的抑制作用及毒性评价

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温州医科大学学报 2017年第8期47卷 571-575页

作者：王建中徐逸刘鹏程陈浩波浙江中医药大学附属温州中医院肿瘤内科浙江温州325000 温州医科大学附属第一医院药剂科浙江温州325015

目的:以榄香烯脂质体(EL)作为对照药物,评价EL结合超声空化技术在抗肿瘤疗效及降低不良反应中的作用。方法:建立大鼠胶质瘤C6细胞裸鼠皮下肿瘤模型并通过尾静脉注射方式给药,EL(浓度为5mg/m L)给药剂量为50mg/kg(0.1m L/10g)。实验分5组... 详细信息

目的:以榄香烯脂质体(EL)作为对照药物,评价EL结合超声空化技术在抗肿瘤疗效及降低不良反应中的作用。方法:建立大鼠胶质瘤C6细胞裸鼠皮下肿瘤模型并通过尾静脉注射方式给药,EL(浓度为5mg/m L)给药剂量为50mg/kg(0.1m L/10g)。实验分5组(n=7):0.9%氯化钠溶液(空白对照)组、榄香烯脂质体(EL)组、榄香烯脂质体+超声造影剂(EL+MB)组、榄香烯脂质体+超声(EL+US)组、榄香烯脂质体+超声造影剂+超声(EL+MB+US)组,每隔2d给药1次,共给药3次,检测裸鼠肿瘤体积变化、肿瘤质量变化、体质量变化和血液白细胞数等指标,取肿瘤组织,HE染色观察肿瘤组织形态学变化,TUNEL试剂盒检测肿瘤细胞凋亡程度,观察超声造影剂联合超声对EL抗肿瘤的疗效与血液学毒性的影响。结果:与EL组比,EL+MB+US组对肿瘤体积增长的抑制作用强(P<0.05),裸鼠体质量变化小,肿瘤细胞凋亡程度增加,白细胞数降低量减小(P<0.05)。结论:与EL相比,EL+MB+US可以更有效地发挥对肿瘤生长的抑制作用,提高裸鼠生存质量,降低血液学毒性,可以作为一个新的肿瘤药物递送系统进一步开发研究。

关键词：榄香烯脂质体超声空化效应药效学

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十二井穴放血对不同程度颅脑创伤大鼠脑水肿及线粒体生物合成的影响

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中国现代医学杂志 2018年第9期28卷 1-5页

作者：沈彤张赛涂悦陈旭义吴焕成天津中医药大学第一附属医院推拿科天津300193 武警后勤学院附属医院脑科中心(天津市神经创伤修复重点实验室) 天津300162 天津市北辰医院脑系科天津300400

目的探讨十二井穴放血对颅脑创伤(TBI)大鼠脑水肿及线粒体生物合成的影响。方法将56只SD大鼠随机等分为7组,即轻度TBI组、轻度TBI加井穴放血组、中度TBI组、中度TBI加井穴放血组、重度TBI组、重度TBI加井穴放血组和对照组,每组8只。应... 详细信息

目的探讨十二井穴放血对颅脑创伤(TBI)大鼠脑水肿及线粒体生物合成的影响。方法将56只SD大鼠随机等分为7组,即轻度TBI组、轻度TBI加井穴放血组、中度TBI组、中度TBI加井穴放血组、重度TBI组、重度TBI加井穴放血组和对照组,每组8只。应用电子控制性脑皮质撞击仪,轻度、中度、重度TBI组的打击深度分别为1、3和4 mm。对照组仅开骨窗后缝合皮肤,不进行打击。井穴放血通过1 ml注射器针头于大鼠双侧前肢趾端的十二井穴点刺出血完成,出血量为每穴10μl,每12 h进行1次放血。手术后72 h,进行神经功能损伤评分(m NSS),随后取10 mg损伤周围脑组织,q RT-PCR检测过氧化物酶体增殖物激活受体γ共激活因子1α(PGC-1α)、线粒体转录因子A(TFAM)基因的表达和线粒体DNA(mt DNA)拷贝数,剩余脑组织进行脑含水量测量。结果 TBI后大鼠的m NSS评分均高于对照组,且随着TBI严重程度的增加,评分依次增高(P0.05);TBI后各组大鼠脑组织含水量与对照组比较均增高,且中度TBI组大鼠在应用井穴放血疗法后脑组织含水量与相应的单纯损伤组大鼠比较降低(P<0.05)。结论井穴放血可能通过激活PGC及下游通路,促进mt DNA的生物合成,从而增强损伤脑组织的能量供应,进而改善脑水肿程度,发挥脑保护作用。

关键词：颅脑创伤十二井穴线粒体DNA 神经功能损伤评分放血疗法

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An ultrasonic-ionic liquid process for the efficient acid catalyzed hydrolysis of feather keratin

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Chinese Journal of Chemical Engineering 2019年第3期27卷 660-667页

作者： Song Ding Yang Sun Hongyue chen Chao xu yi Hu School of Pharmaceutical Sciences Nanjing Tech University School of Biotechnology and Pharmaceutical Engineering of Nanjing Tech University School of Pharmaceutical Sciences State Key Laboratory of Material-Oriented Chemical Engineering Nanjing Tech University

A novel efficient method for hydrolyzing feather keratin using an ultrasonic-ionic liquid coupling process has been developed, with reaction conditions optimized using response surface analysis of data obtained from single factor optimization studies. Ultrasonic irradiation(225 W power) of feathers in 8.4 mol·L^(-1) hydrochloric acid containing 1-butyl-3-methylimidazolium chloride as a cosolvent at 80 °C for 1.4 h, followed by heating at 110 °C for 8.3 h, resulted in hydrolysis of their keratin component in an excellent 83.1% yield. Compared with previous methods, this new method employs reduced amounts of hydrochloric acid, shorter reaction time, and affords amino acid hydrolysis products in higher yield.

关键词： Ionic liquid Ultrasonic Keratin Hydrolysis Amino acid

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Sodium metals for single emitter strong coupling:Alternative plasmonic candidates beyond noble metals

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Science China(Physics,Mechanics & Astronomy) 2024年第8期67卷 106-117页

作者： yi Zhang Shuying chen Yuning Han Xiulai xu Lin Zhou National Laboratory of Solid State Microstructures Collaborative Innovation Center of Advanced MicrostructuresJiangsu Key Laboratory of Artificial Functional MaterialsCollege of Engineering and Applied SciencesNanjing UniversityNanjing 210008China School of Information and Electronic Engineering(Sussex Artificial Intelligence Institute) Zhejiang Gongshang UniversityHangzhou 310018China Department of Physics&Astronomy University College LondonLondon WC1E 6BTUK State Key Laboratory for Mesoscopic Physics and Frontiers Science Center for Nano-optoelectronics School of PhysicsPeking UniversityBeijing 100871China

This work provides a theoretical investigation into the strong coupling between a single quantum emitter(QE)and the surface plasmons of sodium metals in two representative plasmonic systems,i.e.,the semi-infinite metal-dielectric interface and the metal nanoparticles(NPs)of monomer/dimer *** both configurations,sodium metals exhibit distinctly stronger coupling strength and lower optical loss in the optical region than their noble metal counterparts,demonstrating the ideal candidate characteristics for single-molecule-level strong couplings with distinctly facile operation *** results provide new insights into extreme light-matter interactions with potential applications in quantum information,optical sensors,quantum chemistry,etc.

关键词： sodium metals plasmonics single quantum emitter strong coupling pseudomode

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Analysis of kinematic data and determination of ground reaction force of foot in slow squat

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Acta Mechanica Sinica 2013年第1期29卷 143-148页

作者： xu-Shu Zhang Yuan Guo Mei-Wen An Wei-yi chen Institute of Applied Mechanics and Biomedical Engineering Taiyuan University of Technology

In the present paper, the ground reaction force （GRF） acting on foot in slow squat was determined through a force measuring system, and at the same time, the kinematic data of human squat were obtained by analyzing the photographed image sequences. According to the height and body weight, six healthy volunteers were selected, three men in one group and the other three women in another group, and the fundamental parameters of subjects were recorded, including body weight, height and age, etc. Based on the anatomy characteristics, some markers were placed on the right side of joints. While the subject squatted at slow speed on the force platform, the ground reaction forces on the forefoot and heel for each foot were obtained through calibrated force platform. The analysis results show that the reaction force on heel is greater than that on forefoot, and double feet have nearly constant force. Moreover, from processing and analyzing the synchronously photographed image sequences in squat, the kinematic data of human squat were acquired, including mainly the curves of angle, angular velocity and angular acceleration varied with time for knee, hip and ankle joints in a sagittal plane. The obtained results can offer instructive reference for photographing and analyzing the movements of human bodies, diagnosing some diseases, and establishing in the future appropriate mathematical models for the human motion.

关键词： Ground reaction force. Force sensor. Kinematic data. Foot. Squat

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Fingolimod(FTY720) improves postoperative cognitive dysfunction in mice subjected to D-galactose-induced aging

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Neural Regeneration Research 2020年第7期15卷 1308-1315页

作者： Jie Zhang Bin Xiao chen-xu Li yi Wang Department of Anesthesiology Third Xiangya Hospital of Central South UniversityChangshaHunan ProvinceChina Department of Orthopedics the Second Affiliated Hospital of Shaanxi University of Chinese MedicineXianyangShaanxi ProvinceChina

Neurocognitive dysfunction is a common postoperative complication,especially in older adult ***(FTY720)is a sphingosine-1-phosphate receptor modulator that has been found to be neuroprotective in several animal models of central nervous system ***,few reports have examined whether FTY720 could mitigate postoperative cognitive *** this study,we investigated whether FTY720 could prevent postoperative neurocognitive impairment in mice subjected to D-galactose-induced *** induced an accelerated model of aging by administering an intraperitoneal injection of ***,we performed a partial hepatolobectomy under sevoflurane ***720(1 mg/kg)was administered intraperitoneally 3 hours before and 24 hours after anesthesia and *** results indicated that anesthesia and surgery significantly impaired spatial memory in the Y-maze test 6 hours after *** also found that problem solving ability and long-term memory in the puzzle box test on postoperative days 2–4 were significantly improved by FTY720 *** staining and western blot assay demonstrated that FTY720 significantly inhibited microglial activation in the hippocampal CA1 region of mice 6 hours and 3 days after anesthesia,and down-regulated the expression of synaptic-related proteins postsynaptic density protein 95 and GluR2 in the *** results indicate that FTY720 improved postoperative neurocognitive dysfunction in mice subjected to D-galactose-induced *** study was approved by the Experimental Animal Ethics Committee of the Third Xiangya Hospital of Central South University of China(approval ***(LA)2016-025)on September 27,2016.

关键词： D-galactose fengomod(FTY720) hepatectomy microglia nerve regeneration postoperative neurocognitive dysfunction sevoflurane

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Evolution of microstructure in reheated coarse-grained zone of G115 novel martensitic heat-resistant steel

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Journal of Iron and Steel Research International 2022年第2期29卷 327-338页

作者： Zhong-yi chen Zheng-zong chen Dong-xu Kou Yong-qing Li Yong-lin Ma yi-ming Li School of Material and Metallurgy Inner Mongolia University of Science and TechnologyBaotou014010Inner MongoliaChina Institute for Special Steels China Iron and Steel Research InstituteBeijing100081China Technology Center Inner Mongolia North Heavy Industry Group Co.Ltd.Baotou014010Inner MongoliaChina Key Laboratory of Advanced Metals and Materials of Inner Mongolia of Materials and Metallurgy School Inner Mongolia University of Science and TechnologyBaotou014010Inner MongoliaChina

Based on the thermal simulation method,a systematical analysis was conducted on the effect of welding peak temperature and the cooling time that takes place from 800 to 500℃ on microstructure,precipitates,substructure and microhardness of the reheated coarse-grained heat-affected zone(CGHAZ)of G115 novel martensitic heat-resistant *** revealed from the results,the microstructure of un-altered CGHAZ(UACGHAZ)and supercritically CGHAZ(SCCGHAZ)was lath martensite,and structural heredity *** reheated CGHAZ(IRCGHAZ)exhibited martensite and over-tempered martensite,and subcritical CGHAZ(SCGHAZ)displayed martensite and under-tempered *** austenite in UACGHAZ and SCCGHAZ was transformed with the diffusion mechanism during the first thermal cycle,but with the non-diffusion mechanism during the second thermal *** this reason,A_(c1) and A_(c3) during the second thermal cycle were significantly lower than those during the first thermal cycle,and A_(c1) and A_(c3) were reduced by nearly 14 and 44℃,*** the content and stability of the austenite alloy during the second thermal cycle of IRCGHAZ were lower than those during the first thermal cycle,M_(s) increased by nearly 30℃.There were considerable precipitates in the over-tempered region of IRCGHAZ,and the Laves phase was contained,which was not conducive to high-temperature creep ***,the dislocation density and the number of sub-grains in the region were lower,resulting in a sharp decrease in the microhardness,and it was the weak area in the reheated CGHAZ.

关键词： Heat-resistant steel G115 steel Reheated coarse-grained heat-affected zone Microstructure evolution Precipitate

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Phthalocyanine-derived catalysts decorated by metallic nanoclusters for enhanced CO_(2)electroreduction

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Green Energy & Environment 2023年第2期8卷 444-451页

作者： Jiacheng chen Jiayu Li Jing xu Minghui Zhu yi-Fan Han State Key Laboratory of Chemical Engineering School of Chemical EngineeringEast China University of Science and TechnologyShanghai200237China

Electrochemical CO_(2)reduction(CO_(2)RR)over molecular catalysts is a paramount approach for CO_(2)conversion to ***,we report a novel phthalocyanine-derived catalyst synthesized by a two-step method with a much improved ***,the catalyst contains both Ni-N4sites and highly dispersed metallic Ni nanoclusters,leading to an increased CO_(2)RR currents by two *** labelling study and in situ spectroscopic analysis demonstrate that the existence of metallic Ni nanoclusters is the key factor for the activity enhancement and can shift the CO_(2)RR mechanism from being electron transfer(ET)-limited(forming*COO^(-))to concerted proton-electron transfer(CPET)-limited(forming CO).

关键词： Carbon dioxide Electroreduction Hybrid catalyst Nickel-based catalysts Mechanism

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上海市男男同性性行为人群HIV抗体唾液快速检测试剂自检使用情况及影响因素分析

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中国预防医学杂志 2021年第4期22卷 297-300页

作者：鲍燕许祎晨沈冰顾凯侃杨芸王海涛韩磊宁镇上海市静安区疾病预防控制中心上海200072 同济大学医学院上海市疾病预防控制中心

目的探索上海市男男同性性行为人群(men who have sex with men, MSM)对人类免疫缺陷病毒(human immunodeficiency virus, HIV)抗体唾液快速检测试剂自检(口腔自检)方式检测HIV的使用情况和影响因素。方法 2019年1月—2020年12月,社区组... 详细信息

目的探索上海市男男同性性行为人群(men who have sex with men, MSM)对人类免疫缺陷病毒(human immunodeficiency virus, HIV)抗体唾液快速检测试剂自检(口腔自检)方式检测HIV的使用情况和影响因素。方法 2019年1月—2020年12月,社区组织"上海心生"和上海市静安区疾病预防控制中心自愿咨询检测(voluntary counseling testing, VCT)门诊,共同招募MSM为研究对象。采用自行设计的调查问卷,在知情同意前提下,以问卷星网站在线调查的方式开展调查,收集其人口学特征、性行为特征、对口腔自检的认知和使用情况等信息。结果共2 589名MSM纳入研究,使用过口腔自检1 427例(55.12%)。多因素logistic回归分析显示,既往使用口腔自检情况在年龄<50岁(OR=1.87,95%CI:1.18~2.96),最近6个月男性性伴数≥2个(OR=1.33,95%CI:1.12~1.58),最近1年在检测点做过HIV检测(OR=1.92,95%CI:1.53~2.41),朋友/性伴中有人使用口腔自检(OR=8.49, 95%CI:5.78~12.48)或者不清楚朋友/性伴中是否使用过口腔自检(OR=1.54, 95%CI:1.04~2.48)差异有统计学意义(P<0.05)。口腔自检试剂价格从60元下降到40元、20元时弹性系数分别为2.42、1.47。结论上海市MSM口腔自检使用率相对较低,年龄、对高危因素的感知程度以及朋友/性伴推荐是影响HIV口腔自检使用的重要因素。降低试剂价格可能促进口腔自检的使用。

关键词：男男同性性行为人群人类免疫缺陷病毒抗体唾液快速检测影响因素

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