检索结果-南通市图书馆

Effectiveness of sharp recanalization of superior vena cava-right atrium junction occlusion

World Journal of Clinical Cases 2021年第16期9卷 3848-3857页

作者： Xiao-Wen Wu xu-ya zhao Xing Li Jun-Xiang Li Zong-yang Liu Zhi Huang Ling Zhang Chong-yang Sima Yu Huang Lei Chen Shi Zhou Department of Interventional Radiology Guizhou Cancer HospitalGuiyang 550000Guizhou ProvinceChina Department of Interventional Radiology The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550000Guizhou ProvinceChina Department of Nephrology The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550000Guizhou ProvinceChina Department of Nursing Guizhou Cancer HospitalGuiyang 550000Guizhou ProvinceChina Department of Nephrology Guizhou Cancer HospitalGuiyang 550000Guizhou ProvinceChina

BACKGROUND Conventional recanalization techniques may fail in patients with completely occluded superior vena cava(SVC).AIM To analyze the effectiveness and complications of sharp recanalization for completely occluded *** This was a retrospective study of patients that underwent puncture and recanalization of the SVC between January 2016 and December 2017 at our *** recanalization was performed using the RUPS-100 *** patients were followed for 12 *** main outcomes were the patency rate of SVC and arteriovenous fistula flow during *** The procedure was successful in all 14 patients(100%).Blood pressure in the distal SVC decreased in all 14 cases(100%)from 26.4±2.7 cmH2O to 14.7±1.3 cmH2O(P<0.05).The first patency rates of the SVC at 24 h and at 3,6,9 and 12 mo after sharp recanalization were 100%,92.9%,85.7%,78.6%and 71.4%,*** were two(14.3%)severe,one(7.1%)moderate and one(7.1%)minor *** severe complications included one case of pericardial tamponade and one case of *** The results suggest that sharp recanalization can be an additional tool to extend or renew the use of an occluded upper extremity access for *** could be of use in patients with long-term maintenance hemodialysis in whom the maintenance of central venous access is often a challenge.

关键词： Hemodialysis Superior vena cava occlusion Vascular patency Arteriovenous fistula Arteriovenous graft

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

图书馆普通员工职业胜任力研究主报告

引用

国家图书馆学刊 2017年第2期26卷 5-14页

作者：李超徐晟赵雅天津工业大学图书馆天津师范大学心理与行为研究院南开大学商学院信息资源管理系

本研究采用定性与定量相结合的方法,探索我国图书馆普通员工的职业胜任力特征。在专家访谈和关键事件行为访谈基础上,编制"图书馆员自我评价问卷",并以此为测量工具在全国范围内实施问卷调查。根据对2799个有效样本的统计分析,建立我国... 详细信息

本研究采用定性与定量相结合的方法,探索我国图书馆普通员工的职业胜任力特征。在专家访谈和关键事件行为访谈基础上,编制"图书馆员自我评价问卷",并以此为测量工具在全国范围内实施问卷调查。根据对2799个有效样本的统计分析,建立我国图书馆普通员工职业胜任力模型和胜任力测评量表,阐释图书馆普通员工职业胜任力及其子维度的表现特征,探讨个人、教育、工作等因素对胜任力的影响,以及胜任力对工作满意度、离职倾向和组织承诺3个绩效指标的预测作用。

关键词：图书馆普通员工职业胜任力问卷调查

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma(CHANCE001)

引用

Signal Transduction and Targeted Therapy 2023年第3期8卷 1198-1207页

作者： Hai-Dong Zhu Hai-Liang Li Ming-Sheng Huang Wei-Zhu yang Guo-Wen Yin Bin-yan Zhong Jun-Hui Sun Zhi-Cheng Jin Jian-Jian Chen Nai-Jian Ge Wen-Bin Ding Wen-Hui Li Jin-Hua Huang Wei Mu Shan-Zhi Gu Jia-Ping Li Hui zhao Shu-Wei Wen yan-Ming Lei Yu-Sheng Song Chun-Wang Yuan Wei-Dong Wang Ming Huang Wei zhao Jian-Bing Wu Song Wang xu Zhu Jian-Jun Han Wei-Xin Ren Zai-Ming Lu Wen-Ge Xing Yong Fan Hai-Lan Lin Zi-Shu Zhang Guo-Hui xu Wen-Hao Hu Qiang Tu Hong-Ying Su Chuan-Sheng Zheng Yong Chen xu-ya zhao Zhu-Ting Fang Qi Wang Jin-Wei zhao Ai-Bing xu Jian xu Qing-Hua Wu Huan-Zhang Niu Jian Wang Feng Dai Dui-Ping Feng Qing-Dong Li Rong-Shu Shi Jia-Rui Li Guang yang Hai-Bin Shi Jian-Song Ji Yu-E Liu Zheng Cai Po yang yang zhao Xiao-Li Zhu Li-Gong Lu Gao-Jun Teng Center of Interventional Radiology&Vascular Surgery Department of RadiologyZhongda HospitalMedical SchoolSoutheast UniversityNanjing 210009China Department of Minimally invasive Intervention The Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhou 450008China Department of Interventional Radiology the Third Affiliated HospitalSun Yat-Sen UniversityGuangzhou 510630China Department of Interventional Radiology Union Hospital of Fujian Medical UniversityFuzhou 350001China Department of Interventional Radiology Jiangsu Cancer Hospital&Jiangsu Institute of Cancer Research&The Affiliated Cancer Hospital of Nanjing Medical UniversityNanjing 210009China Department of Interventional Radiology The First Affiliated Hospital of Soochow UniversitySoochow UniversitySuzhou 215006China Hepatobiliary and Pancreatic Interventional Treatment Center Division of Hepatobiliary and Pancreatic SurgeryThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Interventional Radiology Eastern Hospital of Hepatobiliary SurgeryNavy Medical University(Second Military Medical University)Shanghai 200438China Department of Interventional Radiology Nantong First People’s HospitalNantong 226001China Department of Interventional Radiology Yancheng Third People’s HospitalYancheng 224008China Department of Minimally Invasive Interventional Therapy Sun YatSen University Cancer CenterGuangzhou 510060China Department of Vascular Surgery Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China. Department of Interventional Radiology Hunan Cancer HospitalChangsha 410031China Department of Interventional Oncology The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080China Department of Interventional Radiology The Hospital of Nantong UniversityNantong 226001China Department of Interventional Therapy Shanxi Tumor HospitalTaiyuan 030001China Department of Interventional Radiology Tibet Autonomous Region People’s

There is considerable potential for integrating transarterial chemoembolization(TACE),programmed death-(ligand)1(PD-[L]1)inhibitors,and molecular targeted treatments(MTT)in hepatocellular carcinoma(HCC).It is necessary to investigate the therapeutic efficacy and safety of TACE combined with PD-(L)1 inhibitors and MTT in real-world *** this nationwide,retrospective,cohort study,826 HCC patients receiving either TACE plus PD-(L)1 blockades and MTT(combination group,n=376)or TACE monotherapy(monotherapy group,n=450)were included from January 2018 to May *** primary endpoint was progression-free survival(PFS)according to modified *** secondary outcomes included overall survival(OS),objective response rate(ORR),and *** performed propensity score matching approaches to reduce bias between two *** matching,228 pairs were included with a predominantly advanced disease *** PFS in combination group was 9.5 months(95%confidence interval[CI],8.4-11.0)versus 8.0 months(95%CI,6.6-9.5)(adjusted hazard ratio[HR],0.70,P=0.002).OS and ORR were also significantly higher in combination group(median OS,19.2[16.1-27.3]vs.15.7 months[13.0-20.2];adjusted HR,0.63,P=0.001;ORR,60.1%vs.32.0%;P<0.001).Grade 3/4 adverse events were observed at a rate of 15.8%and 7.5%in combination and monotherapy groups,*** results suggest that TACE plus PD-(L)1 blockades and MTT could significantly improve PFS,OS,and ORR versus TACE monotherapy for Chinese patients with predominantly advanced HCC in real-world practice,with an acceptable safety profile.

关键词： hepatocellular targeted matching

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Comparative proteomic analysis of plasma exosomes reveals the functional contribution of N-acetyl-alpha-glucosaminidase to Parkinson’s disease

引用

Neural Regeneration Research 2025年第10期20卷 2998-3012页

作者： Yuan zhao Yidan Zhang Xin Liu Jian Zhang ya Gao Shuyue Li Cui Chang Xiang Liu Guofeng yang Department of Geriatrics Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of Neurosurgery The Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina

Parkinson’s disease is the second most common progressive neurodegenerative disorder,and few reliable biomarkers are available to track disease *** proteins,DNA,mRNA,and lipids carried by exosomes reflect intracellular changes,and thus can serve as biomarkers for a variety of *** this study,we investigated alterations in the protein content of plasma exosomes derived from patients with Parkinson’s disease and the potential therapeutic roles of these proteins in Parkinson’s *** a tandem mass tag-based quantitative proteomics approach,we characterized the proteomes of plasma exosomes derived from individual patients,identified exosomal protein signatures specific to patients with Parkinson’s disease,and identified N-acetyl-alpha-glucosaminidase as a differentially expressed protein.N-acetyl-alpha-glucosaminidase expression levels in exosomes from the plasma of patients and healthy controls were validated by enzyme-linked immunosorbent assay and western *** results demonstrated that the exosomal N-acetyl-alpha-glucosaminidase concentration was not only lower in Parkinson’s disease,but also decreased with increasing Hoehn-yahr stage,suggesting that N-acetyl-alpha-glucosaminidase could be used to rapidly evaluate Parkinson’s disease ***,western blot and immunohistochemistry analysis showed that N-acetyl-alpha-glucosaminidase levels were markedly reduced both in cells treated with 1-methyl-4-phenylpyridinium and cells overexpressingα-synuclein compared with control ***,N-acetyl-alpha-glucosaminidase overexpression significantly increased cell viability and inhibitedα-synuclein expression in 1-methyl-4-phenylpyridinium-treated *** together,our findings demonstrate for the first time that exosomal N-acetyl-alpha-glucosaminidase may serve as a biomarker for Parkinson’s disease diagnosis,and that N-acetyl-alpha-glucosaminidase may reduceα-synuclein expression and 1-methyl-4-phenylpyridinium-induced n

关键词： biomarker diagnosis exosomes N-acetyl-alpha-glucosaminidase Parkinson’s disease proteomic α-synuclein

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Repetitive traumatic brain injury–induced complement C1–related inflammation impairs long-term hippocampal neurogenesis

引用

Neural Regeneration Research 2025年第3期20卷 821-835页

作者： Jing Wang Bing Zhang Lanfang Li Xiaomei Tang Jinyu Zeng Yige Song Chao xu Kai zhao Guoqiang Liu Youming Lu Xinyan Li Kai Shu Department of Neurosurgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Neurosurgery Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Pathophysiology School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Institute for Brain Research Wuhan Center of Brain ScienceHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Graduate Student Chongqing Medical UniversityChongqingChina Department of Basic Medicine School of Medical ScienceHubei University for NationalitiesEnshiHubei ProvinceChina Department of Anatomy School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Repetitive traumatic brain injury impacts adult neurogenesis in the hippocampal dentate gyrus,leading to long-term cognitive ***,the mechanism underlying this neurogenesis impairment remains *** this study,we established a male mouse model of repetitive traumatic brain injury and performed long-term evaluation of neurogenesis of the hippocampal dentate gyrus after repetitive traumatic brain *** results showed that repetitive traumatic brain injury inhibited neural stem cell proliferation and development,delayed neuronal maturation,and reduced the complexity of neuronal dendrites and *** with repetitive traumatic brain injuryalso showed deficits in spatial memory ***,following repetitive traumatic brain injury,neuroinflammation was enhanced in the neurogenesis microenvironment where C1q levels were increased,C1q binding protein levels were decreased,and canonical Wnt/β-catenin signaling was *** inhibitor of C1 reversed the long-term impairment of neurogenesis induced by repetitive traumatic brain injury and improved neurological *** findings suggest that repetitive traumatic brain injury–induced C1-related inflammation impairs long-term neurogenesis in the dentate gyrus and contributes to spatial memory retrieval dysfunction.

关键词： complement C1 dendrite dentate gyrus hippocampus neural stem cell neurogenesis neuroinflammation neurological function neuron traumatic brain injury

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

七甲川菁近红外荧光染料对胃癌原位移植模型的靶向识别

引用

中国实验动物学报 2016年第6期24卷 567-571,578页

作者：赵勇张彩勤赵宁宁谭邓旭赵亚张海师长宏第四军医大学实验动物中心西安710032

目的研究七甲川菁近红外荧光(NIRF)染料在胃癌原位移植模型活体成像中的应用效果。方法将标记荧光酶素的人胃癌细胞系Hep G2原位移植裸鼠建立肿瘤模型,同时诱发制备胃溃疡模型;对上述模型分别采用生物发光成像和NIRF成像,观察胃癌组织... 详细信息

目的研究七甲川菁近红外荧光(NIRF)染料在胃癌原位移植模型活体成像中的应用效果。方法将标记荧光酶素的人胃癌细胞系Hep G2原位移植裸鼠建立肿瘤模型,同时诱发制备胃溃疡模型;对上述模型分别采用生物发光成像和NIRF成像,观察胃癌组织对近红外荧光染料的吸收;探索缺氧和阴离子转运肽(OATP)对胃癌组织吸收NIRF染料的影响,明确NIRF染料靶向识别肿瘤细胞的特异性。结果 NIRF信号与生物发光信号在胃癌原位移植模型活体成像中具有较好的相关性。胃癌组织部位可获得较强的NIRF荧光信号,而胃溃疡部位未检测到荧光信号。缺氧能够增强胃癌细胞对NIRF染料的吸收,而阴离子转运肽特异性抑制剂磺溴酞钠(BSP)能够显著降低肿瘤细胞对NIRF染料的吸收。结论七甲川菁近红外荧光染料能够靶向识别胃癌原位移植模型。

关键词：近红外荧光染料胃癌肿瘤原位移植模型裸鼠

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

镁合金表面冷喷涂层防护研究进展

引用

表面技术 2018年第5期47卷 43-56页

作者：虞思琦杨夏炜王非凡李文亚徐雅欣赵耀邦西北工业大学材料学院陕西省摩擦焊接工程技术重点实验室西安710072 北京宇航系统工程研究所北京100076 上海航天精密机械研究所上海201600

镁合金作为最轻质的金属结构材料,由于其密度低和比强度高等优良的物理和力学性能,在航空、航天、汽车以及电子等领域引起广泛关注。然而,镁合金化学性质活泼、耐腐蚀和耐磨损性差等缺点严重制约其进一步应用。近些年发展起来的冷喷涂技... 详细信息

镁合金作为最轻质的金属结构材料,由于其密度低和比强度高等优良的物理和力学性能,在航空、航天、汽车以及电子等领域引起广泛关注。然而,镁合金化学性质活泼、耐腐蚀和耐磨损性差等缺点严重制约其进一步应用。近些年发展起来的冷喷涂技术,在固态下制备涂层,涂层致密且与基体结合良好,因此可为镁合金表面防护提供一种新的有效方法。主要综述了镁合金表面冷喷涂耐腐蚀涂层(纯铝、铝合金和复合材料涂层)和耐磨损涂层(合金和复合材料涂层),论述了影响冷喷涂层耐腐蚀、耐磨损以及其他力学性能(硬度和涂层/基体结合强度)的主要因素,包括杂质元素含量、合金种类以及复合材料涂层中陶瓷颗粒含量、尺寸和形貌等。对比了几种常用表面处理技术制备的纯铝涂层的耐腐蚀性能,并阐述了冷喷涂技术在镁合金表面防护方面的优势。此外,还分析了热处理对冷喷涂纯铝和复合材料涂层耐蚀性的影响。最后提出了目前冷喷涂技术在镁合金防护方面的局限性以及发展难题,对未来研究趋势进行了展望。

关键词：冷喷涂防护涂层镁合金耐腐蚀耐磨损

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

引用

Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-Yun zhao De-En xu Ming-Lei Wu Ji-Chuan Liu Zi-Ling Shi Quan-Hong Ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

界面极化电压的外推法测量研究

引用

物探与化探 2017年第3期41卷 484-488页

作者：莫婉玲孙中华徐娅赵斌华中科技大学化学与化工学院湖北武汉430074 华中科技大学机械科学与工程学院湖北武汉430074

界面极化电压的测量对提高隧道掘进机(TBM)中BEAM电法前探的灵敏度具有一定的实用价值,而岩土与护盾电极之间的界面极化电压用传统方法难以精确测量。为此,本文提出一种界面极化电压的外推测量方法。该方法由一个样品筒和若干等距分布... 详细信息

界面极化电压的测量对提高隧道掘进机(TBM)中BEAM电法前探的灵敏度具有一定的实用价值,而岩土与护盾电极之间的界面极化电压用传统方法难以精确测量。为此,本文提出一种界面极化电压的外推测量方法。该方法由一个样品筒和若干等距分布的电极构成,在样品筒两端施加交流电,测量各电极的交流复电压,根据电极之间的几何关系即可外推得到两端供电电极的界面电压。实验结果表明,该方法能够准确测出泥状岩土与金属电极之间的界面极化电压,且当泥状岩土中含有木炭或水洞等异物时,可以先用该方法测出泥状岩土与护盾电极之间的界面极化电压,然后将其在电法超前探测的总电压中扣除,从而提高隧道超前探测的灵敏度。

关键词：电法勘探面极化隧道超前探测外推法

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Differential distribution of PINK1 and Parkin in the primate brain implies distinct roles

引用

Neural Regeneration Research 2025年第4期20卷 1124-1134页

作者： yanting Liu Wei Huang Jiayi Wen Xin Xiong Ting xu Qi Wang Xiusheng Chen Xianxian zhao Shihua Li Xiaojiang Li Weili yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong-Hongkong-Macao CNS Regeneration Institute of Jinan UniversityJinan UniversityGuangzhouGuangdong ProvinceChina

The vast majority of in vitro studies have demonstrated that PINK1 phosphorylates Parkin to work together in mitophagy to protect against neuronal ***,it remains largely unclear how PINK1 and Parkin are expressed in mammalian *** has been difficult to address because of the intrinsically low levels of PINK1 and undetectable levels of phosphorylated Parkin in small *** this issue is critical for elucidating the in vivo roles of PINK1 and ***,we showed that the PINK1 kinase is selectively expressed as a truncated form(PINK1–55)in the primate *** the present study,we used multiple antibodies,including our recently developed monoclonal anti-PINK1,to validate the selective expression of PINK1 in the primate *** found that PINK1 was stably expressed in the monkey brain at postnatal and adulthood stages,which is consistent with the findings that depleting PINK1 can cause neuronal loss in developing and adult monkey ***1 was enriched in the membrane-bound fractionations,whereas Parkin was soluble with a distinguishable *** double staining experiments showed that PINK1 and Parkin did not colocalize under physiological conditions in cultured monkey astrocytes,though they did colocalize on mitochondria when the cells were exposed to mitochondrial *** findings suggest that PINK1 and Parkin may have distinct roles beyond their well-known function in mitophagy during mitochondrial damage.

关键词： neurodegeneration Parkin Parkinson’s disease PINK1 subcellular distribution

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：