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Controlled Synthesis of Dental Enamel-like Hydroxyapatite Whiskers via Hydrothermal Homogeneous Precipitation

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Journal of Harbin Institute of Technology(New Series) 2013年第6期20卷 77-83页

作者： wen-xu li wen Yang Qian Yu De-Zhen Yu Fu-Ping Wang Dept. of Chemistry Harbin Institute of Technology School of Chemical Engineering & Technology Harbin Institute of Technology School of Materials Science & Engineering Harbin Institute of Technology

Dental enamel-like hydroxyapatite whiskers with high crystallinity and homogeneous morphology were synthesized by a hydrothermal homogeneous precipitation *** composition,crystallinity and morphology of prepared hydroxyapatite whiskers were characterized by Ⅹ-ray diffraction and scanning electron *** effects of urea and sorbitol on their morphology and composition were *** and well crystallized enamel-like hydroxyapatite whiskers with 1.17±0.08 μm in length and 84± 14 nm in width were obtained at 0.80 mol · L-1 urea and 0.26 mol · L-1 *** hydroxyapatite whiskers may be close to nature hydroxyapatite dental enamel in terms of the morphology and composition,suggesting that they could have potential application as dental restorative materials in the field of stomatology.

关键词： hydrothermal homogeneous precipitation dental enamel-like urea sorbitolCLC number:TB321 Document code:AArticle ID:1005-9113(2013)06-0077-07

Measurement of R line Fluorescence in Ruby Using the Diamond Anvil Cell at Low Temperature

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Chinese Physics Letters 2000年第8期17卷 555-557页

作者： xu li-wen CHE Rong-Zheng JIN Chang-Qing Institute of Physics and Center for Condensed Matter Chinese Academy of SciencesBeijing 100080

Using our custom-built high-pressure cryostat we have performed the measurements of the R line fluorescence of ruby in the diamond anvil cell from room temperature down to *** maximum pressure was 11.1 *** computer curve fitting,different equations have been found for functions of wavenumber versus temperature between ambient pressure and 2.7 *** changes of the shape and linewidth of R lines were observed.

关键词： Diamond Fluorescence ambient

Nitrogenous Sesquiterpenoids from the South China Sea Nudibranch Hexabranchus sanguineus and Its Possible Sponge-Prey Acanthella cavernosa: Chiral Separation, Stereochemistry and Chemical Ecology

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Chinese Journal of Chemistry 2022年第2期40卷 235-246页

作者： Shou-Mao Shen Zai-Yong Zhang li-Gong Yao Jian-Rong Wang Yue-Wei Guo xu-wen li State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China School of Chinese Materia Medica Nanjing University of Chinese MedicineNanjingJiangsu 210023China Bohai rim Advanced Research Institute for Drug Discovery 198 Binhai East RoadHigh-tech ZoneYantaiShandong 264000China

A detailed chemical investigation of the South China Sea nudibranch Hexabranchus sanguineus,as well as its possible sponge-prey Acanthella cavernosa,led to the isolation of fifteen new nitrogenous sesquiterpenoids,namely ximaocavernosins A-0,including seven cadinanes(1-7),seven spiroaxanes(12-18)and one aromadendrane(19),together with thirteen known related compounds(8-11 and 20-28).

关键词： Hexabranchus sanguineus Acanthella cavernosa Chiral separation Stereochemistry Chemical ecology

PSD95 Gene Specific siRNAs Attenuate Neuropathic Pain through Modulating Neuron Sensibility and Postsynaptic CaMKIIα Phosphorylation

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Chinese Medical Sciences Journal 2011年第4期26卷 201-207页

作者： Le Shen xu li wen Chen li xu Wei liu xue-rong Yu Yu-guang Huang Department of Anesthesiology Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730 China

Objective To observe the effects of PSD95 gene specific siRNAs on neuropathic pain relief, neuron viability, and postsynaptic calcium/calmodulin-dependent protein kinase IIα (CaMKIIα) phosphorylation in vitro and in vivo. Methods Gene-specific siRNAs of rat PSD95 were synthesized chemically for transfection. Adult male Sprague-Dawley (SD) rats were randomly divided into 3 groups: nave group (n=6), sham group (n=6), and sciatic nerve chronic constriction injury (CCI) group (n=24). The CCI group was further divided into 4 groups (n=6 in each group), which were pretreated with normal saline, transfection vehicle, negative control siRNAs, and PSD95 gene specific siRNAs respectively. All the subgroups received corresponding agents intrathecally for 3 days, started one day before the CCI of sciatic nerve. Both mechanical allodynia and thermal hyperalgesia were measured on post-operative day 3 and 7. PSD95 gene silenced NG108-15 cells were further stimulated by glutamate, with the cell viability and the expression/phosphorylation of CaMKIIα measured by MTT cell proliferation assay and Western blot, respectively. Results The siRNAs decreased PSD95 mRNA level significantly both in vivo and in vitro. Neuropathic pain rats pretreated with PSD95 gene specific siRNAs exhibited significant elevation in the mechanical withdrawal threshold and paw withdrawal thermal latency, without affecting the baseline nociception. PSD95 gene silencing enhanced neuronal tolerance against the glutamate excitotoxicity, meanwhile the phosphorylation of CaMKIIα Thr286 was attenuated. Conclusion Pre-emptive administration of PSD95 gene specific siRNAs may attenuate the central sensitization CaMKIIα-related signaling cascades, leading to the relief of neuropathic pain.

关键词： PSD95 siRNAs neuropathic pain glutamate excitotoxicity calcium/calmodulin- dependent protein kinase IItt

A NEW METHOD FOR CONSTRUCTING FUZZY EVIDENCE BASED ON THE NON-CONSONANT RANDOM SET

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Journal of Electronics(China) 2009年第1期26卷 31-37页

作者： xu Xiaobin wen Chenglin li Zhiliang Institute of Information and Control Hangzhou Dianzi University Hangzhou 310018 China

Natural-language information is often mathematically expressed by fuzzy sets. With the random set theory as a bridge, this kind of information can be transformed into fuzzy evidence in Dempster-Shafer (DS) theory. Then Dempster's combination rule or other combination rules of evi- dence can be used perfectly for fusing natural-language and other information. However, this traditional transformation involves the use of α -cutsets to construct the focal elements which have to be repre- sented as consonant sets. This construction is very inflexible and unreasonable in some practical ap- plications. In this paper, with the desire to overcome this limitation, a method for constructing more general non-consonant focal elements is proposed based on the random set theory. Some examples are given to show the generality and the efficiency of this new method. Finally, we validate that non-consonant constructions provide less degrees of total uncertainty than that of the consonant case in these examples by using the evaluation criterion of total uncertainty.

关键词： Random set theory Fuzzy set Dempster-Shafer (DS) theory Target recognition

5-Alkylpyrrole-2-carboxaldehyde derivatives from the Chinese sponge Mycale lissochela and their PTP1B inhibitory activities

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Chinese Chemical Letters 2017年第6期28卷 1190-1193页

作者： Duo-Qing xue Hai-li liu Si-Han Chen Ernesto Mollo Margherita Gavagnin Jia li xu-wen li Yue-Wei Guo State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 201203 China Institute of Biomolecular Chemistry (ICB) of the National Research Council (CNR) Via Campi Flegrei 34 80078 Pozzuoli Napoli Italy

Two new 5-alkylpyrrole-2-carboxaldehyde derivatives,mycalenitrile-15（1） and mycalenitrile-16（2）,along with five known related ones（3-7）,were isolated from the South China Sea sponge Mycale *** structures of the new compounds were elucidated on the basis of extensive spectroscopic analysis and by comparison of their NMR data with those reported in the *** bioassay,compounds 1 and 7 exhibited significant PTPIB（Protein-tyrosine phosphatase 1B,a recognized target for diabetes and obesity） inhibitory activities with IC（50） values of 8.6 and 3.1 μmoI/L,respectively.A preliminary SAR analysis of the isolated compounds with their PTP1 B inhibitory effects was described.

关键词： 5-Alkylpyrrole-2-carboxaldehyde Sponge Mycale lissochela PTP1B inhibitor Marine natural product

Further New Highly Oxidative Cembranoids from the Hainan Soft Coral Sarcophyton trocheliophorum

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Natural Products and Bioprospecting 2016年第2期6卷 97-102页

作者： wen-Ting Chen lin-Fu liang xu-wen li Wei Xiao Yue-Wei Guo State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of Sciences555 Zu Chong Zhi RoadZhang Jiang High-Tech ParkShanghai 201203People’s Republic of China College of Material Science and Engineering Central South University of Forestry and Technology498 South Shaoshan RoadChangsha 410004People’s Republic of China Jiangsu Kanion Pharmaceutical Co. Ltd.Lianyungang 222001People’s Republic of China

Three new highly oxidative cembranoids,sarcophytrols D-F(1-3),were obtained from the South China Sea soft coral Sarcophyton trocheliophorum,along with two known related ones(4 and 5).Their structures were elucidated by extensive spectroscopic analyses and by comparison with literature *** discovery of these new secondary metabolites enriched the family of cembranoids deduced from the title animal.

关键词： Soft coral Sarcophyton trocheliophorum Cembranoids Sarcophytrol Structure elucidation

Marine alkaloids as the chemical marker for the prey–predator relationship of the sponge Xestospongia *** the nudibranch Jorunna funebris

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Marine life Science & Technology 2021年第3期3卷 375-381页

作者： Qihao Wu Song-Wei li Nicole J.de Voogd Hong Wang li-Gong Yao Yue-Wei Guo xu-wen li State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201203China Open Studio for Druggability Research of Marine Natural Products Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao266237China College of Pharmaceutical Science and Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals Zhejiang University of TechnologyHangzhou310014China Nanjing University of Chinese Medicine Nanjing210023China National Museum of Natural History PO Box 95172300 RALeidenNetherlands Institute of Environmental Sciences Leiden UniversityPO Box 95182300 RALeidenNetherlands

The dietary relationship study between marine sponge Xestospongia *** its nudibranch predators Jorunna funebris based on the discovery of isoquinolinequinones has long been *** this study,chemical investigation of the sponge Xestospongia *** nudibranch *** from the South China Sea yielded a new marine alkaloid neopetroside C(1),together with nine known alkaloids(2-10).The chemical structures of all the compounds were elucidated by extensive spectroscopic *** C(1)featured a riboside of nicotinic acid with a rareα-N glycosildic linkage and an acyl residue of(Z)-2-methylbut-2-enoic acid attached to C-5′.The plausible chemical ecology relationship between sponge Xestospongia *** its nudibranch predator *** was proposed based on the biogenetic relationship of the common marine *** observation of two structural fragments,(Z)-2-methylbut-2-enoyloxy and trigonelline groups in both sponge and nudibranch,indicated that nudibranch might uptake chemicals from sponge and then modify and transform them into chemical weapons to defend against predators.

关键词： Marine alkaloids Jorunna funebris Xestospongia sp.Chemical marker

Polyoxygenated Cembranoids from Soft Coral Lobophytum Crassum and Their Anti-tumoral Activities

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Chinese Journal of Chemistry 2021年第3期39卷 640-646页

作者： Fang-Zhou Yin Xia-Juan Huan Wayan Mudianta Ze-Hong Miao Hong Wang Yue-Wei Guo xu-wen li State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of Sciences555 Zu Chong Zhi RoadZhangjiang Hi-Tech ParkShanghai 201203China Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals and College of Pharmaceutical Science Zhejiang University of TechnologyHangzhouZhejiang 310014China Department of Chemistry Universitas Pendidikan GaneshaBali 81116Indonesia

Main observation and conclusion Four new cembranoids,6-oxo-cembrene-A(1),lobocrassins G-H(2-3),and 14-epi-lobophytolide B(4),along with eight known re-lated compounds(5-12),were isolated from the South China Sea soft coral Lobophytum *** structures were established by extensive spectroscopic analysis and by comparison of the spectral data with those reported in the *** absolute stere-ochemistry of 14-epi-lobophytolide B(4)was established by time-dependent density functional theory electronic circular dichroism(TDDFT-ECD)calculations,whereas that of three known metabolites(6,11 and 12)was also determined,for the first time,by using modified Mosher's method and/or X-ray diffraction *** bioassay,the cembranoids 6,7 and 12 showed significant an-ti-tumoral activity against A549,HT-29,SNU-398 and Capan-1 tumor cell lines with IC_(50) values ranging from 1.5 to 7.4μmol/L.A pre-liminary structure-activity relationship was also discussed.

关键词： Soft coral Lobophytum crassum Cembranoids Anti-tumoral activity Stereochemistry