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Intravitreal injection practice patterns among Chinese ophthalmologists

International Journal of Ophthalmology(English edition) 2024年第9期17卷 1717-1722页

作者： li Su Yin-Chen Shen Hong li Bo Mou Kun liu xun xu Department of Ophthalmology Shanghai General HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200080China National Clinical Research Center for Eye Diseases Shanghai 200080China Shanghai Key Laboratory of Ocular Fundus Diseases Shanghai 200080China Shanghai MicroCall Information Technology Co. Ltd.Shanghai 200436China

AIM:To describe the practice patterns of intravitreal injections(IVIs)among ophthalmologists in ***:This was a cross-sectional online *** who had performed accumulated more than 100 injections were contacted by the Brightness Center,a hospital-based national network,to complete an anonymous,24-question,internet-based *** were surveyed on practices in injection techniques,pre-,and post-injections ***:A total of 333 ophthalmologists from 28 provinces/municipalities/autonomous regions responded to the survey(50.68%response rate).The 91.29%of the respondents evaluated systemic risk factors by medical history,electrocardiogram(ECG)and blood *** the respondents used pre-injection prophylactic *** checked intraocular pressure(IOP,99.1%)and blood pressure(96.1%)before injections.A majority of the respondents performed injections in the operating room(98.8%),wore masks(99.7%),gloves(99.4%)and sterile surgical clothing(96.1%),performed topical anesthetics(97.9%),and applied povidone-iodine(95.8%)*** 61.26%of the respondents dilated *** half of the respondents(51.05%)performed bilateral injections in the same *** temporal quadrant(40.54%)was the most frequent site of *** three quarters used 30-gauge *** respondents(97.9%)measured the site of injection from *** than half(53.45%)performed conjunctiva displacement prior to *** 32.43%of the respondents checked IOP post-injection and 87.99%physicians checked hand motion(HM)or counting fingers(CF)after injection,while 36.94%observed optic nerve *** participants used topical antibiotics *** physicians(91.89%)reviewed patients on the following ***:This study provides a description of the real-world practice patterns in IVIs in China and offers critical information regarding education and training of ophthalmologists and amendment of local society guideli

关键词： intravitreal injections practice pattern topical antibiotics Chinese ophthalmologists

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Positively charged graphene/Fe3O4/polyethylenimine with enhanced drug loading and cellular uptake for magnetic resonance imaging and magnet-responsive cancer therapy

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Nano Research 2017年第7期10卷 2280-2295页

作者： Baoji Du Jianhua liu Guanyu Ding xu Han Dan li ErkangWang Jin Wang State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China University of Chinese Academy of Sciences Beijing 100039 China Department of Radiology The Second Hospital of Jilin University Changchun 130041 China College of Physics Jilin University Changchun 130012 China Department of Chemistry and Physics State University of New York at Stony Brook NY 11794-3400 USA State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of Chemistry Jilin University Changchun 130012 China

Enhanced cellular uptake efficiency of nanoparticles is important for their biomedical applications, including photothermal therapy （PTT） for cancer. In this study, a one-pot method was used to construct a positively charged and magnet-responsive nanocomposite comprising reduced graphene oxide anchoring iron oxide （RGI） with a polyethylenimine （PEI） modification, to improve the efficiency of cell internalization. The surface charge can be finely tuned using PEIs of different molecular weights. The obtained RGIlsk composite （RGI modified by 1.8 kDa PEI） could load indocyanine green （ICG） at a high mass ratio of 10：3 and ablate cancer cells using low-density laser irradiation because of its positively charged surface. In addition, the hybrids of RGI1.8k and ICG could kill most cancer cells at a laser density of 0.7 W/cm2 in vitro and 0.3 W/cm2 in vivo. At the same time, cell viability could be controlled by converting the external magnetic-field direction because of the enrichment of the magnet-responsive composite in vitro and in vivo. Furthermore, RGIr8k-ICGs could be used as T2-weighted magnetic resonance and infrared thermal imaging agents. Coupled with the magnetic target effect, the imaging signal could be improved significantly. Therefore, RGII^sk-ICGs represent a new highly efficient PTT and imaging agent with great potential for cancer treatment.

关键词： surface charge low laser density synergistic therapy magnetic resonanceimaging photothermal therapy drug delivery

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Giant mechanocaloric materials for solid-state cooling

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Chinese Physics B 2020年第7期29卷 172-181页

作者： Junran Zhang Yixuan xu Shihai An Ying Sun Xiaodong li Yanchun li Multidiscipline Research Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China School of Physical Sciences Beihang UniversityBeijing 100191China

This article reviews the research progress of measurement techniques and materials on the mechanocaloric effect over the past few *** materials can be divided into elastocaloric and barocaloric materials depending on the applied uniaxial stress or hydrostatic *** materials include non-magnetic shape memory alloys,polymers,and rare-earth *** materials include magnetic shape memory alloys,ferroelectric ceramics,superionic conductors,and *** mechanocaloric effects of these classes of materials are systematically compared in terms of the isothermal entropy change and adiabatic temperature *** addition to the thermal effects,other characteristics closely related to the application of mechanocaloric materials are also ***,perspectives for further development of mechanocaloric materials in the solid-state cooling area are discussed.

关键词： mechanocaloric materials elastocaloric effect barocaloric effect solid-state cooling

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Chromosome-level assembly of triploid genome of Sichuan pepper(Zanthoxylum armatum)

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Horticultural Plant Journal 2024年第2期10卷 437-449页

作者： lizhi Song Yue Huang Hao Zuo Ning Tang Zhengguo li Wenbiao Jiao Feng xu Qiang xu Zexiong Chen National Key Laboratory for Germplasm Innovation and Utilization for Fruit and Vegetable Horticultural Crops Huazhong Agricultural UniversityWuhanHubei 430070China Chongqing Key Laboratory of Economic Plant Biotechnology Chongqing University of Arts and SciencesChongqing 402160China School of life Sciences Chongqing UniversityChongqing 400030China College of Horticulture and Gardening Yangtze UniversityJingzhouHubei 434025China College of Informatics Huazhong Agricultural UniversityWuhanHubei 430070China

As an important spice species in Rutaceae, the Sichuan pepper (Zanthoxylum armatum) can provide pungent and numbing taste, as well as aroma in its mature fruit. Here we assembled a chromosome-level genome of green prickly ash which was widely cultivated in a major production area including Chongqing and Sichuan province, China. We generated 712 Gb (~112×) PacBio long reads and 511 Gb (~82×) Hi-C data, and yielded an assembly of 99 pseudochromosomes with total size of 5.32 Gb and contig N50 of 796 kb. The genomic analyses and cytogenetic experiments both indicated that the cultivarZhuye Huajiao’ was a triploid. We identified a Zanthoxylum-specific whole genome duplication event emerging about 24.8 million years ago (Mya). We also detected a transposition burst event (0.3-0.4 Mya) responsible for the large genome size of Z. armatum. Metabolomic analysis of the Zanthoxylum fruits during development stages revealed profiles of39 volatile aroma compounds and 528 secondary metabolites, from which six types of sanshools were identified. Based on metabolomic and transcriptomic network analysis, we screened candidate genes encoding long chain acyl-CoA synthetase, fatty acid desaturase,branched-chain amino acid aminotransferase involved in sanshool biosynthesis and three genes encoding terpene synthase during fruit development. The multi-omics data provide insights into the evolution of Zanthoxylum and molecular basis of numbing and aroma flavor of Sichuan pepper.

关键词： Zanthoxylum armatum Genome Sanshool Terpenoid

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Amorphous nickel borate nanosheets as cathode material with high capacity and better cycling performance for zinc ion battery

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Chinese Chemical Letters 2023年第6期34卷 517-520页

作者： Na li Xixi Zhang Shunshun Zhao Chuanlin li Xiaojuan li Tongkai Wang Yupeng Xing Gangmeng Qu Xijin xu School of Physics and Technology University of JinanJi’nan 250022China School of Electronic and Information Engineering(Department of Physics) Qilu University of Technology(Shandong Academy of Sciences)Ji’nan 250353China

Zinc-ion batteries are under current research focus because of their uniqueness in low cost and high ***,the pursuing of high-performance cathode materials of aqueous Zinc ion batteries(AZBs)with low cost,high energy density and long cycle life has become the key problem to be *** we synthesized a series of amorphous nickel borate(AM-NiBO)nanosheets by varying corrosion time with in-situ electrochemical corrosion *** AM-NiBO-T13 as electrode material possesses a high areal capacity of 0.65 m Ah/cm^(2) with the capacity retention of 95.1%after 2000 *** addition,the assembled AM-NiBO-T13//Zn provides high energy density(0.77 m Wh/cm^(2) at 1.76 m W/cm^(2)).The high areal capacity and better cycling performance can be owing to the amorphous nanosheets structure and the stable coordination characteristics of boron and oxygen in borate *** shows that amorphous nickel borate nanosheets have great prospects in the field of energy storage.

关键词： Amorphous Nickel borate Nanosheets structure Alkaline Aqueous zinc ion battery

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Trimodel hierarchical yolk-shell porous materials TS-1@mesocarbon:Synthesis and catalytic application

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Chinese Chemical Letters 2013年第7期24卷 559-562页

作者： Hong-Gen Peng Xiao-Hong li Le xu Peng Wu Shanghai Key Laboratory of Green Chemistry and Chemical Processes Department of ChemistryEast China Normal University

Trimodal hierarchical yolk-shell materials consisting of TS-1 core and mesoporous carbon shell （YS-TS- I@MC） was successfully synthesized by using TS-l@mesosilica as hard template, sucrose as carbon source and organic base tetrapropylammonium hydroxide （TPAOH） as silica etching agent. The resultant YS-TS-I@MC contains the micropores （0.51 nm） in TS-1 core, the mesopores （2.9 rim） in carbon shell as well as a void or a stack pore between TS-1 fragements （TS-1 intercrystal mesopores, -18.4 nm）. Under the rigorous etching conditions, the crystalline structure of TS-1 core was well retained. The YS-TS- I@MC served as a good support for palladium nano-particles （Pd NPs） or Rh（OH）x species, giving rise to efficient bifunctional catalysts for the tandem reactions including one-pot synthesis of propylene oxide or amides.

关键词： Hierarchical porous materials Yolk-shell structure Zeolite Mesoporous carbon

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A meshfree-based local Galerkin method with condensation of degree of freedom for elastic dynamic analysis

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Acta Mechanica Sinica 2014年第1期30卷 92-99页

作者： De-An Hu Yi-Gang Wang Yang-Yang li xu Han Yuan-Tong Gu State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body Hunan University School of Chemistry Physics and Mechanical EngineeringQueensland University of Technology

Condensation technique of degree of freedom is first proposed to improve the computational efficiency of meshfree method with Galerkin weak form for elastic dy- namic analysis. In the present method, scattered nodes with- out connectivity are divided into several subsets by cells with arbitrary shape. Local discrete equation is established over each cell by using moving Kriging interpolation, in which the nodes that located in the cell are used for approxima- tion. Then local discrete equations can be simplified by con- densation of degree of freedom, which transfers equations of inner nodes to equations of boundary nodes based on cells. The global dynamic system equations are obtained by as- sembling all local discrete equations and are solved by using the standard implicit Newmark＇s time integration scheme. In the scheme of present method, the calculation of each cell is carried out by meshfree method, and local search is imple- mented in interpolation. Numerical examples show that the present method has high computational efficiency and good accuracy in solving elastic dynamic problems.

关键词： Meshfree method Local Galerkin method Moving Kriging interpolation - Condensation of degree of freedom Computational efficiency

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Formation of Na_(1+x)V_3O_8 Nanoribbon Thin Film from V_2O_5 Xerogel on Sodium Silicate Glass Substrate

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Chemical Research in Chinese Universities 2007年第4期23卷 381-383页

作者： GUO Yi xu Jin-jie li Jun YANG Wen-sheng College of Chemistry Jilin University Changchun 130012 P. R. China

Na1＋xV3O8 nanoribbon thin film was successfully fabricated by annealing the V2O5 xerogel film on sodium sili-cate glass substrate at 450℃. It has been identified that the amount of sodium ions diffused into the V2O5 xerogel film increases with the high temperature of annealing treatment. The sodium glass substrate serves as a limited sodium source to induce the transformation from V2O5 to Na1＋xV3O8.

关键词： Vanadium pentoxide Sodium silicate glass Nanoribbon Cathode materials

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An optimal differentially private data release mechanism with constrained error

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Frontiers of Computer Science 2022年第1期16卷 187-189页

作者： Hao WANG Zhengquan xu Xiaoshan ZHANG Xiao PENG Kaiju li Key Laboratory of Tourism Multisource Data Perception and Decision Ministry of Culture and TourismCollege of Computer Science and TechnologyChongqing University of Posts and TelecommunicationsChongqing400065China State Key Laboratory of Information Engineering in Surveying Mapping and Remote SensingWuhan UniversityWuhan430079China College of Computer Science Chongqing UniversityChongqing400044China

1 Introduction and main contributions In data-driven applications,such as location based services(LBSs),disease surveillance and social networks,etc.,information fusion is necessary for data owners to obtain better *** the aggregated data may contain individuaFs sensi-tive ***,privacy preserving data fusion has become a substantial issue in data aggregating and mining[1,2].

关键词： LBS release optimal

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Generating Quantitative Product Profile Using Char-Word CNNs

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Applied Mathematics(A Journal of Chinese Universities) 2019年第3期34卷 356-378页

作者： xu Hai-rui ZHANG Wei-cheng li Ming QIN Fei-wei Department of State Key Laboratory of CAD&CG Zhejiang UniversityHangzhou 310027China School of Computer Science and Technology Hangzhou Dianzi UniversityHangzhou 310027China

The online customer reviews provide important information for product improvement and ***,many reviews are redundant with only several short sentences,which may even conflict with each other on the same aspect of a *** it is usually a very challenging task to extract useful design information from the reviews and provide a clear description on the product’s various aspects amongst its *** order to resolve this issue,we propose an approach to build hierarchical product profiles to describe a product’s kernel design aspects *** is achieved via three main strategies:a double propagation strategy to achieve the associated features and customers’descriptions;a deep text processing network to build the aspect hierarchy;an aspect ranking approach to quantify each kernel design *** results validate the effectiveness of the proposed approach on online reviews.

关键词： customer reviews quantitative product profile product aspect ranking deep learning

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