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Nano Research 2025年第1期18卷 607-617页

作者： Ruo-Lin Jiang Hui-Na Liu Yu-Fan Yang Zhi-Cheng Zhang Qi Dai Xiao-Yan Bao Lin-Jie Wu Ya-Xin Qin Xin Tan Xiao-Yan Sun xu-fang ying Zhi-Qing Ben Min Han Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of Radiation Oncology Key Laboratory of Cancer Prevention and InterventionThe Second Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310058China Hangzhou Institute of Innovative Medicine Zhejiang UniversityHangzhou 310058China Jinhua Institute of Zhejiang University Jinhua 321299China National Key Laboratory of Advanced Drug Delivery and Release Systems Zhejiang UniversityHangzhou 310058China Polytechnic institute Zhejiang UniversityHangzhou 310015China

Traditionally,hyaluronic acid has been widely used for drug delivery,but the current application bottleneck is that hyaluronic acid is hydrophilic and electronegative,which makes it difficult to carry hydrophobic drugs and small interfering RNA(siRNA)with the same *** on previous studies,we designed and synthesized hyaluronic acid nanocarriers HA-spermine/N,N,N-trimethylcystamine/DOX-TPP(HSTD)for loading siRNA to overcome the problem of siRNA release caused by strong electrostatic ***,N,N,Ntrimethylcystamine in the carrier can be degraded by intracellular glutathione to completely and rapidly release siRNA,thus promoting ***,when codelivered with the chemotherapy drug doxorubicin(DOX),this novel nanocarrier showed promising synergy in inhibiting tumor growth.

关键词： zwitterionic hyaluronic acid N N N-trimethylcystamine small interfering RNA(siRNA) doxorubicin

Understanding the iodine electrochemical behaviors in aqueous zinc batteries

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Journal of Energy Chemistry 2025年第2期101卷 402-415页

作者： xuefang Xie Xiaoxin xu Shuquan Liang Guozhao fang College of Physical Science and Technology Xinjiang University Xinjiang Key Laboratory of Solid State Physics and Devices Xinjiang University School of Materials Science & Engineering Key Laboratory of Electronic Packaging and Advanced Functional Materials of Hunan Province Central South University National Energy Metal Resources and New Materials Key Laboratory Central South University

Iodine is widely used in aqueous zinc batteries（ZBs） due to its abundant resources,low cost,and active redox *** addition to the active material in zinc-iodine batteries,iodine also plays an important role in other ZBs,such as regulating the electrochemical behavior of zinc ions,promoting the reaction kinetic and reversibility of other redox pairs,catalytic behaviors related to iodine reactions,coupling with other halogen ions,shuttle behaviors of polyiodides,***,there is currently a lack of comprehensive discussion on these ***,this review provides a comprehensive overview of the electrochemical behaviors of iodide in the aqueous *** effect of iodine ions on the Zn2+desolvation behaviors and the interfacial behaviors of Zn anode was *** redox pairs boosting other redox pairs,such as MnO2/Mn2+redox pair and vanadium redox pair to obtain high reversibility and capacity was also ***,the catalytic behaviors related to iodine reactions in aqueous ZBs,synergistic reaction with other halogen ions and suppression of shuttle behaviors for high performance zinc-iodine batteries were systematically ***,future prospects for designing effective iodine electrochemical behaviors with practicability are proposed,which will provide scientific guidance for the practical application of iodine-related aqueous ZBs.

关键词： Catalytic behavior Iodide ion Redox pairs Shuttle effect Zinc batteries

Quantile-based optimization under uncertainties for complex engineering structures using an active learning basis-adaptive PC-Kriging model

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Chinese Journal of Aeronautics 2025年第1期38卷 340-352页

作者： Yulian GONG Jianguo ZHANG Dan xu ying HUANG School of Reliability and Systems Engineering Beihang UniversityBeijing 100191China

The Reliability-Based Design Optimization(RBDO)of complex engineering structures considering uncertainties has problems of being high-dimensional,highly nonlinear,and timeconsuming,which requires a significant amount of sampling simulation *** this paper,a basis-adaptive Polynomial Chaos(PC)-Kriging surrogate model is proposed,in order to relieve the computational burden and enhance the predictive accuracy of a *** active learning basis-adaptive PC-Kriging model is combined with a quantile-based RBDO ***,five engineering cases have been implemented,including a benchmark RBDO problem,three high-dimensional explicit problems,and a high-dimensional implicit *** with Support Vector Regression(SVR),Kriging,and polynomial chaos expansion models,results show that the proposed basis-adaptive PC-Kriging model is more accurate and efficient for RBDO problems of complex engineering structures.

关键词： Reliability-based design optimization Quantile-based Basis-adaptive PC-Kriging Complex engineering structures Active learning Uncertainty

Improved activity and stability of noble metal-free oxygen reduction reaction electrocatalysts

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Science China Materials 2025年第2期68卷 677-678页

作者： Shurui xu Guoyu Zhong Baizeng fang School of Chemical Engineering and Energy Technology Dongguan University of TechnologyDongguan 523808China

The wider commercialization of Proton Exchange Membrane Fuel Cells(PEMFCs)has been significantly hampered by the expensive noble metal catalysts[1],slow oxygen reduction reaction(ORR)and low electrochemical stability of the electrocatalyst[2].The development of noble metal-free electrocatalysts can significantly reduce the manufacturing cost of *** nitrogen-coordinated FeN4 sites are considered to be active for ORR[3,4],their catalytic performance and durability need to be significantly ***,Wu et al.

关键词： noble stability catalysts

Tuning the ion-dipole interactions between fluoro and carbonyl(EC)by electrolyte design for stable lithium metal batteries

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Chinese Chemical Letters 2025年第1期36卷 579-584页

作者： Guihuang fang ying Liu Yangyang Feng ying Pan Hongwei Yang Yongchuan Liu Maoxiang Wu Faculty of Metallurgy and Energy Engineering Kunming University of Science and TechnologyKunming 650093China Key Laboratory of Optoelectronic Materials Chemistry and Physics Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China

Ethylene carbonate(EC)is the conventional and promising solvent to achieve high energy lithium metal ***,the innate low energy level of lowest unoccupied molecular orbital(LUMO)in EC makes it incompatible with lithium metal,causing uncontrolled lithium growth and low Coulombic efficiency(CE).Herein,we introduced bis(2,2,2-trifluoroethyl)carbonate(TFEC),a carbonate with a strong electron-withdrawing effect(-CF_(3)),which enhances the stability of EC at electrode interface by reducing ion-dipole interactions between Li^(+)and *** the interaction between Li and EC weakens,TFEC and more PF_(6)^(-)anions coordinate with Li^(+),promoting the formation of contact ion pairs(CIPs)and aggregates(AGGs),thereby increasing the inorganic composition within the solid electrolyte ***,the distinct solvated sheath structure favors the decomposition of fluorinated solvents and PF_(6)^(-)anions,forming inorganic-rich electrode-electrolyte interfaces(SEI and CEI),thereby ensuring high stability for both the Li anode and high-voltage ***,when applied in the full-cell Li||LiMn_(0.8)Fe_(0.2)PO_(4),it displays consistent cycling performance,exhibiting minimal capacity decay with a retention rate of 62.5%after800 cycles,substantially surpassing that of cells using base electrolytes(29.8%).

关键词： Lithium-ion batteries LiMn_(0.8)Fe_(0.2)PO_(4) High-voltage Solvation structure Ethylene carbonate Bis(2,2,2-trifluoroethyl)carbonate

Atomic cerium-doped CuO_(x) catalysts for efficient electrocatalytic CO_(2) reduction to CH_(4)

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Chinese Chemical Letters 2025年第1期36卷 326-331页

作者： Xiangyu Chen Aihao xu Dong Wei fang Huang Junjie Ma Huibing He Jing xu Guangxi Key Laboratory of Petrochemical Resource Processing and Process Intensification Technology School of Chemistry and Chemical EngineeringGuangxi UniversityNanning 530004China State Key Laboratory of Featured Metal Materials and Life-cycle Safety for Composite Structures Guangxi UniversityNanning 530004China State Key Laboratory of Green Chemical Engineering and Industrial Catalysis School of Chemical EngineeringEast China University of Science and TechnologyShanghai 200237China

Copper(Cu)is widely used in the electrochemical carbon dioxide reduction reaction(ECO_(2)RR)for efficient methane(CH_(4))***,the morphology and valence of Cu-based catalysts are usually unstable under reaction *** this work,we prepared Ce-doped MOF-199 precursor(Ce/HKUST-1)and further obtained nanoparticle electrocatalyst Ce/CuO_(x)-NPs by cyclic voltammetry(CV)*** Faradic efficiency of methane(FE_(CH_(4)))maintains above 62%within a broad potential window of 350 mV and the maximum FE_(CH_(4))reaches 67.4%with a partial current density of 293 mA/cm^(2)at-1.6 V vs.a reversible hydrogen *** characterization and theoretical calculations revealed that the unique electronic structure and large ionic radius of Cerium(Ce)not only promoted the generation of key intermediate*CO but also lowered energy barrier of the*CO to*CHO *** study provides a novel and efficient catalyst for methane production in ECO_(2)RR and offers profound insights into constructing high performance Cu-based catalysts.

关键词： ECO_(2)RR Cu-based catalyst Structure evolution DFT calculation

Unraveling multidimensional land transfers in mountainous areas:influence of grassroots governance,geographic location,livelihood capital,and demographic factors

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Journal of Mountain Science 2025年第2期22卷 611-635页

作者： xu Yinan WANG Weiwen WANG ying Department of Land Resources Management School of Public AdministrationChina University of GeosciencesWuhan 430074China Key Laboratory of the Ministry of Natural Resources for Legal Research Wuhan 430074China College of Geography and Environmental Science Henan UniversityKaifeng 475004China

Cropland abandonment has been a widespread phenomenon in mountainous areas due to the increasing number of natural disasters and the massive migration of rural labor in the process of rapid *** transfer is a crucial prerequisite for ensuring food security and fostering rural *** to promote land transfer in mountainous areas remains a challenging but important ***,there is a dearth of research examining land transfers among farm households that specifically address mountainous regions,and the influence of grassroots governance and geographic location has not been thoroughly elucidated within this particular *** on 895household samples collected in Dabie Mountainous Area in China,this study employs binary and ordinal logistic regression models to provide a more comprehensive analysis on land transfers among rural households and the determinants,including the decision to transfer land,the existence of land transfer rents,the channel of land transfer,the duration of the transfer,the pre-transfer cultivation situation,and the level of satisfaction with the land transfer *** findings reveal that grassroots governance,geographic location,livelihood capital,and demographic factors significantly influence land transfers among rural ***,villagers'public participation positively affects land transfer participation(β=0.235,p<0.05),while the operation of village rules and regulations negatively impacts it(β=-0.296,p<0.05).Village cadre satisfaction positively influences both land transfer rent(β=0.274,p<0.05)and rent satisfaction(β=0.303,p<0.05).Improved civil relations in the village correlate with lower land transfer rent(β=-0.511,p<0.05),while a better social atmosphere is associated with higher satisfaction with transfer rent(β=0.575,p<0.01).Households at higher elevations tend to prefer government-mediated land transfers with longer *** distances to the township and county centers have c

关键词： Land transfer Grassroots governance Geographic location Livelihood capital Demographic factors Dabie Mountainous Area China

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服装数字化斜裁技术的应用研究

毛纺科技 2014年第3期42卷 50-52页

作者：竺梅芳徐颖芳浙江纺织服装职业技术学院时装学院浙江宁波315211

斜裁服装因其特有的风格受到人们的喜爱,但由于受到各种条件的制约其发展极其缓慢,在服装市场中所占的比例极低而价格极高。文章重点探讨利用数字化技术虚拟斜裁服装试穿效果并与真实试穿进行对比;研究利用数字化技术解决斜裁服装制版... 详细信息

斜裁服装因其特有的风格受到人们的喜爱,但由于受到各种条件的制约其发展极其缓慢,在服装市场中所占的比例极低而价格极高。文章重点探讨利用数字化技术虚拟斜裁服装试穿效果并与真实试穿进行对比;研究利用数字化技术解决斜裁服装制版过程中手工操作难以克服的弧线绘制问题、长度修正和数据管理问题。数字化斜裁技术的采用,可降低技术人员制作难度,提高其重复制作可能性和生产效率,减少重复劳动,降低生产成本,为斜裁服装的大批量生产提供有利的条件。

关键词：斜裁数字化技术虚拟技术

银杏叶提取物对肺纤维化FIZZ1／NOTCH信号通路的影响

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中国急救医学 2017年第1期37卷 87-91,F0003页

作者：徐芳黄莺武汉市第一医院呼吸科湖北武汉430022

目的研究博来霉素致肺纤维化（PF）动物模型中银杏叶提取物（GBE）对FIZZ1／NOTCH1信号通路的影响，探索中药银杏叶治疗肺纤维化的作用机制。方法将25只昆明鼠按随机数字表法随机分为5组：对照组、模型组、GBE组、GBE-NOTCH1-shRNA组、... 详细信息

目的研究博来霉素致肺纤维化（PF）动物模型中银杏叶提取物（GBE）对FIZZ1／NOTCH1信号通路的影响，探索中药银杏叶治疗肺纤维化的作用机制。方法将25只昆明鼠按随机数字表法随机分为5组：对照组、模型组、GBE组、GBE-NOTCH1-shRNA组、空白质粒组，每组5只。除对照组外其余各组注入博来霉素（5mg／kg），对照组注入生理盐水（1．25mE／ks）制造阴性对照。空白质粒组于造模第2天进行空质粒尾静脉快速注射（3mL／kg）。GBE组于造模当天开始每天用GBE溶液灌胃[0．6g／（kg·d）]，GBE—NOTCH1-shRNA组在每天GBE灌胃基础上于造模第2天尾静脉注射NOTCH1-shRNA质粒（3mL／kg）。于第28天处死动物，取左肺组织行HE染色观察肺泡炎和肺纤维化程度。取右肺组织Western及RT—PCR方法检测FIZZ1、NOTCH1及α-SMA表达。结果模型组及空白质粒组肺泡炎及纤维化程度较重，GBE组炎症程度显著减轻，纤维组织大量减少，GBE—NOTCH1-shRNA组较GBE组肺泡炎及纤维化程度有所加重；Western结果显示，模型组FIZZ1、NOTCH1、α-SMA表达最高（P〈0．05），空白质粒组α-SMA表达与模型组比较差异无统计学意义（P〉0．05），GBE组NOTCH1、α-SMA表达较模型组下降（P〈0．05），GBE—NOTCH1-shRNA组α-SMA表达较GBE组显著上升（P〈0．05）；RT—PCR结果显示，模型组及空白质粒组NOTCH1、α-SMA表达较对照组显著增高（P〈0．05），GBE—NOTCH1-shRNA组α-SMA表达较GBE组显著上升（P〈0．05）。结论FIZZ1能通过NOTCH信号通路的激活促进成纤维细胞向肌成纤维细胞的转化增殖，导致OL—SMA分泌增多，加重肺纤维的发生发展。GBE能减轻肺纤维化程度，其机制可能通过阻断NOTCH信号通路来抑制FIZZ1诱导α-SMA表达。

关键词：肺纤维化(PE) 银杏叶提取物(GBE) FIZZ1/NOTCH信号通路

The gut microbiome modulate response to immunotherapy in cancer

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Science China(Life Sciences) 2025年第2期68卷 381-396页

作者： Shan-Shan Jiang Zi-Ran Kang ying-xuan Chen Jing-Yuan fang Division of Gastroenterologyand Hepatology Shanghai Instituteof Digestive DiseaseNHC KeyLaboratoryof Digestive DiseasesState KeyLaboratoryfor Oncogenesand Related GenesRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200001China

Gut microbiota have been reported to play an important role in the occurrence and development of malignant ***,clinical studies have identified specific gut microbiota and its metabolites associated with efficacy of immunotherapy in multiple types of *** investigations have elucidated that gut microbiota modulate the antitumor immunity and affect the efficacy of cancer *** microbiota and its metabolites may favorably remodel the tumor microenvironment by engaging innate and/or adaptive immune *** how the gut microbiome interacts with cancer immunotherapy opens new avenues for improving treatment *** microbial transplants,probiotics,dietary interventions,and other strategies targeting the microbiota have shown promise in preclinical studies to enhance the *** clinical trials are evaluating these *** review presents the recent advancements in understanding the dynamic interplay among the host immunity,the microbiome,and cancer immunotherapy,as well as strategies for modulating the microbiome,with a view to translating into clinical applications.

关键词： cancer immunotherapy gut microbiota intratumoral microbiota microbiota-derived metabolites innate and adaptive immunity