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Inhibition of the NLRP3 inflammasome attenuates spiral ganglion neuron degeneration in aminoglycoside-induced hearing loss

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Neural Regeneration Research 2025年第10期20卷 3025-3039页

作者： Jia fang Zhuangzhuang li Pengjun Wang Xiaoxu Zhang Song Mao Yini li Dongzhen Yu Xiaoyan li Yazhi Xing Haibo Shi Shankai Yin Department of Otolaryngology Head and Neck Surgery Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineOtolaryngology Institute of Shanghai Jiao Tong UniversityShanghai Key Laboratory of Sleep Disordered BreathingShanghaiChina Department of Otorhinolaryngology-Head and Neck Surgery Shanghai Children’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina

Aminoglycosides are a widely used class of antibacterials renowned for their effectiveness and broad antimicrobial ***,their use leads to irreversible hearing damage by causing apoptosis of hair cells as their direct *** addition,the hearing damage caused by aminoglycosides involves damage of spiral ganglion neurons upon *** investigate the mechanisms underlying spiral ganglion neuron degeneration induced by aminoglycosides,we used a C57BL/6J mouse model treated with *** found that the mice exhibited auditory deficits following the acute loss of outer hair *** ganglion neurons displayed hallmarks of pyroptosis and exhibited progressive degeneration over *** profiling of these neurons showed significant upregulation of genes associated with inflammation and immune response,particularly those related to the NLRP3 *** of the canonical pyroptotic pathway in spiral ganglion neurons was observed,accompanied by infiltration of macrophages and the release of proinflammatory *** intervention targeting NLRP3 using Mcc950 and genetic intervention using NLRP3 knockout ameliorated spiral ganglion neuron degeneration in the injury *** findings suggest that NLRP3 inflammasome-mediated pyroptosis plays a role in aminoglycoside-induced spiral ganglion neuron *** of this pathway may offer a potential therapeutic strategy for treating sensorineural hearing loss by reducing spiral ganglion neuron degeneration.

关键词： degeneration hearing loss macrophages Mcc950 neuroinflammation NLRP3 inflammasome ototoxicity pyroptosis sensorineural hearing loss spiral ganglion neuron

A new sol-gel process for preparing Ba(Mg_(1/3)Nb_(2/3))O_3 nanopowders

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Rare Metals 2004年第1期23卷 31-31页

作者： liAN fang, xu lihua, li Fushen, and ZHAO Hailei

Commercially available niobium (V) oxide [Nb2O5], with barium acetate [Ba(CH3COO)2] and magnesium acetate [Mg(CH3COO)2-4H2O] was used as the starting material in the sol-gel process for preparing Ba(Mg1/3Nb2/3)O3 (BMN) nanopowders. At first, Nb2O5 reacted with melting sodium hydroxide and transformed into dispersible oxide. The resulting glassy substance after cooling was dispersed and washed several times in distilled water to remove the Na+ ions. The as-prepared colloidal Nb2O5-nH2O was subsequently mixed with acetic solution of barium acetate and magnesium acetate according to the required molar proportions and followed by gelation. The ultrafine BMN powders were finally obtained after heat-treating the gel at 820℃for 1 h, and the as-sintered nanoceramics revealed a high relative density of 98.2%, and a high microwave Q-factor, of 10397 at 1.45GHz.

关键词： Nb2O5.nH2 colloid Ba(Mg1/3Nb2/3)O3 nanopowder sol-gel processing microwave Q-factor

Performance Analysis of a Coupled System based on Organic Rankine Cycle and Double Effect Absorption Refrigeration for Waste Heat Recovery in Data Center

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Journal of Thermal Science 2025年第1期34卷 188-205页

作者： li Peng xu Jiaqi WANG Binbin liU Jianyang ZHAO Wensheng HAN Zhonghe School of Energy Power and Mechanical Engineering North China Electric Power University Hebei Key Laboratory of Low Carbon and High Efficiency Power Generation Technology North China Electric Power University

During data center operation,it generates a significant volume of low-grade waste *** recover waste heat,a coupled system including solar collector,double effect absorption refrigeration and organic Rankine cycle is *** system performance is analyzed in *** the organic Rankine cycle,five organic working fluids(R245fa,R245ca,R123,R11,and R113) are selected.R245fa,R113 and R245ca obtain the maximum net power output,thermal efficiency and exergy efficiency,*** the double effect absorption refrigeration system,the evaporation temperature,condensation temperature,and generation pressure affect the COP and exergy *** the generator pressure is unchanged,the COP increases with increasing evaporation temperature and decreasing condensation *** the COP reaches 1.3,the COP slightly decreases as the evaporation temperature or condensation temperature ***,the exergy efficiency of refrigeration systems exhibits the same trend as the COP,and the exergy efficiency maximum value appears at approximately 0.32.A new performance indicator,rPUE,was defined to evaluate the data center power utilization *** flow distribution ratio and heat source temperature were optimized with multi-objective *** the mass flow distribution rate is 0.6 and the heat source temperature is 441.5 K,rPUE and the total unit production costs of the system obtain the optimal solution.

关键词： Exergy

血清卵泡刺激素和黄体生成素对克氏综合征乳腺肿块良恶性的鉴别价值

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中国临床研究 2019年第9期32卷 1197-1200页

作者：徐莉芳童芳芳谭代林武汉大学人民医院潜江医院潜江市中心医院输血科湖北潜江433100 武汉大学人民医院潜江医院潜江市中心医院检验科湖北潜江433100

目的探讨血清卵泡刺激素(FSH)和黄体生成素(LH)水平在克氏综合征患者乳腺肿块良恶性临床鉴别中的应用及其价值。方法在潜江地区已确诊克氏综合征患者普查的基础上,2015年1月至2017年12月对68例克氏综合征患者的临床资料进行回顾性分析,... 详细信息

目的探讨血清卵泡刺激素(FSH)和黄体生成素(LH)水平在克氏综合征患者乳腺肿块良恶性临床鉴别中的应用及其价值。方法在潜江地区已确诊克氏综合征患者普查的基础上,2015年1月至2017年12月对68例克氏综合征患者的临床资料进行回顾性分析,以行乳腺手术治疗的23例克氏综合征乳腺癌患者作为乳腺癌组,以45例排除乳腺癌的克氏综合征患者作为对照组。比较两组患者FSH、LH、睾酮(T)和泌乳素(PRL)水平,应用ROC曲线分析其取不同截断值的诊断效能。结果乳腺癌组FSH、LH和T水平显著高于对照组(P=0.000,0.000,0.008),两组PRL水平无统计学差异(P=0.757);ROC曲线显示,FSH、LH和T的AUC分别为0.944、0.746和0.738,其中FSH对乳腺癌的诊断效能均高于LH和T(P=0.002,0.002);约登指数提示FSH、LH和T水平诊断乳腺癌的最佳截断值分别为47.722 mIU/ml、22.731 mIU/ml和1.632 ng/ml;FSH、LH和T位于最佳截断值时,FSH诊断克氏综合征乳腺癌的准确率、灵敏度、阳性预测值和阴性预测值均显著高于LH和T(P<0.05)。结论在克氏综合征患者乳腺肿块良恶性的鉴别诊断中,FSH的准确率和灵敏度高,具有重要的临床意义。

关键词：卵泡刺激素黄体生成素克氏综合征乳腺肿块乳腺癌鉴别

流动人口对流入地的环境感知及其对定居意愿的影响——基于福州市的调查

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人文地理 2016年第1期31卷 65-72页

作者：林李月朱宇许丽芳福建师范大学地理研究所福州350007 湿润亚热带生态地理过程教育部重点实验室福州350007

要:基于福州市流动人口调查数据,从生态环境、人文环境和制度环境3个方面分析了流动人口对流入地的环境感知及其群体差异和对定居意愿的影响。研究发现:1流动人口对流入地的环境感知存在层次性,其排序如下:生态环境>人文环境>制度环境;... 详细信息

要:基于福州市流动人口调查数据,从生态环境、人文环境和制度环境3个方面分析了流动人口对流入地的环境感知及其群体差异和对定居意愿的影响。研究发现:1流动人口对流入地的环境感知存在层次性,其排序如下:生态环境>人文环境>制度环境;2流动人口对流入地的环境感知存在群体差异,性别、职业类型、个人及家庭收入和方言适应程度的影响显著;受教育程度和居留时间仅有一定影响;而年龄、婚姻状况的影响不显著;3在控制了个体特征后,流动人口对流入地的环境感知对于提高其定居意愿具有显著的促进作用。

关键词：流动人口环境感知定居意愿福州市

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安徽某硫铁尾矿区农田土壤重金属污染特征

安全与环境学报 2019年第1期19卷 337-344页

作者：邓呈逊徐芳丽岳梅合肥学院生物与环境工程系合肥230601

对安徽省某硫铁矿尾矿区农田土壤、农作物进行重金属污染分析和风险评价,为硫矿区农田重金属污染风险管理与土地利用提供理论依据。布设30个采样点采集土壤及其毛豆样品,ICP-MS法测定Cu、Zn、As、Cd、Pb重金属全量,运用单因子指数、综... 详细信息

对安徽省某硫铁矿尾矿区农田土壤、农作物进行重金属污染分析和风险评价,为硫矿区农田重金属污染风险管理与土地利用提供理论依据。布设30个采样点采集土壤及其毛豆样品,ICP-MS法测定Cu、Zn、As、Cd、Pb重金属全量,运用单因子指数、综合污染指数、潜在生态风险指数法和生物富集系数法对重金属污染程度进行评价。结果表明,研究区土壤p H值在3. 37～4. 60,均值为4. 03,土壤呈强酸性、酸性。比对安徽省土壤重金属背景值,研究区土壤已明显遭受外源重金属污染;比对GB 15618—2018《土壤环境质量农用地土壤污染风险管控标准》风险筛选值,受到Cd、Cu重金属污染,其中60%采样点Cu超标,76. 67%采样点Cd超标,但都远低于标准风险管制值;单因子污染指数评价结果显示该研究区农田以Cu、Cd污染为主;内梅罗综合污染指数评价结果表明研究区农田土壤总体已遭受重金属污染;潜在生态危害指数评价结果显示研究区土壤总体为轻微综合潜在生态危害,Cd在67%以上检测点为中等风险水平、10%为强风险水平。研究区农田农作物毛豆籽粒中Pb、Cd、As质量比均值未超过GB 2762—2017《食品安全国家标准食品中污染物限量》规定的限量值,其对重金属的富集系数(EF)从大到小依次为Cd、Zn、Cu、As、Pb。

关键词：环境学硫铁矿尾矿土壤农田重金属污染

Morphological Mechanism and Experimental Verification of Self-healing of Basalt-fiber Modified Water-soaked Asphalt

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 171-186页

作者： XIAO Minmin DONG Jinyong li Chunyan GUO xu REN Jianguo School of Urban Construction and Safety Engineering Shanghai Institute of TechnologyShanghai 201418China

This study investigates the mechanism of action of representative molecules of basalt fibers on the healing of water-soaked *** parameters,morphological characteristics,interfacial healing energy,and interfacial healing strength were analyzed using molecular dynamics and macroscopic tests under different time,temperature,and water conditions to evaluate the specific states and critical conditions involved in *** results indicate that basalt-fiber molecules can induce rearrangement and a combination of water-soaked asphalt at the healing *** groups with different bonding states increase the interfacial adsorption capacity of water-soaked *** interaction between basalt fiber molecules and water molecules leads to a"hoop"phenomenon,while aromatics-2 molecules exhibit a"ring band aggregation"*** former reduces the miscibility of water and asphalt molecules,while the latter causes slow diffusion of the ***,a micro-macro dual-scale comparison of interfacial healing strength was conducted at temperatures of 297.15 and 312.15 K to identify the strength transition point and critical temperature of 299.4 K during the self-healing process of basalt-fiber modified water-soaked asphalt.

关键词： water-soaked asphalt basalt-fibers self-healing properties moisture status molecular characterization

Characterization of a pangolin SARS-CoV-2-related virus isolate that uses the human ACE2 receptor

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Science China(life Sciences) 2024年第7期67卷 1502-1513页

作者： Luo-Yuan Xia xue-Feng Wang Xiao-Ming Cui Yi-Ming Zhang Zhen-Fei Wang En-Tao li Chang-Fa Fan Ke Song Yuan-Guo li Run-Ze Ye fang-xu li Dai-Yun Zhu Jie Zhang Zhuang-Zhuang Shi Ming-Zhu Zhang liang-Jing li Shi-Jing Shen Song Jin Ya-Wei Zhang Wei-Guang Fu lin Zhao Wen-Hao Wang Tie-Cheng Wang You-Chun Wang Jia-Fu Jiang Yan-ling Hu Na Jia Yu-Wei Gao Wu-Chun Cao Institute of EcoHealth School of Public HealthCheeloo College of MedicineShandong UniversityJinan 250012China Changchun Veterinary Research Institute Changchun 130122China State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyBeijing 100071China Division of Animal Model Research Institute for Laboratory Animal ResourcesNational Institutes for Food and Drug ControlBeijing 102629China National Institutes for Food and Drug Control Beijing 102629China life Sciences Institute Guangxi Medical UniversityNanning 530020China College of life Sciences Shandong Normal UniversityJinan 250014China Research Unit of Discovery and Tracing of Natural Focus Diseases Chinese Academy of Medical SciencesBeijing 100071China

Various SARS-CoV-2-related coronaviruses have been increasingly identified in pangolins,showing a potential threat to *** we report the infectivity and pathogenicity of the SARS-CoV-2-related virus,PCoV-GX/P2V,which was isolated from a Malayan pangolin(Manis javanica).PCoV-GX/P2V could grow in human hepatoma,colorectal adenocarcinoma cells,and human primary nasal epithelial *** replicated more efficiently in cells expressing human angiotensin-converting enzyme 2(hACE2)as SARS-CoV-2 *** intranasal inoculation to the hACE2-transgenic mice,PCoV-GX/P2V not only replicated in nasal turbinate and lungs,but also caused interstitial pneumonia,characterized by infiltration of mixed inflammatory cells and multifocal alveolar *** population immunity established by SARS-CoV-2 infection and vaccination may not protect people from PCoV-GX/P2V *** findings further verify the hACE2 utility of PCoV-GX/P2V by in vivo experiments using authentic viruses and highlight the importance for intensive surveillance to prevent possible cross-species transmission.

关键词： pangolin SARS-CoV-2-related virus infectivity pathogenicity human cell lines human ACE2 receptor hACE2-transgenic mice

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高寒地区冬季火电焊接施工

电焊机 2010年第8期40卷 78-81页

作者：徐方利方伟姚泽军四川电力建设二公司四川成都610051

为了解决高寒地区冬季火电建设焊接施工中遇到的环境温度过低难题,在现场采用搭设防风取暖棚、环境辅助加热等特殊措施,使焊接区域形成较小、较密闭的空间并提高其内部环境温度,以达到各种钢材对焊接环境温度的要求;热处理时适当增加加... 详细信息

为了解决高寒地区冬季火电建设焊接施工中遇到的环境温度过低难题,在现场采用搭设防风取暖棚、环境辅助加热等特殊措施,使焊接区域形成较小、较密闭的空间并提高其内部环境温度,以达到各种钢材对焊接环境温度的要求;热处理时适当增加加热宽度、保温厚度和恒温时间,降低冷却速度;焊后对焊缝进行无损探伤、硬度检测、金相检验及机械性能试验,结果表明焊接质量合格。采用这些特殊措施,使在寒冷的冬季进行焊接也能获得可靠的质量,为工程建设争取到可观的经济效益和宝贵的时间。

关键词：高寒焊接保温棚辅助加热