检索结果-南通市图书馆

Protein arginine methyltransferase-6 regulates heterogeneous nuclear ribonucleoprotein-F expression and is a potential target for the treatment of neuropathic pain

引用

Neural Regeneration Research 2025年第9期20卷 2682-2696页

作者： Xiaoyu Zhang Yuqi liu fangxia xu Chengcheng Zhou Kaimei Lu Bin fang lijuan Wang lina Huang Zifeng xu Department of Anesthesiology International Peace Maternity and Child Health HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Anesthesiology Shanghai General HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Shanghai Key Laboratory of Embryo Original Diseases ShanghaiChina

Protein arginine methyltransferase-6 participates in a range of biological functions,particularly RNA processing,transcription,chromatin remodeling,and endosomal ***,it remains unclear whether protein arginine methyl transferase-6 modifies neuropathic pain and,if so,what the mechanisms of this *** this study,protein arginine methyltransferase-6 expression levels and its effect on neuropathic pain were investigated in the spared nerve injury model,chronic constriction injury model and bone cancer pain model,using immunohistochemistry,western blotting,immunoprecipitation,and label-free proteomic *** results showed that protein arginine methyltransferase-6 mostly co-localized withβ-tubulinⅢin the dorsal root ganglion,and that its expression decreased following spared nerve injury,chronic constriction injury and bone cancer *** addition,PRMT6 knockout(Prmt6~(-/-))mice exhibited pain ***,the development of spared nerve injury-induced hypersensitivity to mechanical pain was attenuated by blocking the decrease in protein arginine methyltransferase-6 ***,when protein arginine methyltransferase-6 expression was downregulated in the dorsal root ganglion in mice without spared nerve injury,increased levels of phosphorylated extracellular signal-regulated kinases were observed in the ipsilateral dorsal horn,and the response to mechanical stimuli was ***,protein arginine methyltransferase-6 appeared to contribute to spared nerve injury-induced neuropathic pain by regulating the expression of heterogeneous nuclear ***,protein arginine methyltransfe rase-6-mediated modulation of hete rogeneous nuclear ribonucleoprotein-F expression required amino atids 319 to 388,but not classical H3R2 *** findings indicated that protein arginine methyltransferase-6 is a potential therapeutic target fo r the treatment of peripheral neuro pathic pain.

关键词： dorsal root ganglion heterogeneous nuclear ribonucleoprotein F neuropathic pain protein arginine methyltransferase-6 sensory neurons

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Dynamic performance enhancement in Ti/Au ohmic contacts on β-Ga2O3-on-Si C substrates: evidence from pulsed measurements

引用

Science China(Information Sciences) 2025年第1期68卷 400-401页

作者： Chenyu liU Yibo WANG Wenhui xu Shuqi HUANG Chunxiao YU Zeyu YANG Xiaole JIA Xiaoxi li Bochang li Zhengdong LUO Cizhe fang Yan liU Tiangui YOU Xin OU Genquan HAN School of Microelectronics Xidian University Suzhou Institute of Nano-Tech and Nano-Bionics Chinese Academy of Sciences Shanghai Institute of Microsystem and Information Technology Chinese Academy of Sciences Hangzhou Institute of Technology Xidian University

Titanium/Gold （Ti/Au） metals have been widely employed as ohmic metal contacts on n+Ga2O3,exhibiting the specific contact resistance （ρc） of 10-5-10-6Ω·cm2[1].But previous studies have revealed the presence of a defective Ga2O3layer and reactive Ti-Ga2O3layer at the annealed Ti/*** an interfacial layer can afect the performance of ohmic contact,which may become more pronounced in power devices subjected to electrical stress and high-frequency ***,there have been no reports on the impact of bias stress effects and dynamic degradation of Ti/Au ohmic contacts on n+Ga2O3.

关键词：

来源：

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Laser‑Induced Highly Stable Conductive Hydrogels for Robust Bioelectronics

引用

Nano-Micro Letters 2025年第3期17卷 117-120页

作者： Yibo li Hao Zhou Huayong Yang Kaichen xu State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310058People’s Republic of China

Despite the promising progress in conductive hydrogels made with pure conducting polymer,great challenges remain in the interface adhesion and robustness in longterm *** address these challenges,*** Hwan Ko and Taek-Soo Kim’s team introduced a laserinduced phase separation and adhesion method for fabricating conductive hydrogels consisting of pure poly(3,4-ethylenedioxythiophene):polystyrene sulfonate on polymer *** laser-induced phase separation and adhesion treated conducting polymers can be selectively transformed into conductive hydrogels that exhibit wet conductivities of 101.4 S cm^(−1)with a spatial resolution down to 5μ***,they maintain impedance and charge-storage capacity even after 1 h of *** micropatterned electrode arrays demonstrate their potential in long-term in vivo signal recordings,highlighting their promising role in the field of bioelectronics.

关键词： Laser processing Conductive hydrogels Stable interface Bio-interfacing electrodes Bioelectronic application

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

复合溶剂萃取N,N-二甲基乙酰胺

引用

浙江大学学报（工学版） 2016年第2期50卷 347-352页

作者：许丽芳王成习李海凤浙江大学化学工程与生物工程学院浙江杭州310027

为了提高低浓度N,N-二甲基乙酰胺水溶液中溶质的萃取效率,提出以二氯甲烷为主萃取剂,邻仲丁基苯酚或邻氯苯酚为助萃剂组成复合溶剂进行萃取分离的方法.在单级萃取装置内,分别测定复合溶剂中邻仲丁基苯酚或邻氯苯酚体积分数为0-35%时的... 详细信息

为了提高低浓度N,N-二甲基乙酰胺水溶液中溶质的萃取效率,提出以二氯甲烷为主萃取剂,邻仲丁基苯酚或邻氯苯酚为助萃剂组成复合溶剂进行萃取分离的方法.在单级萃取装置内,分别测定复合溶剂中邻仲丁基苯酚或邻氯苯酚体积分数为0-35%时的分配系数和萃取率,并用UNIFAC模型对萃取相和萃余相中N,N-二甲基乙酰胺的摩尔分数进行预测.结果表明,助萃剂的加入均能显著提高萃取效果,实测数据与模型计算结果基本吻合.当助萃剂含量小于15%时,2种复合溶剂的萃取效果基本相当,当助萃剂的含量大于15%时,助萃剂邻仲丁基苯酚的萃取效果更优.

关键词： N,N-二甲基乙酰胺萃取二氯甲烷助萃剂 UNIFAC模型

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Study on the Obtaining of Transgenic Wheat with GNA Alien Gene by Biolistic Particle

引用

Agricultural Sciences in China 2002年第1期1卷 25-29页

作者： xu Qiong-fang, li lian-cheng, CHEN Xiao, TIAN fang, MA You-zhi, YE Xing-guo, ZHANG Zeng-yan, xu Hui-jun and XIN Zhi-yong( Key Laboratory of Agricultural Ministry for Crop Genetics and Breeding, Institute of Crop Breeding and Cultivation ,Chinese Academy of Agricultural Sciences, Beijing 100081 ) Key Laboratory of Agricultural Ministry for Crop Genetics and Breeding Institute of Crop Breeding and Cultivation Chinese Academy of Agricultural Sciences Beijing 100081

The immature embryos of wheat plants, cv. Jing 411, 12 - 14 days after pollination, were cultured on SD2 medium for callus induction. After 10 days culture, 800 wheat calli were bombarded by biolistic particle coated with the DNA of plasmid pBI121-2 harboring both Galanthus nivalis agglutinin gene and bar gene. 67 green plants were finally regenerated from the bombardment calli on selection medium containing 4mg/L Basta. The results of bioassay by both inoculating wheat aphids onto the plants and applying Basta solution of 50 mg/L and 75 mg/L onto the wheat leaves in the field, and the molecular analysis, such as PCR and Southern blotting, indicated that 8 T2 plants contaning the target genes were obtained.

关键词： Galanthus nivalis agglutinin bar gene Particle bombardment Transgenic wheat

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于药物分子组装的含有Keggin型金属氧簇的超分子化合物的晶体结构和电化学性质研究

引用

分子科学学报 2009年第3期25卷 205-208页

作者：徐丽芳辽宁农业职业技术学院辽宁营口115009

通过水热方法合成了超分子化合物(Hfcz)3(PMo12O40).3H2O.单晶X射线衍射分析表明化合物结晶于三方晶系,P-3c空间群.化合物中的两种亚单元通过氢键作用形成了3D超分子结构.化合物堆积形成了孔道结构.此外,循环伏安法研究结果表明了化合... 详细信息

通过水热方法合成了超分子化合物(Hfcz)3(PMo12O40).3H2O.单晶X射线衍射分析表明化合物结晶于三方晶系,P-3c空间群.化合物中的两种亚单元通过氢键作用形成了3D超分子结构.化合物堆积形成了孔道结构.此外,循环伏安法研究结果表明了化合物展示三个连续的双电子还原过程.

关键词：多金属氧酸盐有机药物分子超分子

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Tailoring light–Matter Interactions in Overcoupled Resonator for Biomolecule Recognition and Detection

引用

Nano-Micro Letters 2025年第1期17卷 262-280页

作者： Dongxiao li Hong Zhou Zhihao Ren Cheng xu Chengkuo Lee Department of Electrical and Computer Engineering National University of SingaporeSingapore 117583Singapore Center for Intelligent Sensors and MEMS(CISM) National University of SingaporeSingapore 117608Singapore

Plasmonic nanoantennas provide unique opportunities for precise control of light–matter coupling in surface-enhanced infrared absorption(SEIRA)spectroscopy,but most of the resonant systems realized so far suffer from the obstacles of low sensitivity,narrow bandwidth,and asymmetric Fano resonance ***,we demonstrated an overcoupled resonator with a high plasmon-molecule coupling coefficient(μ)(OC-Hμresonator)by precisely controlling the radiation loss channel,the resonator-oscillator coupling channel,and the frequency detuning *** observed a strong dependence of the sensing performance on the coupling state,and demonstrated that OC-Hμresonator has excellent sensing properties of ultra-sensitive(7.25%nm^(−1)),ultra-broadband(3–10μm),and immune asymmetric Fano *** characteristics represent a breakthrough in SEIRA technology and lay the foundation for specific recognition of biomolecules,trace detection,and protein secondary structure analysis using a single array(array size is 100×100μm^(2)).In addition,with the assistance of machine learning,mixture classification,concentration prediction and spectral reconstruction were achieved with the highest accuracy of 100%.Finally,we demonstrated the potential of OC-Hμresonator for SARS-CoV-2 *** findings will promote the wider application of SEIRA technology,while providing new ideas for other enhanced spectroscopy technologies,quantum photonics and studying light–matter interactions.

关键词： Plasmonic nanoantennas light-matter interaction Surface-enhanced infrared absorption Overcoupled Biosensing

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

血、尿β2-微球蛋白对糖尿病肾病早期肾功能损害的诊断价值

引用

现代预防医学 2012年第1期39卷 190-191页

作者：徐莉芳湖北省潜江市中心医院检验科

[目的]探讨血、尿β2-微球蛋白(β2-MG)对糖尿病肾病早期肾功能损害的变化和意义。[方法]采用免疫比浊法对早期糖尿病肾病患者(早期DN组)、单纯糖尿病者(DM组)及健康体检者(正常对照组)的血、尿β2-MG含量水平进行检测。同时对3组研究... 详细信息

[目的]探讨血、尿β2-微球蛋白(β2-MG)对糖尿病肾病早期肾功能损害的变化和意义。[方法]采用免疫比浊法对早期糖尿病肾病患者(早期DN组)、单纯糖尿病者(DM组)及健康体检者(正常对照组)的血、尿β2-MG含量水平进行检测。同时对3组研究对象进行血尿素氮(BUN)、血肌酐(Cr)和24 h尿白蛋白的定量测定。[结果]早期DN组血、尿β2-MG浓度明显高于DM组,DM组血、尿β2-MG浓度明显高于正常对照组,组间差异均有统计学意义(P﹤0.05)。早期DN组24 h尿白蛋白的量显著高于单纯DM组和对照组(P﹤0.05),而单纯DM组和正常对照组差异无统计学意义(P﹥0.05)。血BUN、血Cr在正常对照组、早期DN组和单纯DM组中比较差异均无统计学意义(P﹥0.05)。[结论血、尿β2-MG是早期肾脏损害的灵敏指标,对于糖尿病患者应定期检查血、尿β2-MG的变化,以便及时发现早期肾损害,有效预防慢性肾功能衰竭的发生。

关键词：血β2-微球蛋白尿β2-微球蛋白糖尿病肾病早期肾功能损害

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Optimization Strategies of Na_(3)V_(2)(PO_(4))_(3) Cathode Materials for Sodium‑Ion Batteries

引用

Nano-Micro Letters 2025年第2期17卷 204-251页

作者： Jiawen Hu Xinwei li Qianqian liang li xu Changsheng Ding Yu liu Yanfeng Gao School of Materials Science and Engineering Shanghai UniversityShanghai 200444People’s Republic of China Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 200050People’s Republic of China

Na_(3)V_(2)(PO_(4))_(3)(NVP)has garnered great attentions as a prospective cathode material for sodium-ion batteries(SIBs)by virtue of its decent theoretical capacity,superior ion conductivity and high structural ***,the inherently poor electronic conductivity and sluggish sodium-ion diffusion kinetics of NVP material give rise to inferior rate performance and unsatisfactory energy density,which strictly confine its further application in ***,it is of significance to boost the sodium storage performance of NVP cathode *** to now,many methods have been developed to optimize the electrochemical performance of NVP cathode *** this review,the latest advances in optimization strategies for improving the electrochemical performance of NVP cathode material are well summarized and discussed,including carbon coating or modification,foreign-ion doping or substitution and nanostructure and morphology *** foreign-ion doping or substitution is highlighted,involving Na,V,and PO_(4)^(3−)sites,which include single-site doping,multiple-site doping,single-ion doping,multiple-ion doping and so ***,the challenges and prospects of high-performance NVP cathode material are also put *** is believed that this review can provide a useful reference for designing and developing high-performance NVP cathode material toward the large-scale application in SIBs.

关键词： Sodium-ion batteries Na_(3)V_(2)(PO_(4))_(3) Cathode materials Electrochemical performance Optimization strategies

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于创新链的出版融合发展模式研究

引用

编辑之友 2022年第2期 13-19页

作者：徐丽芳陈铭武汉大学信息管理学院湖北武汉430072 武汉大学数字出版研究所湖北武汉430072

在媒介融合日渐展开的背景下,构建基于传统出版和新兴出版融合的创新共同体变得十分迫切。文章从创新链理论视角出发,提出出版创新链模型,并着眼微观、中观和宏观三个层面提炼出版融合发展模式的关键要素和运行机制:从微观层面分析和归... 详细信息

在媒介融合日渐展开的背景下,构建基于传统出版和新兴出版融合的创新共同体变得十分迫切。文章从创新链理论视角出发,提出出版创新链模型,并着眼微观、中观和宏观三个层面提炼出版融合发展模式的关键要素和运行机制:从微观层面分析和归纳融合发展需要整合的创新要素资源,包括内容、技术、传播渠道;从中观层面将出版融合创新划分为创意研发、知识物化、创新增值三大业务模块;从宏观层面对整个出版融合创新生态进行基本阐释,尝试提出实现和提升融合发展效率的路径选择,为寻求出版融合发展的着力点提供借鉴。

关键词：创新链出版融合出版业媒介融合数字出版

来源：

维普期刊数据库博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：