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Newborns' sleep-wake cycle development on amplitude integrated electroencephalography

World Journal of Pediatrics 2016年第3期12卷 327-334页

作者： xu-fang li Yan-Xia Zhou lian Zhang Department of Neonatology Guangzhou Women and Children's Medical CenterGuangzhouChina Department of Electro-neurophysiology Guangzhou Women and Children's Medical CenterGuangzhouChina

Background:To observe the development of neonatal sleep among healthy infants of different conceptional age(CA)by analyzing the amplitude-integrated electroencephalography(aEEG)of their sleep-wake cycles(SWC).Methods:Bedside aEEG monitoring was carried out for healthy newborns from 32 to 46 weeks CA between September 1,2011 and August 30,*** each aEEG tracing,mean duration of every complete SWC,number of SWC repetition within 12 hours,mean duration of each narrow and broadband of SWC,mean voltage of the upper edge and lower edge of SWC,mean bandwidth of SWC were counted and *** of the correlations between voltages or bandwidth of SWC and CA was performed to assess the developmental changes of central nervous system of newborns with different ***:The SWC of different CA on aEEG showed clearly identifiable trend after 32 weeks of *** occurrence of SWC gradually increases from preterm to post-term infants;term infants had longer SWC *** voltage of upper edge of the broadband decreased at 39 weeks,while the lower edge voltage increases and the bandwidth of broadband declined along with the growing *** upper edge of the narrowband dropped while the lower edge rised gradually,especially in preterm *** width of the narrowband narrowed down while CA ***:The SWC on aEEG of 32-46 weeks infants showed a continuous,dynamic and developmental *** appearance of SWC and the narrowing bandwidth of narrowband is the main indicator to identify the CA-dependent SWC from the preterm to the late preterm *** lower edge of the broadband identifi es the term to post-term period.

关键词： amplitude-integrated electroencephalography conceptional age development newborn sleep-wake cycle

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Magnetic properties and structure of (001)-oriented [CoPt/C]_n /Ag nanocomposite films on the glass substrates

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Rare Metals 2006年第3期25卷 265-269页

作者： JIN Tao xu Xiaohong WANG fang li Xiaoli JIANG Fengxian YANG Zhiguang School of Chemistry and Materials Science Shanxi Normal University Linfen 041004 China

The highly （1301） oriented triple system of [CoPt/C]n/Ag films was deposited on glass substrates by DC and RF magnetron sputtering. After annealing at 600℃ for 30 min, thin films become magnetically hard with coercivities in the range of 160-875 kA/m because of high anisotropy associated with the L10 ordered phase. C doping plays an important role in improving （001） texture and reducing the intergrain interactions. The oriented growth of CoPt films was influenced strongly by the number of repetitions （n） of CoPt/C. By controlling the C content and the number of repetitions （n） of CoPt/C, nearly perfect （001） orientation can be obtained in the [CoPt3nm/C3nm]5/Ag50 nm.

关键词： [CoPt/C]n/Ag multilayer films (001) orientation C content number of repetition

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Clinical Characteristics of H1N1 Influenza A-Associated Mild Encephalopathy with Reversible Splenial Lesion: 4 Pediatric Cases

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Current Medical Science 2021年第4期41卷 815-820页

作者： xu-fang li Bin AI Jia-wei YE li-mei TAN Hua-mei YANG Chun-xiao fang Lan-hui SHE Yi xu Department of Infectious Disease Guangzhou Women and Children's Medical CenterGuangzhou 510000China

Objective Mild encephalopathy with reversible splenial lesion(MERS)is associated with a variety of infections and anti-epileptic drug *** we report the clinical characteristics of H1N1 influenza A-associated MERS based on our experience of four pediatric *** A detailed retrospective analysis of four patients with H1N1 influenza A-associated MERS was performed at Guangzhou Women and Children’s Medical *** All patients exhibited mild influenza-like illness and *** patients presented with a new-onset seizure with fever after 5 years of age.75%patients had altered mental *** all four patients,influenza A(H1N1)viral RNA was detected in throat swab specimens at least *** magnetic resonance images revealed similar ovoid lesions in the corpus callosum,mainly in the splenium and for one patient in the splenium and genu of the corpus *** one patient had an abnormal electroencephalogram *** and protein in the cerebrospinal fluid were normal in all *** patients received oseltamivir and one patient received intravenous *** a result,all patients fully recovered after 2 months and showed no neurologic sequelae at *** This case series provides insight towards clinical features of H1N1 influenza A-associated MERS.

关键词： mild encephalopathy with reversible splenial lesion H1N1 influenza A children corpus callosum encephalopathy

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Construction and expression of eukaryotic plasmids containing lamivudine-resistant or wild-type strains of Hepatitis B Virus genotype C

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World Journal of Gastroenterology 2008年第23期14卷 3733-3738页

作者： Wei-Zhen xu Yong fang Di li Yan Wang Qing-Long Shang Gui-Qiu li xu Teng Hong-Xi Gu Department of Microbiology Harbin Medical University Harbin 150081 Heilongjiang Province China

AIM:To construct eukaryotic expression plasmids of full-length Hepatitis B Virus(HBV) genotype C genome,which contain lamivudine-resistant mutants(YIDD,YVDD) or wild-type strain(YMDD) ,and to observe the expression of HBV DNA and antigens [hepatitis B surface antigen(HBsAg) and hepatitis B e antigen(HBeAg) ] of the recombinant plasmids in HepG2 cells. METHODS:Three HBV full-length genomes were amplified from the plasmids pMD18T-HBV/YIDD,pMD18T-HBV/YVDD and pMD18T-HBV/YMDD,using PCR. Three recombinant plasmids were generated by inserting each of the PCR products into the eukaryotic expression vector pcDNA3.1(+) ,between the EcoRI and HindⅢ sites. After being characterized by restriction endonuclease digestion,and DNA sequence analysis,the recombinant plasmids were transfected into HepG2 cells. At 48 and 72 h post-transfection,the levels of intracellular viral DNA replication were detected by real-time PCR,and the expression of HBsAg and HBeAg in the cell culture supernatant was determined by EliSA. RESULTS:Restriction endonuclease digestion and DNA sequence analysis confirmed that the threerecombinant plasmids were correctly constructed. After transfecting the plasmids into HepG2 cells,high levels of intracellular viral DNA replication were observed,and HBsAg and HBeAg were secreted into the cell culture supernatant. CONCLUSION:Eukaryotic expression plasmids pcDNA3.1(+) -HBV/YIDD,pcDNA3.1(+) -HBV/YVDD or pcDNA3.1(+) -HBV/YMDD,which contained HBV genotype C full-length genome,were successfully constructed. After transfection into HepG2 cells,the recombinant plasmids efficiently expressed HBV DNA,HBsAg and HBeAg. Our results provide an experimental basis for the further study of HBV lamivudine-resistant mutants.

关键词： Hepatitis B virus Lamivudine-resistant mutant Wild-type strain

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Fabrication of poly(2,6-pyridinedicarboxylic acid)/MWNTs modified electrode for simultaneous determination of guanine and adenine in DNA

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Chinese Chemical Letters 2011年第8期22卷 981-984页

作者： Ke Qin Deng Chun Xiang li Yu lin ling Guo Rong xu Xiao fang li Chemistry and Chemical Engineering College Hunan University of Science and Technology Xiangtan 411201 China

The fabrication of poly（2,6-pyridinedicarboxylic acid）/MWNTs modified glass electrode（PPDA/MWNTs/GCE） was proposed and used for individual or simultaneous determination of guanine and *** performances of the PPDA/MWNTs/GCE were characterized with cyclic voltammetry（CV）.The modified electrode exhibited enhanced electrocatalytic behavior and good stability for the detection of guanine and *** pulse voltammetry（DPV） was used to determine the concentration of guanine,*** detection limit（S/N = 3） for guanine and adenine was 0.045μmol/L and 0.05μmol/L,*** electrochemical method for the measurement of guanine and adenine in calf thymus DNA was also developed with this modified electrode and the result was satisfactory.

关键词： Multi-wall carbon nanotubes 2 6-Pyridinedicarboxylic acid Guanine Adenine Calf thymus dsDNA

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Clinical and pathological portraits of axillary presentation breast cancer and effects of preoperative systemic therapy

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Chinese Journal of Cancer Research 2017年第4期29卷 369-373页

作者： ling xu fang li Yinhua liu xuening Duan Jingming Ye Yuanjia Cheng ling Xin Breast Disease Center of Peking University First Hospital Beijing 100034China Department of General Surgery Beijing Aerospace General HospitalBeijing 100076China

There is a lack of investigation into the biological characteristics and preoperative systemic therapy （PST） for occult breast cancer （OBC）. For this study, departmental records in Breast Disease Center of Peking University First Hospital from January 2008 to December 2015 were retrospectively reviewed to identify cases of OBC. Eleven cases were included, and all patients were female, with a median age of 56 （range： 29-75） years. The sensitivity of magnetic resonance imaging （MRD was I00%, and the false positive rate was 33.3%. Based on histologic analysis of the axillary node, 9 （81.8%） cases were grade 3, and 2 （18.2%） cases were grade 2; 4 （36.4%） cases were 〉10% estrogen receptor （ER） positive and 6 （54.5%） human epidermal growth receptor 2 （HER2） positive. Nine cases （81.8%） exhibited over 30% Ki67 expression. PST was performed in 5 of the 11 cases. The lymph node response rate was 100% （5/5）, but no complete remission was achieved. In conclusion, aggressive subtypes were predominant among the included cases, and PST should be considered for OBC treatment options.

关键词： AxiUary presentation breast cancer occult breast cancer (OBC) magnetic resonance imaging (MRI) preoperative systemic therapy (PST)

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In-orbit performance of HE onboard Insight-HXMT in the first 5 years

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Radiation Detection Technology and Methods 2023年第1期7卷 3-14页

作者： xu-fang li Cong-Zhan liu Yi-Fei Zhang Xiao-Bo li Zheng-Wei li xue-Feng Lu Zhi Chang Ming-Yu Ge Juan Zhang Yu-Peng xu fang-Jun Lu li-Ming Song Shuang-Nan Zhang Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of Science19B Yuquan RoadShijingshan DistrictBeijing 100049China

Purpose The high-energy X-ray telescope(HE),one of the three main payloads of the Insight-HXMT mission,is composed of eighteen NaI(Tl)/CsI(Na)phoswich detectors,where NaI(Tl)serves as the primary detector covering 20–250 keV,and CsI(Na)is used as an active shield detector to suppress the background of NaI(Tl)and also serves as an all-sky gammaray burst monitor covering 0.2–*** this paper,we review the in-orbit performance of HE in the first 5 years since Insight-HXMT was launched on June 15,*** The major performances we concern include the gain and energy resolution of NaI(Tl)and CsI(Na)detectors,the performance of pulse shape discriminator(PSD)and system dead *** this work,we investigate these performances mainly using the data of blank-sky observations and the data when the telescope is in earth *** The overall performance of HE/NaI(Tl)is very stable in the first 5 years,whereas the gain of HE/CsI(Na)shows a continuously increasing trend and should be calibrated *** In general,HE is still in good health and well-calibrated status after five-year’s *** in-orbit performance of HE has no significant deviation from *** is expected to be in operation healthily for another several years of extended mission life.

关键词： Insight-HXMT Hard X-ray telescope Scintillation detector In-orbit

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Double [5]carbohelicene: facile synthesis, chiroptical properties,isomerization study, and lasing application

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Science China Chemistry 2025年第1期68卷 233-240页

作者： Peipei liu Yantong li Meng-Xiang Wu Hao Kang Xiao-li Zhao lin xu linlin liu Xiaodong li Junfeng fang Zhiwei fang Ya Cheng Hai-Bo Yang Huakang Yu xueliang Shi State Key Laboratory of Petroleum Molecular & Process Engineering Shanghai Key Laboratory of Green Chemistry and Chemical ProcessesSchool of Chemistry and Molecular Engineering East China Normal University School of Physics and Optoelectronics South China University of Technology Institute of Polymer Optoelectronic Materials & Devices State Key Laboratory of Luminescent Materials & Devices South China University of Technology School of Physics and Electronic Science Engineering Research Center of Nanophotonics & Advanced Instrument Ministry of EducationEast China Normal University State Key Laboratory of Precision Spectroscopy School of Physics and Electronic Science East China Normal University

Double carbohelicenes have attracted considerable attention due to their aesthetic structures, distinct π-conjugation extension, inherent chirality, and intriguing optical and electronic properties. Herein, the concise de novo synthesis of a new double[5]carbohelicene 1 together with its chiroptical properties, isomerization process and lasing application is presented. 1 was synthesized by a simple protocol involving the formation of a 6,6′-bipentacene as the key intermediate. It is worth noting that1 existed as two diastereomers 1-PP/MM and 1-PM, which were successfully isolated and unambiguously confirmed by Xray crystallography. The optical resolution of the racemic 1-PP/MM was successfully achieved by chiral-phase highperformance liquid chromatography（HPLC）, and 1-PP and 1-MM were characterized by circular dichroism. Interestingly, it was found that 1-PP/MM could be completely isomerized to 1-PM upon heating, and the detailed thermodynamics and kinetics of the isomerization process were systematically investigated. 1-PM exhibited deep-red luminescence with emission maximum at 723 nm and fluorescence quantum yield as high as 32.95%. Consequently, we can showcase the lasing application of 1-PM by doping with epoxy resin to assemble a bottle microlaser spontaneously, which the lasing wavelength is 796.6 nm at a threshold of 0.8 m J cm-2. We believe that our studies, including the facile synthesis methodology, detailed isomerization studies, and lasing application, will shed some light on the design and synthesis of novel carbohelical systems with more functions.

关键词： double carbohelicene optical resolution organic laser isomerization X-ray diffraction

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Flotation performance and adsorption mechanism of novel 1-(2-hydroxyphenyl)hex-2-en-1-one oxime flotation collector to malachite

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Transactions of Nonferrous Metals Society of China 2020年第10期30卷 2792-2801页

作者： fang-xu li Xiao-tong ZHOU Ri-xiao liN Guangdong Academy of Sciences Guangzhou 510650China Guangdong Institute of Resources Comprehensive Utilization Guangzhou 510650China State Key Laboratory of Rare Metals Separation and Comprehensive Utilization Guangzhou 510650China Guangdong Provincial Key Laboratory of Development and Comprehensive Utilization of Mineral Resources Guangzhou 510650China

A novel collector 1-(2-hydroxyphenyl)hex-2-en-1-one oxime(HPHO)was synthesized from 2-hydroxy acetophenone and *** flotation performance and adsorption mechanism to malachite were investigated by flotation test,zeta potential,Fourier transform infrared(FTIR)and X-ray photoelectron spectroscopy(XPS)analysis *** with benzohydroxamic acid(BA),1-(2-hydroxyphenyl)ethan-1-one oxime(HPEO)and sodium isobutyl xanthate(SIBX),HPHO exhibited excellent collecting power to malachite without additional reagents,such as Na2S regulator and methyl isobutyl carbinol(MIBC)*** of zeta potential indicated that HPHO was coated on malachite surfaces through a chemisorption *** and XPS data gave clear evidence for the formation of Cu−oxime complex on malachite surfaces after HPHO adsorption through the linkage between C=C,—OH,N—OH group and Cu species.

关键词： malachite flotation collector oxime adsorption mechanism

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Interfacial Zn2+-solvation regulator towards reversible and stable Zn anode

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Journal of Energy Chemistry 2025年第1期100卷 684-692页

作者： Miao Zhou Xiongbin Luo Hang li Shan Guo Zhuang Tong Xiaotao Zhou xu li Zhaohui Hou Shuquan liang Guozhao fang College of Mechanical Engineering Key Laboratory of Hunan Province for Advanced Carbon-based Functional Materials Hunan Institute of Science and Technology School of Materials Science and Engineering Key Laboratory of Electronic Packaging and Advanced Functional Materials of Hunan Province Central South University College of Materials and Metallurgy Guizhou University National Energy Metal Resources and New Materials Key Laboratory Central South University

Aqueous zinc-ion batteries （AZIBs） are fundamentally challenged by the instability of the electrode/electrolyte interface,predominantly due to irreversible zinc （Zn） deposition and hydrogen ***,the intricate mechanisms behind the electrochemical discrepancies induced by interfacial Zn2+-solvation and deposition behavior demand comprehensive *** molecules endowed with special functional groups （such as hydroxyl,carboxyl,etc.） have the potential to significantly optimize the solvation structure of Zn2+and regulate the interfacial electric double layer （EDL）.By increasing nucleation overpotential and decreasing interfacial free energy,these functional groups facilitate a lower critical nucleation radius,thereby forming an asymptotic nucleation model to promote uniform Zn ***,this study presents a pioneering approach by introducing trace amounts of n-butanol as solvation regulators to engineer the homogenized Zn （H-Zn） anode with a uniform and dense *** interfacial reaction and structure evolution are explored by in/ex-situ experimental techniques,indicating that the H-Zn anode exhibits dendrite-free growth,no by-products,and weak hydrogen evolution,in sharp contrast to the bare ***,the H-Zn anode achieves a remarkable Zn utilization rate of approximately 20% and simultaneously sustains a prolonged cycle life exceeding 500 ***,the H-Zn//NH4V4O10（NVO） full battery showcases exceptional cycle stability,retaining 95.04%capacity retention after 400 cycles at a large current density of 5 A *** study enlightens solvation-regulated additives to develop Zn anode with superior utilization efficiency and extended operational lifespan.

关键词： Solvation

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