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Innovative mesenchymal stem cell treatments for fatty liver disease

World Journal of Stem Cells 2024年第9期16卷 846-853页

作者： Fei-Qiong Gao Jia-Qi Zhu xu-dong feng Department of Endocrinology Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhou 310003Zhejiang ProvinceChina Laboratory Medicine Center Department of Clinical LaboratoryZhejiang Provincial People’s HospitalPeople’s Hospital of Hangzhou Medical CollegeHangzhou 310014Zhejiang ProvinceChina Department of Clinical Laboratory Ningbo Medical Center Lihuili HospitalAffiliated Lihuili Hospital of Ningbo UniversityNingbo 315000Zhejiang ProvinceChina

The incidence of non-alcoholic fatty liver disease(NAFLD)and alcohol-associated liver disease(ALD)is increasing year by year due to changes in the contemporary environment and dietary structure,and is an important public health problem *** is an urgent need to continuously improve the understanding of their disease mechanisms and develop novel therapeutic *** stem cells(MSCs)have shown promise as a potential therapeutic strategy in therapeutic studies of NAFLD and *** and ALD have different triggers and their specific mechanisms of disease progression are different,but both involve disease processes such as hepatocellular steatosis and potential fibrosis,cirrhosis,and even hepatocellular *** have metabolic regulatory,anti-apoptotic,antioxidant,and immunomodulatory effects that together promote liver injury repair and functional recovery,and have demonstrated positive results in preclinical *** editorial is a continuum of Jiang et al’s review focusing on the advantages and limitations of MSCs and their derivatives as therapeutics for NAFLD and *** detail how MSCs attenuate the progression of NAFLD by modulating molecular pathways involved in glucolipid metabolism,inflammation,oxidative stress,endoplasmic reticulum stress,and *** on recent advances,we discuss MSCs and their derivatives as therapeutic strategies for NAFLD and ALD,providing useful information for their clinical application.

关键词： Alcohol-associated liver disease Non-alcoholic fatty liver disease Mesenchymal stem cells Cell therapy Inflammation

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Novel intervention for alcohol-associated liver disease

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World Journal of Gastroenterology 2024年第39期30卷 4308-4312页

作者： Fei-Qiong Gao Jia-Qi Zhu xu-dong feng Department of Endocrinology The Affiliated Hangzhou First People's HospitalSchool of MedicineWestlake UniversityHangzhou 310003Zhejiang ProvinceChina Laboratory Medicine Center Department of Clinical LaboratoryZhejiang Provincial People's HospitalPeople's Hospital of Hangzhou Medical CollegeHangzhou 310014Zhejiang ProvinceChina Department of Clinical Laboratory Ningbo Medical Center Lihuili HospitalThe Affiliated Lihuili Hospital of Ningbo UniversityNingbo 315000Zhejiang ProvinceChina

A recently published article in the World Journal of Gastroenterology clarified that elafibranor,a dual peroxisome proliferator activated receptorα/δ(PPARα/δ)agonist,reduced inflammation and fibrosis in alcohol-associated liver disease(ALD).This letter aims to discuss the findings presented in that *** is a global health problem,and no effective drugs has been approved by the Food and Drug Administration to cure ***,finding targeted therapies is of great ***,we focus on the pathogenesis of ALD and the role of PPARα/δin its *** with the conclusion of the article of interest,we think that elafibranor may be a promising therapeutic option for ALD,due to the pivotal involvement of PPARα/δin the pathogenesis of the ***,its treatment dose,timing,and side effects need to be further investigated in future studies.

关键词： Alcohol-associated liver disease Elafibranor Peroxisome proliferator activated receptorα/δ Therapy Pathogenesis

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尼达尼布联合汉防己甲素治疗结缔组织病相关肺间质纤维化患者的临床研究

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中国临床药理学杂志 2024年第19期40卷 2781-2785页

作者：杨东明聂建军任蔚张瑞龚本尚许东风南阳医学高等专科学校第一附属医院呼吸与危重症医学科

目的观察乙磺酸尼达尼布软胶囊联合汉防己甲素片对结缔组织病相关肺间质纤维化患者肺功能和呼吸困难症状的影响。方法将结缔组织病相关肺间质纤维化患者按队列法分为试验组和对照组。对照组根据患者情况给予糖皮质激素、免疫抑制药等... 详细信息

目的观察乙磺酸尼达尼布软胶囊联合汉防己甲素片对结缔组织病相关肺间质纤维化患者肺功能和呼吸困难症状的影响。方法将结缔组织病相关肺间质纤维化患者按队列法分为试验组和对照组。对照组根据患者情况给予糖皮质激素、免疫抑制药等基础治疗；试验组在对照组治疗的基础上，给予乙磺酸尼达尼布软胶囊每次100 mg,bid,口服+汉防己甲素片每次40 mg,tid,口服。2组患者均治疗3个月。比较2组患者的临床疗效、呼吸困难严重程度[改良英国医学研究委员会呼吸困难量表(mMRC)及圣乔治呼吸问卷(SGRQ)]、肺功能指标、肺纤维化积分及血气分析指标，并评价安全性。结果试验组和对照组均分别纳入42例。治疗后，试验组和对照组的总有效率分别为92.86%(39例/42例)和76.19%(32例/42例),在统计学上差异有统计意义(P0.05)。结论乙磺酸尼达尼布软胶囊联合汉防己甲素片治疗较基础治疗更能改善结缔组织病相关肺间质纤维化患者肺纤维化程度及呼吸困难程度、延缓患者肺功能下降。

关键词：乙磺酸尼达尼布软胶囊汉防己甲素片结缔组织病相关肺间质纤维化肺功能呼吸困难症状

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Generation and detection of squeezed state

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Optoelectronics Letters 2008年第3期4卷 231-233页

作者： SHANG xu-dong YU Li feng xue-dong YANG Bo-jun Key Laboratory of Optical Communication and Light wave Technologies Ministry of Education Beijing University ofPosts and Telecommunications Beijing 100876 China

Soliton amplitude squeezed state is obtained and dctected by using asymmetric Sagnac interferometer and balanced homodyne detecting system. An improved photo detector circuit for quantum state detection is introduced. The circuit has a bandwidth of 10MHz and the saturation power is about 19 mW. A maximum photocurrent noise reduction of 1.1 dB below the shot noise is achieved. Taking the detection efficiency into account,the squeezing will be about 1.5 dB.

关键词：压缩态检测技术孤波不对称性

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Block dual Toeplitz Operators on the Orthogonal Complements of Fock Spaces

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Acta Mathematica Sinica,English Series 2024年第8期40卷 1967-1988页

作者： Jian Xiang dong Chun xu xu Yu feng LU School of Mathematical Sciences Dalian University of TechnologyDalian 116024P.R.China School of Mathematics and Information Science Guangzhou UniversityGuangzhou 510006P.R.China

In this paper,we characterize the boundedness and compactness of the block dual Toeplitz operators acting on the orthogonal complement of the Fock spaces,and the compactness of the finite sum of two dual Toeplitz oper... 详细信息

关键词： Block dual Toeplitz operators boundedness compactness Fock space (semi)-commutator

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Fully fluorinated hybrid zeolite imidazole/Prussian blue analogs with combined advantages for efficient oxygen evolution reaction

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Chinese Chemical Letters 2024年第6期35卷 222-228页

作者： Jiayu xu Meng Li Baoxia dong Ligang feng School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225002China

Hybrid metal-organic framework(MOF)derivatives play a significant role in the novel catalyst development in energy conversion ***,we demonstrated the low-temperature fully fluorinated zeolitic imidazole framework(ZIF)coupled with a three-dimensional open framework Prussian blue analog(PBA)with combined advantages for electrocatalytic oxygen evolution reaction(OER)in water splitting *** spectroscopic analysis and the electrochemical studies revealed the combined advantages of efficient electronic effect and active site *** of good conductivity improvement by Ndoped carbon derived from ZIF and the high electrochemical surface area and active site exposure from PBA derivatives,good catalytic performance was obtained on the optimal catalyst of Co Ni ZIF/Co Fe-PBAF-300,which required a low overpotential of 250 m V to reach 10 m A/cm^(2)loaded on the glassy carbon electrode,with Tafel slope of 47.4 m V/dec,and very high dynamic and steady *** addition,the multi-component with the mixed structure from highly polar metal fluorides promoted the easy formation of the active phase as revealed by the post-sample *** current results showed a novel composite catalyst materials development from the hybrid MOF derivatives,which would be promising in the electrolysis of water oxidation reactions and energy-relevant catalysis reactions.

关键词： Metal-organic framework Zeolitic imidazole framework Prussian blue analog Fluoridation Multi-component Oxygen evolution reaction

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Impurity formation mechanism of silicon carbide crystals smelted by Acheson process

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Journal of Iron and Steel Research International 2024年第6期31卷 1367-1375页

作者： dong feng Hong-qiang Ru xu-dong Luo Jie-gang You Ling Zhang School of Materials and Metallurgy University of Science and Technology LiaoningAnshan 114051LiaoningChina Key Laboratory for Anisotropy and Texture of Materials(Ministry of Education) Institute of Advanced CeramicsSchool of Materials Science and EngineeringNortheastern UniversityShenyang 110819LiaoningChina Liaoning Institute of Science and Technology Benxi 117004LiaoningChina

In order to further promote the application of SiC refractories in modern steel metallurgy,the occurrence forms and formation mechanism of impurities in SiC crystals smelted by Acheson process were *** techniques of inductively coupled plasma-atomic emission spectrometry,X-ray diffraction,and scanning electron microscopy were combined to examine the types and occurrence forms of impurities in smelted SiC *** results showed that the main impurities in the SiC are free Si,free C,oxides(CaO·Al_(2)O_(3)·2SiO_(2),3Al_(2)O_(3)·2SiO_(2),CaO·SiO_(2) and SiO_(2))and alloy phases(Fe_(x)Si_(y),Fe_(x)Si_(y)Ti_(z) and Fe_(x)Al_(y)Si_(z)).The formation process of impurities during the smelting of SiC can be described as follows:At high temperature,the SiO_(2) and Fe,Ti related oxide impurities present in the raw materials are reduced to Si,Fe,and Ti metal *** the reduction process,the free Si,Fe_(x)Si_(y) and Fe_(x)Si_(y)Ti_(z) are precipitated from the melt during *** Si primarily exists in aggregated form within the SiC crystal,while the alloy phase is predominantly found at the interface between SiC and free Si,with Fe_(x)Si_(y)Ti_(z) embedded within *** the end of the cooling process,other impurity oxides such as Al_(2)O_(3),CaO,and some unreduced SiO_(2) solidify to form calcium-aluminum-silicate glass phases,predominantly located between SiC *** remaining C from the reaction is mainly dispersed as free C within the SiC crystal and at the interface between SiC and free Si.

关键词： Impurity element Formation mechanism Smelted SiC crystal SiC refractory Occurrence form

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MORPHOLOGY, CRYSTALLIZATION AND MECHANICAL PROPERTIES OF POLY(ε-CAPROLACTONE)/GRAPHENE OXIDE NANOCOMPOSITES

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Chinese Journal of Polymer Science 2013年第8期31卷 1148-1160页

作者： Guang-shuo Wang 魏志勇 Lin Sang Guang-yi Chen Wan-xi Zhang xu-feng dong 齐民 School of Materials Science and Engineering Dalian University of Technology School of Automotive Engineering and State Key Laboratory of Structural Analysis for Industrial Equipment Dalian University of Technology

A series of nanocomposites based on poly（ε-caprolactone）（PCL） and graphene oxide （GO） were prepared by in situ polymerization. Scanning electron microscopy observation revealed not only a well dispersion of GO but also a strong interfacial interaction between GO and the PCL matrix, as evidenced by the presence of some GO nanosheets embedded in the matrix. Effects of GO nanofillers on the crystal structure, crystallization behavior and spherulitic morphology of the PCL matrix were investigated in detail. The results showed that the crystallization temperature of PCL enhanced significantly due to the presence of GO in the nanocomposites, however, the addition of GO did not affect the crystal structure greatly. Thermal stability of PCL remarkably increased with the addition of GO nanosheets, compared with that of pure PCL. Incorporation of GO greatly improved the tensile strength and Young＇s modulus of PCL without a significant loss of the elongation at break.

关键词： Poly(ε-caprolactone) Graphene oxide Morphology Thermal and mechanical properties.

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Simple and Mild Syntheses of Optically Active 2-(N,N-Dialkylamino)oxazolines

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Chemical Research in Chinese Universities 2010年第3期26卷 394-397页

作者： JIA xu-dong DUAN Hai-feng LIN Ying-jie CAO Jun-gang LIANG Da-peng LUO xu-yang JIANG feng GAO Han WU Mao-cheng Department of Organic Chemistry College of Chemistry Jilin University Changchun 130012 P. R. China

Chloroamidinium salts and a-amino alcohols derived from commercially available tetraalkyl ureas and α-amino acids, respectively, can be used for the syntheses of optically active 2-（N,N-dialkylamino）oxazolines in moderate to excellent yields without any catalyst. It is a simple and mild method for the syntheses of optically active oxazolines

关键词： Amino alcohol Oxazoline Chloroamidinium salt Guanidine

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One-pot Three-component Synthesis of 4,4'-Arylidene-bis(3-methyl-pyrazolones) Derivatives in Water

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Chemical Research in Chinese Universities 2012年第6期28卷 999-1002页

作者： JIA xu-dong DUAN Hal-feng LIN Ylng-jle CAO Jun-gang LIANG Da-peng WU Mao-cheng Department of Organic Chemistry College of Chemistry Jilin University Changehun 130012 P. R. China

Aldehydes,hydrazine and ethyl acetoacetate were used for the synthesis of 4,4＇-arylidene-bis（3-methyl-pyrazolones） derivatives in *** this green synthetic protocol,the solvent water itself catalyzed the reaction via hydrogen bonding,thus avoiding the use of any other catalyst to make the work up procedure ***-pot,environmental friendly and convenient are the highlights.

关键词： 4 4'-Arylidene-bis(3-methyl-pyrazolones) Catalysis Multi-component reaction

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