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Visceral response to acute retrograde gastric electrical stimulation in healthy human

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World Journal of Gastroenterology 2005年第29期11卷 4541-4546页

作者： Shu-Kun Yao Mei-Yun Ke Zhi-Feng Wang Da-bo xu Yan-li Zhang Department of Gastroenterology Peking Union Medical College Hospital Beijing 100730 China

AIM: To investigate the visceral response to acute retrograde gastric electrical stimulation (RGES) in healthy humans and to derive optimal parameters for treatment of patients with ***: RGES with a series of effective parameters were performed via a bipolar mucosal electrode implanted along the great curvature 5 cm above pylorus of stomach in 12 healthy human subjects. Symptoms associated with dyspepsia and other discomfort were observed and graded during RGES at different settings, including long pulse and pulse train. Gastric myoelectrical activity at baseline and during different settings of stimulation was recorded by a multi-channel ***: The gastric slow wave was entrained in all the subjects at the pacing parameter of 9 cpm in frequency, 500 ms in pulse width, and 5 mA in *** frequently appeared symptoms during stimulation were satiety, bloating, discomfort, pain, sting, and nausea. The total symptom score for each subject significantly increased as the amplitude or pulse width was adjusted to a higher scale in both long pulse and pulse train. There was a wide diversity of visceral responses to RGES among ***: Acute RGES can result in a series of symptoms associated with dyspepsia, which is beneficial to the treatment of obesity. Optimal parameter should be determined according to the individual sensitivity to electrical stimulation.

关键词： Visceral response Retrograde gastric electrical stimulation Symptom Obesity

Nanostructural evolution of Zn by dry roller vibration milling at room temperature

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Progress in Natural Science:Materials International 2006年第4期16卷 441-444页

作者： WANG Shulin, li Shengjuan, DU Yanchen, xu bo, li Laiqiang and ZHU Yan Department of Power Engineering Department of Medical Apparatus, University of Shanghai for Science and Technology, Shanghai 200093, China Department of Power Engineering University of Shanghai for Science and Technology Shanghai 200093 China Department of Medical Apparatus University of Shanghai for Science and Technology Shanghai 200093 China

It remains open to date to produce stable nanostructures of single element by dry mechanical method at room temperature on a large scale. Here we report nanostructural evolution of zinc by dry roller vibration milling at room temperature, which leads to structurally near perfect zinc flakes sized 3-5 nm in diameter. The synthesized nanostructures are single crystalline, transparent, uniform, randomly oriented, almost equiaxed, and mostly free from defects. The evolution seems to open a way to optimize zinc nanostructures by the mechanical method, offer valuable references to prepare nanostructures of other metals optimally, and shed light on how to lower the size limit by mechanical milling. Single elemental metal nanostructures with excellent properties give rise to new opportunities in scientific research and development of nanotechnology.

关键词： nanoparticles nanostructures vibration milling.

Major risk-stratification models fail to predict outcomes in patients with multivessel coronary artery disease undergoing simultaneous hybrid procedure

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Chinese Medical Journal 2013年第3期126卷 450-456页

作者： WANG Hao-ran ZHENG Zhe XIONG Hui xu bo li li-huan GAO Run-lin HU Sheng-shou Research Center for Cardiac Regenerative Medicine of the Ministry of Health Cardiovascular Institute & Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China

Background The hybrid procedure for coronary heart disease combines minimally invasive coronary artery bypass grafting （CABG） and percutaneous coronary intervention （PCI） and is an alternative to revascularization treatment. We sought to assess the predictive value of four risk-stratification models for risk assessment of major adverse cardiac and cerebrovascular events （MACCE） in patients with multivessel disease undergoing hybrid coronary revascularization. Methods The data of 120 patients were retrospectively collected and the SYNTAX score, EuroSCORE, SinoSCORE and the Global Risk Classification （GRC） calculated for each patient. The outcomes of interest were 2.7-year incidences of MACCE, including death, myocardial infarction, stroke, and any-vessel revascularization. Results During a mean of 2.7-year follow-up, actuarial survival was 99.17%, and no myocardial infarctions occurred. The discriminatory power （area under curve （AUC）） of the SYNTAX score, EuroSCORE, SinoSCORE and GRC for 2.7-year MACCE was 0.60 （95% confidence interval 0.42-0.77）, 0.65 （0.47-0.82）, 0.57 （0.39-0.75） and 0.65 （0.46-0.83）, respectively. The calibration characteristics of the SYNTAX score, EuroSCORE, SinoSCORE and GRC were 3.92 （P=0.86）, 5.39 （P=0.37）, 13.81 （P=0.32） and 0.02 （P=0.89）, respectively. Conclusions In patients with multivessel disease undergoing a hybrid procedure, the SYNTAX score, EuroSCORE, SinoSCORE and GRC were inaccurate in predicting MACCE. Modifying risk-stratification models to improve the predictive value for a hybrid procedure is needed.

关键词： hybrid coronary revascularization risk stratification model multivessel coronary artery disease

Effects of low molecular weight heparin on clot rate and activated clotting time： an in vitro study

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Chinese Medical Journal 2013年第18期126卷 3553-3556页

作者： SHI xu-bo BAI Ying li Jie XIAO Jie WANG Jian-qi ZHENG Hua Cardiovascular Center Beijing Tongren Hospital Capital Medical University Beijing 100730 China

Background Due to lack of point-of-care testing, the use of low-molecular-weight heparin （LMWH） therapy in some special patients is restricted. This study was designed to explore the effects of LMWH on clot rate （CR） and activated clotting time （ACT）, and to search for an appropriate method for bedside monitoring of anticoagulant activity of LMWH. Methods Thirty-two healthy volunteers were selected from the staff of Beijing Tongren Hospital. CR and ACT were measured with different reagents （glass beads, diatomite, kaolin and magnetic bar） on blood samples spiked with increasing concentrations of LMWH （dalteparin, 0.2-1.8 IU/ml）. Correlations between concentrations of LMWH and values of CR and ACT were analysed based on the data obtained and regression analysis was performed to establish a regression equation. Results With the increase in doses of dalteparin, CR values reduced gradually. The values of CR of four reagents （glass beads, diatomite, kaolin and magnetic bar） were 20.4-4.5 IU/min, 27.4-6.9 IU/min, 27.5-7.9 IU/min and 7.8-0.1 IU/min respectively and an linear relationship was observed between the CR values and dalteparin concentrations （P〈0.05）. The values of ACT were 173-615 seconds, 130-270 seconds, 123-226 seconds, 337-1411 seconds respectively, which showed a linear regression between the ACT values and dalteparin concentrations （P〈0.01）. Differences in slope of the regression curves of ACT were observed with all the reagents tested （glass beads 248.2 s/IU, diatomite 74.8 s/IU, kaolin 58.2 s/IU and magnetic bar 1112.2 s/IU, P〈0.01）. While the minimum concentration of dalteparin was 0.2 IU/ml, 0.4 IU/ml, 1.4 IU/ml and 0.2 IU/ml separately, the ACT values of the four coagulants （glass beads, diatomite, kaolin and magnetic bar） were beyond the normal limit and showed a noticeable increase respectively （P〈0.01）. Conclusions This study showed that there was an excellent linear relationship between the CR and ACT values and dalteparin concentrations for all t

关键词： clot rate activated clotting time low molecular weight heparin

Targets capture by distributed active swarms via bio-inspired reinforcement learning

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 210-221页

作者： Kun xu Yue li Jun Sun Shuyuan Du Xinpeng Di Yuguang Yang bo li Institute of Biomechanics and Medical Engineering Applied Mechanics Laboratory Department of Engineering MechanicsTsinghua University Institute of Nuclear and New Energy Technology Tsinghua University Shanghai Aerospace Control Technology Institute Shanghai Key Laboratory of Aerospace Intelligent Control Technology College of Automation Engineering Nanjing University of Aeronautics and Astronautics

Natural swarms arranged from cells to herds are usually decentralized but display intriguing collective intelligence in coordinating individuals across large scales to efficiently achieve their common goals. Learning from nature may provide new strategies for controlling collective dynamics of synthetic swarms to accomplish specific functions. Here, we present a bioinspired computational framework that steers distributed active swarms to collectively capture and merge targets via reinforcement learning. We exploit collective milling structures of natural herds to cage the targets, and adopt a switching control policy inspired by sperms' chiral dynamics to optimize the trajectories of individuals, through which the active swarms can selforganize to enclose single or multiple distant targets in a dynamical, adaptive and scalable manner. There exists a critical swarm size, beyond which the excessive competition between agents would generate large mechanical forces, leading to capture instability but enabling the transition from short-distance to long-distance merging capture of multiple targets. This work provides physical insights into distributed active swarms and could offer a multilevel, decentralized strategy toward controlling swarm robotics in wide applications such as bio-medical devices, machine immunity, and target clearance.

关键词： swarm intelligence robotics multi-tasks artificial intelligence bionics

中国共产党以马克思主义主流话语引领社会变革探析

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毛泽东邓小平理论研究 2021年第8期 63-70,108页

作者：徐立波上海师范大学马克思主义学院上海师范大学21世纪马克思主义研究中心

马克思主义话语中国化的过程,是一个建构话语体系、树立话语权威、掌握话语主动权的过程。百年来,中国共产党紧跟时代发展潮流,不断实现马克思主义话语的创新发展,形成了马克思主义中国化的话语谱系。在中国共产党成立100周年之际,对中... 详细信息

马克思主义话语中国化的过程,是一个建构话语体系、树立话语权威、掌握话语主动权的过程。百年来,中国共产党紧跟时代发展潮流,不断实现马克思主义话语的创新发展,形成了马克思主义中国化的话语谱系。在中国共产党成立100周年之际,对中国共产党不同历史时期马克思主义主流话语的形成与发展历程展开研究,探析中国共产党在不同历史时期以马克思主义主流话语引领社会变革的主要历程和基本经验,对新时代中国特色社会主义话语体系的建构完善具有重要意义。

关键词：中国共产党马克思主义话语变革

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三参数区间数下非线性可拓关联度决策方法

控制与决策 2019年第10期34卷 2203-2212页

作者：许立波李兴森郭研浙江大学宁波理工学院计算机与数据工程学院浙江宁波315000 广东工业大学可拓学与可拓创新方法研究所广州510006

针对属性值为三参数区间数和权重未知的多属性决策问题,提出一种新的基于非线性可拓简单关联度的多属性决策方法和框架.该方法基于可拓简单关联函数提出非线性可拓三参数区间关联度的计算方法,通过定义区间映射变换算子,将不同类型指标... 详细信息

针对属性值为三参数区间数和权重未知的多属性决策问题,提出一种新的基于非线性可拓简单关联度的多属性决策方法和框架.该方法基于可拓简单关联函数提出非线性可拓三参数区间关联度的计算方法,通过定义区间映射变换算子,将不同类型指标的关联度计算均变换为效益型指标的单调递增关联度计算.该方法内含偏好态度系数的设置以反映决策者态度倾向带来的决策不确定性,而且能够体现人们进行决策评价时的非线性思维.最后通过算例分析表明所提出方法的合理性和稳定性.

关键词：决策可拓学三参数区间数关联度

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基于时序推断的拥塞控制策略的性能分析

计算机学报 2007年第9期30卷 1638-1644页

作者：许立波吴国新东南大学计算机网络与信息集成重点实验室南京210096

通过对TD、RED等算法进行较精确的Markov建模,以理论分析和数值模拟的方法对各种拥塞控制策略的性能进行深入的研究和比较,并着重从时间序列的角度分析平均队列长度计算方法的数学过程和理论依据,进而提出基于时序预测推断的平均队列长... 详细信息

通过对TD、RED等算法进行较精确的Markov建模,以理论分析和数值模拟的方法对各种拥塞控制策略的性能进行深入的研究和比较,并着重从时间序列的角度分析平均队列长度计算方法的数学过程和理论依据,进而提出基于时序预测推断的平均队列长度的计算方法,给出相应的数学模型和数值模拟性能曲线,结果证明:新的算法在系统稳定性和资源利用率上表现出明显的优越性,其走势更加接近理想的性能曲线.最后考察了各算法结合优先级丢弃策略的性能表现.

关键词：拥塞控制平均队列长度时间序列马尔可夫链 EWMA

基于匹配路径和概率平衡树的P2P语义路由模型

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软件学报 2006年第10期17卷 2106-2117页

作者：许立波于坤吴国新计算机网络与信息集成教育部重点实验室(东南大学) 江苏南京210096

语义路由是P2P路由技术的关键研究内容之一.智能化路由策略语义表达灵活,但可扩展性和查全率较低;语义覆盖网络可扩展性好,但要么难以组织,要么维护开销很大.提出一种新的基于匹配路径和概率平衡树的P2P语义路由模型(matchpathandprobab... 详细信息

语义路由是P2P路由技术的关键研究内容之一.智能化路由策略语义表达灵活,但可扩展性和查全率较低;语义覆盖网络可扩展性好,但要么难以组织,要么维护开销很大.提出一种新的基于匹配路径和概率平衡树的P2P语义路由模型(matchpathandprobabilitybalancetree,简称MPPBTree),通过层次化和匹配路径组织资源存储结构和节点排布方式,达到一种近似平衡的分布特征,使节点能够根据查询内容本身进行路由决策,并同时保持较低的维护开销.模型支持灵活的语义搜索,拥有良好的可扩展性,保证任意节点的路由都能覆盖全网络.模型不要求任何中心服务的存在,所有的节点只需维护少量局部信息,且都会同时承担索引、存储、中继的功能,以均摊系统运行的负荷.

关键词：语义路由 P2P 匹配概率平衡树