检索结果-南通市图书馆

Leaf Morphology Genes SRL1 and RENL1 Co-Regulate Cellulose Synthesis and Affect Rice Drought Tolerance

Rice science 2024年第1期31卷 103-117,I0020-I0022页

作者： LIU Dan ZHAO Huibo WANG zi’an xu Jing LIU Yiting WANG Jiajia CHEN Minmin LIU Xiong ZHANG Zhihai CEN Jiangsu ZHU Li HU Jiang REN Deyong GAO Zhenyu DONG Guojun ZHANG Qiang SHEN Lan LI Qing QIAN Qian HU Songping ZHANG Guangheng State Key Laboratory of Rice Biology and Breeding China National Rice Research InstituteHangzhou 310006China Research Center of Plant Functional Genes and Tissue Culture Technology College of Bioscience and BioengineeringJiangxi Agricultural UniversityNanchang 330045China Qian Qian Academician Workstation National Nanfan Research Institute(Sanya)Chinese Academy of Agricultural SciencesSanya 572024China

The morphological development of rice(Oryza sativa L.)leaves is closely related to plant architecture,physiological activities,and ***,it is unclear whether there is a co-regulatory relationship between the morphological development of leaves and adaptation to drought *** this study,a drought-sensitive,roll-enhanced,and narrow-leaf mutant(renl1)was induced from a semi-rolled leaf mutant(srl1)by ethyl methane sulfonate(EMS),which was obtained from Nipponbare(NPB)through ***-based cloning and functional validation showed that RENL1 encodes a cellulose synthase,allelic to NRL1/*** RENL1 mutation resulted in reduced vascular bundles,vesicular cells,cellulose,and hemicellulose contents in cell walls,diminishing the water-holding capacity of *** addition,the root system of the renl1 mutant was poorly developed and its ability to scavenge reactive oxygen species(ROS)was decreased,leading to an increase in ROS after drought ***,genetic results showed that RENL1 and SRL1 synergistically regulated cell wall *** results revealed a theoretical basis for further elucidating the molecular regulation mechanism of cellulose on rice drought tolerance,and provided a new genetic resource for enhancing the synergistic regulation network of plant type and stress resistance,thereby realizing simultaneous improvement of multiple traits in rice.

关键词： cellulose cell wall drought tolerance leaf morphology rice

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Analysis of an adult diabetes mellitus caused by a rare mutation of the gene:A case report

引用

World Journal of Clinical Cases 2024年第19期12卷 3942-3949页

作者： Wen-xuan Li Li-Li xu Chuan-Feng Liu Bing-zi Dong Yun-Yang Wang Department of Endocrine and Metabolic Diseases The Affiliated Hospital of Qingdao UniversityQingdao 266003Shandong ProvinceChina

BACKGROUND This study presents the clinical and genetic mutation characteristics of an unusual case of adult-onset diabetes mellitus occurring in adolescence,featuring a unique mutation in the peroxisome proliferator-activated receptor gamma(PPARG)*** Access Statement:Research data supporting this publication are available from the NN repository at ***/download/.CASE SUMMARY The methodology employed entailed meticulous collection of comprehensive clinical data from the probands and their respective family ***,high-throughput sequencing was conducted to analyze the PPARG genes of the patient,her siblings,and their *** results of this investigation revealed that the patient initially exhibited elevated blood glucose levels during pregnancy,accompanied by insulin resistance and ***,these strains displayed increased susceptibility to diabetic kidney disease without any discernible aggregation *** results from the gene detection process demonstrated a heterozygous mutation of guanine(G)at position 284 in the coding region of exon 2 of PPARG,which replaced the base adenine(A)(exon2c.284A>***95Cys).This missense mutation resulted in the substitution of tyrosine with cysteine at the 95th position of the translated ***,both of her siblings harbored a nucleotide heterozygous variation at the same site,and both were diagnosed with *** The PPARG gene mutation,particularly the ***95Cys mutation,may represent a newly identified subtype of maturity-onset diabetes of the *** subtype is characterized by insulin resistance and lipid metabolism disorders.

关键词： Diabetes Gene mutation Maturity-onset diabetes of the young Peroxisome proliferator-activated receptor gamma Lipid metabolism

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Deep learning framework for comprehensive molecular and prognostic stratifications of triple-negative breast cancer

引用

Fundamental Research 2024年第3期4卷 678-689页

作者： Shen Zhao Chao-Yang Yan Hong Lv Jing-Cheng Yang Chao You zi-Ang Li Ding Ma Yi Xiao Jia Hu Wen-Tao Yang Yi-Zhou Jiang Jun xu Zhi-Ming Shao Key Laboratory of Breast Cancer in Shanghai Department of Breast SurgeryFudan University Shanghai Cancer CenterShanghai 200032China Institute for AI in Medicine School of Artificial IntelligenceNanjing University of Information Science and TechnologyNanjing 210044China Department of Pathology Fudan University Shanghai Cancer CenterShanghai 200032China Greater Bay Area Institute of Precision Medicine Guangzhou 511466China Department of Radiology Fudan University Shanghai Cancer CenterShanghai 200032China

Triple-negative breast cancer(TNBC)is the most challenging breast cancer *** stratification and target therapy bring clinical benefit for TNBC patients,but it is difficult to implement comprehensive molecular testing in clinical ***,using our multi-omics TNBC cohort(N=425),a deep learning-based framework was devised and validated for comprehensive predictions of molecular features,subtypes and prognosis from pathological whole slide *** framework first incorporated a neural network to decompose the tissue on WSIs,followed by a second one which was trained based on certain tissue types for predicting different ***-omics molecular features were analyzed including somatic mutations,copy number alterations,germline mutations,biological pathway activities,metabolomics features and immunotherapy *** was shown that the molecular features with therapeutic implications can be predicted including the somatic PIK3CA mutation,germline BRCA2 mutation and PD-L1 protein expression(area under the curve[AUC]:0.78,0.79 and 0.74 respectively).The molecular subtypes of TNBC can be identified(AUC:0.84,0.85,0.93 and 0.73 for the basal-like immune-suppressed,immunomodulatory,luminal androgen receptor,and mesenchymal-like subtypes respectively)and their distinctive morphological patterns were revealed,which provided novel insights into the heterogeneity of TNBC.A neural network integrating image features and clinical covariates stratified patients into groups with different survival outcomes(log-rank P<0.001).Our prediction framework and neural network models were externally validated on the TNBC cases from TCGA(N=143)and appeared robust to the changes in patient *** potential clinical translation,we built a novel online platform,where we modularized and deployed our framework along with the validated *** can realize real-time one-stop prediction for new *** summary,using only pathological WSIs,our proposed framework

关键词： Triple-negative breast cancer Deep learning Digital pathology Patient stratification Online platform

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

BEPCⅡ亮度监测器第一阶段运行的初步结果

引用

中国科学技术大学学报 2008年第11期38卷 1241-1245页

作者：单卿许咨宗伍健汪晓莲王永刚章涛李凯胡涛中国科学技术大学近代物理系高能物理实验室安徽合肥230026 中国科学技术大学近代物理系物理快电子学实验室安徽合肥230026 中国科学院高能物理研究所北京100049

亮度探测器是对撞机束流调试、稳定运行和提高性能的重要工具.一台快亮度监测器首次在BEPCⅡ(北京正负电子对撞机重大改造工程)上实现了逐束团对撞的亮度监测,并且已经成功地用于BEPCⅡ的调束.亮度监测器初步运行结果表明,亮度监测器可... 详细信息

亮度探测器是对撞机束流调试、稳定运行和提高性能的重要工具.一台快亮度监测器首次在BEPCⅡ(北京正负电子对撞机重大改造工程)上实现了逐束团对撞的亮度监测,并且已经成功地用于BEPCⅡ的调束.亮度监测器初步运行结果表明,亮度监测器可以快速实时地给出相对亮度的信息,成功地对每一对束团的状态(时间、空间)进行监视,为高亮度的BEPCⅡ的调试和最佳状态的选择提供了一个有效、可靠的监测手段.

关键词： BEPCⅡ 契仑柯夫探测器单轫致辐射Bhabha过程

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Current Mycoplasma pneumoniae epidemic among children in Shanghai:unusual pneumonia caused by usual pathogen

引用

World Journal of Pediatrics 2024年第1期20卷 5-10页

作者： Xiao-Bo Zhang Wen He Yong-Hao Gui Quan Lu Yong Yin Jian-Hua Zhang Xiao-Yan Dong Ying-Wen Wang Ying-zi Ye Hong xu Jia-Yu Wang Bing Shen Dan-Ping Gu Li-Bo Wang Yi Wang Department of Respiratory Medicine Children's Hospital of Fudan University399 Wanyuan RoadShanghai 201102China State Key Laboratory of Genetic Engineering at School of Life Sciences Institute of Reproduction&DevelopmentChildren's Hospital of Fudan UniversityShanghaiChina Department of Respiratory Medicine Children's Hospital of Shanghai Jiao Tong UniversityShanghaiChina Department of Respiratory Medicine Shanghai Children's Medical CenterAffiliated to Shanghai Jiaotong University School of MedicineShanghaiChina Department of Pediatric Respiratory Xinhua HospitalAffiliated to Shanghai Jiaotong University School of MedicineShanghaiChina Department of Nursing Children's Hospital of Fudan UniversityShanghaiChina Department of Infectious Diseases Children's Hospital of Fudan UniversityShanghaiChina Department of Nephrology Children's Hospital of Fudan UniversityShanghaiChina NHC Key Laboratory of Neonatal Diseases Children's Hospital of Fudan UniversityShanghaiChina Shanghai Shenkang Hospital Development Center ShanghaiChina Center for Medical Quality Control Management of Shanghai ShanghaiChina Department of Neurology Children's Hospital of Fudan University399Wanyuan RoadShanghai 201102China

Mycoplasma pneumoniae(***),primarily transmitted through respiratory droplets when infected individuals cough or sneeze,is a common cause of communityacquired pneumonia,especially among school-age children and *** infection occurs endemically with an epidemic peak every few *** worldwide incidence confirmed by direct test methods was reported to be 8.61%between 2017 and 2020 across all age groups[1].

关键词： pneumonia epidemic respiratory

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

自复位支撑钢框架抗震性能评估与损伤演化分析

引用

工程力学 2024年第7期41卷 68-77页

作者：徐龙河鞠子薇江浩北京交通大学土木建筑工程学院北京100044

为研究自复位耗能(SCED)支撑失效前后支撑钢框架结构的抗震韧性及损伤演化规律,设计了一单榀三层自复位支撑钢框架(SCBSF)并对其进行精细化有限元模拟,探究了支撑第二刚度和摩擦力在考虑支撑失效时对结构宏观响应和关键构件损伤状态的... 详细信息

为研究自复位耗能(SCED)支撑失效前后支撑钢框架结构的抗震韧性及损伤演化规律,设计了一单榀三层自复位支撑钢框架(SCBSF)并对其进行精细化有限元模拟,探究了支撑第二刚度和摩擦力在考虑支撑失效时对结构宏观响应和关键构件损伤状态的影响规律。结果表明,在地震作用下,SCED支撑作为SCBSF第一道抗震防线,激活工作后为结构提供了稳定的耗能与卓越的复位能力,相比屈曲约束支撑(BRB)框架残余变形角最大减小了84.9%,显著降低结构震后修复成本;支撑达到最大行程破坏失效后,结构层间变形加剧,框架梁和柱塑性耗能占比增加了92.33%,主体结构损伤值增加了48.45%,结构的抗震性能与韧性水平明显降低。参数分析结果表明,提升支撑的第二刚度和摩擦力能有效降低结构响应,但具有较大第二刚度和摩擦力的支撑框架仍抵抗不了强震作用时,可能导致更多的支撑失效破坏,结构损伤加剧。因此,设计SCED支撑时,需要适当提高支撑第二刚度和摩擦力,建议第二刚度取值为第一刚度的7/50~4/25,支撑摩擦力与预压力比值取为1~1.2;提升支撑第二刚度相比提升摩擦力对结构损伤值控制效果更好,随着地震动强度增大,摩擦力与第二刚度对结构抗震性能的影响逐渐减小。

关键词：自复位耗能支撑钢框架抗震韧性损伤分析耗能能力残余变形

来源：

维普期刊数据库博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于时间序列分解的京津冀区域PM_(2.5)和O_(3)空间分布特征

引用

环境科学 2024年第5期45卷 2487-2496页

作者：姚青丁净杨旭蔡子颖韩素芹天津市环境气象中心中国气象局‐南开大学大气环境与健康研究联合实验室天津300074

京津冀区域大气污染分布呈现明显的空间差异,厘清不同时间尺度下PM_(2.5)和O_(3)浓度分布有助于制定科学有效的污染防控措施.采用STL方法分解PM_(2.5)和O_(3)浓度,获取长期分量、季节分量和短期分量,研究其变化趋势与空间分布特征.结果... 详细信息

京津冀区域大气污染分布呈现明显的空间差异,厘清不同时间尺度下PM_(2.5)和O_(3)浓度分布有助于制定科学有效的污染防控措施.采用STL方法分解PM_(2.5)和O_(3)浓度,获取长期分量、季节分量和短期分量,研究其变化趋势与空间分布特征.结果表明,2017~2021年京津冀区域PM_(2.5)浓度下降幅度高于O_(3),春、夏季PM_(2.5)和O_(3)浓度呈正相关,秋、冬季呈现负相关,短期分量和季节分量分别对PM_(2.5)和O_(3)浓度的贡献最大.PM_(2.5)的季节分量、短期分量以及O_(3)的长期分量和短期分量均存在2个主成分,对应河北省中南部和京津冀区域北部,在不同时间尺度上京津冀区域PM_(2.5)和O_(3)均存在次区域分布.与原始序列相比,长期分量能够更好地反映PM_(2.5)和O_(3)浓度的演变趋势;季节分量和短期分量的标准差可用于衡量各城市PM_(2.5)和O_(3)浓度波动情况,太行山前各城市PM_(2.5)浓度季节分量和短期分量标准差较高,唐山的O_(3)浓度短期分量的标准差最高.

关键词：时间序列分解 PM_(2.5) 臭氧(O_(3)) 京津冀区域空间分布

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

WavEnhancer: Unifying Wavelet and Transformer for Image Enhancement

引用

Journal of Computer Science & Technology 2024年第2期39卷 336-345页

作者：李梓诺陈绪行郭淑娜王书强潘治文 Department of Computer and Information Science University of MacaoMacao 999078China Research Center for Biomedical Information Technology Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

Image enhancement is a widely used technique in digital image processing that aims to improve image aesthetics and visual quality. However, traditional methods of enhancement based on pixel-level or global-level modifications have limited effectiveness. Recently, as learning-based techniques gain popularity, various studies are now focusing on utilizing networks for image enhancement. However, these techniques often fail to optimize image frequency domains. This study addresses this gap by introducing a transformer-based model for improving images in the wavelet domain. The proposed model refines various frequency bands of an image and prioritizes local details and high-level features. Consequently, the proposed technique produces superior enhancement results. The proposed model’s performance was assessed through comprehensive benchmark evaluations, and the results suggest it outperforms the state-of-the-art techniques.

关键词： transformer wavelet transform image enhancement

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

间充质干细胞对肺内皮细胞的保护作用及机制

引用

生物化学与生物物理进展 2024年第8期51卷 1822-1833页

作者：孟子烨姜淼高敏赵自刚许袖赵振奥河北北方学院微循环研究所张家口075000 河北北方学院基础医学院张家口075000 河北医科大学基础医学院石家庄050017 河北省急危重症发病机制及干预重点实验室张家口075000

急性呼吸窘迫综合征(acute respiratory distress syndrome,ARDS)是临床上常见的严重的呼吸衰竭,死亡率高达40%。毛细血管内皮细胞通透性增加和肺水肿是ARDS的重要特征,修复肺微血管内皮屏障是阻止液体和蛋白质进入肺间质和肺泡腔的关... 详细信息

急性呼吸窘迫综合征(acute respiratory distress syndrome,ARDS)是临床上常见的严重的呼吸衰竭,死亡率高达40%。毛细血管内皮细胞通透性增加和肺水肿是ARDS的重要特征,修复肺微血管内皮屏障是阻止液体和蛋白质进入肺间质和肺泡腔的关键。动物实验和临床试验中发现,间充质干细胞移植可明显改善ARDS,减少炎症反应,降低内皮通透性。静脉移植的间充质干细胞可直接接触内皮细胞,在肺内皮损伤治疗方面可能有独特的优势,其主要通过旁分泌和免疫调节起作用。以往综述大多聚焦间充质干细胞对肺泡上皮的保护作用,本文聚焦肺内皮细胞,综述了间充质干细胞通过旁分泌细胞因子、细胞外囊泡等对内皮的直接保护作用和机制,并分析了间充质干细胞可能通过调节免疫细胞间接保护肺内皮细胞的机制。

关键词：内皮损伤急性呼吸窘迫综合征间充质干细胞肺微血管内皮细胞

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Analysis of status and influencing factors of mental health in patients with systemic lupus erythematosus

引用

World Journal of Psychiatry 2024年第6期14卷 829-837页

作者： xuan Zhang Zhe Wang Gui-Ling Lin Fang-Zhi Wei Yan-Ping Zhuang Wen-Lu xu Qi Zhang Hui-Tao Wu zi-Man He Xi-Yu Yin Ying Liu Long Mi Ai-Min Gong School of Traditional Chinese Medicine Hainan Medical UniversityHaikou 571101Hainan ProvinceChina Department of Rheumatology and Immunology Hainan General HospitalHainan Affiliated Hospital of Hainan Medical UniversityHaikou 570311Hainan ProvinceChina Department of Radiology The First Affiliated Hospital of Hainan Medical UniversityHainan Medical UniversityHaikou 570100Hainan ProvinceChina

BACKGROUND Systemic lupus erythematosus(SLE)is a heterogeneous autoimmune disorder with varied clinical courses and prognoses,not only did the patients suffer from physical impairment,but also various physical and psychiatric *** evidence have suggested that mental disorders in SLE patients,can lead to various adverse *** To explored the features and influencing factors of mental health in patients with SLE and clarifying the correlations between mental health and personality characteristics and perceived social *** results would provide a basis for psychological intervention in patients with *** The clinical data of 168 patients with SLE admitted at the First Affiliated Hospital of Hainan Medical University between June 2020 and June 2022 were *** assessment and correlation analysis were conducted using the Symptom Checklist-90(SCL-90)and Perceived Social Support Scale,and the collected data were compared with the national norms in *** relevant factors influencing mental health were identified by statistical analysis.A general information questionnaire,the Revised Life Orientation Test,and Short-Form 36-Item Health Survey were employed to assess optimism level and quality of life(QoL),*** Patients with SLE obtained higher scores for the somatization,depression,anxiety,and phobic anxiety subscales than national norms(P<0.05).A correlation was identified between total social support and total SCL-90 score or each subscale(P<0.05).The factors significantly affecting patients’mental health were hormone dosage and disease activity index(DAI)(P<0.05).The average optimism score of patients with SLE was 14.36±4.42,and 30 cases were in the middle and lower levels.A positive correlation was found between optimism level and QoL *** Patients with SLE develop psychological disorders at varying degrees,which are significantly influenced by hormone dosage and ***’menta

关键词： Systemic lupus erythematosus Mental health Quality of life Influencing factors

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：