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Collaborative integration of Fe-N_(x)active center into defective sulfur/selenium-doped carbon for efficient oxygen electrocatalysts in liquid and flexible Zn-air batteries

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Chinese Chemical Letters 2024年第9期35卷 421-425页

作者： Yufeng Wu Mingjun Jing Juan Li Wenhui Deng Mingguang Yi Zhanpeng Chen Meixia Yang Jinyang Wu Xinkai xu Yanson Bai Xiaoqing Zou Tianjing Wu Xianyou Wang National Base for International Science&Technology Cooperation National Local Joint Engineering Laboratory for Key Materials of New Energy Storage BatteryKey Laboratory of Environmentally Friendly Chemistry and Application of Ministry of EducationXiangtan UniversityXiangtan 411105China

Strategic active site organization is imperative for the advancement of effective and long-lasting catalysts of oxygen reduction ***,the controllable multi-active site design is a highly intricate topic for catalyst *** pre-trapping and post-activation strategy,Fe-N bonding structure and S,Se functionalized heteroatom are integrated into a conductive porous *** this process,the nitrogen-abundant polymer 1,3,5-triformylbenzene-tris(4-aminophenyl)benzene(Tf-TAPA)adsorbs Fe^(3+)under the intrinsically metal anchoring ability of N atoms and simultaneously in-situ assembles longchain ***,the Fe^(3+)is transformed into Fe-N_(x)moieties with the conversion of the organic chain to incompletely graphitized ***,the alteration of the electronic configuration achieved through the introduction of dual-atom S and Se leads to a pronounced enhancement in catalytic *** from the Fe-N_(x)bonding structure,dense structural defects,and conductive carbon networks,the resultant Fe-S,Se/NCNs possesses a positive half-wave potential of 0.86 V and a 90%current retention rate,outstripping the Pt/C ***,the liquid and flexible ZAB driven by Fe-S,Se/NCNs achieves large power densities of 259.7 and 164.7 m W/cm^(2),*** study provides a new comprehension in developing an efficient and stable M-N-C oxygen electrocatalyst.

关键词： Atomic regulation Chalcogens co-doped Catalytic performance Noble metal-free electrocatalyst Zn-air battery

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Keemun black tea stems and leaves: Comparison of chemical characterization and anti-inflammatory activities

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Food Science and Human Wellness 2024年

作者： Mengting Zhu Xiaoqing Rong Mingchun Wen Piaopiao Long Zongde Jiang Wen xu Daniel Granato Liang Zhang State key laboratory of Tea Plant Biology and Utilization， Anhui Agricultural university key laboratory of Quality Evaluation of Chinese Medicine of the Guangdong Provincial Medical Products Administration， the Second Clinical College， Guangzhou university of Chinese Medicine International Joint laboratory on Tea Chemistry and Health Effects of ministry of education， Anhui Agricultural university Bioactivity & Applications Lab， Department of Biological Sciences， Faculty of Science and Engineering， university of Limerick

This work aims to compare the chemical composition and anti-inflammatory effects on RAW264.7 macrophages of Keemun black tea stems and leaves. Fifty volatile compounds were identified in tea stems and leaves， and aldehydes， alcohols， and esters were the main volatile compound categories. Eleven key volatile compounds， including geraniol， phenylacetaldehyde， methyl salicylate， linalool， etc. contributed to distinguishing the tea stems from the tea leaves. In the quantitative and LC-MS-based metabolomics analysis， higher contents of amino acids， monosaccharides， and quinic acid were found in stems than in leaves. Inversely， higher contents of tea pigments， flavan-3-ols， gallic acid， purine alkaloids， and flavonol glycosides were present in tea leaves than in stems. LC-MS-based metabolomics also revealed that organic acids were the most critical non-volatile compounds responsible for the differences between tea stems and leaves. Furthermore， tea stems had better inhibiting effects of pro-inflammatory cytokines (IL-1β and IL-6) in lipopolysaccharide-challenged RAW264.7 macrophages than tea leaves， while no significant differences exist between leaves and stems for inhibiting the secretion of TNF-α and NO. In conclusion， our results support using Keemun black tea stems as a novel source of anti-inflammatory compounds.

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Long-term changes in radial growth of seven tree species in the mixed broadleaf-Korean pine forest in Northeast china:Are deciduous trees favored by climate change?

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Journal of Forestry Research 2024年第5期35卷 63-77页

作者： Xiufang Gong Danyang Yuan Liangjun Zhu Zongshan Li Xiaochun Wang National Engineering laboratory for Applied Technology of Forestry and Ecology in South china College of Life Science and TechnologyCentral South University of Forestry and TechnologyChangsha 410004People’s Republic of China Center for Ecological Research and key laboratory of Sustainable Forest Ecosystem Management-ministry of education School of ForestryNortheast Forestry UniversityHarbin 150040People’s Republic of China State key laboratory of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085People’s Republic of China

The role of the temperate mixed broadleaf-Korean pine forest(BKF)in global biogeochemical cycles will depend on how the tree species community responds to climate;however,species-specific responses and vulner-abilities of common trees in BKF to extreme climates are poorly *** we used dendrochronological meth-ods to assess radial growth of seven main tree species(Pinus koraiensis,Picea jezoensis,Abies nephrolepis,Fraxinus mandshurica,Phellodendron amurense,Quercus mongolica,and Ulmus davidiana)in an old-growth BKF in response to climate changes in the Xiaoxing’an Mountains and to improve predictions of changes in the tree species *** in most months and winter precipita-tion significantly negatively affected growth of *** and ***,but positively impacted growth of *** and the broadleaf species,especially ***-rica and *** and relative humidity in June significantly positively impacted the growth of most tree *** positive effect of the temperature during the previous non-growing season(PNG)on growth of *** and *** strengthened significantly with rapid warming around 1981,while the impact of PNG temperature on the growth of *** and *** changed from significantly negative to weakly negative or positive at this *** negative response of radial growth of *** and *** to precipitation during the growing season gradually weakened,and the negative response to PNG precipitation was *** the studied species,*** was the most resistant to drought,and *** recovered the best after extreme *** davidiana,*** and *** were more resistant to extreme cold than the other *** warming generally exacerbated the opposite growth patterns of conifer(decline)and broadleaf(increase)*** broadleaf tree species in the old-growth BKF probably will gradually become dominan

关键词： Tree rings Extreme climate Resistance and recovery Broad-leaved and Korean pine mixed forest

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移动医疗智能软件联合OBE-CBCL双轨教学法在骨科住院医师规范化培训中的应用

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沈阳医学院学报 2024年第2期26卷 221-224页

作者：徐陈褚冲冲王照东刘亚军段克友官建中蚌埠医科大学第一附属医院骨科/组织移植安徽普通高校重点实验室(蚌埠医学院) 安徽蚌埠233004

目的:探讨移动医疗智能软件联合OBE-CBCL双轨教学法在骨科住院医师规范化培训中的应用效果。方法:选取2022年1月至9月在我院进行骨科住院医师规范化培训的外科研究生为研究对象,其中1月至3月接受常规教学法为A组,4月至6月接受移动移动... 详细信息

目的:探讨移动医疗智能软件联合OBE-CBCL双轨教学法在骨科住院医师规范化培训中的应用效果。方法:选取2022年1月至9月在我院进行骨科住院医师规范化培训的外科研究生为研究对象,其中1月至3月接受常规教学法为A组,4月至6月接受移动移动医疗智能软件+常规教学法为B组,7月至9月接受移动医疗智能软件+OBE-CBCL双轨教学法为C组。3组出科前参加Mini-CEX、专业理论知识考核及满意度问卷调查。结果:B、C组专业理论知识考核成绩均高于A组,且C组高于B组(P<0.05);B、C组Mini-CEX考核成绩均高于A组(P<0.05);除临床判断能力外,C组Mini-CEX其余6项考核内容均高于B组(P<0.05)。满意度调查中B、C组在加深知识掌握方面评分均高于A组,且C组高于B组(P<0.05);B、C组在提高临床思维、激发学习兴趣方面评分均高于A组(P<0.05);C组在增进团队协助、总体满意度方面评分高于A、B组(P<0.05)。结论:移动医疗智能软件联合OBE-CBCL双轨教学法可显著提高骨科住院医师规范化培训教学效果。

关键词：移动医疗智能软件 OBE-CBCL 骨科住院医师规范化培训

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Network Pharmacology-Based Dissection of the Bioactive Compounds and Pharmacological Mechanisms of Yiqi Fumai Lyophilized Injection for the Treatment of Heart Failure

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World Journal of Traditional Chinese Medicine 2024年第1期10卷 75-82页

作者： Yu-Xi Huang Jing-Jing Fan Lu-Lu xu Rong Yu Yi Kuang Yue Chai Rui Zheng Xiao-Yu Zhang Hong-Cai Shang xue Qiao Min Ye State key laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijingChina key laboratory of Chinese Internal Medicine of ministry of education Dongzhimen HospitalBeijing University of Chinese MedicineBeijingChina Yunnan Baiyao International Medical Research Center Peking UniversityBeijingChina key laboratory of Molecular Cardiovascular Sciences of ministry of education Peking UniversityBeijingChina

Objective:Yiqi Fumai Lyophilized Injection(YQFM),a Chinese medicine injection,has been widely used for the treatment of cardiovascular diseases,especially heart failure(HF).However,bioactive compounds and underlying mechanisms of YQFM in treating HF remain poorly *** and Methods:Network pharmacology was employed to investigate the bioactive compounds and mechanisms of YQFM.A compound-target network was constructed to screen bioactive compounds based on contribution index ***,an adriamycin-induced HF rat model was established to evaluate the cardio-protective effects of YQFM by hematoxylin and eosin staining and enzyme-linked immunosorbent ***:Network pharmacology indicated that YQFM may alleviate HF through 36 compounds and 109 ***,ginsenosides Rb1,Rg1,Re,Rf,Rb2,Rh1,schisandrin,and ginsenoside rc were indicated as the top contributors of YQFM in treating *** was predicted to act on multiple targets such as vascular endothelial growth factor A,interleukin-2(IL-2),IL-6,and IL-1β,as well as to regulate signaling pathways such as hypoxia-inducible factor 1,tumor necrosis factor,VEGF,and *** pharmacological study suggested that YQFM could attenuate cardiac injury and up-regulate plasma concentrations of VEGFR-1 and NO in HF *** Rb1,as the major contributor from network pharmacology analysis,also showed a cardioprotective effect and up-regulation of VEGFR-1 in ***:Ginsenosides and schisandrin were predicted as the most important contributors to the cardioprotective effect of *** Rb1 was proved to alleviate HF and increase the plasma concentration of VEGFR-1.

关键词： Contribution index heart failure network pharmacology traditional Chinese medicine yiqi fumai lyophilized injection

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Role of polyphenols in epilepsy: from the perspective of gut microbiota

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Food Science and Human Wellness 2024年

作者： Xiaoxue xu Jian Shi Yinsi Tang Guiyang Cai Chao Ma Wuyang Wang Rui Feng Tomasz Boczek Zhenwei He Feng Guo Department of Pharmaceutical Toxicology， School of Pharmacy， china Medical university Shenyang Department of Neurology， the First Hospital of china Medical university Department of Pharmacy， the Fourth Affiliated Hospital of china Medical university Department of Gastroenterology， the Fourth Affiliated Hospital of china Medical university Department of Obstetrics and Gynecology， Shengjing Hospital of china Medical university key laboratory of Structure-Based Drug Design & Discovery of ministry of education， School of Pharmaceutical Engineering， Shenyang Pharmaceutical university Jiangsu Province key laboratory of Anesthesiology， xuzhou Medical university Department of Molecular Neurochemistry， Medical university of Lodz Department of Neurology， the Fourth Affiliated Hospital of china Medical university

Epilepsy is a devastating neurological condition that affects over 70 million people worldwide. Apart from idiopathic epilepsy， numerous diseases have been reported to cause secondary epilepsy. Polyphenols， ubiquitously existing in fruits and vegetables， has become a promising neuroprotective candidate against multiple neurological abnormalities due to its interplay with gut microbiome composed of the bacterial population in gastrointestinal system. This bioactive compound is also being tested for the management of epileptogenesis. However， there is still insufficient evidence from mechanistic studies to demonstrate the causal relationship between anti-epileptic effect of polyphenols and microbial alteration. In this review， we provide the brief overview of epilepsy， polyphenols and gut microbiota. We then analysis the association of polyphenols and gut microbiota particularly in the epilepsy and symptomatic seizures-induced by epilepsy-related disorders. We also discuss the possibility for the combined application with probiotics to improve the bioavailability and bioaccessibility of polyphenols for expanding its anti-epileptic function. We finally summarize the therapeutic potential of anti-seizure polyphenols through affecting gut microbiome， and propose that the anti-epileptic effect of polyphenols may be tightly relevant to intestinal bacterial flora for overcoming epilepsy and its comorbidities simultaneously. Therefore， the dietary polyphenols targeting specific bacteria may achieve the outcome of ‘one stone， two birds’.

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花岗岩在不同温度劈裂载荷下的损伤演化与失稳前兆

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Transactions of Nonferrous Metals Society of china 2024年第3期34卷 977-994页

作者：王李昌王璐徐蒙隆威中南大学地球科学与信息物理学院长沙410083 中南大学有色金属成矿预测与地质环境监测教育部重点实验室长沙410083

为了阐明深地钻探中花岗岩在劈裂载荷与高温作用下的复杂机械和损伤特性,对经50~600℃处理的花岗岩试样进行巴西劈裂声发射(AE)试验。结果表明,温度变化会使花岗岩的机械与声发射特性发生改变,从而改变其破裂演化过程。当温度超过500℃... 详细信息

为了阐明深地钻探中花岗岩在劈裂载荷与高温作用下的复杂机械和损伤特性,对经50~600℃处理的花岗岩试样进行巴西劈裂声发射(AE)试验。结果表明,温度变化会使花岗岩的机械与声发射特性发生改变,从而改变其破裂演化过程。当温度超过500℃时,花岗岩的抗拉强度大幅降低,剪切损伤模式占比增加。此外,破裂速率亦呈现明显增长趋势。在基于撞击数和能量计数的损伤参数演化曲线的基础上,定义“损伤参数突变点”来判断作为岩石破坏的前兆信息。基于撞击数的“突变点”比岩石失稳的信号提前到达,且岩石损伤越大,提前的时间越久。通过这个时间差,可以达到预警岩石失稳的效果。

关键词：深地钻探岩石损伤声发射高温劈裂荷载

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原位效应影响下复合材料损伤抗性增强研究

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中南大学学报（自然科学版） 2024年第6期55卷 2348-2358页

作者：袁可徐晨晨王中钢中南大学交通运输工程学院湖南长沙410075 轨道交通安全教育部重点实验室湖南长沙410075

为研究轻量化碳纤维复合材料抗损伤尤其是抗分层能力增强策略,首先对复合材料原位横向拉伸和剪切强度进行参数化分析,指明材料薄层化后能提升材料的原位强度并改善其抗损伤性能。然后,通过短梁弯曲试验分析得到面外载荷作用下基体裂纹... 详细信息

为研究轻量化碳纤维复合材料抗损伤尤其是抗分层能力增强策略,首先对复合材料原位横向拉伸和剪切强度进行参数化分析,指明材料薄层化后能提升材料的原位强度并改善其抗损伤性能。然后,通过短梁弯曲试验分析得到面外载荷作用下基体裂纹扩展是导致层合板内部分层的重要原因,并构建基于经典Hashin准则和考虑原位效应的材料损伤模型,运用该材料模型对短梁弯曲失效行为开展仿真分析。最后,将该损伤模型和材料强化方案推广应用至局部冲击载荷下层合板损伤分析中。研究结果表明:当正交铺层短梁的单层厚度减少到原来的1/4时,其弯曲强度显著提升48%,结构失效位移也显著变大;层间分层被抑制和结构强度提升的原因在于基体中裂纹萌生和扩展被显著推迟。在相同冲击载荷下,薄层化层合板内部分层区域明显减小,表明薄铺层设计方案提升了碳纤维复合材料层合板局部冲击分层抗性。

关键词：碳纤维复合材料原位强度薄铺层分层损伤局部冲击

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Modeling and control of MR damper considering trapped air effect

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Journal of southeast university(English Edition) 2018年第1期34卷 54-61页

作者： xu Feihong xu zhaodong Guo Yingqing Zhang Xiangcheng Zhao Yuliang key laboratory of Concrete and Prestressed Concrete Structure of ministry of education Southeast UniversityNanjing 210096China nanjing Dongrui Damping Control Technology Co. LtdNanjing 210033China School of Mechanics and Engineering Science Zhengzhou UniversityZhengzhou 450001China

Due to the high viscosity of magnetorheological(MR)fluid,eliminating air pockets dissolved in the fluid is very difficult,which results in a force lag *** order to evaluate the performance of a semi-active control system based on the MR damper considering the trapped air effect,a performance test on a MR damper is carried out under different loading cases,and the influence of the input current,excitation amplitude and frequency on the force lag phenomenon is analyzed.A concise and efficient parametric model,combining the simple Bouc-Wen model and a spring with small stiffness,is proposed to portray the experimental characteristics of the MR damper with force lag,and then the response analysis of the semi-active controlled single-degree-of-freedom(SDOF)structure is performed using the classic clipped-optimal control strategy based on acceleration *** results show that the trapped air in the MR fluid can weaken the control effect of the MR damper,and the performance of the semi-active control system will be reduced more obviously and become close to the passive-off control with the increasing content of air trapped in the MR fluid.

关键词： magnetorheological damper performance test air pocket force lag semi-active control

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PRaG 3.0 therapy for human epidermal growth factor receptor 2-positive metastatic pancreatic ductal adenocarcinoma:A case report

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World Journal of Gastroenterology 2024年第9期30卷 1237-1249页

作者： Yue-Hong Kong Mei-Ling xu Jun-Jun Zhang Guang-Qiang Chen Zhi-Hui Hong Hong Zhang Xiao-Xiao Dai Yi-Fu Ma Xiang-Rong Zhao Chen-Yang Zhang Rong-Zheng Chen Peng-Fei Xing Li-Yuan Zhang Center for Cancer Diagnosis and Treatment The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Radiotherapy&Oncology The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Institution of Radiotherapy&Oncology Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Radiology The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Nuclear Medicine The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Clinical laboratory The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Pathology The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina

BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)is a highly fatal disease with limited effective treatment especially after first-line *** human epidermal growth factor receptor 2(HER-2)immunohistochemistry(IHC)positive is associated with more aggressive clinical behavior and shorter overall survival in *** SUMMARY We present a case of multiple metastatic PDAC with IHC mismatch repair proficient but HER-2 IHC weakly positive at diagnosis that didn’t have tumor regression after first-line nab-paclitaxel plus gemcitabine and PD-1 inhibitor treatment.A novel combination therapy PRaG 3.0 of rc48(HER2-antibody-drug conjugate),radio-therapy,PD-1 inhibitor,granulocyte-macrophage colony-stimulating factor and interleukin-2 was then applied as second-line therapy and the patient had confirmed good partial response with progress-free-survival of 6.5 months and overall survival of 14.2 *** had not developed any grade 2 or above treatment-related adverse events at any *** of peripheral CD8^(+) Temra and CD4^(+) Temra were increased during first two activation cycles of PRaG 3.0 treatment containing radiotherapy but deceased to the baseline during the maintenance cycles containing no *** PRaG 3.0 might be a novel strategy for HER2-positive metastatic PDAC patients who failed from previous first-line approach and even PD-1 immunotherapy but needs more data in prospective trials.

关键词： Pancreatic ductal adenocarcinoma PRaG 3.0 therapy Human epidermal growth factor receptor 2 Novel combination therapy Case report

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