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A novel predictor of unsustained return of spontaneous circulation in cardiac arrest patients through a combination of capnography and pulse oximetry: a multicenter observational study

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World Journal of Emergency Medicine 2024年第1期15卷 16-22页

作者： Jing Yang Hanqi Tang Shihuan Shao Feng xu Yangyang Fu Shengyong xu Chen li Yan li Yang liu Joseph Harold Walline Huadong Zhu Yuguo Chen xuezhong Yu jun xu Emergency Department State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100730China Emergency Department Peking University People’s HospitalBeijing 100044China Department of Emergency and Chest Pain Center Shandong Provincial Clinical Research Center for Emergency and Critical Care MedicineKey Laboratory of Emergency and Critical Care Medicine of Shandong ProvinceQilu Hospital of Shandong UniversityJinan 250012China Emergency Department Beijing Jishuitan HospitalBeijing 100035China Emergency Department Tianjin Medical University General HospitalTianjin 300052China Department of Emergency Medicine Penn State Health Milton S.Hershey Medical Center and Penn State College of MedicineHershey 17033USA

BACKGROUND:Unsustained return of spontaneous circulation(ROSC)is a critical barrier to survival in cardiac arrest *** study examined whether end-tidal carbon dioxide(ETCO_(2))and pulse oximetry photoplethysmogram(POP)parameters can be used to identify unsustained ***:We conducted a multicenter observational prospective cohort study of consecutive patients with cardiac arrest from 2013 to ***’general information,ETCO_(2),and POP parameters were collected and statistically ***:The included 105 ROSC episodes(from 80 cardiac arrest patients)comprised 51 sustained ROSC episodes and 54 unsustained ROSC *** 24-hour survival rate was significantly higher in the sustained ROSC group than in the unsustained ROSC group(29.2%vs.9.4%,P<0.05).The logistic regression analysis showed that the difference between after and before ROSC in ETCO_(2)(ΔETCO_(2))and the difference between after and before ROCS in area under the curve of POP(ΔAUCp)were independently associated with sustained ROSC(odds ratio[OR]=0.931,95%confi dence interval[95%CI]0.881-0.984,P=0.011 and OR=0.998,95%CI 0.997-0.999,P<0.001).The area under the receiver operating characteristic curve ofΔETCO_(2),ΔAUCp,and the combination of both to predict unsustained ROSC were 0.752(95%CI 0.660-0.844),0.883(95%CI 0.818-0.948),and 0.902(95%CI 0.842-0.962),***:Patients with unsustained ROSC have a poor *** combination ofΔETCO_(2) andΔAUCp showed signifi cant predictive value for unsustained ROSC.

关键词： Return of spontaneous circulation Pulse oximetry photoplethysmogram End-tidal carbon dioxide Cardiac arrest Cardiopulmonary resuscitation

Subarachnoid hemorrhage misdiagnosed as acute coronary syndrome leading to catastrophic neurologic injury: A case report

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World Journal of Clinical Cases 2024年第1期12卷 148-156页

作者： jun-Ming lin Xiao-jun Yuan Guang li Xin-Rong Gan Wen-Hua xu Department of Orthopaedic Surgery People's Hospital of Yichun CityYichun 336000Jiangxi ProvinceChina

BACKGROUND Elevated levels of cardiac troponin and abnormal electrocardiogram changes are the primary basis for clinical diagnosis of acute coronary syndrome(ACS).Troponin levels in ACS patients can often be more than 50 times the upper reference *** patients with subarachnoid hemorrhage(SAH)also show electrocardiogram abnormalities,myocardial damage,and elevated cardiac *** ACS patients,patients with SAH only have a slight increase in troponin,and the use of anticoagulants or antiplatelet drugs is *** of the opposite treatment modalities,it is essential for clinicians to distinguish between SAH and *** SUMMARY A 56-year-old female patient was admitted to the emergency department at night with a sudden onset of severe back *** final diagnosis was intraspinal hematoma in the thoracic *** performed an emergency thoracic spinal canal hematoma evacuation procedure with the assistance of a ***,diffuse hematoma formation was found in the T7-T10 spinal canal,and no obvious spinal vascular malformation changes were *** head and spinal magnetic resonance imaging(MRI)showed a small amount of SAH in the skull,no obvious abnormalities in the cervical and thoracic spinal canals,and no abnormal signals in the lumbar spinal ***-dominal aorta computed tomography angiography showed no vascular *** motor system examination showed Medical Research Council Scale grade 1/5 strength in both lower extremities,and the patient experienced decreased sensation below the T12 rib margin and reported a Visual Analog Scale score of *** Extremely elevated troponin levels(more than 50 times the normal range)are not unique to coronary artery *** can also result in extremely high troponin levels,and antiplatelet drugs are contraindicated in such *** MRI can help in the early differential diagnosis,as a misdiagnosis of ACS can lead to catastroph

关键词： Acute coronary syndrome Spontaneous spinal subdural hematoma Misdiagnosis Catastrophic neurological injury Case report

Bolstering the Mechanical Robustness of Supramolecular Polymer Network by Mechanical Bond

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Chinese Journal of Polymer Science 2024年第10期42卷 1536-1544,I0012页

作者： Yuan-Hao Wang Jing-Xi Deng jun Zhao Yi Ding li Yang Zhao-Ming Zhang xu-Zhou Yan School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai200240China Frontiers Science Center for Transformative Molecules Shanghai Jiao Tong UniversityShanghai200240China

Supramolecular polymer networks(SPNs)are celebrated for their dynamic nature,yet they often exhibit inadequate mechanical *** far,the quest to bolster the mechanical resilience of SPNs while preserving their dynamic character presents a formidable ***,we introduce[2]rotaxane into SPN to serve as another cross-link,which could effectively enhance the mechanical robustness of the polymer network without losing the dynamic *** with SPN,the dually cross-linked network(DPN)demonstrates superior breaking strength,Young’s modulus,puncture force and toughness,underscoring its superior ***,the cyclic tensile tests reveal that the energy dissipation capacity of DPN rivals,and in some cases surpasses,that of SPN,owing to the efficient energy dissipation pathway facilitated by[2]*** addition,benefiting from stable topological structure of[2]rotaxane,DPN exhibits accelerated recovery from deformation,indicating superior elasticity compared to *** strategy elevates the performance of SPNs across multiple metrics,presenting a promising avenue for the development of high-performance dynamic materials.

关键词： Rotaxane cross-links Dually cross-linked network Supramolecular polymer network Host-guest recognition Dynamic materials

Mode division multiplexing reconstructive spectrometer with an all-fiber photonics lantern

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Frontiers of Optoelectronics 2024年第3期17卷 29-38页

作者： junrui liang jun Ye Xiaoya Ma Yao Lu jun li Jiangming xu Zilun Chen Jinyong Leng Zongfu Jiang Pu Zhou College of Advanced Disciplinary Studies National University of Defense TechnologyChangsha 410073China Nanhu Laser Laboratory National University of Defense TechnologyChangsha 410073China Hunan Provincial Key Laboratory of High Energy Laser Technology National University of Defense TechnologyChangsha 410073China Space Engineering University Beijing 101416China

This study presents a high-accuracy,all-fber mode division multiplexing(MDM)reconstructive spectrometer(RS).The MDM was achieved by utilizing a custom-designed 3×1 mode-selective photonics lantern to launch distinct spatial modes into the multimode fber(MMF).This facilitated the information transmission by increasing light scattering processes,thereby encoding the optical spectra more comprehensively into speckle *** resolution of 2 pm and the recovery of 2000 spectral channels were *** to methods employing single-mode excitation and two-mode excitation,the three-mode excitation method reduced the recovered error by 88%and 50%respectively.A resolution enhancement approach based on alternating mode modulation was proposed,reaching the MMF limit for the 3 dB bandwidth of the spectral correlation *** proof-of-concept study can be further extended to encompass diverse programmable mode *** is not only succinct and highly efcient but also well-suited for a variety of high-accuracy,high-resolution spectral measurement scenarios.

关键词： High-accuracy Resolution enhancement Reconstructive spectrometer Mode division multiplexing Photonics lantern

Enhancing Diagnosis and Treatment Adjustments for Travelers Infected with Burkholderia pseudomallei:A Case Report-Beijing Municipality,China,june 2023

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China CDC weekly 2024年第25期6卷 614-616页

作者： Shijie li Yushan He Yiyang Mao jun liu Wenmiao xu Suyun Qian Quan Wang Pediatric Intensive Care Unit Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijingChina Capital Medical University BeijingChina

Summary What is already known about this topic?Burkholderia pseudomallei(BP)infection leads to melioidosis,a tropical disease endemic to coastal provinces of southern *** in nonendemic areas,do not commonly consider this disease as a primary differential diagnosis for febrile *** is added by this report?This article discusses a case of melioidosis in Northern *** patient,who had recently visited a Southeast Asian region with high melioidosis prevalence,fell ill after exposure to contaminated *** disease progressed quickly and with *** are the implications for public health practice?Healthcare workers need to remain vigilant regarding travel-related diseases for accurate differential diagnosis and to provide timely and effective treatment,especially for patients with recent travel history or symptoms during travel.

关键词： diagnosis China travel

Veratrilla baillonii Franch alleviate the symptoms of diabetes in type 2 diabetic rats induced by high-fat diet and streptozotocin

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Food Science and Human Wellness 2024年第3期13卷 1378-1389页

作者： Chunlan Yan Zhihao Zhang liqun Ma Xinyi xu Muhammad Azhar Xianju Huang Jianxun Shi jun li College of life Sciences South-Central Minzu UniversityWuhan 430074China College of Pharmaceutical Science South-Central Minzu UniversityWuhan 430074China Department of Biosciences COMSATS University IslamabadSahiwal 57000Pakistan Zhejiang Pharmaceutical University Ningbo 315100China Ethnopharmacology Level 3 Laboratory National Administration of Traditional Chinese MedicineSouth-Central Minzu UniversityWuhan 430074China

Our previous research studies have shown that Veratrilla baillonii Franch,a food supplement used by ethnic minorities in Southwest China,has multiple pharmacological activities,such as detoxification,antiinflammatory,antioxidant,and anti-insulin ***,the detailed signal pathways for its salutary effect on damages in multiple organs due to type 2 diabetes mellitus(T2DM)remains *** current study is to evaluate the therapeutic effects of *** on T2DM rats and to explore the underlying *** T2DM rat model was successfully established by a high-sugar and high-fat diet(HFD)combination with intraperitoneal injection of a small dose of streptozotocin(STZ,35 mg/kg).Biochemical analysis and histopatholgical examinations were conducted to evaluate the anti-diabetic potential of water extracts of ***(WVBF).The results showed that the WVBF treatment can improve hyperglycemia and insulin resistance,ameliorate the liver,kidney and pancreas injuries via decreasing inflammatory cytokines such as IL-6 and TNF-α,and oxidative *** investigation suggested that WVBF modulates the signal transductions of the IRS1/PI3K/AKT/GLUT4 and AMPK *** findings demonstrate potentials of WVBF in the treatment of T2DM and possible mechanisms for its hepatoprotective activities.

关键词： Veratrilla baillonii Franch Type 2 diabetes mellitus liver injury Skeletal muscle GLUT4

Effect of Skeleton Grain Size on the Saturation of Gas Hydrate in Natural Sediments

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Journal of Ocean University of China 2024年第3期23卷 676-682页

作者： xu Zhenqiang li Yang College of Marine Sciences Ocean University of ChinaQingdao 266100China China Petroleum&Chemical Corporation Beijing 100728China

Natural gas hydrate is prospected as a new and promising,highly clean energy resource that mainly occurs in perma-frost or at continental *** formation is subject to many soil conditions,such as grain size,matrix materials,pore morphology,and *** this study,we propose that grain size is the most decisive parameter that affects the saturation of gas hydrate in sediments based on data from Ocean Drilling Program Leg 164 and Mallik 5L-38,which represent marine sediments and terrestrial sediments,*** study reveals that high gas hydrate saturation generally occurs in coarse-grained sand,regardless of whether sediment formation is homogeneous or inhomogeneous,and the sorting of sediments may affect the hydrate saturation to a certain *** grain size and sorting of sediments may be the most intuitive proxy method for a rough estimation of hydrate *** study is necessary to fully understand the relationship between hydrate morphology and sediment grain size,even though massive hydrates are typically found in fine clayey-rich sediments.

关键词： grain size saturation gas hydrates ODP Leg 164 Mallik 5L-38

Evidence-based practices in sustainable travel behavior intervention: A knowledge graph-based systematic review

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Journal of Traffic and Transportation Engineering(English Edition) 2024年第2期11卷 293-311页

作者： Jian li Chenjie xu Key Laboratory of Road and Traffic Engineering of the Ministry of Education College of Transportation EngineeringTongji UniversityShanghai 201804China

Sustainable travel behavior intervention is an essential strategy to promote the development of urban *** interventions offer personalized strategies based on certain scenario and participants to promote its effectiveness over hard travel ***,personalized strategies may also bring about difficulties to identify the actual effect of the ***,based on current practice,to make full use of travel behavior interventions,it is necessary to construct a unified methodological evidencebased framework to assess the reliability and effectiveness of travel behavior intervention *** response to these issues,we applied evidence-based knowledge graph to the field of sustainable travel behavior interventions to help decision supporters design sustainable travel behavior interventions wisely and in turn avoid excessive use of hard travel *** introduced concept of evidence-based practice to conduct a systematic analysis concerning reliability and validity of current full volume empirical studies by dimensions of scenarios,types of interventions and *** addition,we took advantage of high extensivity and integrability of knowledge graph to organize evidence-based related *** of the systematic analysis shows that in terms of reliability of evidence,school intervention is the best scenario,knowledge incentive is the best intervention type and promoting public transit and walking proportion are the best ***,the reliability of interventions in workplace,belonging to reward and threat along with aiming at changing travel patterns generally and lowering travel carbon emission need to be *** the study,various research prospects are raised to promote evidence quality in the field of travel behavior intervention *** a pioneer study,our research contributes to the field of urban transportation in introducing concepts of evidence-based practice and enabling optimization and

关键词： Evidence-based decision-making Evidence assessment Knowledge graph Travel behavior intervention Sustainable travel

Advances in the study of mitophagy in osteoarthritis

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第3期25卷 197-211页

作者： Hong CAO xuchang ZHOU Bowen xu Han HU Jianming GUO Miao WANG Nan li jun ZOU Department of Sport Rehabilitation Shanghai University of SportShanghai 200438China National Key Laboratory of Immunity and Inflammation Naval Medical UniversityShanghai 200433China School of Sport Medicine and Rehabilitation Beijing Sport UniversityBeijing 100084China

Osteoarthritis(OA),characterized by cartilage degeneration,synovial inflammation,and subchondral bone remodeling,is among the most common musculoskeletal disorders globally in people over 60 years of *** initiation and progression of OA involves the abnormal metabolism of chondrocytes as an important pathogenic *** degeneration features mitochondrial dysfunction as one of the important causative factors of abnormal chondrocyte ***,maintaining mitochondrial homeostasis is an important strategy to mitigate *** is a vital process for autophagosomes to target,engulf,and remove damaged and dysfunctional mitochondria,thereby maintaining mitochondrial *** studies have revealed a strong association between mitophagy and OA,suggesting that the regulation of mitophagy may be a novel therapeutic direction for *** reviewing the literature on mitophagy and OA published in recent years,this paper elaborates the potential mechanism of mitophagy regulating OA,thus providing a theoretical basis for studies related to mitophagy to develop new treatment options for OA.

关键词： Mitophagy Osteoarthritis Chondrocyte Mitochondria Apoptosis