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CMN: a co-designed neural architecture search for efficient computing-in-memory-based mixture-of-experts

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Science China(Information Sciences) 2024年第10期 100-114页

作者： Shihao HAN Sishuo liU Shucheng DU Mingzi li Zijian YE Xiaoxin xu Yi li Zhongrui WANG Dashan SHANG Department of Electrical and Electronic Engineering The University of Hong Kong ACCESS-AI Chip Center for Emerging Smart Systems InnoHK Centers Key Lab of Fabrication Technologies for Integrated Circuits Chinese Academy of Sciences Laboratory of Microelectronics Devices and Integrated Technology Institute of MicroelectronicsChinese Academy of Sciences University of Chinese Academy of Sciences School of Microelectronics Southern University of Science and Technology

Artificial intelligence(AI) has experienced substantial advancements recently, notably with the advent of large-scale language models(LLMs) employing mixture-of-experts(MoE) techniques, exhibiting human-like cognitive skills. As a promising hardware solution for edge MoE implementations, the computing-in-memory(CIM) architecture collocates memory and computing within a single device, significantly reducing the data movement and the associated energy consumption. However, due to diverse edge application scenarios and constraints, determining the optimal network structures for MoE, such as the expert's location,quantity, and dimension on CIM systems remains elusive. To this end, we introduce a software-hardware co-designed neural architecture search(NAS) framework, CIM-based MoE NAS(CMN), focusing on identifying a high-performing MoE structure under specific hardware constraints. The results of the NYUD-v2 dataset segmentation on the RRAM(SRAM) CIM system reveal that CMN can discover optimized MoE configurations under energy, latency, and performance constraints, achieving 29.67×(43.10×) energy savings,175.44×(109.89×) speedup, and 12.24× smaller model size compared to the baseline MoE-enabled Visual Transformer, respectively. This co-design opens up an avenue toward high-performance MoE deployments in edge CIM systems.

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人UCA1基因转录调控的生物信息学分析与鉴定

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南方医科大学学报 2013年第11期33卷 1596-1599页

作者：薛梅李旭陈葳西安交通大学医学院第一附属医院转化医学中心陕西西安710061 西安交通大学医学院第一附属医院检验科陕西西安710061

目的生物信息学分析与鉴定人类膀胱癌特异性表达的UCA1基因转录调控作用原理。方法运用CpG岛预测软件EMBOSS CpGplot、CpG Island Searcher、Methprimer、CpG finder对UCA1基因启动子CpG岛进行分析。利用转录因子预测软件MatrixCatch和T... 详细信息

目的生物信息学分析与鉴定人类膀胱癌特异性表达的UCA1基因转录调控作用原理。方法运用CpG岛预测软件EMBOSS CpGplot、CpG Island Searcher、Methprimer、CpG finder对UCA1基因启动子CpG岛进行分析。利用转录因子预测软件MatrixCatch和TFSEARCH对UCA1基因核心启动子区可能结合的转录因子进行分析。染色质免疫沉淀技术对所预测到的转录因子进行分子生物学实验验证。结果 CpG岛预测发现UCA1基因全长启动子区中不存在CpG岛,因此UCA1基因属于组织特异性基因与前期研究报道结果一致。生物信息学预测及筛选发现UCA1基因核心启动子存在4个与肿瘤关系密切的转录因子。根据预测结果选取2个转录因子利用染色质免疫沉淀实验鉴定,确定1个转录因子可与UCA1基因核心启动子区结合。结论 UCA1基因启动子区无CpG岛存在,该基因核心启动子区可能与多种转录因子结合,并确定转录因子c-Myb可以与UCA1基因核心启动子区结合。

关键词：生物信息学 UCA1基因转录调控转录因子

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一种变精度约简转化为正区域约简的方法

计算机工程与应用 2019年第17期55卷 51-54,75页

作者：李旭李前辰北京语言大学信息科学学院

正区域约简与变精度约简是决策表属性约简的两种重要类型,基于辨析矩阵的约简方法能够得到所有的约简结果,通过比较两者辨析矩阵的计算过程,在阈值大于0.5的条件下,可以适当改变决策属性的值,使得变精度约简的计算可以转化为正区域约简... 详细信息

正区域约简与变精度约简是决策表属性约简的两种重要类型,基于辨析矩阵的约简方法能够得到所有的约简结果,通过比较两者辨析矩阵的计算过程,在阈值大于0.5的条件下,可以适当改变决策属性的值,使得变精度约简的计算可以转化为正区域约简的计算,从而为变精度约简的计算提供了一种新的计算方法。举例说明,通过上述转换可以简化变精度约简的计算。

关键词：变精度约简正区域约简辨析矩阵决策表粗糙集

电催化氧化法处理酸性大红模拟染料废水的实验研究

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现代化工 2016年第10期36卷 129-133页

作者：许莉尹明杨琦天津大学化工学院天津300072

选取酸性大红(AR73)模拟染料废水,以制得的铌掺杂二氧化钛纳米管修饰的锡锑电极为阳极,钛板为阴极,降解酸性大红染料废水,探究电流密度、初始染料浓度、初始p H、电解质类型对降解效果的影响。结果表明,催化电极主要靠产生的羟基自由基(... 详细信息

选取酸性大红(AR73)模拟染料废水,以制得的铌掺杂二氧化钛纳米管修饰的锡锑电极为阳极,钛板为阴极,降解酸性大红染料废水,探究电流密度、初始染料浓度、初始p H、电解质类型对降解效果的影响。结果表明,催化电极主要靠产生的羟基自由基(·OH)降解有机物,为非活性电极。电流密度越大,降解效果越好,但能耗越大,最佳的电流密度为50 m A/cm^2,并且催化电极处理的废水需要在合适的浓度范围内,超过1.5 g/L时,电极开始失活。所添加的最佳电解质为Na_2SO_4,且p H对降解效果影响不大,电催化氧化降解染料废水可以在一个宽泛的p H环境下进行。

关键词：酸性大红电催化染料废水环境催化

Insights into spinal muscular atrophy from molecular biomarkers

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Neural Regeneration Research 2025年第7期20卷 1849-1863页

作者： Xiaodong Xing Xinzhu liu Xiandeng li Mi li Xian Wu Xiaohui Huang Ajing xu Yan liu Jian Zhang Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina College of Pharmacy Chongqing Medical UniversityChongqingChina

Spinal muscular atrophy is a devastating motor neuron disease characterized by severe cases of fatal muscle *** is one of the most common genetic causes of mortality among infants aged less than 2 *** research is currently receiving more attention,and new candidate biomarkers are constantly being *** review initially discusses the evaluation methods commonly used in clinical practice while briefly outlining their respective pros and *** also describe recent advancements in research and the clinical significance of molecular biomarkers for spinal muscular atrophy,which are classified as either specific or non-specific *** review provides new insights into the pathogenesis of spinal muscular atrophy,the mechanism of biomarkers in response to drug-modified therapies,the selection of biomarker candidates,and would promote the development of future ***,the successful utilization of biomarkers may facilitate the implementation of gene-targeting treatments for patients with spinal muscular atrophy.

关键词： biomarkers disease progression gene-targeting therapy neurofilaments Nusinersen spinal muscular atrophy(SMA) survival motor neuron therapeutic evaluation treatment outcomes

Observation of hyperbaric oxygen therapy's effects on delayed encephalopathy after acute carbon monoxide poisoning

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Observation of hyperbaric oxygen therapy's effects on delaye...

司美格鲁肽治疗2型糖尿病合并多发心血管疾病患者1例

第十六届国际高气压医学学术会议暨第十七届全国高压氧医学学术会议

作者： li li xu Yi liu Hong Mei Chen Taihe Hospital Affiliated To Yunyang Medical College,Hubei,China

Objective:To discuss the effects of hyperbaric oxygenation in delayed encephalopathy after acute carbon monoxide ***:50 patients were divided randomly into control group (19) with drage therapy and experimental group(...

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来源： cnki会议评论

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cnki会议

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中华糖尿病杂志 2022年第11期14卷 1310-1313页

作者：晏群李栩冯波同济大学附属东方医院内分泌科上海200120

该文回顾性分析1例在同济大学附属东方医院内分泌科就诊的2型糖尿病合并多发心血管疾病患者使用口服降糖药治疗后,转换为长效胰高糖素样肽-1(GLP-1)受体激动剂周制剂司美格鲁肽治疗的诊疗过程并进行文献复习。患者为56岁男性,因"发现血... 详细信息

该文回顾性分析1例在同济大学附属东方医院内分泌科就诊的2型糖尿病合并多发心血管疾病患者使用口服降糖药治疗后,转换为长效胰高糖素样肽-1(GLP-1)受体激动剂周制剂司美格鲁肽治疗的诊疗过程并进行文献复习。患者为56岁男性,因"发现血糖升高18年,血糖控制不佳半个月"入院,入院后完善各项检查,明确诊断为2型糖尿病合并多个动脉粥样硬化性心血管疾病。予胰岛素泵联合口服二甲双胍降糖治疗,逐步简化方案为二甲双胍0.5 g,3次/d,司美格鲁肽1 mg,1次/周,血糖控制良好,患者满意。司美格鲁肽是一种新型长效GLP-1受体激动剂,与其他口服降糖药物联合使用可实现平稳降糖的目标,且一周一次的使用相较于GLP-1类似物短效制剂患者依从性好,且对于合并高血压和心血管疾病患者带来更多获益。

关键词：糖尿病,2型司美格鲁肽动脉粥样硬化性心血管疾病

Advancements in life-on-a-chip: The impact of “Beyond limits Manufacturing” technology

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Chinese Chemical Letters 2024年第5期35卷 13-16页

作者： Weiwei He Hongbo Zhang xudong lin lili Zhu Tingting Zheng Hao Pei Yang Tian Min Zhang Guoyue Shi Lei Wu Jianlong Zhao Gulinuer Wumaier Shengqing li Yufang xu Honglin li xuhong Qian Shanghai Key Laboratory of New Drug Design School of PharmacyEast China University of Science and TechnologyShanghai 200237China School of Mechanical and Power Engineering East China University of Science and TechnologyShanghai 200237China Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument School of Biomedical EngineeringShenzhen Campus of Sun Yat-sen UniversityShenzhen 518000China Shanghai Key Laboratory of Green Chemistry and Chemical Processes Department of ChemistrySchool of Chemistry and Molecular EngineeringEast China Normal UniversityShanghai 200241China Shanghai Institute of Microsystem and Information Technology Chinese Academy of SciencesShanghai 200050China Department of Pulmonary and Critical Care Medicine Huashan HospitalFudan UniversityShanghai 200040China Innovation Center for AI and Drug Discovery East China Normal UniversityShanghai 200062China lingang Laboratory Shanghai 200031China

This review explores the concept of life-on-a-chip,which involves the creation of miniaturized biological systems,such as organs,tissues,and model organisms,on microscale platforms called microfluidic *** chips consist of intricately etched channels,wells,and chambers that enable precise control and observation of fluids,cells,and biochemical reactions,facilitating the simulation of various aspects of human or animal physiology and the study of responses to different stimuli,drugs,or disease *** review highlights the application of a novel technology,“Beyond limit Manufacturing”(BLM),in the development of sophisticated three-dimensional cell models and model organism ***-on-a-chip and organ-on-a-chip(OoC)are among the thriving developments in the field of microfluidics,allowing for the reconstruction of living microenvironments and implementation of multiple *** review discusses the latest advancements in life-on-a-chip technology using BLM and outlines potential future research directions,emphasizing the significant role of these chips in studying complex biological processes in a controlled and scalable manner.

关键词： Beyond limit Manufacturing Model-organism-on-a-chip Organ-on-a-chip

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用抑制性消减杂交方法筛选人肾癌相关基因

南方医科大学学报 2008年第1期28卷 89-93页

作者：王莹陈葳李旭西安交通大学医学院第一附属医院实验医学中心陕西西安710061

目的应用抑制性消减杂交技术构建人肾癌差异表达基因文库并进行差异表达基因筛选。方法以肾癌细胞株RLC-310和肾近曲小管细胞株HK-2互为实验组和对照组,提取mRNA,应用抑制性消减杂交技术进行正反两向消减杂交,获得人肾癌细胞差异表达基... 详细信息

目的应用抑制性消减杂交技术构建人肾癌差异表达基因文库并进行差异表达基因筛选。方法以肾癌细胞株RLC-310和肾近曲小管细胞株HK-2互为实验组和对照组,提取mRNA,应用抑制性消减杂交技术进行正反两向消减杂交,获得人肾癌细胞差异表达基因文库,结合反向Northern斑点印迹杂交,筛选差异基因克隆,并进行测序分析。结果正向和反向文库共包含1200多个阳性克隆,经斑点杂交筛选后,对213个差异克隆进行测序并经BLAST分析,得到144个差异表达基因,与肾癌相关的高表达基因67个,低表达基因77个,其中新EST14个,未知功能基因21个;对测序基因进行聚类分析发现与细胞生长、黏附、凋亡等肿瘤细胞生物学行为相关。结论该文库质量可靠,所筛选出的差异基因和新的基因为进一步筛选肾癌特异性相关基因,绘制肾癌差异基因表达谱,最终阐明肾癌发生、发展、转移机制提供了实验材料和研究靶点。

关键词：抑制性消减杂交技术肾癌,差异表达基因