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福建省菊科植物新记录种——光猫儿菊

福建林业科技 2022年第2期49卷 105-108页

作者：林舒晴黄诸侯陈玉燕徐惠龙刘小芬黄泽豪福建中医药大学福建福州350108 晋江市安海医院福建泉州362261

于2021年4月5日,在福建省南安市新田镇发现福建省菊科(Asteraceae)猫儿菊属(Hypochaeris L.)植物新记录种——光猫儿菊(Hypochaeris glabra Linnaeus)。该种植株形态与同属植物假蒲公英猫儿菊(Hypochaeris radicata Linnaeus)、蒲公英属(Tar axacum ***.)植物蒲公英(Taraxacum mongolicum Ha nd.-Mazz.)较为相似,该种为单生茎枝,根为须根系,叶子触感较薄且软,连萼瘦果具有长喙和短喙2种形态等特征可明显区别于假蒲公英猫儿菊,以及该种叶被柔毛、苞片直着向上和种子排列无序等特征区别于蒲公英。

关键词：光猫儿菊猫儿菊属新记录种福建省

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经皮穴位电刺激对选择性脊神经后根切断术患儿苏醒期躁动的影响

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临床麻醉学杂志 2024年第7期40卷 709-713页

作者：利雪阳吴安石昝京伟徐凯刘国凯任惠龙首都医科大学附属北京朝阳医院麻醉科 100020 北京中医药大学东直门医院麻醉科

目的探讨经皮穴位电刺激(TEAS)对选择性脊神经后根切断术(SPR)患儿苏醒期躁动(EA)的影响。方法选择择期在全麻下行SPR的脑瘫患儿42例,男20例,女22例,年龄6~12岁,BMI 13~24 kg/m^(2),ASAⅠ或Ⅱ级。将患儿随机分为两组:经皮穴位电刺激组(T... 详细信息

目的探讨经皮穴位电刺激(TEAS)对选择性脊神经后根切断术(SPR)患儿苏醒期躁动(EA)的影响。方法选择择期在全麻下行SPR的脑瘫患儿42例,男20例,女22例,年龄6~12岁,BMI 13~24 kg/m^(2),ASAⅠ或Ⅱ级。将患儿随机分为两组:经皮穴位电刺激组(T组)和对照组(C组),每组21例。T组于麻醉诱导前30 min给予TEAS双侧合谷穴及内关穴,持续至手术结束。C组在相同的穴位放置电极片,但不予电刺激。所有患儿均采用全凭静脉麻醉。记录入室时、拔管即刻、拔管后5、15、30 min的HR、MAP。记录术中瑞芬太尼和丙泊酚的用量、手术时间、拔管时间。记录拔管后15 min的Wong-Baker面部疼痛表情(FPS-R)评分和儿童麻醉苏醒期躁动评估量表(PAED)评分,并计算苏醒期躁动(EA)发生率。记录术后恶心呕吐(PONV)发生情况。结果与入室时比较,C组拔管即刻、拔管后5、15 min HR明显增快,拔管即刻、拔管后5、15、30 min MAP明显升高(P<0.05);T组拔管即刻、拔管后5、15 min HR明显增快,MAP明显升高(P<0.05)。与C组比较,T组拔管即刻、拔管后5、15、30 min HR明显减慢,MAP明显降低(P<0.05);术中瑞芬太尼用量明显减少,拔管时间明显缩短,术后FPS-R评分、PAED评分和EA发生率明显降低(P<0.05)。两组手术时间、术中丙泊酚用量和PONV发生率差异无统计学意义。结论TEAS可有效预防行SPR的脑瘫患儿EA发生,有利于维持血流动力学平稳,减少阿片类药物用量,减轻患儿术后疼痛,加快麻醉复苏时间。

关键词：经皮穴位电刺激选择性脊神经后根切断术脑瘫儿童苏醒期躁动

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应激对养殖鱼类的影响与防控研究进展

河北渔业 2024年第3期 41-46页

作者：邱惠龙徐晨曦费芳张新会河北科技师范学院海洋资源与环境学院河北秦皇岛066000 秦皇岛北戴河新区水产技术推广站河北秦皇岛066000

综合国内外研究动态,在重点分析养殖鱼类应激类型与发生机理的基础上,探讨防止应激发生和控制应激的措施,如:保持良好水质、使用抗应激和抗菌药物、开发抗氧化应激饲料、选育抗应激品种等。

关键词：养殖鱼类应激防控

不同来源使君子果实、种子形态特征与环境因子的相关性

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亚太传统医药 2022年第11期18卷 49-53页

作者：韦晓敏吴芳蕾林青青徐惠龙徐伟温秀萍杨成梓林羽刘蔚雯福建中医药大学药学院福建福州350122 福建中医药大学生物医药研发中心福建福州350122

目的:研究使君子种质资源的多样性水平。方法:基于相关性分析、聚类分析等方法,对我国3个主要产地使君子的果长、果径、果实重量及种子的长、宽以及重量进行统计分析。结果:居群内和相同产地的居群间使君子果实、种子之间性状差异不显著... 详细信息

目的:研究使君子种质资源的多样性水平。方法:基于相关性分析、聚类分析等方法,对我国3个主要产地使君子的果长、果径、果实重量及种子的长、宽以及重量进行统计分析。结果:居群内和相同产地的居群间使君子果实、种子之间性状差异不显著,不同产地的居群间使君子果实、种子之间性状差异显著;据相关分析表明,使君子性状在不同居群间差异极显著,与生态环境密切相关,居群间的形态分化与地理位置有明显关联。结论:使君子性状与居群间、生态环境、地理位置之间存在不同程度的差异性。

关键词：使君子果实种子形态特征生态环境

热淋清颗粒治疗尿路感染的多中心、开放性、Ⅳ期临床研究

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医学新知 2024年第7期34卷 786-795页

作者：王树声张俊华于雷唐汇龙宋旭叶纯华广东省中医院泌尿外科广州510120 天津中医药大学中医药研究院天津301617 黑龙江省医院泌尿外科哈尔滨150036 湖南中医药大学第一附属医院泌尿外科长沙410021 上海市第七人民医院泌尿外科上海200137 杭州师范大学附属医院泌尿外科杭州310015

目的评价热淋清颗粒在临床使用中的安全性与有效性,以指导优化临床给药方案和提高合理用药水平。方法在51家医院进行开放性、Ⅳ期临床试验,受试者为下焦湿热型单纯性或复杂性尿路感染,单纯性尿路感染患者给予热淋清颗粒每次8 g、每天3次... 详细信息

目的评价热淋清颗粒在临床使用中的安全性与有效性,以指导优化临床给药方案和提高合理用药水平。方法在51家医院进行开放性、Ⅳ期临床试验,受试者为下焦湿热型单纯性或复杂性尿路感染,单纯性尿路感染患者给予热淋清颗粒每次8 g、每天3次,疗程5 d。复杂性尿路感染患者给予热淋清颗粒每次8 g、每天3次,同时联合喹诺酮类抗生素,疗程7~14 d。结局指标为临床疗效、中医证候疗效、细菌清除率以及安全性。结果共纳入2009例受试者,其中11患者失访脱落。全分析集纳入1998例,其中单纯性尿路感染患者1532例,复杂性尿路感染患者466例。临床治愈率为68.57%,单纯性和复杂性尿路感染患者分别为74.41%和49.36%。中医证候痊显率为72.22%,单纯性和复杂性尿路感染患者分别为75.13%和62.66%。单纯性尿路感染中细菌培养阳性者的细菌转阴率为57.75%,细菌清除率为58.02%;复杂性尿路感染中细菌培养阳性者的细菌转阴率为45.59%,细菌清除率为43.92%。药物相关的不良反应发生24例次,其中单纯性尿路感染17例次,复杂性尿路感染7例次。结论热淋清颗粒治疗单纯性尿路感染的有效性和安全性较好,也可改善下焦湿热证中医证候。

关键词：热淋清颗粒尿路感染 Ⅳ期临床试验临床疗效安全性

Hierarchically Micro/Nanostructured Current Collectors Induced by Ultrafast Femtosecond Laser Strategy for High-Performance Lithium-ion Batteries

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Energy & Environmental Materials 2022年第3期5卷 969-976页

作者： Yaya Wang Zexu Zhao Jiang Zhong Tao Wang Lei Wang Hanjiao xu Jinhui Cao Jinhao Li Guanhua Zhang huilong Fei Jian Zhu State Key Laboratory for Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringHunan Key Laboratory of TwoDimensional MaterialsEngineering Research Center of Advanced CatalysisMinistry of EducationHunan UniversityChangsha 410082China State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body Hunan Provincial Key Laboratory of Intelligent Laser ManufacturingHunan UniversityChangsha 410082China College of Mechanical and Vehicle Engineering Hunan UniversityChangsha 410082China

Commercial Cu and Al current collectors for lithium-ion batteries(LIBs)possess high electrical conductivity,suitable chemical and electrochemical ***,the relatively flat surface of traditional current collectors causes weak bonding strength and poor electrochemical contact between current collectors and electrode materials,resulting in potential detachment of active materials and rapid capacity degradation during extended ***,we report an ultrafast femtosecond laser strategy to manufacture hierarchical micro/nanostructures on commercial Al and Cu foils as current collectors for high-performance *** hierarchically micro/nanostructured current collectors(HMNCCs)with high surface area and roughness offer strong adhesion to active materials,fast electronic delivery of entire electrodes,significantly improving reversible capacities and cyclic stability of HMNCCs based ***,LiNi_(0.5)Co_(0.2)Mn_(0.3)O_(2)(NCM523)cathode with Al HMNCC generated a high reversible capacity after 200 cycles(25%higher than that of cathode with Al CC).Besides,graphite anode with Cu HMNCC also maintained prominent reversible capacity even after 600 ***,the full cell assembled by graphite anode with Cu HMNCC and NCM523 cathode with Al HMNCC achieved high reversible capacity and remarkable cycling stability under industrial-grade mass *** study provides promising candidate for achieving high-performance LIBs current collectors.

关键词： currentcollectors femtosecondlaserstrategy hierarchical micro/nanostructures high rate performance lithium-ion battery

Ultra-stable and High-rate Lithium Ion Batteries Based on Metal-organic Framework-derived ln2O3 Nanocrystals/Hierarchically Porous Nitrogen-doped Carbon Anode

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Energy & Environmental Materials 2020年第2期3卷 177-185页

作者： Hanjiao xu Lei Wang Jiang Zhong Tao Wang Jinhui Cao Yaya Wang Xiuqi Li huilong Fei Jian Zhu Xidong Duan State Key Laboratory for Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringHunan Key Laboratory of TwoDimensional MaterialsHunan UniversityChangsha 410082China

Exploring electrode materials with attractive specific capacity and prominent cyclic durability is of the essence for promoting lithium ion batteries(LIBs).In2O3 has shown an extraordinary promise for LIBs with advantageous gravimetric capacity(theoretically 965 mA h g-1) and low working ***,In2O3 still suffers from the inherent weaknesses of metal oxides in practical application,especially low conductivity and incorrigible volume expansion upon the cycling ***,we demonstrate the architecture of metal-organic framework(MOF)-derived In2O3 nanocrystals/hierarchically porous nitrogen-doped carbon composite(In2O3/HPNC) for ultra-stable LIBs *** hierarchically porous structure(micro/meso/macro-pores) with nitrogen doping not only ensures exceptional mechanical strength and accommodates the volume expansion of In2O3 nanocrystals,but also offers electrons and lithium ions efficient interpenetrating pathways to migrate rapidly during charge/discharge ***,In2O3/HPNC exhibits excellent cyclic stability with a high specific capacity of 623 mA h g-1 over2000 cycles at 1000 mA g-1,corresponding to an ultra-low specific capacity decay of 0.017% per cycle(the best among the ln203-based anode for LIBs),and outstanding rate performance,suggesting a critical step toward achieving long-life and high-rate LIBs in practical devices.

关键词： hierarchically porous structure In203 nanocrystals metal-organic frameworks nitrogen-doping carbon ultra-stable lithium ion batteries

A Silicon Monoxide Lithium-Ion Battery Anode with Ultrahigh Areal Capacity

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Nano-Micro Letters 2022年第3期14卷 229-243页

作者： Jiang Zhong Tao Wang Lei Wang Lele Peng Shubin Fu Meng Zhang Jinhui Cao Xiang xu Junfei Liang huilong Fei Xidong Duan Bingan Lu Yiliu Wang Jian Zhu Xiangfeng Duan State Key Laboratory for Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringSchool of Physics and ElectronicsHunan Key Laboratory of Two‑Dimensional MaterialsEngineering Research Center of Advanced Catalysis of the Ministry of EducationHunan UniversityChangsha 410082People’s Republic of China International Graduate School at Shenzhen Tsinghua UniversityShenzhen 518057People’s Republic of China Key Laboratory of Structures Dynamic Behavior and Control of the Ministry of Education Key Laboratory of Smart Prevention and Mitigation of Civil Engineering Disasters of the Ministry of Industry and Information TechnologyHarbin Institute of TechnologyHarbin 150090People’s Republic of China School of Energy and Power Engineering North University of ChinaTaiyuan 030051People’s Republic of China Department of Chemistry and Biochemistry University of CaliforniaLos AngelesCA 90095USA

Silicon monoxide(SiO)is an attractive anode material for next-generation lithium-ion batteries for its ultra-high theoretical capacity of 2680 mAh g−*** studies to date have been limited to electrodes with a rela-tively low mass loading(<3.5 mg cm^(−2)),which has seriously restricted the areal capacity and its potential in practical *** areal capacity with such high-capacity materials is critical for capitalizing their potential in practi-cal ***,we report a monolithic three-dimensional(3D)large-sheet holey gra-phene framework/SiO(LHGF/SiO)composite for high-mass-loading *** specifically using large-sheet holey graphene building blocks,we construct LHGF with super-elasticity and exceptional mechanical robustness,which is essential for accommodating the large volume change of SiO and ensuring the structure integrity even at ultrahigh mass ***,the 3D porous graphene network structure in LHGF ensures excellent electron and ion *** systematically tailoring microstructure design,we show the LHGF/SiO anode with a mass loading of 44 mg cm^(−2)delivers a high areal capacity of 35.4 mAh cm^(−2)at a current of 8.8 mA cm^(−2)and retains a capacity of 10.6 mAh cm^(−2)at 17.6 mA cm^(−2),greatly exceeding those of the state-of-the-art commercial or research ***,we show an LHGF/SiO anode with an ultra-high mass loading of 94 mg cm^(−2)delivers an unprecedented areal capacity up to 140.8 mAh cm^(−2).The achievement of such high areal capacities marks a critical step toward realizing the full potential of high-capacity alloy-type electrode materials in practical lithium-ion batteries.

关键词： Silicon monoxide Large-sheet holey graphene Lithium-ion batteries High mass loading Ultra-high areal capacity

SNX14 deficiency-induced defective axonal mitochondrial transport in Purkinje cells underlies cerebellar ataxia and can be reversed by valproate

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National Science Review 2021年第7期8卷 72-85页

作者： Hongfeng Zhang Yujuan Hong Weijie Yang Ruimin Wang Ting Yao Jian Wang Ke Liu huilong Yuan Chaoqun xu Yuanyuan Zhou Guanxian Li Lishan Zhang Hong Luo Xian Zhang Dan Du Hao Sun Qiuyang Zheng Yun-Wu Zhang Yingjun Zhao Ying Zhou Huaxi xu Xin Wang State Key Laboratory of Cellular Stress Biology Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research Institute of Neuroscience School of Medicine Xiamen University National Institute for Data Science in Health and Medicine School of Medicine Xiamen University Cancer Research Center Department of Stomatology School of Medicine Xiamen University

Loss-of-function mutations in sorting nexin 14(SNX14) cause autosomal recessive spinocerebellar ataxia20, which is a form of early-onset cerebellar ataxia that lacks molecular mechanisms and mouse models. We generated Snx14-deficient mouse models and observed severe motor deficits and cell-autonomous Purkinje cell degeneration. SNX14 deficiency disrupted microtubule organization and mitochondrial transport in axons by destabilizing the microtubule-severing enzyme spastin, which is implicated in dominant hereditary spastic paraplegia with cerebellar ataxia, and compromised axonal integrity and mitochondrial function. Axonal transport disruption and mitochondrial dysfunction further led to degeneration of highenergy-demanding Purkinje cells, which resulted in the pathogenesis of cerebellar ataxia. The antiepileptic drug valproate ameliorated motor deficits and cerebellar degeneration in Snx14-deficient mice via the restoration of mitochondrial transport and function in Purkinje cells. Our study revealed an unprecedented role for SNX14-dependent axonal transport in cerebellar ataxia, demonstrated the convergence of SNX14 and spastin in mitochondrial dysfunction, and suggested valproate as a potential therapeutic agent.

关键词： sorting nexin 14 cerebellar ataxia Purkinje cell degeneration mitochondrial dysfunction axonal transport valproate