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干眼症的药物治疗策略及研究进展

中国处方药 2024年第2期22卷 168-170页

作者：秦红倩许卉烟台大学山东烟台264000

干眼症(DED)是一种复杂的多因素疾病,表现出不同的症状,这些症状可影响视觉功能,导致日常生活活动受限,工作效率降低,从而严重影响生活质量。本综述对目前临床上DED的治疗药物以及市场上正在开发的DED治疗策略进行总结,旨在对临床研究... 详细信息

干眼症(DED)是一种复杂的多因素疾病,表现出不同的症状,这些症状可影响视觉功能,导致日常生活活动受限,工作效率降低,从而严重影响生活质量。本综述对目前临床上DED的治疗药物以及市场上正在开发的DED治疗策略进行总结,旨在对临床研究提供参考。

关键词：干眼症治疗策略人工泪液非甾体抗炎药 Tivanisiran IL-1R拮抗剂 EBI-005

胆道支架联合125I粒子条植入治疗恶性梗阻性黄疸预后因素分析

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介入放射学杂志 2024年第7期33卷 758-762页

作者：郁泽宇余辉刁崚峰尤然冷斌徐清宇尹国文江苏省肿瘤医院(南京医科大学附属肿瘤医院)介入放射科江苏省肿瘤研究所江苏南京210009

目的探讨影响恶性梗阻性黄疸(MOJ)患者胆道支架植入联合125I粒子条内放射治疗预后的因素。方法回顾性分析2019年1月至2023年1月在江苏省肿瘤医院接受胆道支架植入联合125I粒子条内放射治疗的52例MOJ患者临床资料。记录手术前后淋巴免... 详细信息

目的探讨影响恶性梗阻性黄疸(MOJ)患者胆道支架植入联合125I粒子条内放射治疗预后的因素。方法回顾性分析2019年1月至2023年1月在江苏省肿瘤医院接受胆道支架植入联合125I粒子条内放射治疗的52例MOJ患者临床资料。记录手术前后淋巴免疫细胞数差值(ΔX)。采用X-tile软件计算ΔX最优截断值,并将其分为两组。采用单因素和多因素分析确定影响患者总生存期(OS)的危险因素。结果 52例患者生存时间为(201.0±32.1) d。单因素分析结果显示,术后TACE治疗、术前ALT、术前AST、Δ淋巴细胞、ΔCD3+T细胞、ΔCD8+T细胞、Δ自然杀伤细胞(NK)、Δ调节性T细胞(Treg)与OS显著相关,差异有统计学意义(均P<0.05)。多因素分析结果显示,Δ淋巴细胞(P=0.007)、ΔTreg(P=0.038)是OS独立危险因素。结论 MOJ患者Δ淋巴细胞≥0.237或ΔTreg≥0.21接受胆道支架植入联合125I粒子条内放射治疗,可能获得更长OS。

关键词：恶性梗阻性黄疸胆管癌胆道支架 125I粒子预后

Large Tunneling Magnetoresistance and Perfect Spin Filtering Effect in van der Waals Cu/FeX_(2)/h-BN/FeX_(2)/Cu(X=Cl,Br,I)Magnetic Tunnel Junctions

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Chinese Physics Letters 2024年第10期41卷 112-118页

作者： Xinlong Dong Xiaowen Shi Dan Qiao Zeyu Li Yuhao Bai Zhenhua Qiao Xiaohong xu College of Physics and Information Engineering Shanxi Normal UniversityTaiyuan 030031China Key Laboratory of Magnetic Molecules and Magnetic Information Materials of the Ministry of Education Research Institute of Materials ScienceShanxi Normal UniversityTaiyuan 030031China International Center for Quantum Design of Functional Materials University of Science and Technology of ChinaHefei 230026China Hefei National Laboratory University of Science and Technology of ChinaHefei 230088China

The two-dimensional magnetic van der Waals heterojunctions have opened unprecedented opportunities to explore new physics due to their potential for spintronic ***,combing density functional theory with non-equilibriu... 详细信息

关键词： technique. resistance Perfect

Generalization Bounds of ERM Algorithm with Markov Chain Samples

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Acta Mathematicae Applicatae Sinica 2014年第1期30卷 223-238页

作者： bin ZOU Zong-ben xu Jie xu Faculty of Mathematics and Computer Science Hubei University Institute for Information and System Science School of Mathematics and StatisticsXi’an Jiaotong University

One of the main goals of machine learning is to study the generalization performance of learning algorithms. The previous main results describing the generalization ability of learning algorithms are usually based on independent and identically distributed （i.i.d.） samples. However, independence is a very restrictive concept for both theory and real-world applications. In this paper we go far beyond this classical framework by establishing the bounds on the rate of relative uniform convergence for the Empirical Risk Minimization （ERM） algorithm with uniformly ergodic Markov chain samples. We not only obtain generalization bounds of ERM algorithm, but also show that the ERM algorithm with uniformly ergodic Markov chain samples is consistent. The established theory underlies application of ERM type of learning algorithms.

关键词： generalization bounds ERM algorithm relative uniform convergence uniformly ergodic Markovchain learning theory

Insights into the interplay between gut microbiota and lipid metabolism in the obesity management of canines and felines

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Journal of Animal Science and Biotechnology 2024年第5期15卷 1761-1777页

作者： Kaiqi Li Xiangyu Xiao Yuling Li Sichen Lu Jianghang Zi Xiaoqiang Sun Jia xu Hao‑Yu Liu Xiaoqiong Li Tongxing Song Demin Cai Laboratory of Animal Physiology and Molecular Nutrition Jiangsu Key Laboratory of Animal Genetic Breeding and Molecular DesignCollege of Animal Science and TechnologyYangzhou UniversityYangzhou 225009China College of Animal Science and Technology Huazhong Agricultural UniversityWuhan 430070China School of Life Science and Engineering Foshan UniversityFoshan 528231China State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro‑Products Institute of Food ScienceZhejiang Academy of Agricultural SciencesHangzhouZhejiang 310021People’s Republic of China College of Agriculture Jinhua PolytechnicJinhua 321017China

Obesity is a prevalent chronic disease that has significant negative impacts on humans and our companion animals,including dogs and *** occurs with multiple comorbidities,such as diabetes,hypertension,heart disease and osteoarthritis in dogs and cats.A direct link between lipid metabolism dysregulation and obesity-associated diseases has been ***,the understanding of such pathophysiology in companion animals is *** review aims to address the role of lipid metabolism in various metabolic disorders associated with obesity,emphasizing the involvement of the gut ***,we also discuss the management of obesity,including approaches like nutritional interventions,thus providing novel insights into obesity prevention and treatment for canines and felines.

关键词： Cat Dog Gut microbiota Lipid metabolism Obesity Management

An optimized high-throughput SARS-CoV-2 dual reporter trans-complementation system for antiviral screening in vitro and in vivo

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Virologica Sinica 2024年第3期39卷 447-458页

作者： Yingjian Li xue Tan Jikai Deng xuemei Liu Qianyun Liu Zhen Zhang Xiaoya Huang Chao Shen Ke xu Li Zhou Yu Chen State Key Laboratory of Virology RNA InstituteCollege of Life Sciences and Frontier Science Center for Immunology and MetabolismWuhan UniversityWuhan430072China Institute for Vaccine Research at Animal Bio-safety Level III Laboratory Wuhan University School of MedicineWuhan430071China

The severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is still epidemic around the *** manipulation of SARS-CoV-2 is restricted to biosafety level 3 laboratories(BSL-3).In this study,we developed a SARS-CoV-2ΔN-GFP-HiBiT replicon delivery particles(RDPs)encoding a dual reporter gene,GFP-HiBiT,capable of producing both GFP signal and luciferase *** optimal selection of the reporter gene,GFP-HiBiT demonstrated superior stability and convenience for antiviral ***,we established a RDP infection mouse model by delivering the N gene into K18-hACE2 KI mouse through *** mouse model supports RDP replication and can be utilized for in vivo antiviral *** summary,the RDP system serves as a valuable tool for efficient antiviral screening and studying the gene function of ***,this system can be manipulated in BSL-2 laboratories,decreasing the threshold of experimental requirements.

关键词： SARS-CoV-2 RDP Antiviral evaluation Mouse model BSL-2

Volatiles from Sophora japonica flowers attract Harmonia axyridis adults(Coleoptera: Coccinellidae)

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Journal of Integrative Agriculture 2019年第4期18卷 873-883页

作者： XIU Chun-li xu bin PAN Hong-sheng ZHANG Wei YANG Yi-zhong LU Yan-hui State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant Protection Chinese Academy of Agricultural Sciences College of Horticulture and Plant Protection Yangzhou University Lixiahe Regional Institute of Agricultural Sciences of Jiangsu Institute of Plant Protection Xinjiang Academy of Agricultural Sciences

The multicolored Asian lady beetle, Harmonia axyridis(Coleoptera: Coccinellidae), is a common generalist predator in China and is occasionally found gathering on the Chinese pagoda tree, Sophora japonica, in summer. In a field investigation, we found that H. axyridis adults preferred S. japonica during its flowering period even though their optimal prey(aphid) is absent at this time. In addition, male and female adults were attracted to S. japonica flowers to a similar extent in a Y-tube olfactometer assay. Using coupled gas chromatography-electroantennogram detection(GC-EAD), we identified a flower odor component(nonanal) that elicited a significant electrophysiological response in H. axyridis. Electroantennogram(EAG) dose-dependent responses revealed that the amplitude of the adult beetle's EAG response increased with increasing concentration of nonanal, peaking at 10 mg mL^(–1). In Y-tube olfactometer behavioral tests, H. axyridis adults preferred a 10 mg mL^(–1) nonanal source over a 100 mg mL^(–1) diluent. Under field conditions, the adults were significantly attracted to both concentrations(10 and 100 mg mL^(–1)), and high concentrations generally had greater attraction. All these results suggest that nonanal, a volatile compound of S. japonica flowers, greatly attracts H. axyridis adults. This study provides a basis for the development of synthetic attractants of H. axyridis, with the potential to promote biocontrol services of this generalist predator in the native area(e.g., China) and to suppress its population by mass trapping in its invasive areas.

关键词： flower preference plant volatile electrophysiological response behavioral response attractants

Sporophytic control of tapetal development and pollen fertility by a mitogen-activated protein kinase cascade in rice

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Journal of Integrative Plant Biology 2024年第7期66卷 1500-1516页

作者： Jianguo Zeng Manman Duan Yiqing Wang Guangtao Li Yujing You Jie Shi Changhao Liu Jinyang Zhang Juan xu Shuqun Zhang Jing Zhao Department of Plant Pathology Nanjing Agricultural UniversityNanjing 210095China State Key Laboratory of Plant Physiology and Biochemistry College of Life SciencesZhejiang UniversityHangzhou 310058China Division of Biochemistry University of MissouriColumbia65211MOUSA

Tapetum,the innermost layer of the anther wall,provides essential nutrients and materials for pollen *** degradation of anther tapetal cells is a prerequisite for normal pollen development in flowering *** cells facilitate male gametogenesis by providing cellular contents after highly coordinated programmed cell death(PCD).Tapetal development is regulated by a transcriptional ***,the signaling pathway(s)involved in this process are poorly *** this study,we report that a mitogen-activated protein kinase(MAPK)cascade composed of OsYDA1/OsYDA2-OsMKK4-OsMPK6 plays an important role in tapetal development and male gametophyte *** of function of this MAPK cascade leads to anther indehiscence,enlarged tapetum,and aborted pollen *** cells in osmkk4 and osmpk6 mutants exhibit an increased presence of lipid body-like structures within the cytoplasm,which is accompanied by a delayed occurrence of *** of a constitutively active version of OsMPK6(CA-OsMPK6)can rescue the pollen defects in osmkk4 mutants,confirming that OsMPK6 functions downstream of OsMKK4 in this *** crosses also demonstrated that the MAPK cascade sporophyticly regulates pollen *** study reveals a novel function of rice MAPK cascade in plant male reproductive biology.

关键词： degradation MAPK cascade pollen fertility rice tapetum

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中国儿童遗传性肾脏病数据库的建立及应用

中华医学杂志 2024年第16期104卷 1356-1359页

作者：徐虹国家儿童医学中心复旦大学附属儿科医院上海市肾脏发育和儿童肾脏病研究中心肾脏疾病全国重点实验室，上海201102

遗传性肾脏病是儿童和青少年慢性肾脏病的重要病因,也是成人期慢性肾脏病发病和进展中不容忽视的因素。构建遗传性肾脏病注册共享系统,形成具有中国人群特异性代表性数据,对于实现表型-基因型刻画、提高精准管理水平和病因机制研究具有... 详细信息

遗传性肾脏病是儿童和青少年慢性肾脏病的重要病因,也是成人期慢性肾脏病发病和进展中不容忽视的因素。构建遗传性肾脏病注册共享系统,形成具有中国人群特异性代表性数据,对于实现表型-基因型刻画、提高精准管理水平和病因机制研究具有重要意义。疾病异质性高、患者散在分布等特点使遗传性肾脏病缺乏认识和统一管理规范。由儿童肾脏病专科医师和遗传学专家主导,通过整合各中心数据源可发挥临床资源优势。聚焦不同亚类病种队列,整合分析基因型、多组学和临床结局等数据,可实现遗传性肾脏病疾病全链条诊治关键点的突破。

关键词：儿童遗传性肾脏病数据库基因表型