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Clinicopathological and prognostic analysis of 429 patients with intrahepatic cholangiocarcinoma

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World Journal of Gastroenterology 2009年第47期15卷 5976-5982页

作者： Wei-feng Shen Wei Zhong feng xu Tong Kan Li Geng feng Xie Cheng-Jun Sui Jia-Mei Yang Department of Special Treatment Eastern Hepatobiliary Surgery Hospital Second Military Medical University 225 Changhai Road Shanghai 200438 China Department of Gastroenterology Changzheng Hospital Second Military Medical University 415 Fengyang Road Shanghai 200003 China

AIM:To understand the clinicopathological characteristics and treatment selections and improve survival and provide valuable information for patients with intrahepatic cholangiocarcinoma(ICC). METHODS:We retrospectively evaluated 5311 liver cancer patients who received resection between October 1999 and December *** these,429(8.1%)patients were diagnosed with ICC,and their clinicopathological, surgical,and survival characteristics were analyzed. RESULTS:Upper abdominal discomfort or pain(65.0%), no symptoms(12.1%),and hypodynamia(8.2%)were the major causes for medical *** tests showed 198(46.4%)patients were HBsAg positive, 90(21.3%)hadα-fetoprotein>20μg/L,50(11.9%) carcinoembryonic antigen>10μg/L,and 242(57.5%) carbohydrate antigen 19-9(CA19-9)>37 U/*** data was available for 329(76.7%)patients and their mean survival time was 12.4 *** overall survival of the patients with R0,R1 resection and punching exploration were 18.3,6.6 and 5.6 mo,respectively. Additionally,CA19-9>37 U/mL was associated with lymph node metastases,but inversely associated *** analysis indicated that radical resection,lymph node metastases,macroscopic tumor thrombi and size,and CA19-9 were associated with prognosis. CONCLUSION:Surgical radical resection is still the most effective means to cure *** laboratory tests(such as CA19-9)can effectively predict the survival of the patients with ICC.

关键词： Intrahepatic cholangiocarcinoma Diagnosis Pathology Surgery Survival

Infection of post-harvest peaches by Monilinia fructicola accelerates sucrose decomposition and stimulates the Embden–Meyerhof–Parnas pathway

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Horticulture Research 2018年第1期5卷 299-307页

作者： Jingyu Kou Yingying Wei Xingxing He Jiayu xu feng xu Xingfeng Shao Department of Food Science and Engineering Ningbo UniversityNingboChina

To study the changes in sugar metabolism caused by fungal infection in post-harvest peaches,fruit from two cultivars(‘Baifeng’and‘Yulu’)was inoculated with Monilinia fructicola and stored at 10°*** disease development,soluble sugar content was monitored,as well as the activities and expression of selected *** progression was accompanied by a decrease in sucrose content and increases in reducing sugars and soluble solids,consistent with higher enzyme activities for acid invertase,neutral invertase and sucrose synthase-cleavage,and lower activities for sucrose synthase-synthesis and sucrose phosphate *** of phosphofructokinase,hexokinase,and pyruvate kinase,which are related to hexose metabolism,also *** changes stimulate the Embden–Meyerhof–Parnas(EMP)*** conclude that the fungal disease in peach fruit accelerates the decomposition of sucrose,thereby providing more glucose as a substrate to the EMP pathway.

关键词： cultivar sugar metabolism

N,O Co-Doping Enhanced Adsorption of Chloramphenicol for Highly Efficient and Robust Electrocatalytic Hydrodechlorination

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Chinese Journal of Chemistry 2024年第20期42卷 2445-2452页

作者： xue-feng Cheng Qiang Cao Qing Liu Hao-Yu Zhang Qing-feng xu Jian-Mei Lu College of Chemistry Chemical Engineering and Materials ScienceCollaborative Innovation Center of Suzhou Nano Science and TechnologySoochow UniversitySuzhouJiangsu 215123China

Electrocatalysis technology can effectively promote the hydrodechlorination of chloramphenicol(CAP)to reduce the ***,there are still some challenges such as low degradation rate and poor ***,we prepared porous N,O co-doped carbon supported Pd nanoparticles composites(Pd NPs/NO-C)for electrocatalytic degradation of *** doping of N and O not only effectively enhanced the interaction between substrate and CAP,promoting the mass transfer process,but also enhanced the anchoring effect on Pd nanoparticles,avoiding the occurrence of *** prepared composites achieved removal efficiency of CAP over 99%within 1 h,and the rate constant was as high as 6.72 h^(–1),outperforming previous reported ***,Pd NPs/NO-C composites showed a wide range of pH tolerance,excellent ion interference resistance and long-term *** work unravels the importance of mass transfer processes in solution to electrocatalytic hydrodechlorination and provides new research ideas for catalysts design.

关键词： Chloramphenicol Hydrodechlorination Electrocatalysis N,O co-doped carbon Mass transfer Supported catalysts Nanoparticles Low-dimensionalmaterials

Properties of quark matter in a new quasiparticle model with QCD running coupling

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Science China(Physics,Mechanics & Astronomy) 2016年第6期59卷 49-57页

作者： Zhen Yan Lu Guang Xiong Peng Jian feng xu Shi Peng Zhang School of Physical Sciences University of Chinese Academy of Sciences Theoretical Physics Center for Science Facilities Institute of High Energy Physics

The running of the QCD coupling in the effective mass causes thermodynamic inconsistency problem in the conventional quasiparticle model. We provide a novel treatment which removes the inconsistency by an effective bag constant. The chemical potential dependence of the renormalization subtraction point is constrained by the Cauchy condition in the chemical potential space. The stability and microscopic properties of strange quark matter are then studied within the completely self-consistent quasiparticle model, and the obtained equation of state of quark matter is applied to the investigation of strange stars. It is found that our improved model can describe well compact stars with mass about two times the solar mass, which indicates that such massive compact stars could be strange stars.

关键词： quark matter quasiparticle model thermodynamic inconsistency

Protective effects of 2,4-dihydroxybenzophenone against acetaminophen-induced hepatotoxicity in mice

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World Journal of Gastroenterology 2011年第21期17卷 2663-2666页

作者： Yue-Ying He Bao-xu Zhang feng-Lan Jia Department of Toxicology School of Public Health Peking University Beijing 100191 China

AIM:To examine the effects of 2,4-dihydroxybenzophenone(BP-1),a benzophenone derivative used as an ultraviolet light absorbent,on acetaminophen(APAP)induced hepatotoxicity in C57BL/6J ***:Mice were administered orally with BP-1 at doses of 200,400 and 800 mg/kg body weight respectively every morning for 4 d before a hepatotoxic dose of APAP(350 mg/kg body weight) was given *** four hours after APAP intoxication,the serum enzyme including serum alaine aminotransferase(ALT),aspartate aminotransferase(AST),lactate dehydrogenase(LDH) were measured and liver histopathologic changes were ***:BP-1 administration dramatically reduced serum ALT,AST and LDH *** histopathological examination showed that BP-1 administration antagonized APAP-induced liver pathological damage in a dose-dependent *** tests showed that APAP-induced hepatic lipid peroxidation was reduced significantly by BP-1 pretreatment,and glutathione depletion was ameliorated ***:BP-1 can effectively protect C57BL/6J mice from APAP-induced hepatotoxicity,and reduction of oxidative stress might be part of the protection mechanism.

关键词： 2 4-dihydroxybenzophenone Acetaminophen Hepatotoxicity

The Influences of Macro- and Microphysical Characteristics of Sea-Fog on Fog-Water Chemical Composition

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Advances in Atmospheric Sciences 2014年第3期31卷 624-636页

作者： YUE Yanyu NIU Shengjie ZHAO Lijuan ZHANG Yu xu feng Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Key Laboratory for Aerosol-Cloud-Precipitation of China Meteorological AdministrationNanjing University of Information Science & Technology Wuhan Central Meteorological Observatory Zhanjiang Meteorological Bureau Guangdong Ocean University

ABSTRACT During a sea-fog field observation campaign on Donghai Island in the spring of 2011, fog-water, visibility, meteorological elements, and fog droplet spectra were measured. The main cations and anions in 191 fog-water samples were Na＋, NH2, H＋, NO3, C1- and SO] , and the average concentrations of cations and anions were 2630 and 2970 p-eq L 1, respectively. The concentrations of Na＋ and C1- originated from the ocean were high. The enhancement of anthropogenic pollution might have contributed to the high concentration of NH＋, H＋, and NO^-3. The average values ofpH and electrical conductivity （EC） were 3.34 and 505 uS cm-1, respectively, with a negative correlation between them. Cold fronts associated with cyclonic circulations promoted the decline of ion loadings. Air masses from coastal areas had the highest ion loadings, contrary to those from the sea. The ranges of wind speed, wind direction and temperature corresponding to the maximum total ion concentration （TIC） were 3.5-4 m s-1, 79°-90° and 21°C-22°C, respectively. In view of the low correlation coefficients, a new parameter Lr was proposed as a predictive parameter for TIC and the correlation coefficient increased to 0.74. Based on aerosol concentrations during the sea-fog cases in 2010, we confirmed that fog-water chemical composition also depended on the species and sizes of aerosol particles. When a dust storm passed through Donghai Island, the number concentration of large aerosol particles （with diameter 〉 1 p-m） increased. This caused the ratio of CaZ＋/Na＋ in fog-water to increase significantly.

关键词： ion concentration synoptic weather system meteorological element fog microphysics aerosol

Mechanical Properties of ZnO Nanowires Under Different Loading Modes

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Nano Research 2010年第4期3卷 271-280页

作者： feng xu Qingqun Qin Ashish Mishra Yi Gu Yong Zhu Department of Mechanical and Aerospace Engineering North Carolina State UniversityRaleighNorth Carolina 27695USA Department of Physics and Astronomy Washington State UniversityPullmanWashington 99164USA

A systematic experimental and theoretical investigation of the elastic and failure properties of ZnO nanowires (NWs) under different loading modes has been carried out. In situ scanning electron microscopy (SEM) tension and buckling tests on single ZnO NWs along the polar direction [0001] were conducted. Both tensile modulus (from tension) and bending modulus (from buckling) were found to increase as the NW diameter decreased from 80 to 20 nm. The bending modulus increased more rapidly than the tensile modulus, which demonstrates that the elasticity size effects in ZnO NWs are mainly due to surface stiffening. Two models based on continuum mechanics were able to fit the experimental data very well. The tension experiments showed that fracture strain and strength of ZnO NWs increased as the NW diameter decreased. The excellent resilience of ZnO NWs is advantageous for their applications in nanoscale actuation, sensing, and energy conversion.

关键词： ZnO nanowire mechanical property size effect Young’s modulus fracture

Particle sizing in dense two-phase droplet systems by ultrasonic attenuation and velocity spectra

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Science China(Technological Sciences) 2009年第6期52卷 1502-1510页

作者： SU Mingxu CAI XiaoShu xuE MingHua DONG LiLi xu feng Institute of Particle and Two-phase Flow Measurement University of Shanghai for Science and TechnologyShanghai 200093China

Size and size distribution of particles in particulate two-phase flow play an important role in a wide variety of industrial areas,while their measurement still remains a hard task till *** wave as a mechanical vibration contains plenty of information about medium when it passes *** the size distribution could be extracted from the measured ultrasonic attenuation and velocity spectra by means of well established models and data processing *** paper contributes to the extraction of information of droplet size of a two-phase fat emulsion simultaneously from signals of broad-band ultrasonic attenuation and velocity *** to the formulated single particle scattering model,the relationship between particle size distribution and ultrasonic spectrum is *** sensitivities of ultrasonic spectra to the variation of particle size are ***-guishing features for attenuation and velocity spectra are *** calculations of inversion by optimum regularization factor method are carried out to yield the typical numerical results for *** on the proposed inversion algorithm and theoretical model,a fat emulsion sam-ple with a volume fraction up to 20% is measured and *** validate the proposed ultrasonic spectrum particle sizing method,the results are compared to those obtained from optical measure-ment.

关键词： two-phase flow ultrasonic particle sizing inversion

Theoretical Study on the Reaction Mechanism between Dichlorocarbene and Armchair Single-walled Carbon Nanotubes

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Chinese Journal of Structural Chemistry 2006年第9期25卷 1120-1128页

作者： LI Rui-Fang SHANG Zhen-feng xu Xiu-Fang WANG Gui-Chang Department of Chemistry Nankai University Tianjin 300071 China

The reaction mechanism between CC12 and armchair single-walled carbon nanotubes （ASWCNTs）（3,3） and （4,4） has been studied by semiempirical AM1 and ab initio methods. The activation barriers of CC12 adding to ASWCNT （3,3） and （4,4） are computed and compared. The lower barrier of CC12 forms cycloaddition isomer on （3,3） maybe because the strain energy of （3,3） is larger than that of （4,4）. Our theoretical results are consistent with the experimental results.

关键词： armchair single-walled carbon nanotubes dichlorocarbene reaction mechanism theoretical study